Assistant Professor Public Health
Resume:
April ****
CURRICULUM VITAE
Name:
XINZHI RICHARD CHEN, MD, PhD, MSN, MSc, BSN
Business Address:
University of Pittsburgh
School of Nursing
318A Victoria Building
Pittsburgh, PA 15261
Email Address:
*********@****.***
Business Phone:
Business Fax:
Education and Training
Undergraduate
1992-1997
Dalian Medical University, Dalian, P.R. China
M.D. equivalent
Medicine
2016-2017
Duquesne University School of Nursing, Pittsburgh, PA, USA
BSN Nursing
Graduate
2000-2003
Dalian Medical University, Dalian, P.R. China
M.Sc.
Public Health (Biochem-Toxicology)
2004-2009
University of Wisconsin-Madison, Madison, WI USA
Ph.D.
Neuroscience
2017-2020
Duquesne University School of Nursing, Pittsburgh, PA USA
MSN
Nursing Education
Postgraduate
2009-2012
National Institute of Aging, NIH, Baltimore, MD USA
Neuroscience
Appointments and Positions
Academic
2023 to present
University of Pittsburgh School of Nursing
Department of Acute & Tertiary Care, Pittsburgh, PA USA
Assistant Professor
2021 to 2023
Misericordia University, Nursing Department ABSN, Coraopolis, PA USA
Assistant professor
2016 to 2021
Duquesne University School of Nursing, Pittsburgh, PA USA
Adjunct faculty
2013 to 2015
University of Pittsburgh, School of Medicine
Department of Neurology, Pittsburgh, PA USA
Research Associate
2009-2012
BioVisions, Inc. /National institute of Aging, NIH
Baltimore, MD USA
Research Scientist /postdoc fellow
2004 to 2009
University of Wisconsin-Madison, School of Medicine
Department of Neurological Surgery, Madison, WI USA
Research Assistant
2005
University of Wisconsin-Madison, School of Medicine
Department of Zoology Madison, WI USA
Teaching Assistant
1997 to 2004
Dalian Medical University,
Department of Public Health Dalian, P.R. China
Assistant Professor/ Instructor (Primary)
1997 to 2003
Sino-Japanese Cooperation Medicament Science Research Institute, Dalian, P.R. China
Scientist (Secondary)
Non-Academic
2016-present
Steel City interpreters, Pittsburgh, PA USA
Professional Medical Interpreter (Mandarin)
2016-2021
University of Pittsburgh Medical Center
Montefiore Hospital, Pittsburgh, PA USA
Senior Professional staff Nurse
1996-1997
The First Affiliated Hospital of Dalian Medical University, Dalian, P.R. China
Medical Intern
Certification and Licensure
2016 to present
Pennsylvania State Board of Nursing, RN689713
2016 to present
American Heart Association, Basic Cardiac Life Support
Membership in Professional and Scientific Societies
2021- present
American Nurses Association/Pennsylvania State Nurses Association
Member
2010-2015
Sigma Xi
Member
2006- 2018
Society for Neuroscience
Member
1997-2003
Toxicology Professional Committee of Dalian Preventive Medicine, Dalian, P.R. China
Board member
1997-2003
Advanced teaching professionals, Dalian, P.R. China
Board member
Honors
1992-1997
Excellent Student Scholarship, Dalian Medical University, Dalian, P.R. China
1997
Excellent grad student of Liaoning province (State level), the Educational Committee of Liaoning, P.R. China
2007 & 2008
Vilas travel grant award, University of Wisconsin-Madison, Madison, WI USA
Publications
Refereed Articles * = Data Based; £ = Senior Author;
1.
Chen, X., Hong, X., Chen, Z., Lu, Y., Zhong, L. (2000). Effects of epidermal growth factor on morphology and MTT reduction of Hela cells. Journal of Dalian Medical University. 3:179-181.
2.
Chen, X., Lu, Y., Hong, X., Ye, J., Song, S., Zhong, L. (2000). The preventive effects of meglumine observed on the cisplatin-induced nephrotoxicity. Journal of Dalian Medical University. 4: 249-253.
3.
Chen, X., Lu, Y., Hong, X., Ye, J., Guan, Y., Zhong, L. (2000). The preventive effects of meglumine on nephrotoxicity induced by cisplatin. Journal of Health Toxicology. 4: 71
4.
