Makiko Uchida

**** ******** **, #** • Glendale CA 91208

646-***-**** • acrt59@r.postjobfree.com

Summary of Qualifications

Research Scientist with a proven track record of leadership and outstanding performance.

Solid biophysical laboratory experience, including managing projects and developing new processes.

Strong data analysis skills, with experience maximizing productivity and accuracy.

Exceptional knowledge of the spectroscopy technique.

Master of Medical Science, Albert Einstein College of Medicine, Yeshiva University; earned 2006.

BS, Biology, minor in Chemistry, Hunter College, City University of New York; earned 2000.

Proficient with Microsoft Office; MATLAB; PovlLay; Pearl; Visual Molecular Dynamics.

Areas of Expertise

Ultra Performance Liquid Chromatography cIEF DLS

HPLC-SEC/IEX/RP Differential Scanning Calorimetry CE-SDS

Fourier Transform Infrared Spectroscopy DSF HIAC

Fluorescence Spectroscopy Micro Flow Imaging Circular Dichroism

Analytical Ultracentrifugation Filed Flow Fractionation SEC-MALLS

Professional Experience

Merck & Co., Inc. 2009-Present

Scientist, Biochemical & Biophysical Analytical Team, Process & Analytical Development

Led the Analytical Team on two projects involving immunotherapy-monoclonal antibody pipelines.

Initiated idea of a noble method of rapid screening to determine the best drug formulation within a weeks’ time and for application to a Phase III project.

Trained team members on high throughput techniques to expand the ability to better formulate drugs.

Used a variety of spectroscopy methods to document reproducible data of drug product stability.

Designed and optimized protocols of biophysical analytical techniques to quantify protein aggregation and achieve quality analytical data for biochemical, biophysical and sub-visible partial techniques.

Achievements:

Earned excellent performance evaluations for job efficiency, productivity and accuracy.

Managed analysis, processing, organization and documentation of a cancer immunotherapy drug that was approved in 2014.

Achieved faster, smoother and more productive workflow processes while coordinating efforts of the Drug Formulation Team and the Analytical Team.

Makiko Uchida

2121 Valderas Dr, #90 • Glendale CA 91208

646-***-**** • acrt59@r.postjobfree.com

Professional Experience (continued)

Merck & Co., Inc. 2009-Present

Scientist, Biochemical & Biophysical Analytical Team, Process & Analytical Development

Achievements:

Developed methods that were documented in many technical reports and memorandums, and applied for regular basis testing samples by team members.

Created a high throughput method and techniques that improved drug formulation quality.

Authored “Methods Qualification and Application of Diffusion Interaction parameter and Virial Coefficient” in the Journal of Biological Macromolecules 62(2013).

Previously:

Research Scientist, Anti-Aging Medicine, University of Tokyo Hospital 2007-2009

Studied the correlation between female organ cancer and estrogen hormone and its receptor, Efp, Estrogen Responsive finger-Binding Protein.

Also performed genetic polymophism studies for osteosclerosis.

Increased the transcriptional activity of NF-KappaB pathway.

Used Luciferase assay; cell differentiation assay; cell proliferation assay; and immunohistochemistry.

Graduate Researcher, Biophysics Department, Albert Einstein College of Medicine 2004-2007

Studied fatty acid binding protein on the human brain to find a cure for degenerative brain disease using a variety of spectroscopy techniques.

Used mass spectroscopy; fluorescence spectroscopy; CD spectroscopy; mutagenesis; and electron paramagnetic resonance spectroscopy combined with spin labeling.

Research Assistant, Molecular Developmental Biology Lab, Rockefeller University 2002-2003

Helped identify the molecular signals of eye (lens) formation and nervous system formation in vertebrate embryo and mammalian stem cells.

Formulated techniques in developing non-invasive prenatal diagnosis.

Education

Master of Medical Science, Albert Einstein College of Medicine, Yeshiva University; earned 2006

BS, Biology, minor in Chemistry, Hunter College, City University of New York; earned 2000

BA, English Literature, Waseda University in Japan; earned 1995

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