Noble K Kurian, PhD

EDUCATION

Cochin University of Science and Technology May 2016

PhD Biotechnology

Grade: CGPA 9

Thesis title: Melanins from Marine bacteria; Characterization, Production and Applications University of Kerala Oct 2008

MSc Biotechnology

Grade: 83%

University First Rank

Dissertation title: Exploring estrogen responsiveness of Sos 1 with respect to its spatiotemporal distribution in MCF 7 cell lines

University of Kerala April 2005

BSc Biotechnology

Grade:83%

Dissertation title: Direct and Indirect organogenesis of Eryngium foetidum L. Center for Bioinformatics & Computational Biology Nov 2007 Post Graduate Diploma in Bioinformatics

Grade: A

RESEARCH EXPERIENCE

Post-Doctoral Researcher, National Institute for Research 2017-2018 in Reproductive Health-ICMR

Molecular and Cellular Biology Laboratory

Mentor: Dr. Deepak Modi

• Involved in culturing and isolation of membrane vesicles from Streptococcus agalactiae using gradient ultra-centrifugation and further characterization using Electron microscopy

• Toxicity of the vesicle was tested ex vivo in mice placental tissue and in vitro to Ishikawa cell lines. The treated tissues were sectioned and observed with various staining techniques

• The work was done in collaboration with Prof. Aniriban Banerjee at Indian Institute Technology, Powai, Mumbai

This work resulted in publishing 2 publication in journals including Journal of Assisted Reproduction and Genetics. This work was funded by Kerala Science, Technology and Environment Council Graduate Student, Cochin University of 2012-2016

Science & Technology

Department of Biotechnology

Pandakasalayil Hill View

Kampancode, Kollam, Kerala, INDIA

691532

Phone no +91-960*******

Email: ad1q2u@r.postjobfree.com

Mentor: Prof. Sarita G Bhat

• Work mainly focused on isolating characterizing bacteria from deep sea sediments and screening for melanin production

• Bacterial characterization using 16S rDNA PCR amplification and following Sangers sequencing of the gene.

• Melanin produced was characterized using XRD, FT-IR, NMR, HPLC, Electron microscopy techniques

• Various activities of the pigments were examined using biochemical and in vitro assays in cell lines like L929, RAW etc.

• Formulation of cosmetic cream with high SPF potential using melanin isolated This work resulted 9 publications in journals including Applied Biological Chemistry. This work was funded by Department of Science and Technology-INSPIRE- India Research Assistant, National Institute for 2009-2010 Interdisciplinary Science & Technology

Department of Biotechnology, Biofuel Section

Mentor: Prof. Ashok Pandey, Dr. Rajeev K Sukumaran

• Involved in production of bioethanol from lignocellulosic biomass like sugar cane bagasse, rice straw etc.

• Optimizing various pretreatment strategies for maximum sugar yield

• Recovering lignin from the treatment waste liquid and using it for various value-added application

• Ethanol fermentation and its analysis using gas chromatography This work resulted in 2 publications in journals including Bioresource Technology. This work was funded by TIFAC, Department of Science and Technology, India TEACHING EXPERIENCE

Assistant Professor, Chandigarh University 2022-2023 University Institute of Biotechnology

Classes: BSc Biochemistry, Biotechnology, MSc Biotechnology, Industrial Microbiology Courses: Immunology, Advanced Molecular Genetics, Microbiology, Food Science & Technology, Environmental Biotechnology, Genomics, transcriptomics & proteomics Responsibilities: Involved in delivering lectures and practical classes, Making course content and assignments, Evaluation of answer sheets, guiding MSc students in Review article writing. Published one research article during the tenure in American Journal of Reproductive Immunology and one book chapter in Elsevier Book series in final rounds of revision Assistant Professor, Atmiya University 2021-2022

Department of Microbiology

Classes: BSc Microbiology, Biotechnology, MSc Microbiology Courses: Molecular Biology, Genetic Engineering, Environmental Biotechnology, Research Methodology

Responsibilities: Involved in delivering lectures and practical classes, making course content and assignments, designing course syllabus, Evaluation of answer sheets, guiding MSc Biotechnology students for dissertation

Published three research articles in journals including Reproduction and Fertility and three working preprints during the tenure

Assistant Professor, RNB Global University 2019-2021 Department of Biotechnology

Classes: BSc Biotechnology, BSc Agriculture

Courses: Immunology, Genomics & proteomics, Molecular Biology, Environmental Science Responsibilities: Involved in delivering lectures and practical classes, Making course content and assignments, Designing course syllabus and convening board of studies meetings for course approvals, Evaluation of answer sheets

Published one preprint during the tenure

Guest Faculty, Mahatma Gandhi University 2018-2019 Institute for Intensive Research in Basic Science

Classes: MS Chemistry

Courses: Ecology, Evolution, Environmental Science, Bioinformatics, Instrumentation Responsibilities: Involved in delivering lectures and practical classes, Making course content and assignments, Evaluation of answer sheets

