Hengguang Li, Ph.D.

*** ******** ***, ***********, ** 27560

Phone: 410-***-**** (cell)

E-mail: ad4jbv@r.postjobfree.com; ad4jbv@r.postjobfree.com

US Citizen

Specialties

Variety of Small molecules and macro compounds, in the research and applications of material, medicine, pharmaceutics, agriculture, environment, new energy and the relevant areas in the manner of forensic / medicinal / organic synthetic/ computational / biological or bioorganic / analytic / natural products / protein/ peptide / nucleotide / physical / pharmaceutical chemistry, and chemical process engineering, technique transfer and commercialization.

Selected Key Skills and Qualifications

Organic Synthetic and Medicinal Chemistry

Multi-steps synthesis, asymmetric synthesis, solid phase synthesis including peptide synthesis, oligosaccharide synthesis, oligonucleotide synthesis, parallel synthesis, combinatorial chemistry.

Computational Chemistry

Computer aide drug design, SAR, QSAR and molecular modeling (CoMFA, SYBYL, ICM, in Silico), Docking.

Conjugation and synthesis

Carbohydrate-peptide / protein conjugation, Vaccine related carbohydrate conjugates; Carbon Nano tube modification and conjugation; Oligonucleotide (DNA, RNA, Aptamer) conjugation. Multivalent scaffold design, synthesizing and assembling.

Analytical and Pharmaceutical Chemistry

Drug delivery; Pro-drug strategy.

Pre-formulation.

Pharmacokinetics and Pharmacodynamics.

Drug metabolism.

Bio-analysis and DMPK, ADME, Metabolic and Proteomic Studies, and optimization and validation. Drug delivery approaches, Pre-formulation and formulation including oral and injectable formula and topical cream formula.

The analysis of method developments for all over 10 years.

Instrumental skill and experience

HPLC, LC/MS/MS, GC, GC/MS, NMR, ESI-MS, MALDI-TOF, ICP-MS, FT-IR, UV/Vis, CD, Dionx- HPAEC, PAGE, Nano drop OD, EMS, DSC, AA, TGA, KF, TLC, ICP, viscosity meter, centrifuge, lyophilize, Polarimetry, fluorimeter, calorimetry, atomic absorption/emission spectrometry, X- ray crystallography, auto separation chromatographic systems, and so forth.

Specific Chemistry

Carbohydrate chemistry, peptide chemistry, nucleoside chemistry, bioorganic chemistry, click-chemistry, physical chemistry, enzymatic chemistry. Biological chemistry, including MIC, ELISAs, Cell membrane transport assays, new materials including polymers and Nano materials.

Chemical engineering

Carbon Capture and Conversion into Energy; Process chemistry; Commercial or Kilo scale and pilot plant experience; Technique transfer.

Regulatory Experience

GLP, GMP, USP, FDA

Natural products

Purifying of any ingredients by the means of various techniques, such as extractions, filtrations, centrifugations, chromatographic and so on. Structure identification and characterization. Compounds synthesis and bioactive evaluations.

Sustainable bio-renewable energy

Algae based bio-fuel and bio-alcohol generations, algae cultivation; Cellulose converted to alcohol.

Employment Record

Cheminformatics Curator 9/2023 - present

EPA 109 T.W. Alexander Drive

RTP, NC 27711

Adjunct Professor, part time. 1/2022 - present

Fayetteville State University

VP of Active Pharmaceutical Ingredients (API), contract 5/2023-10/203

Shanghai Kesheng LLC, Huahai Pharmaceutic Inc.

In charge of API process R&D, including small molecules and macro compounds, such as oligonucleotides, polypeptides, and the conjugates.

Research Scientist, contract 7/2022- 5/2023

Catalent Pharma Solutions

Duke University

Inorganic chemistry, ICP-MS, partials sizing; Nano particles, and Teaching.

Assistant Professor and The Core Facility Supervisor 8/2017-7/2022

Fayetteville State University, Department of Chemistry and Physics, Fayetteville.

Teaching General Chemistry; Organic Chemistry, Physic Science. Instruments management.

Adjunct Professor, part time. 7/2013-8/2017

Campbell University.

Teaching general chemistry, and organic chemistry.

Voluntary Scientific Manager, founder. 1/2012-7/2013

Genotech Inc. and Global Bio-Science Research (GBR) Inc.

Having been helping to start up the business of straws and algae based sustainable bio-fuel, such as bio-diesel and bio-alcohol.

