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CURRICULUM VITAE

Seth Charles Lummus, D.O., M.S.

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*** ***** *** **. ********, Colorado, 81120. Cell phone: 719-***-**** EDUCATION

• University of Colorado at Colorado Springs

B.A., Biology

B.A., Chemistry

GPA: 3.89

Magna cum Laude with Highest Distinction (Honors)

May, 2006

• Colorado State University

M.S., Biomedical Sciences; Emphasis on Anatomy and Physiology GPA: 4.00

August, 2007

• Kansas City University of Medicine and Biosciences D.O., Osteopathic Medicine

Magna cum Laude

Ranked 7th of 220

May, 2011

POST-GRADUATE MEDICAL TRAINING

• Anatomic and Clinical Pathology Residency: 2011-2016 Department of Pathology, University of Colorado Denver

• Pediatric Pathology Fellowship 2015 - 2016

Department of Pathology, Children’s Hospital Colorado

• Neuropathology Fellowship 2016 - 2018

Department of Pathology, Stanford University

HONORS AND AWARDS

• Harry B. Neustein Award 2015

o For platform presentation on: Elevated Cell Cycle and Muted Host Immunity Underlie the Biology of Infant Ependymomas at the 100th annual fall meeting of the Society for Pediatric Pathology, Toronto, Ontario, Canada on October 2nd, 2015

• Medical Student Teaching Award

Department of Pathology, University of Colorado Denver 2012 o I received this award based on my performance in and dedication to medical student teaching as a first- year resident

o I received this again as a third-year resident 2014

• Dean’s Award

Kansas City University of Medicine and Biosciences 2011 2

o This award is given to one graduate per year. It is presented in recognition of significant and meritorious contributions to the University community; particularly through participation in both student affairs and the general program while enhancing the overall quality and spirit of the college as well as the general field of medicine.

• Dr. David B. Wheeler Memorial Award in Pathology Kansas City University of Medicine and Biosciences 2011 o This award is given to one graduate per year at the Kansas City University of Medicine and Biosciences. It is presented in recognition of excellence in pathology and for continued commitment to advancing the field. This was presented to me by my friend and mentor, Ed Friedlander MD.

• Psi Sigma Alpha National Osteopathic Medical Honor Society Kansas City University of Medicine and Biosciences 2011 PROFESSIONAL BOARD CERTIFICATION

• Anatomic and Clinical Pathology 2016

• Pediatric Pathology 2017

• USMLE Step 1: Pass with a score of 235 (98)

• USMLE Step 2: Clinical Knowledge: Pass

• COMLEX Level 1: Pass with a score of 628 (91)

• COMLEX Level 2: Clinical Skills and Clinical Knowledge: Pass for both examinations

• COMLEX Level 3: Pass

Note: COMLEX is considered an equivalent to the USMLE that is designed for osteopathic students and graduates. LICENSURE

• State of Colorado, Medical Training License 2011 – 2014

• State of Colorado, Full Medical License 2014 – Current

• State of California, Full Medical License 2016 – Current

• State of Vermont, Full Medical License 2018 – Current

• State of New Hampshire, Full Medical License 2018 – Current CERTIFICATIONS

• State of Colorado Substitute Teacher 2019

• Wilderness First Responder 05/2004

• Swift-water Rescue technician 05/2004 - 2008

• ACLS Certification 06/2011

MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS

• American Society of Clinical Pathologists 2011 - Current

• College of American Pathologists 2011 – Current

• United States and Canadian Academy of Pathology 2014 – Current

• The American Association of Neuropathologists 2015 – Current POSITIONS HELD DURING RESIDENCY

• Chief Resident, Department of Pathology, University of Colorado Denver 2014- 2015

• College of American Pathologists 2012 – 2015

o Resident’s Forum Delegate

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• Department of Pathology, University of Colorado Denver 2011 – 2015 o Curriculum Committee

TEACHING EXPERIENCE

• Department of Pathology, University of Colorado Denver School of Medicine o Multiple Small Group Teaching Sessions, 1st and 2nd Year Medical Students 2011 – 2016 o Multiple presentations at multidisciplinary tumor boards 2011 – 2016 o Neuroanatomy Laboratory Classes for 1st and 2nd Year Medical Students 2013 – 2015

