Curriculum Vitae

Date of preparation: March, **24

Personal Data:

Name: Robert L. Ullrich

Contact Information:

Email: ad4qlr@r.postjobfree.com

Mobile: 409-***-****

Academic and Professional Appointments:

2023- Adjunct Professor, Center for Radiological Research, Columbia University Irving Medical Center

2015-2023 Institutional Vice-Chair and American Director, Radiation Effects

Research Foundation, Hiroshima, Japan

2015-2023 Institutional Chief of Research, Radiation Effects Research Foundation, Hiroshima, Japan

2008-2015 Professor (tenured), Departments of Radiation Oncology and of Biochemistry and Molecular Biology, University of Texas Medical Branch (UTMB)

2001-2008 Professor (tenured), Departments of Environmental and Radiological Health Sciences and of Clinical Sciences, Colorado State University (CSU)

1988-2001 Professor (tenured), Dept. of Human Biological Chemistry and

Genetics, The University of Texas Medical Branch

1988-2001 Professor (tenured), Dept. of Radiation Oncology, The University of Texas Medical Branch

1975-1988 Research Associate to Senior Scientist/Director, Pathology Section (Radiation Carcinogenesis), Biology Division, Oak Ridge National Laboratory (ORNL)

Education:

06/1975 Ph.D. University of Rochester, Rochester, NY

Biophysics/Radiation Biology

Title of dissertation: Interrelationship between the

early inflammatory response and subsequent fibrosis

after radiation exposure.

Name of Advisor: George W. Casarett

Citation of publication: R.L. Ullrich and G.W. Casarett. Interrelationship between the early inflammatory response and subsequent fibrosis after radiation exposure. Radiat. Res. 72(1):107-121, 1977

06/1971 M.S. Creighton University, Omaha, Nebraska Biology/Physiology

06/1969 B.S. Creighton University, Omaha, Nebraska Biology/Chemistry

Training:

06/1982 Harvard Business School, Cambridge, MA

Executive Leadership Program on Management of Scientific Organizations

Professional Societies:

Radiation Research Society

American Association for Cancer Research

Honors and Awards:

2022: Inaugural Fellow, Radiation Research Society

2020: Lauriston S. Taylor Medal and Lecture, National Council on Radiation Protection and Measurements (NCRP)

2012-2014: John Costanzi Professor, UTMB

2012: Failla Medal, Radiation Research Society

2008-2014: John Sealy Distinguished Chair in Cancer Biology, UTMB

2006- Distinguished Emeritus Member, NCRP

2002-2008: Barbara Cox Anthony Distinguished University Chair, CSU

1997-2001: Vincent P. Collins Distinguished Professor, UTMB

1987: Radiation (R.J.M. Fry) Research Award, Radiation Research Society

Administrative Leadership:

2015-2023 Institutional Vice-Chair and American Director, Radiation Effects

Research Foundation, Hiroshima, Japan

2015-2023 Institutional Chief of Research, Radiation Effects Research Foundation,

Hiroshima, Japan

2013-2015 Associate Chief of Research, Radiation Effects Research

Foundation, Hiroshima, Japan

2009-2015 Interim Director, University of Texas Medical Branch Cancer Center

and Director, Sealy Center for Cancer Biology

2005-2020. Director, Multi-Institutional Specialized Center of Research on

Radiation Carcinogenesis (Colorado State/University of Texas Medical

Branch/University of Texas Southwestern/Washington

University/University of Chicago

2004-2008. Program Leader, Carcinogenesis and Chemoprevention Program,

University of Colorado Consortium Cancer Center

2004-2008 Institutional Representative Director: Colorado State

University Component, University of Colorado Consortium

Comprehensive Cancer Center

2001-2008. Director: Radiological Health Sciences and Cancer Research Program

of Research and Scholarly Excellence (PRSE), Colorado State

University

2001-2008. Director of Research, Robert H. and Mary G. Flint Animal Cancer

Center, Colorado State University

1988-2001 Vice-Chair, Department of Radiation Oncology, The University Texas

Medical Branch

1977-1988. Section Head, Pathology (Radiation Carcinogenesis) Section, Biology

Division, Oak Ridge National Laboratory

Educational Contributions

Advising and Mentorship:

Faculty Mentees: Kowetha Davidson (ORNL); Peggy Terzaghi- Howe (ORNL); Michael Cornforth (UTMB);Yongjia Yu (UTMB); Susan Bailey (CSU); Michael Weil (CSU); Mark Emmett (UTMB)

