Assistant University
Resume:
Yu-Shen Lin
U. S . Permanent Res ident
https://www. linkedin.com/in/yu-
shen-lin-40568338
*** ** ** * * St .
Sea t t l e, WA 98115
Ce l l Phone : 612-***-****
E-mail: *********@*****.***
Highly influential R&D scientist with 10+ years of experience in colloidal and nanoparticle synthesis, nanoparticle drug formulation, material characterization, bioconjugation chemistry, bioanalytical assay, and tissue culture. Led Oncothyreon “Protocell” scientific research development project. Internationally recognized with 34 publications (h-index 23), 3 issued international patents, and over 3800 citations worldwide. Seeking R&D opportunities in product development and commercialization.
Educat i on
2007 – 2012 Ph.D. Chemistry University of Minnesota, Twin Cities, USA 2002 – 2004 M.S. Chemistry National Taiwan University, Taiwan 1998 – 2002 B.S. Chemistry National Chung Cheng University, Taiwan Exper i ence
Dec. 2014 – May 2016 Scientist Oncothyreon Inc., Seattle y Led development of lipid coated mesoporous silica nanoparticles (Protocell) for targeted nucleic acid delivery. y Technical lead for material synthesis and lipid formulation. y Led assay development and method transfer from research to manufacturing. y Developed scaling process for silica nanoparticle synthesis from laboratory use to GMP manufacturing process. y Work resulted in 3 provisional patents.
Jan. 2014 – Nov. 2014 Research Asst. Professor The University of New Mexico, Albuquerque y Developed nanoconstructs for anti-cancer drug delivery in support of Leukemia & Lymphoma Society. y Demonstrated in vivo single cell targeting and cargo delivery using protocell via surface conjugation and formulation. y Developed unique shaped mesoporous silica nanoparticle for improved therapeutic cargo packaging and delivery. y Delivered national spoken report at NCI PI conference. June 2012 – Dec. 2013 Postdoctoral Fellow The University of New Mexico, Albuquerque y Investigated basic science of nanoparticle surface chemistry and in vivo stability. y Developed highly stable and targeted nanotheranostics for in vivo applications. y Leveraged chick embryo chorioallantoic membrane (CAM) models for evaluation of nanoparticle circulation. y Work resulted in 6 peer-reviewed papers and 2 international patents. y Mentored graduate student and undergraduate students. Sep. 2007 – April 2012 Research Assistant University of Minnesota, Twin Cities y Developed highly stable and multifunctional porous silica therapeutics based on covalent surface functionalization. y Investigated nanoparticle-biological safety, including silica, mesoporous silica, titania, and graphene/graphene oxide. y Developed widely adopted hemolytic assay for evaluation of nanoparticles safety in whole blood. y Trained graduate and undergraduate students in inorganic chemical synthesis and manuscript/proposal writing. y Work yielded 11 refereed papers with 1400 citations and 1 international patent. Sep. 2002 – June 2014 Research Assistant National Taiwan University, Taipei y Developed synthetic protocols of inorganic nanomaterials for applications including fluorescence probes, MRI contrast agents, and catalysts.
y Work resulted in 17 peer-reviewed papers with 2220 citations. Skills
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• Nanomaterial drug formulation, including synthesis, surface modification (silane chemistry), bioconjugation, characterization of nanoparticles and colloids, and specific experience formulating liposomes, Stöber silica, mesoporous silica, gold, silver, iron oxide, lanthanide oxide, graphene drug delivery vehicles.
• Characterization of nanoparticles with TEM, SEM, AFM, EDS, XRD, BET, UV-visible spectrometer/Nanodrop, ICP- OES/MS, TGA/DSC analysis, fluorescence measurements, dynamic light scattering and zeta-potential measurements, optical and fluorescent microscope, FT-IR and Raman spectrometer, relaxation time measurements.
• Basic cell/tissue culture skills, cell-based viability assays, gene transfection, endotoxin assays, cell staining, bio-TEM sample preparation, flow cytometry (FACS Calibur and CytoFlex), SDS-PAGE.
• Project management, report and personnel training. Pat ent s
• U.S. patent No. WO2015042268: Torroidal Mesoporous Silica Nanoparticles and Related Protocells.
