MATLAB/Data analysis/design/development/research/root cause analysis

MADHAVI TIPPANI

Arlington, TX Email: *******.*******@****.***.*** Cell: +1-469-***-**** https://www.linkedin.com/in/madhavi-tippani-51931254

SUMMARY:

Biomedical Engineer, proficient in application development/testing/deployment and code generation. Experienced in data collection/processing, statistical data analysis with proven analytical and problem solving skills. Skilled at medical image/signal processing (image reconstruction, segmentation, calibration etc.), and troubleshooting/preventive maintenance, root cause analysis.

EDUCATION:

The University of Texas at Arlington and the University of Texas Southwestern Medical Center, Dallas

Master of Science in Bioengineering and Biomedical Engineering

CGPA-4.0/4.0 Aug’2014 – May’2016

Jawaharlal Technological University, India

Bachelor of Technology in Biomedical Engineering

CGPA-3.3/4.0

Sep’2009 – May’2013

FUNCTIONAL EXPERTISE and SKILLS:

MATLAB and SIMULINK, R, Python, SQLite, LabVIEW, SolidWorks, C, GPU programming, MS Office Suite, Image J, DSP, AutoCAD, Photoshop, EEGLAB, GMP, GLP, GCP, FDA, and ISO Regulations, Hypothesis Testing (F, T, P tests etc.), Documentation, Optical fiber polish

PROFESSIONAL EXPERIENCE:

Research Programmer - Ophthalmology department, UT Southwestern Medical Center, Dallas, Texas.

Oct’16 – Present

Recreated the IMAGEJ Directionality plugin in MATLAB to overcome the speed & memory drawbacks in IMAGEJ.

Developed a tool to perform correlation analysis on corneal microscopic (in vitro and in vivo) data to validate that cell patterning depends on collagen organization, generated and presented the analysis reports.

Study the changes in gene and protein expression during the regenerative phase of healing in the rabbit cornea, to form the base for finding novel therapies to treat corneal scarring (major cause of blindness) in humans.

Design and validate database and data transfer protocols for time efficient data processing and maintaining inventory.

Calibrate and trouble shoot the high-resolution (electron, fluorescent and in-vivo) microscopes for imaging collagen fibrils in cornea.

Effectively participate with groups to come up with novel solutions to the engineering problems that evolve during design process.

Volunteer data analyst - Bioengineering department, UT Arlington, Texas.

Jul’16 – Sep’16

Collected EEG data from control group before and after the LLLT (Low-Level Laser Treatment) and analyzed the signals on EEGLAB (MATLAB) to prove the positive effects of laser treatment over disabled veterans.

Designed a FFT based bandpass filter for the EEG signals for noise reduction and recruits human subjects for the study.

Research Assistant - Ophthalmology department, UT Southwestern Medical Center, Dallas, Texas.

Sep’15 – May’16

Installed system software following manufacturer’s manual and performed routine tests to ensure efficient results.

Designed protocols and developed algorithms for 2D and 3D image reconstruction to access corneal pathology and monitor the corneal response to various treatments.

Programmed User defined MATLAB functions for decoding (DICOM, Volume) header files and perform signal processing.

Deployed a GUI based tool using MATLAB compiler, for quantitative data analysis of 3-Dimensional confocal imaging in vivo.

Research and Laboratory Assistant - Bioengineering department, UT Arlington, Texas.

Oct’14 – May’15

Developed protocols for optimal probe geometry (with maximum laser diodes and detectors) for high-resolution images that help surgeons differentiate the cancer tissue from normal tissue.

Designed a 3D model of probe (on SOLIDWORKS) and developed the mold on a glass plate for data collection.

Performed Data collection, Data scrubbing, Data analysis (F and T Tests), Data modeling and Data visualization.

Collaborated with technicians: provided them the timely equipment performance and documented the machine technical errors.

Sales Executive -Aspirejobz.com Services Pvt. Ltd., Hyderabad, India.

Dec’13 – Jun’14

Achieved increased productivity as a team lead (team of 4 members).

Implemented improved marketing strategies and marketed company products and services, thus increasing company sales by 8%.