Doctoral Students: Major Professor:

Stephen Ethier; Laurel Adams; Charlotte Toewater; Eli Hanania; Brian Ponnaiya; David Reisman; Farzan Siddiqui; Jennifer Malone; Eli Williams (Joint/Susan Bailey); Lila Ramaiah; Greg Wilkerson; Rebecca Klingler; Tonya Sirisalee Magers, Abby Williams; Kristin Fabre; Xiangfei Liu; Ron Carsten; Carla Kantara (Joint/Pomila Singh)

Educational Administration and Leadership:

2008-2014 Director/PI: NIH T32, Multidisciplinary Training in Cancer Research, The University of Texas Medical Branch

2001-2008 Director/PI: NIH T32, Health Sciences Basic to Cancer Research, Colorado State University

1984-1989 Director/PI: NIH T32, Radiation Biology Training Program, Oak Ridge National Laboratory/University of Tennessee

Other Professional Activities:

State of Texas:

Cancer Prevention and Research Institute of Texas (CPRIT):

2012 Future Directions Working Group

2010-2013 Scientific Advisory Committee

National and International:

Radiation Research Society:

2002-2005 Vice-President elect (02-03); Vice President/President elect (03-04);

President (04-05)

1996-1998 Finance Committee

1995-1998 Member of Council, Radiation Research Society

1983-90 Associate Editor, Radiation Research

National Council on Radiation Protection and Measurements:

2006-present Distinguished Emeritus Member

1996-2002 Board of Directors

1993-2000 Chair, Nominating Committee

1990-1992 Scientific Committee 1-3 on Collective Dose

1988-2006 Member of Council

1977-1990 Scientific Committee 40, on the Biological Basis for Radiation Protection Criteria

International Commission on Radiation Protection:

1998-2009 Committee 1 (Vice-Chair 2001-2009)

1997-2006 Task Group on Estimates of Radiation-Induced Cancer at Low Doses

National Academy of Sciences/National Research Council:

1999-2005 Committee on Health Risks of Exposure to Low Levels of Ionizing Radiation (BEIR VII-Phase 2)

1997-1998 Committee on Health Risks of Exposure to Low Levels of Ionizing Radiation (BEIR VII-Phase 1)

1995-1996 Panel on Space Radiation Effects/Committee on Space Biology and Medicine/Space Studies Board

1979-1980 Consultant, NAS - Committee on Federal Research on Biological & Health Effects of Ionizing Radiation

National Institutes of Health:

1996-1998 Cancer Prevention and Control Programs Review Committee/Subcommittee E-Epidemiology

1994-1996 Cancer Center and Research Programs Review Committee/Subcommittee C-Basic Sciences

1987-1990 Radiation Study Section

Department of Energy:

1998 Chair, Low Dose Program Planning Committee

1992 Co-Chair, Radon Program Review Committee

NASA:

1996-1997Select Panel on Animal Experimentation at the Frontiers of Molecular,

Cellular and Tissue Radiobiology

1996-1997 Radiation Hazards to Crews of Interplanetary Missions:

Biological Issues and Research Strategies

European Union:

2002-2007 Advisory Committee for RISCRAD program

United Nations/World Health Organization (WHO):

2001-2003 United Nations Scientific Committee on Effects of Atomic Radiation

(UNSCEAR)

International Association for Research on Cancer:

2000-2014 Member, Working groups on evaluation of ionizing

radiation as a human carcinogen (animal carcinogenesis subgroups (2000; 2009 chair); mechanisms of radiation carcinogenesis (2012); Monographs: Vols. 75 (2000); 100D (2009); 100G (2012); 100K (2014)

Publications:

1Igor Shuryak, Zhenqiu Liu, Eric Wang, Robert L. Ullrich, David J. Brenner. Causal machine learning analysis of leukemia and solid tumor incidence data in Japanese atomic bomb survivors. Submitted.

2Zhenqiu Liu, Tomoki Nakamizo, Munchika Misumi, Satoru Ono, Igor Shuryak, David Brenner, Robert Ullrich. The Promise and Challenges of Deep Learning for Radiation Risk Prediction. Submitted.