Senior Scientist, contract, closed. 7/2011-12/2011

Aptagen LLC.

Implemented projects and Accomplishments: Oligonucleotide (DNA, RNA, LNA, PNA) or aptamer or aptabody for academic and industrial applications, biosensor and/or biomarker discovery, diagnostic and therapeutic drug discovery; Customer Service or/and CRO.

Director of Discovery Chemistry, switch to aptamer area. 9/2008-8/2011

Institute of Chemical Biology & Drug Discovery,

State University of New York at Stony Brook.

Implemented projects and Accomplishments: DTRA project of Botulinum neurotoxin inhibitors; Anti infectious disease reagents; Anti-cancer targeting reagents, including mostly heterocyclic compounds and the third generation baccatin conjugates compounds.

Asymmetric synthesis of natural and unnatural amino acids.

Synthetic methods and process development.

Performed variety of parallel, multi-steps or combinatorial synthesizing.

Customer Service or/and CRO: Had been servicing in contract for the Institute Members and the collaborators, and other costumers to meet their needs of drug design, SAR or QSAR studies, compounds synthesis, and lead-optimization.

R & D Research Scientist, Group leader of replacement antibiotics,

R&D was closed 4/2006-9/2008

IDEXX Pharmaceutical Inc.

Implemented projects and Accomplishments: Replacement antibiotics and Diagnostic reagents development. Led and developed a series of novel antimicrobial reagents including macrolides, beta-lactams and fluoroquinolones to enhance their activities, reduce the toxicity and improve their pharmacokinetic properties. Developed a topical formula of antibiotic for animal care. Developed a series of protein conjugates of immunogenic reagents bio-makers for renal diseases diagnosis.

Research Scientist, company was closed. 3/2002-9/2002

DarPharma Inc.

Implemented projects and Accomplishments: Central nervous system drug development.

Synthesized various dopamine agonists for pre-clinic trails of the treatment for Parkinson’s disease.

Assistant Professor. 5/1998-8/1999

Sichuan Industrial Institute of Antibiotics.

Research areas: Process Chemistry, focused on API techniques transfer from lab to industry. Antibiotic R & D; Computer aided drug design; total synthesis of chiral antibiotics. 3-Dimensional QSAR studies of β-lactams antibiotics. β-Lactams asymmetric synthesis and bioactive evaluation.

Implemented projects and Accomplishments: Designed and screened mono-ring based novel β-lactams with higher potency against β-lactam resistant bacteria. Established a small library of synthetic optically active compounds. Screened the synthesized compounds that are potential anti Gram-negative and Gram-positive bacteria.

Chief Scientific Officer (Co-founder) 1/1998-10/1999

Hengdian Molecular Laboratory Inc.

Duty: Directed and oversaw the whole projects of synthesizing bioactive compounds and the pharmaceutical intermediates, as well as solution phase peptide synthesizing.

Process Chemistry Engineering Manager 11/1986-5/1998

Sichuan Industrial Institute of Antibiotics.

Research areas: chemical process engineering in industry of antibiotics.

Accomplishments: Developed several of new techniques of aminoglycoside antibiotics producing processes from bench scale (mg) up to commercial scale (kilo g) under GMP conditions, involved fermentation extraction, purification and semi-synthesis, and their quality control. Injectable formulas developments.

Education

Postdoctoral Researcher in medicinal and biological chemistry 10/2002-4/2006

Institute of Human Virology, University of Maryland.

Research areas: Design and synthesis of peptide and glycopeptide based HIV / AIDS vaccine and inhibitors. Method development, multi-step synthesis of the templates, and macromolecular ligations. Accomplishments: Designed and synthesized novel multivalent peptide, gp120/gp41 miniproteins, and oligosaccharides cluster as HIV vaccines or inhibitors.

Postdoctoral Fellow in Drug delivery 7/1999-2/2002

School of Pharmacy and Bioscience, University of California.

College of Pharmacy, University of Georgia.

Implemented projects and Accomplishments: Designed and synthesized peptide and cholic acid conjugates linked by a biodegradable bond for the epithelia cell membrane transporting, peptides prodrug and methotrexate prodrug oral absorption; developed a class of boron cage coupled cholesterol fatty acids as pro-drug targeted to brain tissue for boron neutron capture therapy.

Ph. D. in Organic Chemistry and Medicinal Chemistry 9/1996-7/1999

Sichuan University, Chengdu, China.

