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Clinical Research Medical

Location:

Memphis, TN

Posted:

February 19, 2016

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Resume:

CURRICULUM VITAE

YUN JIAO

Department of Developmental Neurobiology

St. Jude Children's Research Hospital

*** ***** ****** *****

Memphis, Tennessee 38015

Telephone: 901-***-****

Email: actl61@r.postjobfree.com

EDUCATION:

2015.2 – 5 SOCRA Certification Review Course St. Jude Children Research Hospital.

2011 - 2012 Clinical Research Certificate University of Tennessee Health Science Center.

1982 - 1987 M.D. Hebei Medical University, China.

CLINIC AND CLINICAL RESEARCH EXPERIENCE:

2010 – Present Research Coordinator (Collaboration project), Department of Orthopedic Surgery, University of Tennessee Health Science Center (UTHSC) Memphis TN

1.Coordinated study on the clinical data including the diagnosis and pathology aspects, and drug treatments.

2.Assisted in the designing, implementations ensure the study following of trial protocols.

3.Preparing reports, and publications.

Two collaborative clinical research studies I involve:

Collaboration with Beijing TianTan Hospital. Study on gender and age difference of disease incidence and genetic basis of moyamoya disease.

Collaboration with the Fourth Hospital Affiliated of Hebei Medical University. Study on genetic basis of esophageal Cancer. Grant founding: The genetic basis of esophageal Cancer Study. Department of HeBei Science and Technology, Jan. 2012- Dec 2016.

1993- 1996 Attending Physician and Instructor

1987- 1992 Resident and Clinical Research Fellow

Department of Neurology, the Second Affiliated Hospital, Hebei Medical University, ShijiaZhuang, China

1.Clinical work: Clinical rotation on outpatient clinics, Inpatient ward and Emergency room.

2.Research study: The pathogenesis of Guillain-Barre Syndrome (GBS). The effects of tumor neurosis factor in stroke.

3.Clinical Research: Involved in phase two and three trails related to stroke and neural degeneration disease.

ACADEMIC RESEARCH EXPERIENCE:

2006 - Present Lab Supervisor

2003 - 2006 Lab Specialists

Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN

1.Research Science Project: Focused on recapitulate the pathology of human PD by using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. Study the genetics and cell biology and chemical toxicity (Parquet), aging in Parkinson’s disease and neurodegenerative disease.

2.Lab Management: Operation of the laboratory technical and financial, maintains laboratory documentation and materials. Maintain Department’s histology core equipment, technical support services within and outside the institution. Act as liaison between laboratories, agencies, and departmental core facilities.

2002 - 2003 Senior Research Associate

Department of Medicine, Research Associate, University of Tennessee Health Science Center, Memphis, TN

Investigated the Molecular Mechanisms of Nociception by study Cyclooxygenase (COX) deficient mice.

1999 - 2002 Research Associate

1996 - 1999 Research Postdoctoral Fellows

Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN

Research mainly focused on the study of the anatomical and functional organization of basal ganglia, especially on intercellular labeling of striate projection neurons.

PROFESSIONAL SOCIETIES MEMBERSHIP:

1. The Society of Clinical Research Associates (SOCRA)

2. Society for Neuroscience

3. Parkinson disease Foundation

4. Chinese Society of Neurology

HONORS AND AWARDS:

1998, Neuroscience Postdoctoral Fellowship The Neuroscience Institute of University of Tennessee Health Science Center.

PUBLICATIONS:

Clinical study Publication:

1.Sex difference in EGFR pathways in mouse kidney-implication of the gender difference in cancer treatment with drugs targeted EGFR .Fengxia Liu, Yan Jiao, Yun Jiao, Weikuan Gu, Qingyi Liu (Submission to Cancer Science 2015).

2.Gastric cancer drug trials - are women second class citizens? Wang L, Jiao Y, Jiao Y, Cao Y, Gu W. Nat Rev Clin Oncol. 2014 Jul;11(7).

3.High-sensitivity C-Reactive Protein Is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese. Huang Y, Jing J, Zhao XQ, Wang CX, Wang YL, Liu GF, Wang CJ, Liu LP, Yang XM, Jiao Y, Jiao Y, Wang LS, Wang YJ, Gu WK. CNS Neurosci Ther. 2012 Mar;18(3):261-6.

4.Study on the immuno-competent cells in Guillain-Barre Syndrome. Jiao Y, Wang. HX, Feng HD, Li CY. J of Clinical neurological disease 1998 11; 175-176.

5.Assay of tumor neurosis factors in acute stroke patients, Jiao Y., Wang X, et al. (1998). Tian jing Academic Medicine, 262; 108-109.

6.Primary orthostic hypotension clinical assay. Jiao, Y, Tian, LW, Kang, JQ. (1994). Clinical report. 9:126-127.

7.Study on the relationship of clinical manifestations and pathological change of brain tissue caused by living brain cysticercoids. Jiao. BZ, Meng. XQ, Jiao. Y. (1993). Chinese J. of Neurology and Psychiatry. 4:274.

8.Sterotoxial surgery sucking of the intercerebral hemorrhage. Tai. LW, Jiao. Y, Zhu. WX. (1993). J. Brain and nerve disease, 1: 137-139.

Science Research Publication:

9.Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice. Jiao Y, Dou Y, Lockwood G, Pani A, Smeyne RJ.

J Parkinsons Dis. 2015 Jan 29

10.HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta. Smeyne M, Sladen P, Jiao Y, Dragatsis I, Smeyne RJ.Neuroscience. 2015.03.015.