3Liang-Hao Ding, Christina M. Fallgren, Yongjia Yu, Maureen McCarthy, Elijah F. Edmondson, Robert L. Ullrich, Michael. M. Weil, Michael D. Story. Orthologs of Human Circulating miRNAs Associated with Hepatocellular Carcinoma Are Elevated in Mouse Plasma Months before Tumor Detection. Scientific Reports 12: 10927, 2022.

4Brooke L Barnette, Yongjia Yu, Robert L Ullrich, Mark R Emmett. Mitochondrial Effects in Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge Irradiation. Int J. Mol. Sci. 22: 11806, 2021.

5Liang-Hao Ding, Yongjia Yu, Elijah F. Edmondson, Michael. M. Weil, Laurentiu M. Pop, Maureen McCarthy, Robert L. Ullrich, Michael D. Story. Comparative Transcriptome Analysis Links HZE Ion Radiation-Induced Hepatocellular Carcinoma (HCC) in Mice to a Subtype of HCC in Humans. Scientific Reports 7:11(1):14052, 2021

6Evagelia C. Laiakis, Igor Shuryak, Annabella Deziel, Yiwen Wang, Brooke L. Barnette, Yongjia Yu, Robert L. Ullrich, Albert J. Fornace Jr, Mark R. Emmett. Effects of low dose space radiation exposures on the splenic metabolome. Int. J. Mol. Sci. 22(6), 3070; 2021.

7Anna M. Nia, Alexander Shavkunov, Robert L. Ullrich, Mark R. Emmett. 137Cs γ ray and 28Si Irradiation Induced Murine Hepatocellular Carcinoma Lipid Changes in Liver Assessed by MALDI-MSI Combined with Spatial Shrunken Centroid Clustering Algorithm. ACS Omega 5:25164−25174, 2020.

8Anna M. Nia, Kamil Khanipov, Brooke L. Barnette, Robert L. Ullrich, George Golovko, Mark R. Emmett. Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma. BMC Genomics, 21:453, 2020.

9Anna M. Nia, Tianlong Chen, Brooke L. Barnette, Kamil Khanipov, Robert L. Ullrich, Suresh K. Bhavnani, Mark R. Emmett. Efficient Identification of Multiple Pathways: RNA-Seq Analysis of Livers from 56Fe Ion Irradiated Mice. BMC Bioinformatics 21:118, 2020.

10E.J Grant, K. Ozasa, N. Ban, A.B. De Gonzales, J. Cologne, H.M. Cullings, R.L. Ullrich. The evaluation of effects of low dose radiation exposure in the life span study of atomic bomb survivors. Health Physics 108: 551-556, 2015.

11Carla Kantara, Stephanie M. Moya, Courtney W. Houchen, Shahid Umar, Robert L. Ullrich, Pomila Singh, Darrell H. Carney. TP508, A Novel Regenerative Peptide, Mitigates Radiation-Induced Gastrointestinal Damage By Preserving Crypt Integrity And Activating Crypt Stem Cells. Lab Investigation, 95(11): 1222-1233, 2015.

12Crowley KD, Cullings HM, Landes RD, Shore RE, Ullrich RL. Comments on Estimating Risks of Low Radiation Doses-A Critical Review of the BEIR VII Report and Its Use of the Linear No-Threshold (LNT) Hypothesis by Edward J. Calabrese and Michael K. O'Connor. Radiat Res, 183:476-81, 2015.

13Melpo Christofidou-Solomidou, Ralph Pietrofesa, Evguenia Arguiri, Kelly Schweitzer, Evgeny Berdyshev, Maureen McCarthy, Astrid Corbitt, Joshua Alwood, Yongjia Yu, Ruth Globus, Charalambos Solomides, Robert Ullrich, and Irina Petrache. Space Radiation Associated Lung Injury in a Murine Model. Am J Physiol Lung Cell Mol Physiol. 308(5):L416-28, 2015.

14Carla Kantara, Malaney O'Connell, Gurinder Luthra, Aakash Gajjar, Robert Ullrich, Shubhashish Sarkar, and Pomila Singh. Methods for Detecting Circulating Cancer Stem Cells (CCSCs) as a Novel Approach for Diagnosis of Colon Cancer Relapse/Metastasis. Lab. Investigation 95:100-112, 2014

15Paula C. Genik, Irina Vyazunova, Leta S. Steffen, Jeffery W. Bacherb, Helle Bielefeldt-Ohmann, Scott McKercher, Robert L. Ullrich, Christina M. Fallgren, Michael M. Weil, F. Andrew Ray. Leukemogenesis in Heterozygous PU.1 Knockout Mice. Radiation Research, 182:310-315,2014.

