Huang *

CURRICULUM VITAE

ZHEPING HUANG

(Oct *, 2023)

Contact Information

Email: ad1gmp@r.postjobfree.com

Address: * **** ******, **********, ** 02806

Cell Phone: 401-***-****

EDUCATION

PROFESSIONAL EXPERIENCE

2017-current Research Fellow at Women & Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University.

2016-2017 Postdoc Fellow at the Department of Immunology, University of Connecticut Medical School.

2009-2016 Postdoctoral Associate at Women & Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University.

2008-2009 Postdoctoral Fellow at the University of Arizona. 2004-2008 Postdoctoral Fellow at the University of Michigan. 1994-2000 Physician, Department of respiratory disease, Huadong Hospital (affiliated 2000-2003 Ph.D Fudan University Shanghai Medical College. Shanghai, China

Major: Developmental Biology.

Supervisor: Prof. Jiake Tso.

1991-1994 Master’s Degree Fudan University Shanghai Medical College. Shanghai, China

Major: Internal Medicine (clinical research)

Supervisor: Prof. Huiru Zhu

1983-1988 Bachelor's Degree Fujian Medical University School of Medicine. Fuzhou, China

Major: Clinical Medicine.

Huang 2

with Fudan University), Shanghai, China.

1988-1991 Pediatrician in Yongding District Hospital, Longyan, Fujian, China. RESEARCH PROJECTS

1. The molecular mechanisms of preeclampsia and roles of trehalose in preeclampsia. 2. microRNA-regulated adipose tissue macrophage and B cell activation under obese stress. 3. Genetic stress and toxicant-induced pregnancy disruption. 4. Strain-induced release of EGFR ligands during fetal lung development. 5. The protective role of Nrf2 in arsenic-induced toxicity and carcinogenicity; regulation of the transcription factor Nrf2 by chemo-preventive compounds. 6. Golgi’s defect in Alzheimer’s disease.

7. Post-translational regulation of AANAT and TPH1 in the melatonin synthesis pathway. PUBLICATIONS

1. Cui Y*, Zhuang M*, Huang Z*, Guo Y, Chen F, Li Y, Long Y, Liu Y, Zeng G, Feng X, Chen X. 2023. An antihypertensive drug-AT1 inhibitor attenuated BRCA development caused by chronic psychological stress via Ang II/PARP1/FN1 pathway. Submitted to BBA - Molecular Basis of Disease (*Equal contribution) (Manuscript status: in revision). 2. Huang Z, Cheng S, Jash S, Farce J, Agudelo A, Higashiyama T, Hanna N, Nakashima A, Saito S, Padbury J, Schuster J, Sharma S. 2023. Exploiting sweet relief for preeclampsia by targeting autophagy-lysosomal machinery and proteinopathy. Experimental & Molecular Medicine. In print.

3. Lu C, Huang Z, He H, E Yiting. 2023. Teacher-student Relationships and Hope among Rural Adolescents: A Moderated Mediation Model. Asia Pacific Journal of Education. https://doi.org/10.1080/02188791.2023.2286199.

4. Cheng S, Huang Z, Nakashima A, Sharma S. 2023. Gestational Age-Dependent Regulation of Transthyretin in Mice during Pregnancy. Biology. 12,1048. 5. Lu C, Huang Z, E Yiting. 2023. Peer trust and prosocial behavior among rural left-behind adolescents: the moderating role of hope. Journal of Moral Education. https://doi.org/10.1080/03057240.2023.2220934.

6. Huang Z, Li Y, Konishi K, Sakai Y, Tashiro K, Fukami T, Borjigin J. 2023. In vitro deacetylation of N-acetylserotonin by arylacetamide deacetylase. Journal of Pineal Research. 75(1): e12870.

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7. Lu C, Li Y, Huang Z*. 2022. Sars-Cov-2, its variants, and the impact of the pandemic on adolescent mental health. Biomedical Journal of Scientific & Technical Research. 4(5):359**-***** (review) (Corresponding Author).

