Chemist

Daria Kalinina, PhD

**** ******** ****** ****. **********, Fl 919-***-**** *********@*****.*** Summary Innovative and results oriented scientific professional with over 15 years of experience in method development and validation, synthesis, detection, isolation, purification and characterization of various organic and inorganic compounds. Proven strengths in multi-tasking, ability to meet deadlines in a fast- paced environment preserving quality and scientific integrity. Extensive expertise in working and maintaining diverse analytical instrumentation including but not limited to HPLC, LC-MS, UV-Vis, FT- IR, 1D/2D NMR, Raman spectroscopy, Karl Fischer coulometric titrator, viscometry. Comprehensive knowledge of preparation, distribution and implementation of SOPs and validation protocols in GLP and GMP environments. Excels in providing innovative solutions, problem solving and delivering high quality data in an efficient manner in support of multiple programs, as well as proven ability to work in a team environment, saliently communicate successes and challenges while managing laboratory staff. Experience ALERA LABS –Durham, NC, USA

Scientist, January 2014 to present

• Method development, validation and transfer of LC-MS, HPLC (DAD, SEC, IEX, RI, fluorescence, ELSD), GPC, UV-Vis and FT-IR methods to quantitatively and qualitatively analyze small molecule and biological molecules for APIs, solid oral dosage forms, topical formulations, impurities, and drug degradation products in compliance with FDA cGLP/cGMP regulations.

• Structure elucidation/identification of drug degradation products, impurities, and leachable/extractable compounds by HPLC-DAD, LC-MS, FT-IR, UV-Vis, and NMR (1D and 2D).

• Preparation of stability protocols, execution of stability studies of intermediate and finished drug products .

• Successful planning and execution of forced degradation studies for drug substances and drug products.

• Routine testing of customer samples (enzymes, hormones, drugs, vitamins, pigments, biological matter, such as liver, ovaries, serum, plasma, brain, plant matter, etc.) according to approved procedures using HPLC, LC-MS, GC-MS, Karl Fischer coulometric titrator, UV-Vis, plate reader, FT-IR, NMR, cone plate viscometer.

• Review peer data for scientific methodology and regulatory compliance with cGMP/cGLP standards.

• Preparation of IQ/OQ protocols and SOPs (Training, Operation, Calibration and Preventative Maintenance), as well as their implementation.

• Regular calibration and maintenance of analytical equipment (HPLC, LC-MS, UV-Vis, Karl Fischer coulometric titrator, pH meters, cone plate viscometer, analytical balances, etc.), including IQ and OQ and PQ of new equipment and technologies.

• Project management including supervision of junior chemists, client communication, regulatory compliance and documentation (protocols, reports, etc.).

• Author detailed written reports and certificates of analysis used for FDA report filings Daria Kalinina, PhD

WISEMAN CONSULTING – Toronto, ON, Canada/Chapel Hill, NC, USA Consulting Chemist, January 2013 to December 2013

• Assisted in the development of technology used to extract oil from tar sands, and international technology transfer.

• Determined technological opportunities, including anticipating and exploring potential market needs.

• Sucessfully conducted evaluation and feasibility studies of projects for businesses, patent and literature searches, preparation of technical documentation, presentation of results to potential investors.

YORK UNIVERSITY – Toronto, ON, Canada

Research Assistant, December 2006 to October 2012

• Designed novel multi-step syntheses, isolated, purified (HPLC, LC-MS, extraction, column chromatography, various TLC methods, sublimation, distillation) and characterized (1H-NMR, 13C- NMR, HSQC, HMBC, COSY, DEPT-135, MS, LC, and elemental analysis) multinuclear ruthenium and iron complexes that have potential application in molecular electronics and catalysis.

• The multinuclear complexes were studied using modern analytical instrumentation including UV-Vis, FT-IR, electrochemistry (DPV, CV), spectroelectrochemistry.

• Excellent written and oral communication skills, authored several high impact peer-reviewed scientific papers and presented at national conferences.

• Trained and supervised laboratory staff both on instrumentation and safe laboratory techniques. YORK UNIVERSITY – Toronto, ON, Canada

Research Assistant, September 2004 to November 2006

• Synthesized, purified (HPLC, TLC, sublimation, recrystallization) and characterized (NMR, LC-MS, elemental analysis), various air and moisture sensitive inorganic biomimics.

• Demonstrated trends between the nature of the substituent and its position on a quinone and spectroscopic properties (DFT, TD-DFT, FT-IR, UV-Vis, electrochemistry, spectroelectrochemistry).