16Michael M. Weil, Andrew Ray, Jeffrey W. Bacher, Joel S. Bedford, Leta Steffen, Lianghao Ding, Helle Bielefeldt-Ohmann, Paula C. Genik, Bradford Loucas, Yongjia Yu, Maureen McCarthy, Astrid Corbin, Lauren Macias, Daniel Olivares, Christina M. Fallgren, Michael D. Story, and Robert L. Ullrich. Effects of 350 MeV/n 28Si and 600MeV/n 56Fe ions on the induction of acute myeloid leukemia and hepatocellular carcinoma. PLoS One Aug 15;9(8):e104819. doi: 10.1371/journal.pone.0104819. eCollection 2014.

17Carla Kantara, Ixiu Ortiz, Joyce Kuo, Robert Davey, Kenneth Escobar, Robert Ullrich, and Pomila Singh. Curcumin promotes autophagic survival of a sub-set of DCLK1+vecolon cancer stem cells, which is ablated by DCLK1-siRNA Cancer Research 74: 2487-2498, 2014.

18Leta S. Steffen, Jeffery W. Bacher, Yuanlin Peng, Paula C. Genik, Phuong N. Le, F. Andrew Ray, Joel S. Bedford, Christina M. Fallgren, Susan M. Bailey, Robert L. Ullrich, Michael M. Weil, Liang-Hao Ding, Michael D. Story. Molecular characterization of murine acute myeloid leukemia induced by 56Fe ion and 137Cs gamma-ray irradiation. Mutagenesis 28: 71-79, 2013.

19Shubhashish Sarkar, Carla Kantara, Ixiu Ortiz, Rafal Swiercz, Joyce Kuo, Robert Davey, Kenneth Escobar, Robert Ullrich, and Pomila Singh. Progastrin overexpression imparts metastatic potential and increases stem cell populations co-expressing AnnexinA2. Int J Cancer 131(7): 1088-99, 2012.

20Bielefeldt-Ohmann H, Genik PC, Fallgren CM, Ullrich RL, Weil MM. Animal Studies of Charged Particle-induced Carcinogenesis. Health Phys. 103: 568-76, 2012.

21Igor Shuryak, David J. Brenner, and Robert L. Ullrich. Gamma rays and neutrons produce cancer through different mechanisms. PLoS One. 2011; 6(12):e28559. Epub 2011 Dec 14.

22Kristin M. Fabre, Lila Ramaiah, Ryan C. Dregalla, Christian Desaintes, Michael M. Weil, Susan M. Bailey, and Robert L. Ullrich. Murine Prkdc polymorphisms impact DNA-PKcs function. Radiation Research 175: 493-500, 2011

23Igor Shuryak, Robert L. Ullrich, Rainer K. Sachs, and David J. Brenner. The Balance Between Initiation and Promotion in Radiation-Induced Murine Carcinogenesis. Radiation Research 174: 357-366, 2010.

24S.M. Bailey, E.S. Williams, R.L Ullrich. The role of telomere dysfunction in driving genomic instability. Radiation Health Risk Sciences, 199-203, 2009.

25El Ghissassi F, Baan R, Straif K, Grosse Y, Secretan B, Bouvard V, Ullrich RL. A review of human carcinogens – part D: radiation. WHO International Agency for Research on Cancer Monograph Working Group. Lancet Oncol 10: 751-752, 2009.

26M. M. Weil, J. S. Bedford, E. J. Ehrhart, F. A. Ray, P. C. Genik, C. Fallgren, M. Callan, R. L. Ullrich. Incidence of acute myeloid leukemia and hepatocellular carcinoma in 1 GeV/n 56Fe irradiated mice. Radiation Research, 172: 213-219, 2009.

27Yuanlin Peng, Thomas B. Borak, Simon D. Bouffler, Robert L. Ullrich, Michael M. Weil, and Joel S. Bedford. Radiation Leukemogenesis in Mice: Loss of PU.1 on Chromosome 2 in CBA/Ca and C57BL/6 Mice after Irradiation with 1 GeV/n 56Fe Ions or γ-Rays. Part II. Theoretical Considerations Based on Microdosimetry and the Initial Induction of Chromosome Aberrations. Radiation Research 171: 484-493, 2009.