8. Cheng S, Huang Z, Jash S, Wu K, Saito S, Nakashima A, Sharma S. 2022. Hypoxia- reoxygenation impairs autophagy-lysosomal machinery in primary human trophoblasts mimicking placental pathology of early-onset preeclampsia. International Journal of Molecular Sciences.23,5466.

9. Cheng S, Huang Z, Banerjee S, Jash S, Baxbaum JN, Sharma S. 2022. Evidence from human placenta, ER-stressed trophoblasts and transgenic mice links transthyretin proteinopathy to preeclampathsia. Hypertension. 79(8):1738-1754. 10. Banerjee S, Huang Z, Wang Z, Nakashima A, Saito S, Sharma S, Cheng S. 2021. Etiological value of sterile inflammation in preeclampsia: is it a non-infectious pregnancy complication? Frontiers in cellular and infection microbiology. 11:694298. 11. Cheng S, Banerjee S, Daiello LA, Nakashima A, Jash S, Huang Z, Drake JD, Ernerudh J, Berg G, Padbury J, Saito S, Ott BR, Sharma S. 2021. Novel blood test for early biomarker of preeclampsia and Alzheimer’s disease. Scientific Reports.11(1):15934. 12. Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, et al. 2020. Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia. Autophagy. 16(10):1771–1785.

13. Cheng SB, Nakashima A, Huber WJ, Davis S, Banerjee S, Huang Z, et al. 2019. Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors. Cell death and disease. 10: 927.

14. Li C*, Ying W*, Huang Z, et al. 2017. IRF6 regulates alternative activation by suppressing PPARγ in male murine macrophages. Endocrinology. 158(9):2837-2847. 15. Kalkunte S*, Huang Z*, Lippe E, Roberston L, Sharma S. 2017. Polychlorinated biphenyls target the Notch/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. (*Equal contribution). Scientific Reports. 7:39885. 16. Wadas B, Borjigin J, Huang Z, Oh JH, Hwang CS, Varshavsky A. 2016. Degradation of AANAT, a Circadian Regulator, by the N-end Rule Pathway. Journal of Biological Chemistry. 291(33):171**-*****.

17. Chen X *, Jiang Y*, Huang Z*, Li D, Chen X, Cao M, Meng Q, Pang H, Sun L, Zhao Y, Cai L. 2016. miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting sCLU. (*Equal contribution). Scientific Reports. 6:19455. Huang 4

18. Lin Q, Aihara A, Chung W, Li Y, Chen X, Huang Z, Weng S, Carlson RI, Nadolny C, Wands JR, Dong X. 2014. LRH1 promotes pancreatic cancer metastasis. Cancer Letter. 350(1-2):15-24.

19. Joshi G, Chi Y, Huang Z, and Wang Y. 2014. Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production. Proceedings of the National Academy of Sciences of the United States of America. 111(13): E1230-1239. 20. Lin Q, Aihara A, Chung W, Li Y, Huang Z, Chen X, Weng S, Carlson RI, Wands JR, Dong X. 2014. LRH1 as a driving factor in pancreatic cancer growth. Cancer Letter. 345(1):85-90.

21. Wang Y, Huang Z, Nayak PS, Matthews BD, Warburton D, Shi W, Sanchez-Esteban J. 2013. Strain-induced differentiation of fetal type II epithelial cells is mediated via integrin α6β1-ADAM17/TACE signaling pathway. Journal of Biological Chemistry. 288(35):25646- 57.

22. Hokenson MA, Wang Y, Hawwa RL, Huang Z, Sharma S, Sanchez-Esteban J. 2013. Reduced IL-10 production in fetal type II epithelial cells exposed to mechanical stretch is mediated via activation of the IL-6-SOCS3 signaling pathway. PLoS One. 8(3):e59598. 23. Huang Z, Wang Y, Nayak PS, Dammann CE, Sanchez-Esteban J. 2012. Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions. Journal of Biological Chemistry. 287(22):18091-102.

