JACOB K. ADIEY, PhD

San Jose, CA

408-***-****

E-mail: ad2zhd@r.postjobfree.com

WORK / RESEARCH EXPERIENCES

CSBIO, Milpitas, CA Apr 2023-Present

Chemist- Manufacturing cGMP

Peptide synthesis with Synthesizers (Solid phase peptide synthesis)

Purification with Preparative HPLC

Documentations

ThermoFisher Scientific, Fremont, CA January 2019 – Apr 2023

Staff Scientist-Bioconjugation / Synthetic Organic Chemistry

As part of NPD (New product Development) (Toxicology) group, I Design and synthesize Haptens that I purify by HPLC or ISCO and conjugate them to BSA, KLH, ED28 to make immunogens for anti-body discovery and production.

I perform equipments (HPLC, Lyophilizer, LCMS) maintenance and troubleshooting

I am the DEA’s coordinator for controlled substance (handling and disposal)

As part of manufacturing support team, I synthesize haptens and conjugate them to BSA, Enzymes, etc… and transfer them to Manufacturing-Operation in cGMP environment.

I do Documentation: BOMs (Bill of materials), SOPs; MPIs (Manufacturing Process Instruction) and batch records as Manufacturing supporting documents.

I maintain Chemicals and Haptens Inventory

CSBIO, Menlo Park, CA November 2016 – November 2018

Chemist III

Bioconjugation

Peptide Chemistry:

oSolid Phase synthesis using a synthesizer (20-40 Amino acids)

oSolution Phase (from synthesis to conjugation with NOTA; DOTA and more; lactam to stapple, fluorescent dyes. Peptides conjugated to dyes and PEG

3-Dyes synthesis

Stanford School of Medicine (BioADD Lab), Palo Alto, CA August 2015 – November 2016

Senior Chemist

Bioconjugations (Streptavidin to anti-body: IA2-IA1, …etc..)

Peptide Synthesis (Solution Phase)

Oligonucleotide’s synthesis (conjugation)

Synthesis of small Molecules (Glucose and derivatives) to support formulation

Formulation (from Hydrogel to Liposome)

HPLC (analytical and preparative), UV; Florescence

Reviva Pharmaceuticals, San Jose, CA April 2008– August 2015

Senior Scientist: Synthetic Organic Chemistry - Medicinal Chemistry

Preparation of novel piperazine derivatives (Small Molecules) [5 steps synthesis] as atypical antipsychotic agent (Phase 3 Clinical trial).

Composition and Synthesis of new class of Indanone (Small Molecules) [7 multi-steps synthesis] based Cholinesterase Inhibitors.

Preparation of cycloalkyl methylamines (Small Molecule) [ 5 to 10 multi-steps steps synthesis] derivatives as obesity agent (preclinical).

Preparation of novel benzimidazole (Small Molecule) derivatives as GERD agent.

Preparation of novel Melatonin derivatives (preclinical) (Small Molecules) [5 to 10 steps synthesis]

7 years experiences in contract work with multidisciplinary team of medicinal and

synthetic chemist and external collaborators

FSU Chemistry Department, Tallahassee, FL Jun 2003-April 2008

Research Assistant

Drug Discovery Program involving Taxol-related drug (Natural Product Synthesis) [up to 10 steps synthesis]

Design and Synthesis 6 -hydroxy Paclitaxel (Natural Product Synthesis) [6 multi-steps synthesis]. (Purities and impurities of all Compounds was analyzed and identified by MS (Electron ionization and fragmentation), HPLC, GC,

Structure Elucidation by NMR (1D, 2D); DCPL. NOE, COSY, NOESY)

EDUCATION

Florida State University Tallahassee, FL February 2001-Jun 2003

Postdoctoral Research Fellowship

Synthetic Organic Chemistry and Analytical Chemistry

Designed and Synthesized AB ring of Taxol (for Cancer drug discovery) a natural product anti-cancer agent

Pierre & Marie Curie University (Paris VI University) September 1997-December 2000

Chemistry Department CNRS, UMR, 7573 E.N.S.C.P.

(School of Chemical Engineering of Paris)

Ph.D. in Chemistry

MAJOR: Organic Synthesis

Total Synthesis of Ambruticin, a natural product antibiotic [up to 20 multi-steps synthesis]

Suziki, Heck and Buchwald reactions for Heterocyclic compounds synthesis (small Molecules) [5 multi-steps synthesis]

LANGUAGES

French: Fluent English: Fluent

PUBLICATIONS

1. K. Adiey, V. Michelet*, S. Tanier, G. Dujardin and J.P. Genet* “New Aspects in the Stereoselective Ethynylation of -C-Glycoside Aldehydes. Application to the Synthesis of an Ambruticin Fragment” Eur. J. Org. Chem. 2003, 2947-2958.

2. C. dupuis, K. Adiey, L. Charruault, V. Michelet*, M. Savignac, J-P. Genet “Suzuki cross-coupling of arylboronic acids mediated by a hydro-soluble Pd(0)/TPPTS catalyst “ Tetrahedron Letters 2001, 42, 6523-6526.

3. K. Adiey, V. Michelet*,, B. Bulic, J. P. Genet*. G. Dujardin, E. brown, L. Toupet “A New Synthetic Approach Toward -Ambruticin Analogs: Preparation of a C10-C11 cis-Isomer Fragment “ Eur. J. Org Chem. 1999, 11, 2885-2892.

PATENTS

1. Adiey, k ;Bhat, L.;. WO/2009/154993, PCT/US2009/045320

Compositions, Synthesis and methods of utilizing Piperazine based antipsychotic agents

2. Adiey, k ; Bhat, L WO/2010/099503, PCT/US2010/025688

Compositions, Synthesis and methods of utilizing Quinazolinedione Derivatives.

3. Adiey, k.; Bhat, L. WO/2010/099502, PCT/US2010/025687.

Compositions, Synthesis and methods of utilizing Arylpiperazine Derivatives

4. Adiey, k. Bhat, L.WO/2012/003501, PCT/US2011/042887

Compositions, Synthesis and methods of using cycloalkylmethylamine derivatives

5. Adiey, k ;Bhat, L WO/2013/102195, PCT/US2012/072283

Compositions, Synthesis, and methods of utilizing phenylcycloalkymethylamine derivatives

6 Adiey, K; Bhat, L. WO/201********

Composition, Synthetisis, and methods of using phenylcycloalkylmethylamine Derivatives

7 Adiey, k.; Bhat, L.; WO/2014/0024709

Methods of using cycloalkylmethylamine Derivatives

8 Adiey, k.; Bhat, L.; WO/2014/0155392 : Methods of utilizing arylpiperazine Derivatives

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