28Yuanlin Peng, Natalie Brown, Rosemary Finnon, Christy L. Warner, Xianan Liu, Paula C. Genik, Matthew A. Callan, F. Andrew Ray, Thomas B. Borak, Christophe Badie, Simon D. Bouffler, Robert L. Ullrich, Joel S. Bedford, and Michael M. Weil. Radiation Leukemogenesis in Mice: Loss of PU.1 on Chromosome 2 in CBA/Ca and C57BL/6 Mice after Irradiation with 1 GeV/n 56Fe Ions, X- or γ-rays. Part I. Experimental Observations. Radiation Research 171: 474-483, 2009

29Eli S. Williams, Rebekah Klingler, Brian Ponnaiya, Tonya Hardt, Evelin Schrock, Susan P. Lees-Miller, Katheryn Meek, Robert L. Ullrich, and Susan M. Bailey. Telomere Dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Research 69: 2100-2107, 2009.

30T. Magers, R. Klingler, M. Lavin, R. Ullrich. Characterizing the role of ATM heterozygotes in radiation-induced mammary cancer using an in vitro mammary stem cell system. Cancer Research 68: 603-610, 2008.

31L. Ramaiah, M. Weil, C. Desaintes, R. Ullrich. Characterization of DNA repair in mice congenic for the polymorphic DNA repair gene Prkdc: implications for susceptibility to breast cancer. Toxicologic Pathology 36: 150-160, 2008.

32R. Tanner Hagelstrom, Kristin F. Askin, Abby J. Williams, Lila Ramaiah, Christian Desaintes, Howard Liber, Robert L. Ullrich, and Susan M. Bailey. DNA-PKcs & ATM influence the generation of ionizing radiation-induced bystander signals. Oncogene: 27(53):6761-9, 2008.

33Robert L. Ullrich. Etiology of Cancer: Physical Factors. In: Principals and Practice of Oncology. 8th edition. DeVita, Hellman, and Rosenberg (eds.), 211-226, 2008.

34F. Siddiqui, P. Avery, CY Li, S LaRue, M.W. Dewhirst, R. Ullrich. Induction of human heat shock promoter hsp70b by nutritional stress: Implications for cancer gene therapy. Cancer Investigation: 26(6):553-61, 2008.

35Carsten RE, Bachand A, Bailey SM, Ullrich RL. Resveratrol reduces radiation-induced chromosome aberration frequency in mouse bone marrow cells. Radiation Research, 169: 633-638, 2008.

36Eli S. Williams, Jan Stap, Jeroen Essers, Brian Ponnaiya, Martijn S. Luijsterburg, Prezemek M, Krawczyk, Robert L. Ullrich, Jacob A. Aten, and Susan M. Bailey. DNA double strand breaks are not sufficient to initiate the recruitment of TRF-2. Nature Genetics: 39(6), 696-698, 2007.

37Farzan Siddiqui, Chuan-Yuan Li, Susan M. LaRue, Jean M. Poulson, Paul R. Avery, Amy F. Pruitt, Xiuwu Zhang, Robert L. Ullrich, Donald E. Thrall, Mark W. Dewhirst, and Marlene L. Hauck. A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcoma. Molecular Cancer Therapeutics, 6: 380-389, 2007.

38J. Malone and R. L. Ullrich. Identification of radiation-responsive genes in MCF-10A cells using a gene-trap strategy. Radiation Research, 167: 176-184, 2007.

39Ying Zhang, Junqing Zhou, Xiaofan Cao, Qinming Zhang, Chang U.K. Lim, Susan M. Bailey, Robert L. Ullrich and Howard L. Liber. Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells. Cancer Letters, 250:63-73, 2007.

40Susan M. Bailey, Eli S. Williams, Robert L. Ullrich. The role of telomere dysfunction in driving genomic instability. Int. Congress Series 129*-***-***. 2007.

41A. L. Brooks, M Coleman, E Douple, E. J. Hall, R. Mitchel, R. L. Ullrich, and A. J. Wyrobek. Biological Effects of Low Doses of Ionizing Radiation. In: Advances in Medical Physics. A. Wolbarst, R. Zamenhof, and W. Hendee, (eds.), pp. 255-286, 2006.

42Farzan Siddiqui, E. J. Ehrhart, Brad Charles, Laura Chubb, Chuan-Yuan Li, Xiuwu Zhang, Susan M. Larue, Paul R. Avery, Mark W. Dewhirst, Robert L. Ullrich. Anti- angiogenic effects of interleuken-12 delivered by a novel hyperthermia induced gene construct. Int J of Hyperthermia, 22(7), 587-606, 2006.