24. Wang Y, Huang Z, Nayak PS, Sanchez-Esteban J. 2012. An experimental system to study mechanotransduction in fetal lung cells. Journal of Visualized Experiments. 60: e3543, doi: 10.3791/3543.

25. Hawwa RL, Hokenson MA, Wang Y, Huang Z, Sharma S, Sanchez-Esteban J. 2011. Differential expression of MMP-2 and -9 and their inhibitors in fetal lung cells exposed to mechanical stretch: Regulation by IL-10. Lung. 189(4):341-9. 26. Hawwa RL, Hokenson MA, Wang Y, Huang Z, Sharma S, Sanchez-Esteban J. 2011. IL-10 inhibits inflammatory cytokines released by fetal mouse lung fibroblasts exposed to mechanical stretch. Pediatric Pulmonology. 46(7):640-9.

27. Jiang C, Jiang Y, Huang Z, Shen W, Wang J, Shen Q. 2010. Evaluation of the immunogenicity of a single chain chimeric peptide composed of hCGβ and oLHα for inhibition of the growth of hCGβ expressing cancer cells. Cancer Immunology, Immunotherapy. 59(12):1771-9.

28. Wang Y, Maciejewski BS, Drouillard D, Santos M, Hokenson MA, Hawwa RL, Huang Z, Sanchez-Esteban J. 2010. A role for caveolin-1 in mechanotransduction of fetal type II epithelial cells. American Journal of Physiology: Lung cellular and molecular physiology. 298(6):775-83.

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29. Huang Z, Liu T, Borjigin J. 2010. The N-terminal residues regulate proteasomal degradation of AANAT. Journal of Pineal Research. 48(3):290-6. 30. Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, Zhang DD. 2010. The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes. 59(4): 850-60. 31. Chattoraj A, Liu T, Zhang LS, Huang Z, Borjigin J. 2009. Melatonin formation in mammals: in vivo perspectives. Reviews in Endocrine and Metabolic Disorders. 10(4):237-43. (review) 32. Jiang T*, Huang Z*, Chan JY, Zhang DD. 2009. Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicology and Applied Pharmacology. 240(1):8-14

(* Equal contribution).

33. Zhao F, Wu T, Lau A, Jiang T, Huang Z, Wang XJ, Chen W, Wong PK, Zhang DD. 2009. Nrf2 promotes neuronal cell differentiation. Free Radical Biology & Medicine. 47(6):867-79. 34. Sun Z, Huang Z, Zhang DD. 2009. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One. 4(8):e6588.

35. Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, Zhang DD. 2009. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Molecular Cell. 34(6):663-73.

36. Huang Z, Chattoraj A, Li X, Snyder SH, Borjigin J. 2009. The increased degradation of NAT-H28Y mutant protein is due to a reduced interaction with 14-3-3. Journal of Pineal Research. 46(1):119-20.

37. Huang Z, Liu T, Chattoraj A, Ahmed S, Wang M, Deng J, Sun X, Borjigin J. 2008. Posttranslational regulation of TPH1 is responsible for the night surge of 5-HT output in the rat pineal gland. Journal of Pineal Research. 45(4):506-514.(letter to editor). 38. Wang J, Huang ZP, Nie GY, Salamonsen L, Shen QX. 2007. Immunoneutralization of endometrial monoclonal nonspecific suppressor factor beta (MNSFβ) inhibits mouse embryo implantation in vivo. Molecular Reproduction and Development. 74(11):1419-27. 39. Wang J*, Huang ZP*, Yang ZM, Shen WX, Tso JK, Shen QX. 2006. Uterine expression of adenovirus E4 promoter binding protein 4 (E4BP4) during the embryo implantation period in mice. Fen Zi Xi Bao Sheng Wu Xue Bao. 39(2):123-31 (*Equal contribution). 40. Huang Z, Deng J, Borjigin J. 2005. A novel H28Y mutation in LEC rats leads to decreased NAT protein stability in vivo and in vitro. Journal of Pineal Research. 39(1):84–90. Huang 6