• U.S. patent No. WO2015042279: Core and Surface Modification of Mesoporous Silica Nanoparticles to Achieve Cell Specific Targeting In Vivo.
• U.S. patent No. WO2012051341: Hydrothermal Process for Enhanced Stability of Mesoporous Silica Nanoparticles. Honors and Awards
• Cancer Nanoscience and Microsystems Training Center (CNTC) Postdoctoral Fellowship, UNM, 2013-2014
• Doctoral Dissertation Fellowship 2011-12, University of Minnesota, 2011-2012
• Robert L. Ferm Outstanding Graduate Teaching Award, University of Minnesota, 2007-2008
• Thank a Teacher Award from Center for Teaching and Learning, University of Minnesota, 2007
• Taiwan Merit Scholarship from National Science Council of Taiwan, 2007-2009
• Excellent Teaching Assistant Award, National Taiwan University, 2006-2007
• Yen Thesis Award for outstanding master research, Department of Chemistry, National Taiwan University, 2004
• Excellence in Master Degree Thesis Award from Dean of College of Science, National Taiwan University, 2004
• Graduate Research Poster Award, National Taiwan University, 2004
• Outstanding Teaching Assistant Award, National Taiwan University, 2002-2003
• Undergraduate Student Research Project Scholarship from National Science Council of Taiwan, 2001-2002
• Honorary Member of the Phi Tau Phi, Scholastic Honor Society of Taiwan, 2002
• Principal’s Scholarship for Undergraduates, National Chung Cheng University, 1998-2002 Prof es s i ona l Af f i l i at i on and Serv i ces y Journal referees for ACS Nano, ACS Biomaterials and Engineering, Journal of the American Chemical Society, Chemistry of Material, Nanoscale, Journal of Food Protection, Zeitschrift für Anorganische und Allgemeine Chemie, Bioresource Technology, Materials Research Society. y Member of ACS and MRS.
Se l ec t ed Publ i cat i ons (15 f i rs t -authored papers f rom 34 publ i cat i ons wi th 3878 c i tat i on) 1. Lin, Y.-S.; Haynes, C. L. Synthesis and Characterization of Biocompatiable and Size-Tunable Multifunctional Porous Silica Nanoparticles, Chem. Mater. 2009, 21, 3979-3986. (232 citations) 2. Lin, Y.-S.; Haynes, C. L. Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity, J. Am. Chem. Soc. 2010, 132, 4834-4842. (341 citations) 3. Lin, Y.-S.*; Liao, K.-H.*; Haynes, C. L.; Macosko, C. W. Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblast Cells, ACS Appl. Mater. Interfaces 2011, 3, 2607-2615. (363 citations) 4. Lin, Y.-S.; Abadeer, N.; Hurley, K. R.; Haynes, C. L. Ultrastable, Redispersible, and Small Highly Organomodified Mesoporous Silica Nanotherapeutics, J. Am. Chem. Soc. 2011, 133, 204**-*****. (67 citations) 5. Lin, Y.-S.*; Hurley, K. R.*; Haynes, C. L. Critical Considerations in the Biomedical Use of Mesoporous Silica Nanoparticles, J. Phys. Chem. Lett. 2012, 3, 364-374. (Cover article, 86 citations) 6. Lin, Y.-S.*; Townson, J. L.*; Agola, J. O.; Brinker, C. J. Re-Examining the Size/Charge Paradigm: Differing In Vivo Characteristics of Size and Charge-Matched Mesoporous Silica Nanoparticles, J. Am. Chem. Soc. 2013, 135, 16030- 16033. (24 citations)
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Re f erences
Professor Christy L. Haynes (Ph.D. advisor)
Department of Chemistry,
University of Minnesota-Twin Cities
Minneapolis, Minnesota, USA 55455
E-mail address: *******@***.***
Professor C. Jeffrey Brinker (Postdoc advisor)
Department of Chemical and Biomolecular Engineering, The University of New Mexico and Sandia National Laboratories, Albuquerque, New Mexico, USA 87131
E-mail address: *******@******.***
Dr. Scott R. Peterson
Chief Scientific Officer
Cascadian Therapeutics,
Seattle, Washington, USA 98121
E-mail address: *********@***********.***
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