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Microsoft Office Research

Location:
Tamil Nadu, India
Posted:
October 28, 2016

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Resume:

MURUGESAN ARUMUGAM

UGC-BSR Fellow, Department of Pharmacy

Annamalai University, Annamalai Nagar, Tamilnadu state, India

Mobile: +91-887******* Email: acwfct@r.postjobfree.com

Career Objective

Looking to secure a position in a research organization, where I can bring immediate and strategic value and develop current skill set further. As a highly-motivated and results orientated researcher within the drug discovery sector, I have a proven track record of providing exemplary levels of service to a broad range of assay development, including in-vivo receptor occupancy assays and biomarker assays in animal models.

Positions Held

University Grant Commission- Basic Science Research (UGC-BSR) Fellow, (Sponsored by the Government of India)

PhD Scholar

Department of Pharmacy

Annamalai University, Tamilnadu state, India

Feb 2012 to Oct 2016

Research Associate

Drug metabolism & Pharmacokinetics (DMPK) Lab

Discovery Research, Suven Life Sciences Ltd, Hyderabad, India

Feb 2008 to Sep 2011

Assistant Professor

Mohamed Sathak A. J. College of Pharmacy, Chennai, India

July 2007 to Jan 2008

Professional Experience

Quantification of Lymphocyte population in human peripheral blood using validated flowcytometry.

Successfully established a novel animal model to test the antimigraine compound efficacy using fluorometry and fluorescence microscopy techniques.

With my expertise in in-vivo brain receptor occupancy studies, I served as a primary inventor for studies sponsored by Elli Lilly and company, held at Suven Life Sciences Ltd, Hyderabad, India.

Established novel biomarker assays for Alzheimer’s and neuropathic pain by ELISA technique.

Highly skilled at micro dissections of various brain regions.

Adept in biomarker assay method development and validation.

Well familiar with various surgical procedures in laboratory animals.

Proficient in nonspecific binding assays of NCE’s.

Experience in laboratory animals care, maintenance and breeding of various strains of mice and rats.

Principal contributor in the preparation of Investigational New Drug (IND) application for USFDA review in Suven-Eli Lilly collaborative project.

Preparing a draft study protocol for the clients like Eli Lilly, USA.

Prepared posters for conference proceeding and manuscript for publications.

Data processing, statical analysis, etc.

Teaching/demonstrating Pharmacology to the undergraduate Pharmacy student.

Awards and honors

Part of a winning team of the drug discovery challenge 2015 at the “Workshop: Researcher Mobility in Drug Discovery” organized by the Drug discovery pathway group, United Kingdom.

Received, Young scientist - International travel award from the Department of science and technology, the Government of India to attend the Workshop: Researcher mobility in drug discovery, 7-8th December 2015, Milton Keynes, UK.

Received, Travel grant (cost related to accommodation and food) from the Royal society of chemistry to attend the Workshop: Researcher mobility in drug discovery, 7-8th December 2015, Milton Keynes, UK.

The organization committee of the International Headache Academy has been nominated as one among the 60 neurologists around the world to participate, iHEAD meeting 2014, 31st October to 2nd November held at Leiden University, the Netherlands.

Received, travel grant (include accommodation cost) from the International Headache Society, London to attend iHEAD meeting 2014 at Leiden University, the Netherlands.

I pioneered to procure the prestigious 3R’s facility approval from Eli Lilly & CO, USA to authorize the use of animals for in vivo research at the department of Pharmacology and then to the entire Annamalai University.

Participated, Novartis Biotechnology Leadership Camp, July 7-10, 2013 Hyderabad, India on behalf of Tamilnadu State.

Resource Person for the provision of hands on training in experimental pharmacology: animal handling, University Grant Commission, Government of India sponsored, March 05, 2012, Annamalai University, India

Participated as one among the 50 selected meritorious students in India for a workshop on good laboratory practice and good clinical practice, Government of India sponsored, held during 28th May - 2nd Jun 2012, CERD, Loyola college, Chennai

Received, a meritorious University Grant Commission Basic Science Research (UGC-BSR) fellowship, Sponsored by Government of India to carry out Ph.D.

Procured a generous financial assistantship from Vidyaratnam Oushadhasala, India to carry out M. Pharm dissertation work entitled “Antidiabetic, antioxidant and toxicity studies of MEHANIL - A poly herbal formulation” at the Amala Cancer Research Center, India.

Worked hard to make MEHANIL available in clinics in the form of tablets.

Publications

Murugesan Arumugam & Varadarajan Parthasarathy. Reduction of CD4+CD25+ regulatory T-cells in migraine: Is migraine an autoimmune disorder? Journal of Neuroimmunology, January 15, 2016; Volume 290, Pages 54–59

Murugesan Arumugam & Varadarajan Parthasarathy. Increased incidence of migraine in women correlates with Obstetrics and Gynaecological surgical procedures, International Journal of Surgery, 2015 Oct; 22:105-9.

Murugesan Arumugam & Varadarajan Parthasarathy. Effect of certain clinically proved anti migraine compounds on Capsaicin induced plasma protein extravasation into the Rabbit regional brain. Under review. Medicina.