Zhong, L., Chen, X., Lu, Y., Nan, H. (2001). The preventive effects of flavanols on Rat’s nephrotoxicity induced by cisplatin. Journal of Health Toxicology. 2: 54
5.
Chen, X., Lu, Y., Hong, X., Guan, Y., Zhong, L. (2002). The preventive effects of meglumine on Rat’s nephrotoxicity induced by cisplatin and discussion on its mechanism. Journal of China Public Heath. 1:53-54.
6.
Lu, Y., Li, Q., Chen, X., Liu, X., Ye, J., Song, S., Zhong, L. (2002). Protective effects of glutathione on cisplatin-induced toxicity to primary cultured rat renal tubular epithelial cells without sex-dependent difference. Journal of Dalian Medical University. 4: 244-246.
7.
Lu, Y., Li, Q., Gong, D., Dai, Z., Chen, X., Song, S., Zhong, L. (2003). The use of primary cell cultures to test drug-induced short-term toxicity. Journal of Health Toxicology. 17(2):12-114.
8.
Hong, X., Chen, X., Ye, J., Liu, X., Li, Q.,Song, S. Zhong, L. (2003). Inhibitory effect of cisplatin on proteasome. Journal of Health Toxicology. 17 (2): 84-86.
9.
Li, H., Chen, X., Zhong, L. (2003). Preventive effects of flavones on nephrotoxicity of cisplatin in Rats. Journal of Shenyang medical college. 5 (2): 109-111.
10.
Lu, Y., Chen, X., Zhong, L. (2003). Renal glutathione system and its toxicological significance. Journal of Environmental Hygiene. 30 (5): 274-278.
11.
Chen, X., Hong, X., Li, H., Lu, Y., Du, B., Zhong, L. (2003). Establishment of over-expressing ERCC1 protein cell line. Journal of Dalian Medical University. 25 (3): 163-168.
12.
* £Wang, H., Lian, H., Xu, J., Li, H., Chen, X. (2003). The preventive effects of silibinin on the cardiac toxicity caused by doxorubicin. Adverse Drug Reactions Journal. 6 (5): 371-374.
13.
Lu, Y., Li, Y., Du, B., Chen, X., Zhong, L. (2004). Decrease in accumulation of platinum in cisplatin treated HEK293 cells caused by non-protein sulfhydryl. Journal of Health Toxicology. 18 (3): 167-168.
14.
Li, H., Chen, X., Zhong, L. (2005). Study on DNA damage induced by aristolochic acid in vitro. Journal of Health Toxicology. 19 (4): 290-292.
15.
Du, B., Jiang, L., Xia, Q, Lu, Y. Chen, X., Zhong, L. (2006). The synergistic anti-proliferative effect of curcumin and fluorouracil on human colon cancer cell line HT-29. Acta Nutriment Sinica. (1): 75-79.
16.
Adibhatla, R. M., Hatcher, J. F., Larsen, E. C., Chen, X., Sun, D., & Tsao, F. H. (2006). CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. J Biol Chem, 281(10), 6718-6725. https://doi.org/10.1074/jbc.M512112200
17.
Luo, J., Wang, Y., Chen, X., Chen, H., Kintner, D. B., Shull, G. E., Philipson, K. D., & Sun, D. (2007). Increased tolerance to ischemic neuronal damage by knockdown of Na+-Ca2+ exchanger isoform 1. Ann N Y Acad Sci, 1099, 292-305 https://doi.org/10.1196/annals.1387.016
18.
Luo, J., Wang, Y., Chen, H., Kintner, D. B., Cramer, S. W., Gerdts, J. K., Chen, X., Shull, G. E., Philipson, K. D., & Sun, D. (2008). A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage. J Cereb Blood Flow Metab, 28(4), 737-746. https://doi.org/10.1038/sj.jcbfm.9600561
19.
Wang, Y., Luo, J., Chen, X., Chen, H., Cramer, S. W., & Sun, D. (2008). Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia. Eur J Neurosci, 28(1), 51-61. https://doi.org/10.1111/j.1460-9568.2008.06304.x
20.
Chen, X., Kintner, D. B., Luo, J., Baba, A., Matsuda, T., & Sun, D. (2008). Endoplasmic reticulum Ca2+ dysregulation and endoplasmic reticulum stress following in vitro neuronal ischemia: role of Na+-K+-Cl- cotransporter. J Neurochem, 106(4), 1563-1576. https://doi.org/10.1111/j.1471-4159.2008.05501.x
21.
