GARIMA PANDEY, Ph.D.

** ******** **.

Reading, MA 01867

Email: ad3omy@r.postjobfree.com

Contact No. +1-857-***-****

Permanent Resident: USA (Green Card Holder)

OBJECTIVE

I am a dedicated and innovative synthetic organic and process chemist with a proven track record in synthetic route scouting, execution, and scale-up. Seeking a challenging position pharmaceutical and biotech company.

QUALIFICATIONS

Skilled synthetic organic and process chemist with CRO/CDMO experience.

Proficient in small molecule, peptide, and lipids synthesis including method development, optimization, and scale up/down.

Expertise in multistep synthesis from mg to Kg scale.

Hands-on experience in purification techniques; flash chromatography, ultra-filtration, distillation, and recrystallization to obtain pristine quality compounds.

Expert in modern analytical techniques; NMR, LC-MS, GC-MS, MALDI, HPLC, UHPLC, IR, UV, and elemental analysis.

Thorough knowledge of using chemical databases; Reaxys, Scifinder, and Beilstein for designing new routes and improving existing routes of synthesis.

Proficient in using Microsoft Word, Excel, Outlook, Teams, PowerPoint, ChemDraw, and GraphPad Prism, and analytical data processing software MestReNova.

Thorough and detail- oriented chemist with a diligent approach to safety and regulatory guidelines.

Experience with electronic lab notebook (ELN)-LIMS and Dotmatics

Good communication skill, team player and have problem solving approach.

PROFESSIONAL EXPERIENCE

Senior Scientist Dec 2018 – Dec 2023

Organix Chemistry Solutions LLC.

240 Salem St. Woburn, MA, USA.

Developed, optimized and scaled-up organic synthetic reactions/routes for small molecules and lipids, purified by chromatography, crystallization and characterized by NMR, LCMS and HPLC.

Synthesized neutral and ionic lipids for mRNA Lipid nano particles (LNP) formulation processes.

Demonstrated purification skills in the process development by using variety of chromatography (normal phase, reverse phase and preparative HPLC) techniques.

Delivered high purity neutral/ionic lipids and bioconjugates using PEG as a linker (based on HPLC, NMR) to the clients in a timely manner.

Maintained all the experimental records electronically.

Expert in characterizing the synthesized compound based on 1D/2D NMR.

Prepared presentations/reports and presented in clients’ meetings.

Organized project related documents such as purchase orders, data sheets, and MSDS.

Worked within a dynamic and interdisciplinary environment to achieve results

Experienced in high-throughput reaction design and execution

Effective communication and collaboration skills in a team environment

Postdoctoral Research Associate Oct 2016- May 2018

University of Massachusetts Boston

Boston, MA, USA.

Developed Organofluoride Hydrazone derivatives as multifunctional Anti-Alzheimer's agents and a novel green synthetic approach for forming biphenyls using solid acid catalysis.

(Key Responsibilities: Organic Synthesis, Peptide synthesis, Purification, and characterization)

Taught Physiological Chemistry to freshmen in nursing.

Visiting Research Fellow Aug 2016- Sept 2016

College of Health and Rehabilitation Sciences

Boston University, Boston, USA.

Learned and implemented chemical biology and biochemistry techniques for the assigned project, “Targeting cytoskeletal protein-protein interfaces that regulate the shock absorber function of the proximal aorta for therapy of cardiovascular aging”.

EDUCATION

Ph.D. Organic Chemistry 2010- 2016

CSIR-Central Drug Research Institute, Lucknow

Awarded by Jawaharlal Nehru University, New Delhi, India.

Dissertation: “Syntheses of Possible Antimalarial Agents and Novel Aza Polycycles.”

Developed efficient organic Synthetic route/methodology for biologically important compounds.

Developed a general synthetic route to the synthesis of indoloazocines, develop method for purification and characterize them based on HPLC, NMR, and LCMS.

Developed Substituent-guided switch between C-H activation and decarboxylative cross-Coupling methodology for the palladium/ copper-catalyzed cascade reactions of 2-aminobenzoates with 2-haloarylaldehyde (Mainly responsible for: organic synthesis route scouting, purification, and characterization)

MS Research Dissertation 2009- 2010

Delhi University, New Delhi, India.

