Occupational and Environmental Epidemiology

Cali Chang, Sc.D.

** **** **** ****, ******* Ranch, CA, 91766• 617-***-**** acqoty@r.postjobfree.com

SUMMARY

Passionate about environmental science, environmental health, occupational safety and health related fields. Experienced in on-site fieldwork sampling for sample and data collection, and am seasoned with lab skills. Detailed oriented and organized when it comes to project planning and execution. Skilled in communicating with other teams, and resolve issues within a limited time frame. Never afraid to learn new things and take on new challenges. As an epidemiologist, I strongly believe that every man and women has their right to understand what potential exposure they may be under, and figure out a solution for them. RESEARCH INTEREST AND EXPERTISE

Public Health

Environmental Science

Environmental Safety and Health

Occupational Safety and Health

Environmental and Occupational Epidemiology

Epidemiology

Exposure Assessment

Occupational exposure to combustion sources and its adverse cardiovascular outcomes

Crossover study design, repeated measurements, and data analysis

Metabolomics

Mediation Analysis

EDUCATION

Sc.D. in Environmental and Occupational Epidemiology Harvard School of Public Health, Boston, MA 2008-2013

Minor I: Biostatistics

Minor II: Biomarkers

Doctoral thesis title: A metabonomic assessment of welding fume exposure M.S. in Environmental and Occupational Safety and Health Harvard School of Public Health, Boston, MA 2006-2008 B.S. in Public Health

Taipei Medical University, Taipei City, Taiwan, R.O.C. 1999-2004 Cali Chang, Sc.D.

22 Turn Post Lane, Philips Ranch, CA, 91766• 617-***-**** acqoty@r.postjobfree.com RESEARCH and WORKING EXPERIENCES

Compliance Consultant/Project manager May 2014-Present Everest Group USA, Inc. Mira Loma, CA

Develop a compliance program for Everest Group USA, Inc, and its affiliated factories to follow. Supervise the implementation of the program with appropriate timeline.

Ensure company follows the applicable Environmental and Ethical guidelines and regulations locally and globally. Many of Everest Group USA, Inc.’s facilities are international factories; it is essential for them to follow the applicable laws and regulations.

Manage multiple projects to ensure deadlines are met internally and on customers’ schedules.

Primary Investigator as Doctoral Candidate 2008-2013 Harvard School of Public Health, Boston, MA

Academic Advisor: Dr. David Christiani

Dissertation: A Metabonomic Assessment of Welding Fume Exposure.

Characterized physico-chemical properties of the welding fume particles in different size fractions. Identified metabolic profiles that are associated with welding fume exposure, and their associated cardiovascular outcomes.

Responsibilities:

o Organized fieldwork sampling and investigation to collect participant samples and data for further analysis.

o Analyzed collected data using R 2.15.1.

o Analyzed before exposure and after exposure serum samples to obtain metabolic profiles of the participants.

o Prepared thesis and journal manuscript. Journal article submissions is currently in progress.

Manuscript available upon request.

Primary Investigator

Harvard School of Public Health, Education and Research Center, Boston, MA 2010-2011 Supervisor: Dr. David Christiani

Awarded with NIEHS funded pilot grant T42 OH008416-06

Project title: Metabonomic applications in assessing occupational exposure to nano- metallic particles derived from welding fume.

Two manuscripts titled “Serum metabonomic assessment of occupational exposure to metal-rich particles derived from welding fume” and “Metabonomic approach in understanding adverse cardiovascular effects of occupational welding fume exposure” are in revision process for journal submission.

This pilot project is an extension of the previous project awarded in 2009-2010. We decided to further explore the possible pathways that are found to be linked to welding fume exposure and cardiovascular outcomes.

Responsibilities:

o Project leader

Cali Chang, Sc.D.

22 Turn Post Lane, Philips Ranch, CA, 91766• 617-***-**** acqoty@r.postjobfree.com

Organized and lead fieldwork sampling and investigation by coordinating with our counterpart at the Local 29 International Brotherhood of Boilermakers, Blacksmiths, Forgers and Helpers located in Quincy, Massachusetts.

Coordinate with other units and teams for fieldwork sampling staff, and resolve related issues within a limited time frame.

Review questionnaire, IRB documents needed for this project.

Sampling protocol QA/QC

o Prepared collected serum samples and analyzed the samples using 1H (Nuclear Magnetic Resonance) NMR spectroscopy.

o Collected urine and serum samples from participants during fieldwork sampling, and analyzed metabolic profiles in the biological samples using 1H-NMR. o Grant proposal writing and preparation. Statistical analyses using R 2.15.1 o Journal manuscript writing and submission.

Researcher

Harvard Law School, Work Life Labor Program, Cambridge, MA 2009-2010 Supervisor: Dr. John Trumpbour

Responsibilities: Allocate scientific articles and information from other countries that are related to nanotechnology R&D.

Participated in 2010 Taiwan Nano Exhibition.

Primary Investigator

Harvard School of Public Health, Education and Research Center, Boston, MA 2009-2010 Supervisor: Dr. David Christiani

Awarded with NIEHS funded pilot grant T42 OH008416-06

Project title: Cardiovascular effects of occupational exposure to metallic nanoparticles derived from welding fumes.

o Aim 1: this study aims to investigate the physicochemical properties of particles derived during real time welding processes generated during actual welding processes and to assess the particle size specific toxicological properties. A compact cascade impactor (Harvard CCI) was stationed within the welding booth to sample particles by size. Size fractionated particles were extracted and used for both off- line physicochemical analysis and in-vitro cellular toxicological characterization.