Liu, Y., Kintner, D. B., Chanana, V., Algharabli, J., Chen, X., Gao, Y., Chen, J., Ferrazzano, P., Olson, J. K., & Sun, D. (2010). Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis. J Neurosci, 30(45), 152**-*****. https://doi.org/10.1523/JNEUROSCI.3950-10.2010
22.
Kintner, D. B., Chen, X., Currie, J., Chanana, V., Ferrazzano, P., Baba, A., Matsuda, T., Cohen, M., Orlowski, J., Chiu, S. Y., Taunton, J., & Sun, D. (2010). Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia. J Biol Chem, 285(45), 351**-*****. https://doi.org/10.1074/jbc.M110.101212
23.
Chen X*, Vitzthum, L*., Kintner, D. B., Huang, Y., Chiu, S. Y., Williams, J., & Sun, D. (2010). Study of Na+/H+ exchange-mediated pHi regulations in neuronal soma and neurites in compartmentalized microfluidic devices. *Contribute equally. Integr Biol (Camb), 2(1), 58-64. https://doi.org/10.1039/b918440f
24.
Chen, X., Kintner, D. B., Baba, A., Matsuda, T., Shull, G. E., & Sun, D. (2010). Protein aggregation in neurons following OGD: a role for Na+ and Ca2+ ionic dysregulation. J Neurochem, 112(1), 173-182. https://doi.org/10.1111/j.1471-4159.2009.06438.x
25.
Ferrazzano, P., Shi, Y., Manhas, N., Wang, Y., Hutchinson, B., Chen, X., Chanana, V., Gerdts, J., Meyerand, M. E., & Sun, D. (2011). Inhibiting the Na+/H+ exchanger reduces reperfusion injury: a small animal MRI study. Front Biosci (Elite Ed), 3(1), 81-88. https://doi.org/10.2741/e222
26.
Liu, D., Pitta, M., Jiang, H., Lee, J. H., Zhang, G., Chen, X., Kawamoto, E. M., & Mattson, M. P. (2013). Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol Aging, 34(6), 1564-1580. https://doi.org/10.1016/j.neurobiolaging.2012.11.020
27.
Jing, Z., Xing, J., Chen, X., Stetler, R. A., Weng, Z., Gan, Y., Zhang, F., Gao, Y., Chen, J., Leak, R. K., & Cao, G. (2014). Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury. J Cereb Blood Flow Metab, 34(10), 1613-1621. https://doi.org/10.1038/jcbfm.2014.119
28.
Chen, X., Arumugam, T. V., Cheng, Y. L., Lee, J. H., Chigurupati, S., Mattson, M. P., & Basta, M. (2018). Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke. Neuromolecular Med, 20(1), 63-72. https://doi.org/10.1007/s12017-017-8474-6
Published Abstracts
1.
Adibhatla, R.M., Hatcher, J.F., Larsen, E.C., Chen, X. (2006). CDP-choline partly restores phosphatidylcholine levels by affecting PLA2 and CTP-phosphocholine cytidylyltransferase after stroke. American society for neurochemistry, PTW05-7.
2.
Adibhatla RM, Hatcher JF, Larsen EC, Chen X, Sun D and Dempsey RJ. CDP-choline partly restores the phosphatidylcholine levels by differentially affecting secretory phospholipase A(2) IIA and CTP-phosphocholine cytidylyltransferase after stroke. Poster presented at Experimental Biology, San Francisco, CA, Apr 2006.
3.
Chen X, Wang Y, Chen H, Kintner DB, Philipson KD, Sun D. Knockdown of Na+/Ca2+ exchanger isoform 1 (NCX1) with SiRNA is neuroprotective in cerebral focal ischemia. (83.19/LL79) Poster presented at 36th annual meeting of Society for Neuroscience, Atlanta,GA, Oct 2006.
4.
Chen X, Luo J, Kintner DB, Wang Y, Sun D. Na+-K+-Cl- cotransporter contributes to neuronal ER stress and mitochondrial dysfunction following ischemia. (84.8/LL97) Poster presented at 36th annual meeting of Society for Neuroscience, Atlanta,GA, Oct 2006.
5.
Chen X, and Sun D. Na+-K+-Cl- cotransporter contributes to ER stress in neurons following in vitro ischemia. (55.23/R21) Poster presented at 37th annual meeting of Society for Neuroscience, San Diego, CA, Nov 2007.