43F. Siddiqui, CY Li, S LaRue, M.W. Dewhirst, R. L. Ullrich. Characterization of a recombinant adenovirus vector encoding heat inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. Int J. of Hyperthermia, 22(2), 117-134, 2006.

44F. Darakhshan, C. Badie, J. Moody, M. Coster, R. Finnon, P. Finnon, A. A. Edwards, M. Szłuińska, C. J. Skidmore, K. Yoshida, R. L. Ullrich, R. Cox and S. D. Bouffler. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Carcinogenesis, 27:311-318, 2006.

45D. Pati, B. Haddad, H.Thompson, F.S. Kitrel, A. Shepard, C. Montagna, M. McCarthy, R.L. Ullrich, and D. Medina. Hormone-induced chromosomal instability in p53 null mammary epithelium. Cancer Research, 64: 5608-56-16, 2004.

46Robert L. Ullrich. Etiology of Cancer: Physical Factors. In: Principals and Practice of Oncology. 7th edition. DeVita, Hellman, and Rosenberg (eds.), pp 201-215, 2004.

47Susan M. Bailey, Michael N. Cornforth, Robert L. Ullrich and Edwin H. Goodwin. Dysfunctional Mammalian Telomeres Join with DNA Double-Strand Breaks. DNA Repair 3: 349-357, 2004.

48Susan M. Bailey, Mark A. Brenneman, James Halbrook, Jac A. Nickoloff, Robert L. Ullrich and Edwin H. Goodwin, The Kinase Activity of DNA-PK is Required to Protect Mammalian Telomeres. DNA Repair 3: 225-231, 2004.

49Daniel Medina, Frances S. Kittrel, Ann Shepard, L. Clifton Stephens, Cheng Jiang, Johnny Lu, D. Craig Allred, Maureen McCarthy, and Robert L. Ullrich. Biological and genetic properties of the p53 null preneoplastic mammary epithelium. The FASEB Journal: 16:881-883, 2002.

50Daniel Medina, Robert Ullrich, Ray Meyn, Roger Wiseman, and Larry Donehower. Environmental carcinogens and p53 tumor suppressor gene interactions for mammary carcinogenesis in a transgenic mouse model. Environmental and Molecular Mutagenesis 39: 178-183, 2002.

51Michael M. Weil, Frances S. Kittrel, Yongjia Yu, Maureen McCarthy, Ryan C. Zabrisky, and Robert L. Ullrich. Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice. Oncogene 20:4409-4411,2001.

52Yongjia Yu, Ryuichi Okayasu, Michael Weil, Andy Silver, Maureen McCarthy, Ryan Zabriskie, Roger Cox2, and Robert L. Ullrich. Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA PKcs) gene. Cancer Research 61: 1820-1824, 2001.

53Robert L. Ullrich. Etiology of Cancer: Physical Factors. In: Principals and Practice of Oncology. 6th edition. DeVita, Hellman, and Rosenberg (eds.), pp 195-207, 2001.

54Ryuichi Okayasu, K. Suetomi, Y. Yu, A. Silver, J.S. Bedford, R. Cox and Robert L. Ullrich. A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive Balb/c mouse. Cancer Research 60: 4342-4345, 2000.

55T.M. Goepfert, M, McCarthy, F.S. Kittrell, C. Stephens, R.L. Ullrich, B.R. Brinkley, and D. Medina. Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells. The FASEB Journal 14:2221-2229, 2000.

56R. L. Ullrich and C. M. Davis. Radiation-induced genomic instability in vivo. Rad. Res. 152:170-173, 1999.

57R. Okayasu, S. Takahashi, Yamada, S., T. Hei, and R. L. Ullrich. Asbestos and DNA double strand breaks. Ca. Res. 59:298-300, 1999.

58R. L. Ullrich. Risks for radiation-induced breast cancer. The debate continues (invited editorial). Rad. Res., 151:123-124, 1999.

59R. L. Ullrich and B. Ponnaiya. Radiation-induced instability and its relation to radiation carcinogenesis, Intl. J. Rad. Bio., 74:747-754, 1998.

60R.J.M. Fry, A. Grosovsky, P. C. Hanawalt, R.F. Jostes, J.B. Little, W.F. Morgan, N.L. Oleinick, and R.L. Ullrich, The Impact of Biology on Risk Assessment, Radiation Research, 150:695-705, 1998.