Gopinadh Bhyrapuneni, Vishwottam Kandikere, Nageswararao Muddana, Ramanatha Saralaya, Murugesan Arumugam et al., Neuronal nicotinic acetylcholine α4β2 receptor occupancy assay in rats using unlabeled ZW-104 as a tracer, Alzheimer's and Dementia, 7 (4), 1, July 2011, S649-S650.

Formulation Development and Evaluation of Carprofen Microspheres, international Journal of PharmTech Research, Vol.2, No.3, pp 1674-1676.

Paper presented at annual meetings

Murugesan Arumugam & Varadarajan Parthasarathy. “Significance of age factor on Migraine prevalence”, poster presentation, iHEAD meeting 2014, Leiden University, the Netherlands. .

Co-author, Development of selective and potent unlabeled ZW-104 ligand for neuronal nicotinic acetylcholine α4β2 receptors for receptor occupancy studies in rats, American Association of Pharmaceutical Scientist, 2012, USA.

Co-author, Neuronal nicotinic acetylcholine α4β2 receptor occupancy assay in rats using unlabeled ZW-104 as a tracer, Alzheimer's and Dementia, 7 (4), 1, July 2011, S649-S650

Co-author, In-Vivo Histamine H3 antagonist receptor occupancy assay in Rats using nonradioactive tracer, Society for Neuroscience Annual Meeting, 2010, USA.

Co-author, The effect of selective Histamine H3 receptor Antagonists on tele-methylhistamine levels in rats, Americans Association of Pharmaceutical Scientist, 2010, USA.

Co-author, Brain Distribution of Methyllycaconitine: A potent and selective Neuronal Nicotinic Acetylcholine Receptor Antagonist, Society for Neuroscience Annual Meeting, 2009, USA.

Softwares known

With my expertise in Microsoft office, especially Microsoft XLS and Graph Pad prism, I have been proceed many decision making data and results of Suven Life Sciences Ltd’s in-house projects and clients like Elli Lilly and company

Expertise in Windows, ACD Lab, Chemoffice, MDL chime and computer simulated Animal Models.

Professional Society Membership

Associate member, The Royal Society of Chemistry, Member ID: 589734

Associate member, International Headache Society, Member ID: AMIN01.

Student member, American Association of Pharmaceutical Scientist, Member ID: 228387.

Student member, American Academy of Neurology, Member ID: 235071.

Student member, American Association of Pharmacology and Experimental Therapeutics, Member ID: 23087.

Student member, European behavioural pharmacology Society, Member ID: 1007.

Student member, International Brain Research Organization.

Student member, Society for the Advancement of Animal Wellbeing.

Life member, Indian Pharmacy Graduation Association, LM. NO: 621.

Registered Indian Pharmacist, Reg. No: 10236/A1, S.No: 17619.

Ph.D Thesis

Title: Investigation of Autoimmunity in Migraine Headache

Migraine is believed to be a chronic neurological disorder with the exact etiology being unknown. But, there is a debate on the role of immune dysfunction in migraine pathophysiology. Hence, I made a debut attempt to explore the link between autoimmunity especially lymphocyte subsets populations and migraine pathophysiology. In addition to this, I also attempted to develop a novel animal model for migraine headache. Thus, I successfully developed a novel animal model to adapt at the early stage of anti-migraine drug development. This study was collaborated with Eli Lilly & CO, USA and the final results of the study is “under review” in the “Medicina” for publication.

In clinical studies, we also have demonstrated the increased incidence of migraine in women is correlated with obstetrics and gynaecological surgical procedures. These results are published in the “International Journal of Surgery”. In addition, part of the data from the present study was presented in the international headache academy (iHEAD) meeting 2014, Leiden University, the Netherlands. On top of this, very first time I identified that, the immuno regulator CD4+CD25+ levels were less in migraine patients compared to the healthy volunteers. The results of the present study indicate that failure of immuno regulation could be implicated in the pathophysiology of migraine and the data was published in “Journal of Neuroimmunology”.

Countries Visited

The Netherlands

United Kingdom

Curriculum

Annamalai University, India OGPA Year

Doctor of Philosophy in Pharmacy 2012-2015

Master of pharmacy in Pharmacology 8.03/10.0 2005-2007

Bachelor of Pharmacy 7. 29/10.0 2001-2005

Diploma in Pharmacy 76.27 1999-2001

Reference

Dr. K. Kannan, M.Pharm, PhD

Professor and Head

Department of Pharmacy

Annamalai University, Annamalai Nagar-608002

Mobile: +91-948*******

E-mail: acwfct@r.postjobfree.com

Dr. K. K. Perumal, MD, PhD

Professor in Medicine

Raja Muthiah Medical College and Hospital

Annamalai University, Annamalai Nagar-608002

Mobile: +91-944*******

E-mail: acwfct@r.postjobfree.com

DECLARATION

I hereby declare that the above particulars are true to the best of my knowledge.

Sincerely Yours

MURUGESAN A



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