6.
Kintner DB, Chen X, Cramer SW, Luo J, and Sun D. Dysregulation of endoplasmic reticulum calcium in response to oxygen glucose deprivation and reoxygenation: neurons vs. astrocytes. (55.24/R22) Poster presented at 37th annual meeting of Society for Neuroscience, San Diego, CA, Nov 2007.
7.
Vitzthum L, Chen X, Kintner DB, Huang Y, Williams J, Sun D. The role of Na+/H+ exchangers in the pH regulation of neuronal dendrites: A novel approach with microfluidic devices. (150.4/Y29) Poster presented at 38th annual meeting of Society for Neuroscience, Washington, DC, Nov 2008.
8.
Kintner DB, Chen X, Matsuda T, Baba A, Cohen M, Taunton J, Sun D. A role for NHE1 and NCX in dysregulation of dendritic ionic homeostasis following in vitro ischemia. (646.18/W31) Poster presented at 38th annual meeting of Society for Neuroscience, Washington, DC, Nov 2008.
9.
Chen X, and Sun D. Inhibition of Na+-K+-Cl- cotransporter attenuates ERAD dysfunction in neurons following in vitro ischemia. (646.20/W33) Poster presented at 38th annual meeting of Society for Neuroscience, Washington, DC, Nov 2008.
10.
Sun D, Chen X, Cohen M, Chiu B, Taunton J and Kintner DB. The concerted role of Na+/H+ exchanger and reversal of Na+/Ca2+ exchange in the dysregulation of dendritic Na+ and Ca2+ homeostasis and mitochondrial damage following in vitro ischemia. Poster presented at 39th Annual Meeting of the Society-for-Neuroscience, Chicago, IL, 2009
11.
Liu Y, Kintner DB, Chen X, Algharabli J, Olson J and Sun D. Activation of microglia following in vitro ischemia depends on Na+/H+ exchange-mediated H+ homeostasis. Poster presented at 39th Annual Meeting of the Society-for-Neuroscience, Chicago, IL, 2009
12.
Chen X, Mattson M and Basta M. Inhibition and Scavenging of Complement as Therapeutic Targets in the Mouse Model of Acute Ischemic Stroke (S103) Poster presented at 136th annual meeting of American Neurological Association, San Diego, CA, September 2011
13.
Liu D, Pitta M, Jiang H, Lee JH, Chen X, Zhang G, Mughal M and Mattson M. The NAD+ precursor nicotinamide ameliorates cognitive decline in a mouse model of Alzheimer’s Disease: evidence for the involvement of CREB, mitochondrial resistance to oxidative stress and autophagy. (665.07/K11) Poster presented at 41th annual meeting of Society for Neuroscience, Washington, DC, Nov 2011.
14.
Chen X, Lee JH, Wan R., Mughal MR, Liu D, Basta M, and Mattson M. Therapeutic efficacy of natural inhibitors of the complement cascade in a mouse model of focal ischemic. (62.04/FF10) Poster presented at 41th annual meeting of Society for Neuroscience, Washington, DC, Nov 2011.
15.
Chen X, Mattson M, Basta M. Inhibition and Scavenging of Complement as Therapeutic Targets in the Mouse Model of Acute Ischemic Stroke: S103. Annals of Neurology. 2011 Oct;70. https://onlinelibrary.wiley.com/doi/10.1002/ana.22579
Invited Reviews
1.
Chen, X., Zhao, S., Song, Y., Shi, Y., Leak, R. K., & Cao, G. (2015). The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia. Curr Top Med Chem, 15(21), 2211-2221. https://doi.org/10.2174/1568026615666150610142234
Book Chapters
1.
Chen, X., and Sun, D. (2008). ER Ca2+ dysregulation and ER stress in cerebral ischemic damage. New Frontiers in Neurological Research. 1-18.
2.
Eitan, O., Chen, X., Basta, M., Mattson, M. (2011). Roles of Innate Immunity and Inflammation in the Aging Brain. Inflammation, Life Style and Chronic Diseases. 1-36.
Other Publications
1.
Chen, X. (2003). The role of nucleotide excision repair in nephrotoxins-induced DNA damage in human embryonic kidney 293 cells. Master’s thesis, Dalian Medical University, Dalian, China
2.