• The Children’s Hospital Colorado

o Multiple presentations at multidisciplinary tumor boards 2011 – 2016

• Colorado State University

o Graduate Teaching Assistant, Anatomy 2007

• University of Colorado at Colorado Springs

o Science Learning Center Tutor 2004 - 2006

o Gross Anatomy Laboratory Instructor 2004 – 2006

o General Biology Laboratory Instructor 2004

• Stanford University Medical School

o Multiple Small Group Teaching Sessions, 2nd Year Medical Students 2016-2018 o Multiple multidisciplinary tumor board presentations 2016-2018 o Multiple Morbidity and Mortality conference presentations 2016-2018

• Stanford University, Lucile Packard Children’s Hospital o Multiple multidisciplinary tumor board presentations 2016-2018 o Multiple Morbidity and Mortality conference presentations 2016-2018 SCHOLARSHIPS

• Morgan Berthrong Fellowship 2005

o This award was in the amount of 1,000 dollars, and it was awarded to me as an outstanding applicant by the biology department of the University of Colorado. As a fellow, I was awarded instructor teaching positions in the biology department.

• Undergraduate Research Scholar Award 2006

o This award was in the amount of 1,000 dollars, and it was awarded to me for my original research project proposal on the elucidation of C-type nerve fibers of the patellar tendon as described above.

• Dr. Strickland Physicians’ Hall of Sponsors Scholarship 2010 o This scholarship was in the amount of 750 dollars, and it was awarded to me as an outstanding applicant by the Kansas City University of Medicine and Biosciences.

• Dr. Strickland Physicians’ Hall of Sponsors Scholarship 2011 o This scholarship was in the amount of 1300 dollars, and it was awarded to me as an outstanding applicant by the Kansas City University of Medicine and Biosciences. PREVIOUS PROFESSIONAL POSITIONS

• Class-Five Whitewater Rafting Guide, Guide Instructor, and Trip Leader 2002- 2010

• Cardiovascular/ ECG Technician and Telemetry Technician 2006 - 2007 4

OTHER PREVIOUS EXPERIENCES AND POSITIONS

• President and Founder of the Fit Doctors Association – KCUMB interest group 2009-2011

• Bodies Revealed Exhibit Inside-Guide Volunteer 2008

• Cardiovascular/ECG Technician and Telemetry Technician 2006-2007

• President of βββ Biological Honor Society

University of Colorado at Colorado Springs Chapter 2006

• Wilderness First Responder 2002-2006

• Swift-Water Rescue Technician 2002-2008

• Humanitarian work in Jamaican orphanage and Deaf village 2005

• Lifeguard 2001-2002

• Car-Wash Manager 2002-2004

RESEARCH PROJECTS

• Neuropathology, Neurosurgery, and Neuroradiology, Stanford University o Multiple clinical research topics, manuscripts in process 2016-2018

• Foreman Laboratory, Children’s Colorado 2015-2016 o Neuro-oncology research with focus on infantile ependymomas

• Denver Health Cytology Laboratory 2012-2013

o Topic: Does the High Risk (HR) Human Papilloma Virus (HPV) RLU/CO ratio obtained in positive Hybrid Capture II RNA probing correlate with persistence of HPV and/or cytologic/histologic findings of cervical intraepithelial neoplasia CIN?

o This study consisted of a retrospective chart review of over 4,000 patients with a positive HPV high risk test result from Pap test specimens. A correlation was found with the duration of infection and significance of dysplasia to the value of the ratio obtained from the RNA probing method.

• Berry-Lowe Laboratory, University of Colorado at Colorado Springs 2005-2006 o Team leader

o I used techniques such as PCR, gel electrophoresis, and western blots to help characterize metabolic genes and proteins of the Chlamydomonas reinhardtii Chloroplasts. This research was conducted at the University of Colorado during my undergraduate years.

• Pigage Laboratory, University of Colorado at Colorado Springs 2005-2006 o Individual research project as undergraduate at the University of Colorado o I utilized immunohistochemistry techniques to locate the preponderance of C-type nerve fibers in various regions of the human patellar tendon, and I correlated this with the existence of the chronic pain mediator, substance P.

GRANTS

• The University of Colorado Undergraduate Research Scholar Award 2005 o This grant was in the amount 1,000 dollars, and it was awarded to me for my original research project proposal on the elucidation of C-type nerve fibers of the patellar tendon as described above.