Developed molecular-based thin films as an interface of electrochromic & multiple channels sensing devices, using metal-organic frameworks (MOFs).

PUBLICATIONS

G. Pandey, S. K. Tripathi, V. Bulbule, Contemporary chemical approaches for green and sustainable drug: A volume in Advances in Green and Sustainable Chemistry, 2022. pages 377-419, Chapter 12 “Antibody-drug conjugates for targeted delivery” (Book chapter).

A. Baier, A. Kokel, W. Horton, E. Gizińska, G. Pandey, R. Szyszka, B. Török, M. Török, Organofluorine Hydrazone Derivatives as Multifunctional Anti-Alzheimer's Agents with CK2 Inhibitory and Antioxidant Features; Chem Med Chem. 2021. 16(12):1927-1932.

G. Pandey and B. Torok, K-10 montmorillonite-catalyzed solid phase diazotations: environmentally benign coupling of diazonium salts with aromatic hydrocarbons to biaryls. Green Chemistry. 2017. 19, 5390-95.

G. Pandey and S. Batra, Microwave-assisted palladium catalyzed isocyanide Insertion in 2-bromophenylureas for efficient synthesis of 4-substituted imino 4H-benzo[d][1,3] oxazine-2-amine. RSC Advances. 2015. 5, 28875-78.

G. Pandey, R. Kant and S. Batra, A general route to the synthesis of indoloazocines using allyl bromides prepared from Morita-Baylis-Hillman adducts, Tetrahedron Letters. 2015. 56, 930-33.

G. Pandey, S. Bhowmik and S. Batra, Synthesis of 4-substituted imino-4H-benzo[d][1,3]thiazin-2-amines via palladium-catalyzed isocyanide insertion in 2-bromophenylthioureas. RSC Advances. 2014. 4, 41433-36.

G. Pandey, S. Bhowmik and S. Batra, Synthesis of 3H-Pyrazolo[3,4-c]-isoquinolines and Thieno [3,2-c]-isoquinolines via cascade imination/ intramolecular decarboxylative coupling. Organic Letters. 2013. 15, 5044-47.

S. Bhowmik, G. Pandey and S. Batra; Substituent-guided switch between C-H activation and decarboxylative cross-Coupling during palladium/ copper-catalyzed cascade reactions of 2-aminobenzoates with 2-haloarylaldehyde. Chemistry-A European Journal. 2013. 19, 10487-91.

M. Nayak, G. Pandey and S. Batra; Synthesis of pyrrolo[1,2-a] pyrazines and pyrazino[1,2-a] indoles by curtius reaction in Morita–Baylis–Hillman derivatives. Tetrahedron. 2011. 67, 6563-69.

CONFERENCES

Poster presented on Discovery of cannabinoid based novel id-1 down regulators for late-stage cancers, Discovery on Target, Boston, MA, USA. (2019).

Attended Northeastern Section of the American Chemical Society Process Chemistry Symposium (NESACS), Merck Boston Auditorium (2017).

Organized one-day symposium on “Drug Discovery in India: Past, Present and Future” at CSIR-Central Drug Research Institute, Lucknow (2015).

Attended International Conference of IXth Junior National Organic Symposium Trust (JNOST), at Indian Institute of Science Education and Research (IISER), Bhopal, India (2013).

Attended 5th International Current Trends in Drug Discovery Research (CTDDR) symposium on “Drug Development for Orphan/Neglected Diseases” at CSIR-Central Drug Research Institute, Lucknow, India (Feb 2013).

Attended 12th Chemistry Research Society of India (CRSI) national symposium in chemistry at CSIR-Central Drug Research Institute, Lucknow, India (July 2012).

AWARDS

CDRI-incentive awards (2013).

Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), India (2012- 2015).

Junior Research Fellowship from CSIR, India (2010-2012).

Qualified Graduate Aptitude Test in Engineering (GATE) organized by the Ministry of Human Resource Development, Govt. of India (2010).

REVIEWER ACTIVITIES

Nanotechnology for Environmental Engineering (Springer Journal).

Oriental Journal of Chemistry.

Journal of Chemistry- Hindawi

American Society of Civil Engineers.

Contact this candidate