Chen, X. (2009). Dissertation: ER Ca dysregulation and ER stress in ischemic neurons: role of Na -K -Cl cotransporter. Doctoral dissertation, University of Wisconsin-Madison, Madison, WI
Patent
2012-present
Combination therapy using immunoglobulin and C1-inhibitor. co-inventor. WO EP US CN JP KR AU CA DK ES HK AU2012311483B2 Xinzhi CHEN Csl Behring Gmbh PCT/EP2012/068643
Other Scholarly Activities
Journal Reviewer
2009- 2018
Ageing Research Reviews
International Journal of Nanomedicine
International Journal of Stroke
Journal of Central Nervous System Disease
Journal of Cerebral Blood Flow & Metabolism
Journal of Neurochemistry
Neurobiology of Aging
NeuroMolecular Medicine
Teaching
Primary Teacher
Term/Years
Course Number &Title
No. of
Students
Level
Didactic or
Clinical
2021-2023 Summer
NSG 401 - Functional Health Patterns of Adults III- Misericordia University
~25/term
ABSN
Didactic/sim
2021-2023 Summer
NSG 303 - Functional Health Patterns of Adults II- Misericordia University
~25/term
ABSN
Didactic/lab/sim
2021-2022 Fall
NSG 201 - Foundations Essential to Professional Nursing Practice- Misericordia University
~25/term
ABSN
Didactic/lab
1997-2004 Fall,
Spring
Nutrition; Food science; Toxicology; Environmental health; Occupational medicine-Dalian Medical University
800/year
Junior/ Senior MSc and ADN/ BSN
Didactic/lab/clinical
Clinical/Skills Lab Teacher
2024 Spring
NUR 1020C Advanced Nursing Management of the Adult with Acute/Complex Health Problems
7
Junior BSN
Clinical
2023 Fall
NUR 1020C Advanced Nursing Management of the Adult with Acute/Complex Health Problems
8
Junior BSN
Clinical
2021-2023 Summer
NSG 404C Functional Health Patterns Adults IV (Critical care)-Misericordia University
8-16/term
ABSN
Clinical/Sim
2021-2023 Summer
NSG 303L - Functional Health Patterns of Adults II Lab- Misericordia University
~25/term
ABSN
Lab/sim
2018 to 2021 Fall, Spring, Summer
UPNS 323 Adult Health and Illness -Duquesne University
8/semester
Junior /Senior BSN/ABSN
Lab/clinical/
2018 to 2021 Fall, Spring, Summer
UPNS 200 Fundamentals of Nursing Practice and Clinical Ethics-Duquesne University
8/semester
Junior /Senior BSN/ABSN
Lab/clinical/
2005
Teaching Assistant: Zoology 152 -University of Wisconsin-Madison
30
sophomore BSc.
Teaching Assistant
Guest Lecturer
Term
Course Number &Title
No. of Students
Level
Topic
2022 Fall
MHH314 Environmental Health
~20
Junior BSc.
Health and Safety in Healthcare
Specialized Contribution
1998-2003
The original question bank establishment for Chinese national medical licensing examination (MLE) system and training instructor.
Mentoring Activities
2023
Ashley Yang- BSN student
University of Pittsburgh URMP
2009
Yadira Arellano-Undergraduate student
University of Texas at El Paso
2007
Adriana Rosale-Undergraduate Student
UW-Madison Integrated Biological Sciences Summer Research Program/ the Ronald McNair Post-Baccalaureate Achievement Program
2006
Sam Cramer-Undergraduate student
University of Wisconsin-Madison
2005
Josiah Gerdts- Undergraduate student
University of Wisconsin-Madison
2003
Huimin Wang- Research fellow
Dalian medical university
Service
University
2023- present
NDFO- University of Pittsburgh-SON
2021-2023
Misericordia Interprofessional Education Connection (MIPEC)- Misericordia University
2021-2023
NDFO- Misericordia University
School of Nursing
2023-present
BSN Council - University of Pittsburgh SON
2021-2023
Undergraduate scholarship committee at the Department of nursing- Misericordia University
2021- 2023
Facilitator of Open House, the White Coat Ceremony, the Pinning Graduation Ceremony for ABSN nursing students at Misericordia University-Pittsburgh campus
Community Service/Activities
2016-present
Professional Medical Interpreter (Mandarin), Steel City interpreters, Pittsburgh, PA USA
I certify that this curriculum vitae is a current and accurate statement of my professional record.
Signature: Date: 04-30-2024
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