Coordinated work schedules with clients and submitted daily logs to client for review.

Intern, Biomedical Technician - Care Hospitals, Hyderabad, India.

May’12 – Jun’12

Trained on patient care protocols, hazardous chemicals, medical lab record policies and repair documentation.

Performed testing, root cause analysis, system restoration, evaluated life expectancy, and worked on spare parts replacement

Worked with dialysis unit and documented the procedure, machine needs, media used and different catheter needs.

Gained knowledge about cardiac angiography and balloon procedures, studied about stent categories (drug eluting, Bioresorbable etc.) and wire gauges used during tricky angioplasties.

PROJECTS

Image processing and 3D reconstruction of MRI Brain images

Developed MATLAB code to display 2D and 3D contour map of tumor and brain tissue to visualize the approximate position and size of tumor in the brain. It also displays the montage view of 53 consecutive brain images. Documented the project with comments on the code.

Corneal Image Processing Analytical tool

Developed an analytical tool on MATLAB to study the cellular events of wound healing after a corneal surgery or an infection and generate an analysis report (text file) on it. The tool was tested using corneal data of mice and rabbits collected through in vivo confocal microscope. The tool has features (built with User defined functions) allowing a user to:

- Input Volume files of different sizes from a confocal microscope and project side, front, top and 3D views of the 2D corneal image stack

- Pick a desired Region of Interest (ROI) from the stack and perform analysis such as smoothening with different masks

- Calculate the stromal haze area from the generated intensity curve; calculate the epithelial, stromal and endothelial thicknesses

Wireless Data Communication and Energy Transfer for Implantable Devices

Developed a magnetic coil to achieve non-invasive energy transfer into the implantable devices, to avoid multiple surgeries for recharging the implantable. ‘Witricity’, a phenomenon of magnetic resonance is proposed to exchange energy efficiently between strongly coupled resonant objects in a certain range. Additionally, RF communication was established with the implantable device using a microcontroller AT89C52 (programmed using Keil microvision 3) to modify the operational parameters as per the requirements

Study the dependency of exercise levels on disease duration

The main objective for carrying out the study is to check if the improvement in exercise duration is dependent on the patient’s disease history. Regression analysis was performed at 5% level of significance, a linear relationship with negative correlation between the “disease duration”, and the “percentage improvement in exercise” was observed .i.e. with increase in disease duration the improvement in exercise decreases.

Segmentation of Heart structure from surroundings

Segmentation techniques like Thresholding, Region Growing, Erosion, Dilation, Opening and Closing etc. were performed on a CT heart image and the results were compared to check the efficient technique. Segmentation was performed to examine the contrast-enhanced heart by eliminating the additional structures like bones and parts of large blood vessels of lung surrounding the heart and parts of patient table.

Study on effect of cancer severity on lifespan of patients

Performed statistical data analysis on the data set containing an assay on cutaneous melanoma (malignant cancer). Hypotheses testing was performed in ‘R’, F-tests and T-tests were performed on all combinations of data categories (disease severity levels) and concluded that average lifetime decreased with increased severity. Performed normality check and concluded the lifetime of patient follows approximately normal distribution. Documented the results of five number summary, boxplot, normality and hypotheses tests.

Frequency Domain Photon migration in tissue

Demonstrated Frequency Domain optical migration technique by measuring the absorption coefficient and reduced scattering coefficient of 1% concentration intralipid using a laser (633nm, 90MHz). Laboratory safety rules for using laser were followed and learned side effects of laser.

LabView projects.

- Image Acquisition and Processing – developed a VI to acquire and store video images and process them, Implementation of edge detection algorithm in LabVIEW.

- Interfaced photo detector with LabView and plotted SNR of photo-detector, to measure the profile of a collimated laser beam.

- Signal Acquisition and Processing using LabView and DAQ card – developed a VI to generate waveform and display frequency spectrum and a VI to acquire analog signal and display frequency spectrum.

- Developed a VI (User Interface) with all prompts for temperature conversion from Fahrenheit to Celsius and vice versa.

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