Gilles H. Michel, PhD

Cambridge, MA 281-***-**** ad2f2h@r.postjobfree.com linkedin.com/in/gilles-michel-a2716298

Associate Director

Science professional with experience in academic research and in the biopharmaceutical industry in the U.S. Extensive working knowledge and experience in R & D, cell line development, gene and cell therapies, cell engineering, virology (development of vaccines against infectious diseases), cell and molecular biology. Proven aptitude for devising and implementing innovative experiments and solutions to increase effectiveness and safety of vaccines. Proficient knowledge and hands-on experience in gene editing technologies and molecular cloning techniques with emphasis on cell line development and vaccine vector design. Familiarity with current Good Laboratory Practices (GLP). Demonstrated interpersonal skills with the ability to develop relationships with multiple scientific partners.

Areas of Expertise

Cell Line Development R & D Cell Line Engineering Gene Therapy Cell and Molecular Biology Virology Molecular Cloning Techniques Vectorology Vaccine Vector Design GLP Fluent in French

Experience

Takeda, Cambridge, MA 2020 – June 30, 2023

Associate Scientific Fellow

Cell Line Development (Biotherapeutics Process Development)

MilliporeSigma, St Louis, MO 2017 - 2020

Senior Scientist

Managed projects and research teams.

BioProtection Systems Corporation a subsidiary of New Link Genetics, Ames, IA 2010 - 2016

Scientist

University of Texas Medical Branch (UTMB), Department of Microbiology and Immunology, Galveston, TX

Post-Doctoral Fellow 2005 - 2010

Additional Relevant Experience

Beckmann Research Institute, City of Hope, National Medical Center, Duarte, CA

Research Fellow

Patents

Lentiviral Vectors for Site-Specific Gene Integration, United States Patent 7,531,647 May 12, 2009. Inventors: Jiing-Kuan Yee, Arcadia, CA (US) and Gilles Michel, Galveston, TX (US).

Abstracts And Presentations

Novel Cell Line Engineering & Development Summit (Engineer & Develop a Stable, Scalable Host Cell Line for ATMP to Accelerate Speed-to-Clinic): Inducible Expression Systems for Mammalian Cells, Back Bay, Boston, MA, May 9-May 11, 2023, Oral presentation.

Generation of stable TetON3G transactivator cell lines in HEK293 suspension cells, Takeda, Lexington, MA, Oct 2022, Poster presentation

American Society for Virology, 30th Annual Meetings, July 16-20, 2011, University of Minnesota, Minneapolis, MI, Oral Presentation: Viral vaccine enhancement with alpha-Gal epitopes. Gilles Michel, Ramon Flick, Laura Kaniewski, Serguei Kisselev, Ramesh Koukuntla, Bob Mandell, BioProtection Systems Corporation, and Brian Martin, Carol Martin, Newlink Genetics.

6th International Conference on Emerging Zoonoses, February 24-27, 2011, Cancun, Mexico, A chimeric bivalent vaccine platform targeting both Yellow Fever virus and Lassa virus, Gilles H. Michel, Ramesh KoukuntlHaarberg, Laura Mogler, Alexander N. Freiberg, Robert B. Mandell, Ramon Flick. BioProtection Systems Corporation, Ames, IA 50010.

7th Annual Meeting of the American Society of Gene Therapy, June 2-6, 2004, Minneapolis, Minnesota, Poster Presentation: Design of an HIV Vector for Site-Specific Gene Insertion, Gilles Michel, Ying Yu and Jiing-Kuan Lee, Laboratory of Virology, City of Hope National Medical Center, Duarte, California.

Research Publications

Michel G., Yu Y., Chang T. and Yee J.K. Site-specific gene insertion mediated by Cre-loxP-carrying lentiviral vector. Molecular Therapy (2010) 18 (10): 1814-21.

Michel G., Petrakova O., Atasheva S. and Frolov I. (2007). Adaptation of Venezuelan equine encephalitis virus lacking51-nt conserved sequence element to replication in mammalian and mosquito cells. Virology. 362:475-87.

Michel G., Mercken M., Murayama M., Noguchi K., Ishiguro K., Imahori K., and Takashima A. (1998). Characterization of tau phosphorylation in glycogen synthase kinase-3 beta and cyclin dependent kinase-5 activator (p23) transfected cells. Biochemical. Biophysical. Acta. 1380:177-82.

Rouille Y. Michel G., Chauvet MY., Chauvet J. and Acher R. (1989). Hydrins, hydroosmotic neurohypophysial peptides: osmoregulatory adaptation in amphibians through vasotocin precursor processing. Proceedings of the National Academy of Sciences of the United States. 86: 5272-5275.

Education

Ph D. in Biochemistry

University of Paris VI (Pierre et Marie Curie), Paris, France

Teaching Experience

Science teacher at the French International School (high school students) in Tokyo, Japan 1998-1999

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