• Saucony Run for Good 2008

o This grant was in the amount of 10,000 dollars. I wrote it for the funding of a collaborative effort by the Kansas City Track Club, the Kansas City University of Medicine and Biosciences (KCUMB), and Score One for Health to help fight childhood obesity. Saucony’s goal was to fight obesity by promoting running activities for children. The program this grant funded was aimed at supporting a fun-run, medical student mentoring, and running supplies such as shoes for elementary school children in the urban core Kansas City School districts. The grant also funded a nutritionist to assist the 5

KCUMB medical student volunteers with nutrition education for the elementary school students. With this grant, we encouraged interest in healthy living lifestyles and active physical activity. PUBLICATIONS

1. Lummus S, Kleinschmidt-DeMasters BK. Methylene blue "avatar" brain. J Neuropathol Exp Neurol. 2013;72(3):263-5.

2. Lummus S, Kleinschmidt-DeMasters BK. Predominantly periventricular necrotizing encephalitis due to toxoplasmosis: two unusual cases and review of literature. Clin Neuropathol. 2014 Jan-Feb;33(1):29-37. doi: 10.5414/NP300655.

3. Lummus S, Aisner D, Sams S, Foreman N, Lillehei K, Kleinschmidt-DeMasters BK. Massive Dissemination From Spinal Cord Gangliogliomas Negative for BRAF V600E: Report of Two Rare Adult Cases. Am J Clin Pathol. 2014 Aug;142(2):254-60. doi: 10.1309/AJCPIBSV67UVJRQV. 4. S. Lummus, R. Breeze, M.S. Lucia, B.K. Kleinschmidt-DeMasters. Histopathological Features of Intracranial Vascular Involvement in Fibromuscular Dysplasia, Ehlers-Danlos type IV, and Neurofibromatosis I. J Neuropathol Exp Neurol. 2014 Oct;73(10):916-32. doi: 10.1097/NEN.0000000000000113. 5. Lummus SC, Donson AM, Gowan K. et al. p16 Loss and E2F/cell cycle deregulation in infant posterior fossa ependymoma. Pediatr Blood Cancer. 2017 May 26. doi: 10.1002/pbc.26656. 6. V. Aladimir, AM. Donson, Lummus. S. et al. Characterization of 2 Novel Ependymoma Cell Lines With Chromosome 1 q Gain Derived From Posterior Fossa Tumors of Childhood. J Neuropathol Exp Neurol. Vol. 76, No. 7, July 2017.

7. Connolly I D, Johnson E, Lummus S, et al. (January 22, 2018) Massive Intradural Chondroma Masquerading as Lower Body Parkinsonism. Cureus 10(1): e2099. DOI 10.7759/cureus.2099 8. Culbertson CJ, Lummus SC, Gold CA. Teaching NeuroImages: Myeloperoxidase-anti-neutrophil cytoplasmic antibody-positive hypertrophic pachymeningitis. Neurology. 2017 Nov 21;89(21):e253. doi: 10.1212/WNL.0000000000004673.

9. Bush D. et al. (2018) Neonatal Onset Interstitial Lung Disease as a Primary Presenting Manifestation of Mucopolysaccharidosis Type I. In: . JIMD Reports. Springer, Berlin, Heidelberg 10. Perfusion MRI-based fractional tumor burden differentiates between tumor and treatment effect in recurrent glioblastomas and informs clinical decision-making. American Journal of Neuroradiology. In Press. MANUSCRIPTS IN PROGRESS

1. Seth Lummus; Reuben Antony; Lee-Way Jin; Hannes Vogel. Cortical mimic of pilocytic astrocytoma in infantile Alexander Disease: A case report

2. Seth Lummus; Samuel Cheshier; Donald Born. Lymphatic malformation occurring within the lateral ventricle: A case report.

3. Seth Lummus, Hannes Vogel, A survey of interneurons within hemimegalencephaly surgical resections, 10 cases.

4. Adrienne M. Moraff, Jonathan J. Liu, Huy M. Do, Michael Zhang, Johnny H. Wong, Seth Lummus, Hannes Vogel, and Gary K. Steinberg. A Rare Collision: Histologically Proven Glioblastoma and Arteriovenous Malformation Coexisting in a Single Lesion.

