Project Medical

Kelvin He, Ph D

E-mail: **.**********@*****.***

Cell phone: 201-***-****

Professional Summary:

Technical experience in pharmaceutical company and research labs using problem solving methodologies to obtain result ahead of the competition. Expertise in Clinical SAS programming for Biostatistics. Self-motivated, goal-oriented, highly analytical, and able to work in a team environment and independently.

Novartis, NJ Feb 2016 - now Statistical Programmer

•Developed and validated SAS programs for analysis datasets, pooled datasets.

•Developed and validated SAS programs for data summary tables/listing/graphs, ad-hoc reports.

•Created E-Sub deliverables: Define.pdf and SAS xpt files.

•Generated programming specifications for analysis datasets, pooled datasets, deliverables.

•Wrote, updated, and documented Macros and SAS programs.

•Ran SAS programs in the Windows/UNIX operating system environment.

Robert Wood Johnson Medical School Dept. of Neurology May 2012 - Sept 2013 Research associate II

•Identified biomarkers of Parkinson’s Disease by analyzing Patient’s samples of Parkinson’s disease.

•Cloned 8 new full-length natural antisense transcripts of SNCA gene (encoding α-synuclein) by 5’-RACE and 3’-RACE.

•Designed experiments to discover that some important mRNAs and non-coding RNAs are regulated by DJ-1.

•Evaluated and validated their relationship by RT-qPCR with microarray technique. Investigated project and made recommendations that provided team with additional visibility and improved project efficiency.

•Mentored and evaluated junior level scientists, supervised experiments, including sample preparation, instrument operation, troubleshooting, and data analysis. Designed and reviewed their deliverables as needed in an accurate and timely manner, effectively coordinated efforts and tracked the progress for multiple projects.

Mount Sinai School of Medicine Dept. of Neurology June 2007 - May 2013 Postdoctoral Fellow

•Project 1: beclin 1 structure-function analysis

Discovered that Atg14L and UVRAG compete beclin 1 and form two different beclin 1-vps34 subcomplexes to exert their effect on arrays of VPS34-related activities including autophagy.

•Project 2: Atg14L KO mouse generation and characterization

Generated an Atg14L KO mouse model and found its homozygous mouse is embryonic lethal. Its heterozygous mouse has higher tumorgenesis than wild type mouse. Identified Atg14L as a key member of autophagosome formation.

•Project 3: Role of Nrbf2 in the autophagy pathway

Identified Nrbf2 as a new component of Beclin 1-Atg14L protein complex; Found that Nrbf2 regulates autophagy and prevents liver injury by modulating beclin 1/Atg14Llinked class III phosphatidylinositol-3 kinase activity. Collaborated with researchers from partner labs. Generated and maintained experimental reports, manuscripts, grants, and patent.

EDUCATION

PhD in Genetics State Key Laboratory of Medical Genetics, Central South University, China

M.Sc. in Biochemistry & Molecular Biology Hunan Agricultural University, China

B.Sc. in Biology (Honor Graduate) Hunan University of Science and Technology, China

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