Associate Scientist at Pfizer, Science Teacher at Waterford High Schoo

Tessa A. (Hibbs) Castleberry

Permanent Address

** ****** ****

Mystic, CT 06355

Objective: Associate Scientist Position

Education: 2008 M.S. Education, University of New Haven

**** *.*. *****gy, Brown University

1994 B.S. Biology (Genetics & Developmental Biology option),

Minor in Microbiology, The Pennsylvania State University

Professional Work Experience:

8/2008-present Waterford Public Schools, Waterford, CT

Science Teacher—Biology, Integrated Science, Environmental Science

Grades 9-12

1/1997-6/2006 Pfizer Global Research and Development, Groton, CT

Dept. of Cardiovascular and Metabolic Diseases, Osteoporosis Group

Senior Associate Scientist in Cell & Molecular Biology Lab

Published 9 peer-reviewed research articles in scientific journals.

Presented work at poster sessions at international scientific meetings.

Techniques include DNA and RNA isolation and quantitation, ligations,

transformation, transfection, restriction enzyme usage, PCR, primer

generation, isolation of nucleic acid fragments for use as probes, Northerns,

Southerns, Westerns, RNase protection, immunohistochemistry, library

screening, cAMP assays, fluorescence polarization assays, ELISA, luciferase

assays, siRNA and antisense protocols, cell culture, and calcium content assay.

6/1994-1/1997 Pfizer Global Research and Development, Groton, CT

Dept. of Cancer, Inflammation, Immunology and Infectious Disease

Inflammation Group, Assistant Scientist

Performed human blood assays, washed monocyte assays and HL60

protein synthetic assays measuring activity of compounds on production of

IL-1α, IL-1B, IL-2, IL-6 and TNFα cytokines. Analyzed nNOS inhibitors.

1/1993-8/1993 Pfizer Global Research and Development, Groton, CT

Cooperative Education student in the Department of Immunology and

Infectious Diseases, Immunostimulation Group

Techniques include cytokine bioassays, elisa, microbicidal assays using

viable counts and fluorescent microscopy, peritoneal and bronchioalveolar

lavage, small animal injection(i.p., s.c., p.o.) and dissection.

8/1991-12/1992 Ecology Laboratory, The Pennsylvania State University

Laboratory and Field Assistant

Performed plant genetic experiments evaluating pollen performance.

Investigated plant genetic trait inheritance using agarose gel electrophoresis

Publications:

Research Papers:

Pettipher, E. R., T. A. Hibbs, M. A. Smith, and R. J. Griffiths. 1997. Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor. Inflammation research 46, supplement 2: S135-136.

Kleinman, E. F., E. Campbell, L. A. Giordano, V. L. Cohan, T. H. Jenkinson, J. B. Cheng, J. T. Shirley,

E. R. Pettipher, E. B. Salter, T. A. Hibbs, F. M. DiCapua, and J. Bordner. 1998. Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNFα inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4. J. Med. Chem. 41: 266-270.

Hibbs, T. A., B. Lu, S. L. Smock, P. Vestergaard, L. C. Pan, and T. A. Owen. 1999. Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins Lipid Med. 57: 133-147.

Smock, S. L., T. A. Castleberry, B. Lu, R. J. Mather, L. C. Pan, and T. A. Owen. 1999. Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype. Gene. 237: 393-402.

Castleberry, T. A., B. Lu, S. L. Smock, and T. A. Owen. 2001. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins Lipid Med. 65: 167-187.

Lu, B., S. L. Smock, T. A. Castleberry, and T. A. Owen. 2001. Molecular cloning and functional characterization of the canine androgen receptor. Mol. Cell. Biochem. 226: 129-140.

Smock, S. L., G. A. Vogt, T. A. Castleberry, B. Lu, and T. A. Owen. 2002. Molecular cloning and functional characterization of the canine parathyroid hormone receptor 1 (PTH1). Mol. Biol. Reports. 28: 235-43.

Owen, T. A., S. L. Smock, S. Prakash, L. Pinder, D. Brees, D. Krull, T. A. Castleberry, Y. C. Clancy, S. C. Marks, Jr., F. F. Safadi, and S. N. Popoff. 2003. Identification and characterization of the genes encoding human and mouse osteoactivin. Crit. Rev. Eukaryot. Gene Exp. 13: 205-220.

Owen, T. A., S. L. Smock, B. Lu, and T. A. Castleberry. 2005. High degree of conservation among primate prostaglandin E2 receptor EP4 subtypes. Manuscript in preparation.

Book Chapters:

Paralkar, V. M., W. A. Grasser, A. P. Baumann, T. A. Castleberry, T. A. Owen, and S. Vukicevic. 2002. Prostate derived factor and growth and differentiation factor-8: Newly discovered members of the TGF-B superfamily. Bone Morphogenetic Proteins. S. Vukicevic and K. T. Sampath, eds. Birkhauser Verlag, Basel. pp. 19 - 30.

Published Meeting Abstracts:

Smock, S. L., G. A. Vogt, T. A. Castleberry, B. Lu, and T. A. Owen. 1999. Molecular cloning and functional characterization of the canine parathyroid hormone receptor 1 (PTH1). American Society for Bone and Mineral Research. J. Bone and Min. Res. 14S: 288.

Owen, T. A., T. A. Castleberry, B. Lu, and S. L. Smock. 1999. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype. American Society for Bone and Mineral Research. J. Bone and Min. Res. 14S: 454.

Lu, B., S. L. Smock, T. A. Castleberry, and T. A. Owen. 1999. Molecular cloning and functional characterization of the canine androgen receptor. American Society for Cell Biology. Mol. Biol. of the Cell. 10: 325a.

Owen, T. A., S. L. Smock, C. Banjeree, K. S. Harrington, B. Lu, T. A. Castleberry, L. C. Pan, S. C. Marks, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein. 2001. Osteoblastic expression of the rat osteocalcin-EGFP transgene in mice and ex vivo. J. Bone and Min. Res. 16S: 262.

Owen, T. A., S. L. Smock, B. Lu, and T. A. Castleberry. 2001. Cloning, expression,

and functional characterization of three non-human primate

prostaglandin E2 EP4 subtype receptors. J. Bone and Min. Res. 16S: 491.

Owen, T. A., S. L. Smock, T. A. Castleberry, B. Lu, F. F. Safadi, and S. N. Popoff.

2001. Identification and characterization of the gene encoding human

osteoactivin. J. Bone and Min. Res. 16S: 489.

Popoff, S. N., F. F. Safadi, M. D’Angelo, A. Selim, S. L. Smock, T. A.

Castleberry, B. Lu, and T. A. Owen. 2001. Connective tissue growth factor

(CTGF) promotes osteoblast differentiation and stimulates bone formation. J.

Bone and Min. Res. 16S: 495.

Owen, T. A., S. L. Smock, Y. C. Clancy, S. Prakash, T. A. Castleberry, M. R.

Moalli, and L. C. Pan. 2003. Role of c-src inhibition in the differentiation of rat

osteoblasts in vitro. J. Bone and Min. Res. 18S: S340.

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