61R. Okayasu, K. Suetomi, and R. L. Ullrich. Wortmannin inhibits double strand break repair in normal human cells, Radiation Research, 149:440-445, 1998.

62B. Ponnaiya, M. N. Cornforth and R. L. Ullrich. Radiation-induced chromosomal instability in Balb/c and C57Bl/6 mice: the difference is as clear as black and white, Radiation Research, 147:121-125, 1997.

63B. Ponnaiya, M. N. Cornforth and R. L. Ullrich. Induction of chromosomal instability in human mammary cells by neutrons and g-rays, Radiation Research, 147:288-294, 199

64R.L. Ullrich, N.D. Bowles, L.C. Satterfield, and C.M. Davis. Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation, Radiation Research, 146:353-355, 1996.

65C. S. Selvanayagam, M. N. Cornforth and R. L. Ullrich. Latent expression of p53 mutations and radiation-induced mammary cancer, Cancer Research, 55:3310-3317, 1995.

66E.G. Hanania, W.A. Au, R.L. Ullrich and J. Papaconstantinou. Regulation of retinoblastoma gene expression in a mouse mammary tumor model, Cancer Gene Therapy, 2:251-261, 1995.

67E.G. Hanania, W.A. Au, R.L. Ullrich and J. Papaconstantinou. Involvement of the retinoblastoma gene in a mouse mammary tumor model, Cancer Research, Therapy, and Control 4:67-76, 1994.

68R.L. Ullrich, B. Allen, W. Lee, L. C. Satterfield, and M. C. Jernigan. Induction of Phenotypically altered mammary epithelial cells by neutrons and gamma rays, Radiat. Res., 129:102-106, 1992.

69R.L. Ullrich. Cellular and molecular changes in mammary epithelial cells following irradiation, Radiat. Res., 128:136-140, 1991.

70R.L. Ullrich, R.J. Preston, and C. Selvanayagam. Radiation induced mouse mammary cancer. J. of Radiation Research, 32:104-109, 1991.

71R.L. Ullrich and M. Terzaghi-Howe. Neutron dose effects and carcinogenesis. J. Nuclear Science, 4:129-138, 1991.

72W. Gunzburg, B. Salmons, and R. Ullrich. Tumorigenic conversion of in vivo differentiation competent mammary cells by introduction and expression of ras or mil (raf) but not myc., in ras Oncogenes, D. Spandidos, ed., Plenum Press, 1989.

73E.J. Hall, J. Bedford, R.J.M. Fry, and R.L. Ullrich. Basic radiobiology. American Journal of Clinical Oncology, 11:220-252, 1988.

74W.H. Gunzburg, Salmons, A. Schlaeffli, S. Moritz-Legrand, W. Jones, N. H. Sarkar, and R.L. Ullrich. Expression of the oncogenes mil and ras abolishes the in vivo differentiation of mammary epithelial cells. Carcinogenesis 9:1849-1856, 1988.

75S.J. Kennel, T.K. Lankford, R.L. Ullrich, and R.J. Jamasbi. Treatment of mice with monoclonal antibodies specific for lung endothelial cells enhances lung tumor colony formation. Cancer Res. 4964-4968, 1988.

76R.L. Ullrich. Low dose and dose rate effects of radiation. In: Radiological Accidents - Perspectives and Emergency Planning. American Nuclear Society, pp. 341-344, 1987.

77L.M. Adams, S.P. Ethier, and R.L. Ullrich. Enhanced in vitro proliferation and in vivo tumorigenic potential of mammary epithelium from BALB/c in vivo to gamma radiation and/or 7,12 dimethylbenz[a]anthracene. Cancer Res. 47:4425-4431, 1987.

78R.L. Ullrich, M.C. Jernigan, L.C. Satterfield, and N.D. Bowles. Time-dose relationships for the induction of mammary and lung tumors in BALB/c mice following gamma ray irradiation. Radiat. Res. 111:179-184, 1987.

79R.L. Ullrich and R.J. Preston. Myeloid leukemia incidence in male RFM mice following irradiation with x-rays or fission spectrum neutrons. Radiat. Res. 109:165-170, 1987.

80R.J.M. Fry and R.L. Ullrich. Combined effects of radiation and other agents. In: Radiation Carcinogenesis (A.C. Upton, ed.), Amsterdam, Elsevier/North Holland Biomedical Press, pp. 437 448, 1986.