Assistant Professor, SNGIST Arts & 2015-2016

Science College

Department of Bioscience

Classes: BSc Biochemistry, Biotechnology, Microbiology MSc Biotechnology, Microbiology, Biochemistry

Courses: Immunology, Cancer Biology, Plant and Animal Biotechnology, Microbiology, Plant and Animal Biochemistry, Molecular Biology

Responsibilities: Involved in delivering lectures and practical classes, Making course content and assignments, Evaluation of answer sheets, Involved in guiding MSc dissertation students Two articles published in peer reviewed journals during the tenure INDUSTRY EXPERIENCE

Trainee at Bioinformatics Department at Jubilant Biosys, Bangalore for a duration of one month from May – June 2009

MENTORING EXPERIENCE

Mentor of Mr. Jayaram Prasad at SNGIST Arts and Science College 2015-2016 Current status: Graduate student, University of Nebraska Mentor of Ms. Jigna Chavda at Atmiya University 2021-2022 Current status: Laboratory Technician, Medical Laboratory, Rajkot FELLOWSHIPS

KSCSTE Post-Doctoral Fellowship 2017-2018

Role: Post-Doctoral Fellow

INR 600000

DST- INSPIRE Junior & Senior Research Fellow 2012-2016 Role: Graduate Fellow

INR 1000000

HONORS & AWARDS

Best Graphical Abstract Award, Reproduction & Fertility Journal 2023 Best Poster Award, Christ College, Rajkot 2022

CSIR NET Lectureship, CSIR India 2008

First Rank in Masters, University of Kerala 2008

PUBLICATIONS

21 publications in peer reviewed journals with 1433 citations with h index of 9 and cumulative impact factor of 20.00

SCI/Scopus

Rao, V. A., Kurian, N. K., & Rao, K. A. (2023). Cytokines, NK cells and regulatory T cell functions in normal pregnancy and reproductive failures. American Journal of Reproductive Immunology 89(2). Noble K Kurian, Deepak Modi, (2022) Mechanisms of Group B Streptococcus mediated preterm birth: Lessons learnt from animal models, Reproduction and Fertility 3 (3) Banappagoudar, S. B., Mayank, D., Ravi, D. N. K., Kanna, R. K., & Kurian, N. K. (2021). Anti-Bacterial Sanitary Napkin Using Biomaterial Application. NVEO-NATURAL VOLATILES & ESSENTIAL OILS Journal NVEO, 122**-*****.

Sreeja Narayanan*, Noble K Kurian*, Sarita G Bhat (2019), Ultra-small pyomelanin nanogranules abiotically derived from bacteria-secreted homogentisic acid show potential applications in inflammation and cancer, BioNanoScience (*contributed equally) Petrosyan, T. R., Hovsepyan, A. S., Avetisyan, S. V., & Kurian, N. K. In-vitro Effects of Bacterial Melanin in Macrophage RAW 264.7 Cell Culture. Advances in Neuroimmune Biology, 1-12. Noble K Kurian, Deepak Modi, (2019) Extracellular vesicle mediated embryo- endometrial cross talk during implantation, Journal of Assisted Reproduction and Genetics .36(2), 189-198 Noble K Kurian, Sarita G Bhat (2018). Data on the characterization of non- cytotoxic pyomelanin produced by marine Pseudomonas stutzeri BTCZ10 with cosmetological importance, Data in Brief, 18, 1889

Noble K Kurian, Sarita G Bhat (2018). Food, cosmetic and biological applications of characterized DOPA-melanin from Vibrio alginolyticus strain BTKKS3, Applied Biological Chemistry, 1-9 Noble K Kurian, Harisree P Nair, Sarita G Bhat (2018) Characterization of melanin producing bacteria isolated from 96m depth Arabian sea sediments, Research Journal of Biotechnology. Noble K Kurian, Sarita G Bhat (2017). Protoprotection and Anti-inflammatory properties of non– cytotoxic melanin from marine isolate Providencia rettgeri strain BTKKS1, Bioscience Biotechnology Research Asia 14(4).

Laxmi, M., Kurian, N. K., Smitha, S., & Bhat, S. G. (2016). Melanin and bacteriocin from marine bacteria inhibit biofilms of foodborne pathogens. Indian J Biotechnol 15(3), 392-399. Jayaram Prasad S, Jayalakshmi M Menon, Vijil V V, Aswathi P S, Nimitha K N, Athira L,Vijayalakshmi S V, Sruthi P S, Sughi S, Noble K Kurian, (2016) Amorphous Crystalline DOPA- Melanin from Mineral Beach Sand Isolate Bacillus cereus BTSNGIST5, Int J Adv Biotechnol Res 7(4), 1593-1599. Kurian, N.K., Nair, H.P., Bhat, S.G. (2015). Evaluation of Anti-inflammatory property of Melanin from marine Bacillus sp BTCZ31, Asian J Pharm Clin Res 8 (3),251-255. Raveendran Sindhu, Parameswaran Binod, Karri Satyanagalakshmi, Kanakambaran Usha Janu,Kuttavan Valappil Sajna, Noble Kurien, Rajeev K Sukumaran and Ashok Pandey, Formic acid as a potential pretreatment agent for conversion of sugarcane bagasse to ethanol; Applied Biochemistry and Biotechnology, doi 10.1007/s12010-010-9004-2

Parameswaran Binod,Raveendran Sindhu,Reeta Rani Singhania,Surender Vikram,Lalitha Devi,, Satya Nagalakshmi, Noble Kurien., Rajeev K. Sukumaran and Ashok Pandey, Bioethanol production from rice straw: An overview, Bioresource Technology,101 (2010), 4767–477. Non-SCI

Vijayababu, P., & Kurian, N. K. (2021). Melanin and its Precursors as Effective Antiviral Compounds: with a Special Focus on SARS CoV2.