11.Neurochemical measurement of adenosine in discrete brain regions of five strains of inbred mice. Pani AK, Jiao Y, Sample KJ, Smeyne RJ. PLoS One. 2014 Mar 18;9(3).

12.Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. Adeosun SO, Hou X, Jiao Y, Zheng B, Henry S, Hill R, He Z, Pani A, Kyle P, Ou X, Mosley T, Farley JM, Stockmeier C, Paul I, Bigler S, Brinton RD, Smeyne R, Wang JM. PLoS One. 2012;7(11).

13. Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice. Gerecke KM, Jiao Y, Pagala V, Smeyne RJ. PLoS One. 2012;7(8

14.Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice. Sadasivan S, Pond BB, Pani AK, Qu C, Jiao Y, Smeyne RJ.

PLoS One. 2012;7(3)

15.Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta. Jiao Y, Lu L, Williams RW, Smeyne RJ.

PLoS One. 2012;7(1).

16.Exercise protects against MPTP-induced neurotoxicity in mice. Gerecke KM, Jiao Y, Pani A, Pagala V, Smeyne RJ. Brain Res. 2010 Jun 23;1341:72-83.

17.Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL.

Hum Mol Genet. 2010 May 1;19(9):1633-50

18.Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Jang H, Boltz D, Sturm-Ramirez K, Shepherd KR, Jiao Y, Webster R, Smeyne RJ. Proc Natl Acad Sci U S A. 2009

19.Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Boyd JD, Jang H, Shepherd KR, Faherty C, Slack S, Jiao Y, Smeyne RJ. Brain Res. 2007 Oct 17;1175:107-16.

20.GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. Smeyne M, Boyd J, Raviie Shepherd K, Jiao Y, Pond BB, Hatler M, Wolf R, Henderson C, Smeyne RJ. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1977-82.

21.Glia cell number modulates sensitivity to MPTP in mice. Smeyne M, Jiao Y, Shepherd KR, Smeyne RJ. Glia. 2005 Nov 1;52(2):144-52.

22.Single-cell RT-PCR, in situ hybridization histochemical, and immunohistochemical studies of substance P and enkephalin co-occurrence in striatal projection neurons in rats. Wang HB, Laverghetta AV, Foehring R, Deng YP, Sun Z, Yamamoto K, Lei WL, Jiao Y, Reiner A. J Chem Neuroanat. 2006 Apr;31(3):178-99.

23. Nociception and the differential expression of cyclooxygenase-1 (COX-1), the COX-1 variant retaining intron-1 (COX-1v), and COX-2 in mouse dorsal root ganglia (DRG). Dou W, Jiao Y, Goorha S, Raghow R, Ballou LR., Prostaglandins Other Lipid Mediat. 2004 Oct; 74(1-4):29-43.

24. Evidence for differential cortical input to direct pathway versus indirect pathway striatal projection neurons in rats. Lei W, Jiao Y, Del Mar N, Reiner A. J Neurosci. 2004 Sep 22;24(38):8289-99.

25. Differential morphology of pyramidal tract-type and intratelencephalically projecting-type corticostriatal neurons and their intrastriatal terminals in rats. Reiner A, Jiao Y, Del Mar N, Laverghetta AV, Lei WL. J Comp Neurol. 2003 Mar 17;457(4):420-40.

26.Pathway tracing using biotinylated dextran amines. Reiner A, Veenman CL, Medina L, Jiao Y, Del Mar N, Honig MG. J Neurosci Methods. 2000 Nov 15;103(1):23-37. Review.

27.Identification of the anterior nucleus of the ansa lenticularis in birds as the homolog of the mammalian subthalamic nucleus. Jiao Y, Medina L, Veenman CL, Toledo C, Puelles L, Reiner A. J Neurosci. 2000 Sep 15;20(18):6998-7010.

28. A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections. Jiao Y, Sun Z, Lee T, Fusco FR, Kimble TD, Meade CA, Cuthbertson S, Reiner A. J Neurosci Methods. 1999 Nov 15;93(2):149-62.

29. The functional anatomy of the basal ganglia of birds. Medina L, Jiao Y, Reiner A.

Eur J Morphol. 1999 Apr; 37(2-3):160-5.

30.Cellular localization of huntingtin in striatal and cortical neurons in rats: lack of correlation with neuronal vulnerability in Huntington's disease. Fusco FR, Chen Q, Lamoreaux WJ, Figueredo-Cardenas G, Jiao Y, Coffman JA, Surmeier DJ, Honig MG, Carlock LR, Reiner A. J Neurosci. 1999 Feb 15;19(4):1189-202.

31.Physiological and molecular properties of AMPA/Kainate receptors expressed by striatal medium spiny neurons. Stefani.A, Quan C, Jorge Flores-Hernandez, Jiao Y, Anton Reiner Surmeier DJ Dev. Neuroscience. 1998; 20 (2-3) 242-252.

Reference:

Richard J. Smeyne, Ph.D. Member

Developmental Neurobiology

St. Jude Children's Research Hospital

262 Danny Thomas Place, Memphis, TN 38105-3678

Tel: 901-***-****

Fax: 901-***-****

Email: actl61@r.postjobfree.com

Anton J. Reiner, Ph.D. Professor

Department of Anatomy and Neurobiology

University of Tennessee Health Science Center

855 Monroe Avenue, Memphis, TN 38163