ABSTRACTS / MEETING PRESENTATIONS

1. Seth C Lummus, Andrew M Donson, Bette K Kleinschmidt-DeMasters, Nicholas K Foreman. Elevated Cell Cycle and Muted Host Immunity Underlie the Biology of Infant Ependymomas. Presented in platform presentation format at the 100th annual fall meeting of the Society for Pediatric Pathology, Toronto, Ontario, Canada on October 2nd, 2015

2. S Lummus, BK Kleinschmidt-DeMasters. Apicomplexan abscess case presentation. Diagnostic slide session. AANP annual meeting, Denver, CO. 2015

3. S Lummus. J Shows, M Handler, B.K. Kleinschmidt-DeMasters. Brain Stones Within The Pediatric Population Are Associated With A Variety Of Entities. Presented in poster format at the CAP annual meeting in Chicago, IL 2014.

4. K Mrachek, S Lummus, D Ney, D Damek, B.K. Kleinschmidt-DeMasters. Erdheim-Chester disease mimicking CLIPPERS. Presented in poster format at the CAP annual meeting in Chicago, IL 2014. 6

5. C Marshall, S Lummus, B. K. Kleinschmidt-DeMasters. Ehlers-Danlos with Periventricular Heterotopias: First Reported Autopsy Case Shows No Filaminopathy. Presented in poster format at the CAP annual meeting in Chicago, IL 2014.

6. S. Lummus, N. Foreman, B.K. Kleinschmidt-DeMasters. VE1 Immunoreactivity patterns in epithelioid glioblastomas positive for BRAF V600E mutation. Presented in poster format at the AANP meeting in Portland, OR 2014.

7. S. Lummus, R. Breeze, M.S. Lucia, B.K. Kleinschmidt-DeMasters. Histopathological Features of Intracranial Vascular Involvement in Fibromuscular Dysplasia, Ehlers-Danlos type IV, and Neurofibromatosis I. Presented in poster format at the AANP meeting in Portland, OR 2014. 8. S. Lummus, Z. Pan. Acute myeloid leukemia with a diagnostic dilemma of extensive bone marrow necrosis and abundant Charcot-Leyden crystals: Report of a case with review of the literature. Poster presented at College of American Pathologists Annual Meeting, Oct. 13, 2013 Orlando FL 9. S. Lummus, A. Donson, N. Foreman, B.K. Kleinschmidt-DeMasters. Low rate of BRAF V600E mutation in adult posterior fossa and spinal cord gangliogliomas compared to pediatric gangliogliomas. Poster presented at CAP annual meeting, Oct. 13, 2013 Orlando FL

10. S. Lummus, R. Breeze, M.S. Lucia, B.K. Kleinschmidt-DeMasters. Fibromuscular dysplasia (FMD) in intracranial and cranial vasculature: a series detailing histopathological features. Poster presented at CAP annual meeting, Oct .13, 2013 Orlando FL

11. S. Lummus, L. Gaido, J. Harper. Does the High Risk (HR) Human Papilloma Virus (HPV) RLU/CO ratio obtained in positive Hybrid Capture II RNA probing correlate with persistence of HPV and/or cytologic/histologic findings of cervical intraepithelial neoplasia CIN? Poster presented at ASCP annual meeting, Nov. 1, 2012, Boston MA. Oral platform presentation at ASCP annual meeting, Nov. 2, 2012, Boston, MA.

12. S. Lummus. Preponderance of pain fibers in the human patellar tendon. Poster presented at the Colorado Springs Research Symposium, Colorado Springs, CO, March 2006. 7

REFERENCES

Michael S. B. Edwards, M.D. Professor Emeritus of Pediatric Neurosurgery, Lucile Packard Children’s Hospital, Stanford University

Stanford University Medical Center

300 Pasteur Drive

Palo Alto, CA 94305

Phone: 650-***-****

E-Mail: adbs0i@r.postjobfree.com

Philip J. Boyer, M.D., Ph.D. Associate Professor, Department of Pathology East Carolina University, Brody School of Medicine Brody Building, 7S20

600 Moye Boulevard, Mailstop 642

Greenville, NC 27834

Phone: 252-***-****

E-Mail: adbs0i@r.postjobfree.com

Bette K. DeMasters, M.D. Professor, Departments of Pathology, Neurology, and Neurosurgery University of Colorado Denver

12605 E. 16th Ave., Mailstop F768

Aurora, CO 80045

Phone: 720-***-****

E-Mail: adbs0i@r.postjobfree.com

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