Dissertation: “3-Dimensional QSAR study of β-lactams antibiotics, asymmetric synthesis of new β-lactams and their bio-activities evaluation”.

M. S. in Organic Chemistry and Bioorganic Chemistry 9/1993-6/1995

Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences. Shanghai. China.

Sichuan University, Chengdu, China. 2/1992-9/1993

Thesis: “Enzymatic kinetic resolution as key step in a total synthesis of natural products”.

B. S. in Analytic Chemistry 2/1981-11/1986

Sichuan University, Chengdu, China.

Thesis: “Synthesis and the analysis of N4Si3 by CO2 laser irradiation”.

Affiliations

American Chemical Society

American Association Pharmaceutical Scientists

Honors

2020 Respected Scientist VDGOOD "Lifetime Achievement Award" in the International

Scientist Awards on Engineering, Science, and Medicine. India.

2017 Editorial Board Member of Archives of Organic and Inorganic Chemical Sciences.

2017 Editorial Board Member of Organic and Medicinal Chemistry International Journal

2017 Editorial Board Member of International Journal of Scientific Engineering and Science

2016 Editorial Board Member of MOJ Journal of Bioorganic & Organic Chemistry

2016 Editorial Board Member of AS Pharmaceutical Sciences

1997 Yong Medicinal Chemist Award, Servia, France

1996 Outstanding Ph.D. Candidate Award, Sichuan University, China

1995 Advancement in Science and Technology Award, Chengdu, China

1993 Guanghua Scholarship for Graduate Students, Chengdu, China

Patents

1.Hengguang Li, A clean, renewable and sustainable hydrogen generator for engine fuel. CN2023080401779810.

2.Yerramilli V, Murthy S. N. Atkinson, Michael Randolph Ll, Hengguang Cox, Christopher Alan Macrolides Having Antibiotic Activity US 201******** A1.

3.Yeramilli Murthy, Hengguang Li, Edward Obare, Process for Preparing Cefsulodin Sodium. US patent, Publication date: 05/06/2010, Patent application number: 201********.

4.Yeramilli Murthy, Hengguang Li, Muhalakshmi Padmanabhan, Michael Atkinson, SDMA Immunoassay. US patent, 2012 pending.

5.Yerramilli VSN Murthy, Edward Obare, Hengguang Li: Single dose roxithromycin. IDEXX Laboratories January 2009: US 200********

6.Lai-Xi Wang, Jiahong Ni, Hengguang Li, Suddham Singh: Scaffolded maleimide clusters for multivalent peptide assembly. University of Maryland Biotechnology Institute April 2009: US 7524821

7.Lai-Xi Wang, Hengguang Li: Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric GP120. University of Maryland Biotechnology Institute. August 2005: US 200********

8.Hengguang Li, Shuhua Cheng, Titrimeter and Quantitatively Moving Device of Liquid, Chinese Patent No. ZL 93 2 38513.3, April 15, 1993.

Selected Publications

1.Taipeng Shen, Jessie Cook, Yuan Ren, Lu Zhang, Zhuzhong Cheng, Jinyi Liang, Hengguang Li, Synthesis and in Vitro Anticancer Activity of LCA-AZT Conjugate, Drug Design Development and Delivery Journal, Volume: 3.1, 1-4, 2020.

2.Li H, Mark Z, Graylion M, Shen T., A Potentially Useful Procedure for Conversion of Ethers to Esters. J Med Chem Drug Des 2(2): dx.doi.org/10.16966/2578-9589.115 (2019)

3.Hengguang Li, Grace M Chavis, Pseudo aptamer expands aptamer’s applications, MOJ Biorg Org Chem. 2018;2(3):145 153.

4.Hengguang Li, Darren Pearson, Conjugates toward Medicines, J Pharmacol Med Chem 2017;1(1):32-39.

5.Hengguang Li, Haijing Song, Svein Oie, Robbert D. Lu, Synthesis of cholic acid-peptide Conjugates with a negatively charged ester linkage for oral delivery, JOM Medicinal Chemistry, Volume 7(2): 769-776 (2017).

6.Hiroki Moriwaki, Daniel Resch, Hengguang Li, Ryosuke Takeda, José Luis Aceña and Vadim A. Soloshonok, Iwao Ojima1, Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)-amino] acetyl}amino)benzophenone; a case of configurationally stable stereogenic nitrogen, Beilstein J. Org. Chem. 10(1):442-8, February 2014.