Menon, J. M., Vijil, V. V., Aswathi, P. S., Nimitha, K. N., Vijayalakshmi, S., Sruthi, P., & Kurian, N. K.

(2016). Evaluation of anti-melanogenic activity of Pterocarpus santalinus L. using bacterial system. Biotechnological Research, 2(2), 58-60.

Kurian, N. K., Nair, H. P., & Bhat, S. G. (2014). Melanin producing Pseudomonas stutzeri BTCZ10 from marine sediment at 96 m depth (Sagar Sampada cruise# 305). International Journal of Current Biotechnology, 2(5), 6-11.

Book

Noble K Kurian, A Complete Lab Manual for Biotechnology, 02/2023: Published by Notion Press, ISBN: 979-88-89756-99-6.

Book Chapters

Urja Narang, Noble K Kurian, Sinan Bayram (2023). An enigmatic secondary metabolite: Microbial melanins and their applications, in Fungal Secondary Metabolites: Synthesis and Application in Agroecosystem, ISBN:978-0323952415 (Accepted)

Noble K Kurian, Sarita G Bhat, Bacterial Melanins (Book Chapter), Microbial Bioproducts, edited by Sarita G Bhat, Padma Nambisan, 01/2014: pages 97-110; Directorate of Public Relations and Publications, Cochin University of Science and Technology., ISBN: 978-93-80095-51-6. Preprints & Working Papers

Kurian, N. K. (2022). Extraction and Purification of Melanin From Various Cells and Tissues. Preprints Jigna, C., & Gordhanbhai, P. M. Kurian, N. K (2022). Bacterial melanin with immense cosmetic potential produced by marine bacteria Bacillus pumilus MIN3. Preprints Gordhanbhai, P. M., Jigna, C., & Kurian, N. K. (2022). Halophilic bacteria Bacillus altitudinis MIM2 producing melanin isolated from Mundra port, Kutch, Gujarat, India. bioRxiv. Kurian, N.K. Novel Coronavirus (COVID-19) in India. Preprints 2020, 202******* (doi: 10.20944/preprints202003.0436.v1).

PRESENTATIONS

Invited Talks

Presented a keynote talk on the’ The Black Gold of Bacteria’ at Kalinga University, Raipur on 12th November 2021

Presented in a webinar titled ‘How to prepare for Competitive Examinations conducted by MES College, Marampally, Ernakulam on September 2020

Poster and Oral Presentations in conferences

Kurian N K, Laxmi M, Nair H P, Bhat S G (2016) Melanins with Anti-biofilm and Anticancer activities from marine Pseudoalteromonas lipolytica BTCZ28, International Conference on Materials for the Milleneium, MATCON 2016, CUSAT, Kochi

Noble K Kurian. Laxmi M, Harisree P Nair, Sarita G Bhat, Melanins with Anti-biofilm and Anti- inflammatory activities from marine Pseudomonas stutzeri BTCZ10, Proceedings of India International Science festival, IIT Delhi, New Delhi, 12/2015. Noble K Kurian, Amritha CK, Harisree P Nair, Sarita G Bhat, A novel melanin producing Pseudoalteromonas lipolytica BTCZ28 isolated from 96m depth marine sediments, Proceedings 24th Swadeshi Science Congress, Thunjath Ezhuthachan Malayalam University,Tirur; 11/2014. Noble K Kurian, Sarita G Bhat, Melanin production by marine Vibrio alginolyticus BTKK1, Proceedings of National Symposium: Emerging trends in Biotechnology; 01/2012 R.P.Pandey, Noble K Kurian, Md. Shahnawaz, P. W. Ramteke, A. K. Srivastava (2020) Screening of Osmotolerant bacteria from Thar Desert, Rajasthan, National Symposium on Plant Disease Management for Food Security under Climate Change Scenario At: ICAR-Indian Institute of Wheat and Barley Research, Karnal

JOURNAL ROLES

Review Editor at Frontiers in Microbiology

Founding editor in chief of Biotechnological Research Editorial board member of Acta Scientific Microbiology REFERENCES

Dr. Deepak Modi

Senior Scientist

Post Doc Mentor

National Institute for Research in

Reproductive Health (ICMR)

Parel, Mumbai

ad1q2u@r.postjobfree.com

Prof. Sarita G Bhat

Professor

PhD Mentor

Department of Biotechnology

Cochin University,

Kochi, Kerala

ad1q2u@r.postjobfree.com

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