• Presentation of results at national conferences, regular internal communications and professional reports on the progress of all projects.

• Provided training and technical guidance to junior chemists to ensure the quality of work and timely completion of projects.

YORK UNIVERSITY – Toronto, ON, Canada

Teaching Assistant, September 2004 to May 2012

• Fostered a professional, positive, active and engaging environment for students through weekly laboratory assistance. Hands-on training of various laboratory techniques as well as the safe operation of analytical instruments.

• Evaluated students’ work including the grading of reports, assignments and tests. Provided constructive feedback to bolster student understanding. TRENT UNIVERSITY – Peterborough, ON, Canada

Materials Chemist, May 2003 to May 2004

• Performed synthesis, purification and characterization of sol-gels. This work contributed to the information included in the patent, filed by the industry partner.

• Developed new protocols for coating silicon wafers. 2001 Atlantic Shores Blvd. Hallandale, FL 919-***-**** *********@*****.*** Daria Kalinina, PhD

• Operated and maintained laboratory instruments and equipment, such as Raman spectroscopy, FT- IR, and UV-Vis spectrometer, melting point apparatus, pH meter, and calibrated analytical balances, pH meters, burettes, and pipettes.

• Completed monthly reports to the industry partner to present progress report, discuss future development direction, and consult on technical issues. Education Ph.D., Chemistry, York University, Toronto, ON, Canada 2012 Advisors: Distinguished Research Professor A.B.P. Lever, Professor P.G. Potvin M.Sc., Chemistry, York University, Toronto, ON, Canada 2006 Advisors: Distinguished Research Professor A.B.P. Lever, Professor P.G. Potvin B.Sc., Environmental Chemistry, Trent University, Peterborough, ON, Canada 2003 Publications and Presentations

• Kalinina, D.; Dares, C. J.; Lever, A. B. P. “Synthesis, Characterization, and DFT Investigation of a Series of Multinuclear Ruthenium Complexes Incorporating Non-innocent Ligands”, Oral Presentation at the 94th Annual Canadian Chemistry Conference, June 2011.

• Abboud, M.; Kalinina, D.; Potvin, P. G. “Pyrrole-substituted tridentate complexes of Ru(II): Spectroscopy, electrochemistry, photosensitization and the role of orbital mixing” Inorganica Chimica Acta 2009, 14, 4953.

• Kalinina, D.; Dares, C. J.; Kalurachchi, H.; Potvin, P. G.; Lever, A. B. P. “Spectroscopic, Electrochemical and Computational Aspects of the Charge Distribution in Ru(acac)2(R-o- benzoquinonediimine) Complexes” Inorg. Chem. 2008, 47, 10110.

• Lever, A. B. P.; Kalinina, D.; Dares, C. J.; Krainova, J. “o-benzoquinonediimine: An Exceptionally Non- innocent Ligand”, Oral Presentation at the 236th Annual American Chemical Society Meeting, August 2008. (Given by A. B. P. Lever).

• Kalinina, D. K.; Dares, C. J.; Lever, A. B. P. “Aspects of Ruthenium Benzoquinone Chemistry”, Oral Presentation at the 40th Annual Inorganic Discussion Weekend Conference, November 2007.

• Kalinina, D. K.; Dares, C. J.; Lever, A. B. P. “Strongly Coupled Ruthenium Benzoquinonediimine Complexes”, Oral Presentation at the 39th Annual Inorganic Discussion Weekend Conference, October 2006.

• Kalinina, D.; Kaluarachchi; Potvin, P. G.; Lever, A. B. P. “Characterization of Non-innocent Ruthenium Benzoquinone Complexes”, Poster Presentation at the 38th Annual Inorganic Discussion Weekend, November 2005.

Keywords MS Word, MS Excel, MS Access, MS PowerPoint, MS Outlook, QuarkExpress, Adobe, EndNote, ChemSketch, MathType, MestReNova, SigmaPlot, SigmaStat, HyperChem, EndNote, Gaussian, Minitab, ChemOffice, OceanView spectrometer operating software, Bruker TopSpin, SciFinder, Ortep, ChemStation, Analyst.. HPLC, LC-MS, Karl Fischer coulometric titrator, fluorescence, FT-IR, UV-Vis, NMR, SEC, GPC, IEX, RI, viscometry, method development and validation, GLP, GMP, SOP, IQ, OQ, USR, synthesis, purification, structure elucidation, electrochemistry, characterization, dry-box, Schlenk techniques, safety protocols

2001 Atlantic Shores Blvd. Hallandale, FL 919-***-**** *********@*****.***

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