7.Hiroki Moriwaki, Hengguang Li, Daniel Resch, Iwao Ojima, José Luis Aceña and Vadim Sholoshonok, Inexpensive chemical method for preparation of enantiomerically pure phenylalanine. Amino Acids (2014) 46(4):945–952.

8.Jingsong Wang, Hengguang Li, Guozhang Zou, Laixi Wang, Novel template-assembled oligosaccharide clusters as epitope mimics for HIV-neutralizing antibody 2G12. Design, synthesis, and antibody binding study, Org. Biomol. Chem., 2007, 5, 1529 – 1540.

9.Hengguang Li, Yongjun Guan, Agnieszka Szczepanska, Antonio J. Moreno-Vargas, Ana T. Carmona, Inmaculada Robina, George K. Lewis and Lai-Xi Wang, Synthesis and anti-HIV activity of trivalent CD4-mimetic miniproteins, Bioorg. Med. Chem. 2007, 15(12), 4220-4228.

10.Lai-Xi Wang, Bing Li, Hengguang Li, and Jinsong Wang, Toward a glycopeptide-based HIV-1 vaccine, Retrovirology, 2006; 3(Suppl 1): S75.

11.Ying Zheng, Jingsong Wang, Bing Li, Steve Hauser, Hengguang Li, Lai-xi Wang, “Glycopeptide synthesis through endoglycosidase-catalyzed oligosaccharide transfer of sugar oxazolines. Probing substrate structural requirement. Chemistry: A European Journal, 2006, 12, 3355-3364.

12.Hengguang Li, Bin Li, Haijing Song, Lieonid Breydo, Ilia Baskakov, Lai-xi Wang, Enzymatic Double Glycosylation for Glycopeptide Assembly, Efficient Synthesis of HIV-1 V3 Domain Glycopeptides Carrying Two N-Glycans, J. Org. Chem. 2005, 70, 9990-9996.

13.Lai-xi Wang., Haijing Song., Shuwen L., Hong L., Shibo J., Jiahong N., Hengguang Li, Chemoenzymatic Synthesis of HIV-1 Gp41 glycopeptides. Effects of Glycosylation on the Anti-HIV Activity and α–Helix Bundle-Forming Ability of Peptide C34, Chem. Bio. Chem., 2005, 6, 1068-1074.

14.Steve Hauser, Haijing Song, Hengguang Li, Lai-xi Wang, A novel fluorescence-based assay for the transglycosylation activity of endo-β-N-acetylglucosaminidases, Biochemical and Biophysical Research Communications, 2005, 328, 580-585.

15.Hengguang Li, Suddham Singh, Ying Zeng, Haijing Song, Lai-xi Wang, Chemoenzymatic Synthesis of CD52 Glycoproteins Carrying Native N-Glycans, Bioorg Med. Chem. Lett., 2005, 15, 895-898.

16.Hengguang Li, Haijing Song, Alonso Heredia, Nhut Le, George Lewis, Robert Redfield, and Lai-xi Wang, Synthetic bivalent CD4-mimetic miniproteins show enhanced anti-HIV activity over the monovalent miniprotein, Bioconjugate Chem., 2004, 15, 783-789.

17.Hengguang Li, Lai-xi Wang, Design and synthesis of a template-assembled oligomannose cluster as epitope mimic for human HIV-neutralizing antibody 2G12, Org. Biomol. Chem., 2004, 2, 483-488.

18.Kannan P. Naicker, Hengguang Li, Alonso Heredia, Haijing Song, Lai-xi Wang, Design and synthesis of α-Gal-conjugated peptide T20 as novel antiviral agent for HIV immuno-targeting, Org. Biomol. Chem., 2004, 2 (5), 660-664.

19.Lai-xi Wang, Jiahong Ni, Suddham Singh, Hengguang Li, Binding of high-mannose type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12. Implications for HIV-1 vaccine design. Chemistry & Biology, 2004, 11, 127-134.

20.Hengguang Li, Lai-xi Wang, Cholic acid as a novel template for multivanlent peptide assembling, Org. Biomol. Chem., 2003, 1, 3507-3513.

21.Fars Alanazi, Hengguang Li, David S. Halpern, Svein Oie, D. Robert Lu, Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains, International Journal of Pharmaceutics, 2003, 255, 189-197.

22.Jian Hu, Tong Wu, Hengguang Li, Rugang Xie, Ya Gan, Ding Lu, Stereoselective Synthesis of Optic Active 3-(1-hydroxy)-4-ethyoxyl-β-lactams, Chinese Journal of Chemistry, 2001, 59, 279-283.