41. Huang P, Huang ZP, Shen WY Shen QX. 2005. Expression of recombinant implantation serine proteinase-2 (ISP2) in insect cells. Reproduction & Contraception. 25(8):451-5 42. Hou LL, Jiang S, Shen WY, Huang ZP, Shen QX. 2004. Expression of human follicle stimulating hormone in insect cells. Shi Yan Sheng Wu Xue Bao. 37(2):133-8. 43. Huang ZP, Yu H, Yang ZM, Shen WX, Wang J, Shen QX. 2004. Uterine expression of implantation serine proteinase 2 during the implantation period and in vivo inhibitory effect of its antibody on the embryo implantation in mice. Reproduction, Fertility, and Development. 16(3):379-84.

44. Huang ZP, Wang J, Yu H, Shen WX, Huang P. 2003. Cloning, expression, and antibody production of mouse ISP2. Acta Biochimica et Biophysica Sinica. 35(7):649-54. 45. Huang ZP, Ni H, Yang ZM, Wang J, Tso JK, and Shen QX. 2003. Expression of regulator of G-protein signaling protein 2 (RGS2) in the mouse uterus at implantation sites. Reproduction. 126(3):309-16.

46. Huang ZP, Wang J, Shen WX, Huang P, and Shen QX. 2002. The screening of mouse genes for blastocyst implantation using PCR subtraction. Reproduction and Contraception. 13(1): 237-45. 47. Huang ZP, Ke BX, Wang J, and Shen QX. 2002. Expression of monoclonal nonspecific suppressor factor β in E. coli, preparation of its antibodies and its tissue orientation in the mouse endometrium. Shi Yan Sheng Wu Xue Bao. 35 (2): 89-97. (Chinese). 48. Huang ZP, Zhu HR, Yu XZ, Zhang RF, Wu SM. 1999. Detection of Specific IgE for pollens of Platanus orientalis L in serum with BSA-ELISA. Chinese Journal of Microbiology and Immunology. 17(2): 127. (Chinese).

PRESENTATIONS

2022 Oral presentation: “Sweet Relief for Preeclampsia: Targeting Autophagy and Protein

-opathy”. The 41st Annual Meeting of the American Society for Reproductive Immunology. Nashville, Tennessee.

2011 Oral presentation: “Stretch-Induced Differentiation of Fetal Type II Epithelial Cells Requires an Intact EGFR”. Pediatric Academic Societies & Asian Society for Pediatric Research Joint Meeting. Denver, Colorado. Huang 7

2003 Oral presentation: “The identification of implantation-related genes and the function study of implantation serine proteinase 2”. Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada. 2003 Oral presentation: “Antibody production, Immuno-staining Analysis and Inhibitory Effect of ISP2 Antibody,” The Ninth National Symposium on Reproductive Biology. Haikou, Hainan Province, China.

1997 Oral presentation: “Detection of Specific IgE for Platanus orientalis L in Serum with BSA- ELISA”, 2nd National Symposium on Asthma. Qingdao, Shandong Province, China.

Teaching

2013 Molecular Biology Techniques. College of Pharmacy, University of Rhode Island. Approved Patents

1. Jian Wang, Qingxiang Shen, Zheping Huang. MNSF ’s function and application in embryo implantation. CN101028522 B

2. Jian Wang, Qingxiang Shen, Zheping Huang. E4BP4’s function and application in embryo implantation. CN 101024089 A

Expertise

1. Ph.D. degree in developmental biology. 17 years of biomedical and toxicological research experience, skilled in the field of molecular biology, familiar with the usage of animal models of human disease.

2. Received 8 years of training at a medical school in China with 9 years of clinical experience in China, proficient in diagnosis and treatment of respiratory diseases. [No US medical license]

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