Chemical Engineering Professional Experience
Resume:
Lady Mae Alabanza
Gurnee, IL 60031
Email: *********@*****.***
Summary
A process research and scale-up scientist with over 10 years pharmaceutical experience in the bulk preparation of APIs and their intermediates under strict adherence to cGMPs, safety and environmental regulations. I have a B.S. degree in Chemical Engineering and a Masters in Chemistry.
Technical Skills
Fortran, Matlab, Simulink and Polymath
ChemProject
ChemDraw/ISIS
ChemCad
Microsoft Office
ACD Labs
CambridgeSoft Electronic Laboratory Notebook
NMR, HPLC, LC/MS, UPLC, TGA, KF and CombiFlash Torrent
Kaleidograph
Professional Experience
AbbVie (former Abbott Labs) June 2013-Present
Scientist I
Department: GPRD Chemistry
Group: Pressure and Catalyst Group
Performed process research on high pressure catalytic reactions (hydrogenations, carbonylations, asymmetric hydrogenations, isotope incorporations)
Used reactions’ uptake data to monitor reactions and to analyze kinetic properties
Responsible for providing robust procedures to be used in the pilot plant
Oversee pilot plant operations while process is being executed in the pilot plant
Responsible for providing technical package to be utilized by third party vendors
Proficient in running air sensitive reactions (couplings and asymmetric hydrogenations)
Performed HPLC, LCMS, UPLC, TGA, KF, GCMS and NMR to analyze products and impurities
Roche, Nutley NJ Aug 2004-April 2013
Scientist (Associate): 2004-2008
Sr. Scientist (Sr. Associate): 2008-2013
Department: Process Research & Synthesis
Group: Early Scale Up Group
Performed process research (50 mg to 10 g scale) on multi-step synthesis to obtain robust procedures for scale up in the preparation of “small molecule” drug substances (APIs)
Performed chemical reactions in the kilo- lab (25 g to 5 kg scale reactions) for the preparation of APIs to support all preclinical and clinical activities from the clinical lead selection point through entry-into-human to Phase I/II
Proficient in running high pressure (hydrogenation) equipment and reactors
Proficient in running chemical reactions using various size flasks (up to 22 L 3N flasks) and reactors (30 L to 55 L)
Ordered and sourced raw materials and reagents needed for project campaigns
Performed all job duties according to the cGMPs and Roche SOPs and Safety and Environmental policies
Utilized TLC, NMR, HPLC and LC/MS to monitor reaction status and product/reagent purity
Documented experiments and results in laboratory notebook accurately in compliance with GMP and department’s SOPs
Highlighted any significant processing issues of lab-scale processes for scale-up into fixed equipments
Collaborated with team members to alleviate any scale-up problems during tech transfer meetings
Created and managed ChemProject files for cost calculation studies of active projects for the department
Recognized as a super user for department’s NMR machine by knowing how to trouble-shoot and ensuring proper daily operation of the instrument
Managed department stockroom for common solvents and inorganic chemicals
Represented department on “White-Label Consumables” and “Chemicals” sourcing teams to help procurement in sourcing more cost effective common chemicals, lab supplies and consumable items
Productive team-player, who is flexible to accommodate any variable work assignments and environments
Professional Accomplishments
Developed and optimized a scalable and robust four-step synthesis of a pyridazinone intermediate that improved the yield from 75% to 95% and eliminated chromatography during isolation
Selected to be an assessment investigator for several potential electronic lab notebook software to be used by Roche
Designated to create and manage ChemProject files to be used for project cost calculations for the entire department
Collaborated with the procurement department and various solvent vendors to successfully source a more cost effective solvent provider for the department
Streamlined the resupply of common solvents for the department by supervising the chosen solvent vendor to ensure proper regular inventory maintenance and solvent delivery
Laboratory notebook has become an exemplary model for the department
Acquired numerous Special Recognition Awards for projects that were completed way before the deadline and APIs amounts above target expectations
Education
Master of Science, Chemistry- Stevens Institute Of Technology, Hoboken NJ (May 2012)
Graduated with 3.9 GPA
Bachelor of Science, Chemical Engineering-Rutgers University, New Brunswick NJ (May 2004)
Minor in Biological Science
Graduated with 3.7 GPA and with High Honors
Publications
“Convenient Synthesis of 5,7-Dichlorothiazolo[5,4-d]Pyrimidine,” L. Shu, L.M. Alabanza, and C. Gu, Heterocycles, Vol. 85, No. 7, 2012
“A Concise Synthesis of a Tetrahydropyrazolopyrazine Building Block,” Lianhe Shu, Ping Wang, Chen Gu, Lisa Garofalo, Lady Mae Alabanza, and Yan Dong, Org. Process Res. Dev., 26 Oct 2012
“Process Research on a Phenoxybutyric Acid LTB4 Receptor Antagonist, Efficient Kilogram-Scale Synthesis of a 3,5-Bisarylphenol Core,” Lianhe Shu, Roumen Radinov, Romyr Dominique, James Wright, Lady Mae Alabanza, Yan Dong, and Ping Wang. Org. Process Res. Dev., 30 Nov 2012
“An Efficient Large-Scale Synthesis of a Naphthylacetic Acid CRTH2 Receptor Antagonist,” Lianhe Shu, Ping Wang, Chen Gu, Liu Wen, Lady Mae Alabanza, and Zhang, Yingchao, Org. Process Res. Dev., April 2013
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