23.Hengguang Li, Tong Wu, Rugang Xie, Jian Hu, Jianwei Wuang, Xiaobing Hu, Stereoselective Synthesis of N-benzyl-3-(S)-phthalimido-4(S)-[4(S)-2,2-dimethyl-1.3- dioxolan-4-yl]- 2-oxo- azetidine, Chemical Journal of Chinese University, 1999, 10, 1554~1558.

24.Hengguang Li, Deying Wu, Rugang Xie, Comparative molecule force field analysis (CoMFA) study of monocyclic β–lactam against E. Coli. receptor, Chinese Pharmaceutical Journal, 1999, 12, (10), 489-497.

25.Hengguang Li, Jian Hu, Rugang Xie, Tong Wu, Jianwei Wuang, Xiaobing Hu, Enantiospecitic synthesis of substituted β-lactams from (R)-Glyceraldehyde Acetonide, Chinese Journal of Antibiotics, 1999, 24 (5), 339-343.

26.Hengguang Li, Rugang Xie, Tong Wu, et al., Enantiospecific Synthesis of 1N-Sulfa-3-Nitro-4- (1,2-Acetonide)-2-Azetidinones, The Fifth International Symposium for Chinese Organic Chemists (symposium on Frontier Organic Chemistry), Chemical Journal of Chinese University, 1998, 19(8), 253~254.

27.Donghong Li, Fang Li, Hengguang Li, Shuhua Chen, Huaming Zhao, Synthesis of Novel Molecular Tweezer from Estradiol and Study of Their Molecular Recognition, Journal of Sichuan University (Natural Science Edition), 1998, 35(5), 747~752.

28.Laicai Li, Shuang Mao, Hengguang Li, A Theoretical Study on The Activity-Structure Relationship of monocyclic lactams, Journal of Sichuan Normal University (Natural Science Edition), 1998, 21(6), 648~650.

29.Zhiyu Liu, Hengguang Li, Shuhua Cheng, Natural Products Synthesis by Retro Diels-Alder Reaction XIV. Stereospecific Synthesis of -Epoformin and -Epiepoformin, Acta Chimica Sinica, 1997, 55, 611~616.

30.Hengguang Li, Zhiyu Liu, Shuhua Cheng, Preparation of Methylboric Acid in High Yield, Chinese Chemical Reagents, 1997, 19(3), 185; 149.

31.Donghong Li, Hengguang Li, Shuhua Cheng, Design and Synthesis of Estradiol Dimer Reseptors, Chinese Journal of Organic Chemistry, 1997, 17, 340~343.

32.Shuhua Cheng, Yan Chen, Hengguang Li, Synthesis, Configuration and Properties of Estrogerin Steroid-porphyrin Enzyme Model Compounds, Acta Chimica Sinica,1997, 55, 716~722.

33.Hengguang Li, Deyin Wu, et al., A Study of MM and CoMFA of N-sulfacid-b-lactam Antibiotics, The fifth China-Japan Joint Symposium on Drug Design and Development, September 3~7, 1997, 32~34.

34.Hengguang Li, Tong Wu, Rugang Xie, Yieming Lei, β-lactams Asymmetric Synthesis I, The 8th National Antibiotic Symposium, Hangzhou, China. Sept. 1997, 267-269.

35.Hengguang Li, Haijing Song, The Prospect of β-lactam in Usage and Development, Medicinal Information of Research, Shanghai, 1996, 6, 1~10.

36.Shuhua Cheng, Hengguang Li, et al., Synthesis and configuration of estrogenic steroid-bisporphyrin enzyme model compounds, Journal of Sichuan University (Natural Science Edition), 1996, 33(6), 785~788.

37.Zhiyu Liu, Hengguang Li, Shuhua Cheng, Beker s Yeast-Catalyzed Isomerization of 1,4,4α,8α-tetrahydro-1,4-methanonaphthalene-5,8,dione, Chinese Journal of Organic Chemistry, 1995, 15, 619~621.

38.Zhiyu Liu, Hengguang Li, Shuhua Cheng, The Stereocontroled Total Synthesis of Natural Product Epoformin and Epoisoformin, Chinese Chemical Society, The 6th Conference on Synthetic Organic Chemistry, Book of Abstracts. Fudan University Pressed. Shanghai, China. Oct. 27~30, 1995, 121.

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