81D. Medina, C.J. Osborn, F.S. Kittrell, and R.L. Ullrich. Properties of mouse mammary epithelial cell lines characterized by in vivo transplantation and in vitro immunocytochemical methods. JNCI 76:1143-1156, 1986.

82R.L. Ullrich. The rate of progression of radiation-transformed mammary epithelial cells is enhanced after low dose rate neutron irradiation. Radiat. Res. 105:68-75, 1986.

83S.P. Ethier and R.L. Ullrich. Factors influencing the expression of ductal dysplasias in mammary outgrowths derived from monodispersed mammary epithelial cells. Cancer Research 44:4523-4527, 1984.

84S.P. Ethier, L.M. Adams and R.L. Ullrich. Morphological and histological characteristics of mammary dysplasias occurring in cell dissociation derived mammary outgrowths. Cancer Research 44:4517-4522, 1984.

85L.M. Adams, S.P. Ethier and R.L. Ullrich. The survival of mouse mammary epithelial cells after in vivo gamma ray irradiation. Radiat. Res. 100:264-272, 1984.

86R.L. Ullrich. Tumor induction in BALB/c mice after fractionated or protracted exposures to fission-spectrum neutrons. Radiat. Res. 97:587-597, 1984.

87R.J.M. Fry, P. Powers-Risius, E.L. Alpen, E.J. Ainsworth and R.L. Ullrich. High-LET radiation carcinogenesis. In: Advances in Space Research 3:241-248, 1983.

88J.B. Storer and R.L. Ullrich. Life shortening in BALB/c mice following brief, protracted or fractionated exposures to neutrons. Radiat. Res. 96:355-347, 1983.

89R.L. Ullrich. Tumor induction in BALB/c mice female mice after fission neutron or gamma irradiation. Radiat. Res. 93:506-515, 1983.

90S.P. Ethier and R.L. Ullrich. Induction of mammary tumors in virgin female BALB/c mice by single doses of 7,12-dimethylbenz(a)anthracene (DMBA). J. Natl. Cancer Inst. 69:1199-1202, 1982.

91R.L. Ullrich. Lung tumor induction in mice: Neutron RBE at low doses. In: Proceedings of the European Seminar on Neutron Carcinogenesis (J.G. Broerse and G.W. Gerber, eds.), CEC, Luxemburg, pp. 43-55, 1982.

92S.P. Ethier and R.L. Ullrich. Detection of ductal dysplasia in mammary outgrowths derived from carcinogen treated virgin female BALB/c mice. Cancer Res. 42:1753-1760, 1982.

93J.B. Storer, T.J. Mitchell and R.L. Ullrich. Causes of death and their contribution to radiation-induced life shortening in intact and ovariectomized mice. Radiat. Res. 89:618-643, 1982.

94R.L. Ullrich and K.R. Meyer. The influence of butylated hydroxytoluene-induced cell proliferation on mouse lung damage after x-rays or fission neutrons. Radiat. Res. 89:428-432, 1982.

95J.B. Storer, R.L. Ullrich and R.J.M. Fry. Whole Animal Methods in Radiation Research. In: Trends in Bioassay Methodology: in vivo, in vitro and Mathematical Approaches (W.F. Roub, ed.), Washington, DC, pp. 67-80, 1981.

96J. B. Storer, R.J.M. Fry, and R.L. Ullrich. Somatic effects of radiation. In: The Mouse in Biomedical Research (H.L. Foster, J.D. Small, and J.G. Fox, ed.), Academic Press, New York, Vol. IV, pp. 133-146, 1982.

97R.L. Ullrich. Radiation Carcinogenesis. In: Radiotracers in Biology and Medicine, Vol. VI, Radiation Biology (D.J. Pizzarello, ed.), CRC Press Inc., Boca Raton, FL, 1982.

98K.R. Meyer and R.L. Ullrich. Effects of x-rays and fission neutrons on an induced proliferative response in lung type 2 epithelial cells. Radiat. Res. 85:380-389, 1981.

99H.P. Witschi, W.M. Haschek, K.R. Meyer, R.L. Ullrich and W.E. Dalbey. A pathogenic mechanism in lung fibrosis. Chest 78:3955, 1980.

100R.L. Ullrich. The effects of split doses of x-rays or neutrons on lung tumor formation in RFM

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