Thesis published: C. Chang, P. Demokritou, M. Shafer and D. Christiani. “Physicochemical and toxicological characteristics of welding fume derived particles generated from real time welding processes”. Environmental Science: Processes & Impacts 15, 214-224 (2013).

Responsibilities:

o Project leader

Organized and lead fieldwork sampling and investigation by coordinating with our counterpart at the Local 29 International Brotherhood of Boilermakers, Blacksmiths, Forgers and Helpers located in Quincy, Massachusetts.

Planned and secure onsite fieldwork sampling date and supplies. Coordinate with other units and teams for fieldwork sampling staff, and resolve related issues within a limited time frame.

Review questionnaire, IRB documents needed for this project. Cali Chang, Sc.D.

22 Turn Post Lane, Philips Ranch, CA, 91766• 617-***-**** acqoty@r.postjobfree.com

Coordinate and plan on-site fieldwork sampling dates, personnel, and supplies. Resolve related issues within a limited time frame.

Sampling protocol QA/QC

o Assembled and operated Harvard Compact Cascade Impactor (Harvard CCI) onsite during fieldwork investigation to collected metal rich particles derived from welding fume.

o Grant proposal writing and preparation.

o Journal manuscript writing and submission.

o Statistical analyses using R 2.15.1

Research Assistant

Harvard School of Public Health, Boston, MA 2007-2008 Supervisor: Dr. David Christiani

Project 1: Arsenic Exposure and Birth Outcomes in Bangladesh. o Responsibilities

Lab sample processing: pretreatment of toenail and hair samples collected from participants. Samples were pre-treated using pre-developed microwave digestion protocol.

Analyze water and digested biological samples using ICP-MS to acquire metal concentrations within samples.

Questionnaire data entry and QC/QA using SAS.

Project 2: Cardiopulmonary Effects of Particulate Exposure. o Responsibilities

On-site fieldwork sampling and investigation.

Supplies and equipment assurance:

Ensured enough supplies for sampling is prepared

Ensured all equipment used during the sampling processes were functional, calibrated, and cleaned.

Allocated all lab results and organized results by participant.

Merged sample data and questionnaire results into study database using SAS and Microsoft Excel.

Research Assistant

Institute of Occupational Safety and Health, Division of Occupational Medicine Shih-Ji District, New Taipei City, Taiwan 2003-2006

Supervisor: Dr. Chih-Hong Pan (2004-2006)

o Project 1: Cohort Study of Professional Chefs Exposed to Cooking Oil Fume.

Responsibilities

o Pre-treatment of urine samples collected from participants following pre- developed protocol Analyzing pre-treated samples using HPLC to obtain 1-OHP concentration within samples.

o Evaluated the association between oxidative stress and cooking oil exposure among professional chefs using SPSS V10.

o Project 2: Health Effect Survey for workers of Biohazard Exposure in the Air of Workplace in Hospitals.

Cali Chang, Sc.D.

22 Turn Post Lane, Philips Ranch, CA, 91766• 617-***-**** acqoty@r.postjobfree.com

Responsibilities

o Questionnaire entry

Supervisor: Dr. Ming-Hsiu Lin (2003-2004)

o Project title: Adverse Health Outcomes of Coke-Oven Workers. o Responsibilities

Questionnaire data entry and QA/QC.

AWARDS AND GRANTS

NIH PHS training grant T42-OH008416-07 (2008-2013)

NIOSH funded Harvard Education and Research Center (ERC) pilot project training grant T42-OH-008416-06 (2010-2011)

NIOSH funded Harvard Education and Research Center (ERC) pilot project grant T42-OH- 008416-06 (2009-2010)

PUBLICATIONS

Gaughan DM, Siegel PD, Hughes MD, Chang CY, Law BF, Campbell CR, Richards JC, Kales SF, Chertok M, Kobzik L, Nguyen PS, O'Do, nnell CR, Kiefer M, Wagner GR, Christiani DC.

“Arterial Stiffness, Oxidative Stress and Smoke Exposure in Wildland Firefighters” Am J Ind Med. 2014 Jul;57(7):748-56. doi: 10.1002/ajim.22331. Epub 2014 Jun 6.

Wei Y, Wang Z, Chang CY, Fan T, Su L, Chen F, Christiani DC. “Global metabolomics profiling reveals an association of metal fume exposure and plasma unsaturated fatty acids.” PLoS One. 2013 Oct 15;8(10):e77413. doi: 10.1371/journal.pone.0077413. eCollection 2013. TEACHING AND OTHER RELATED EXPERIENCES

Harvard School of Public Health

2008-2012 Head Teaching Assistant of Harvard-Kaohsiung Medical University (KMU) exchange program

2010-2011 Head Teaching Assistant of Introduction of Environmental Health

2008-2010 Head Teaching Assistant of Occupational Health Policy and Administration

2008-2009 Head Teaching Assistant of Practice of Occupational Health

2006-2007 Student Coordinator of Harvard-Kaohsiung Medical University (KMU) exchange program.

PROFESSIONAL SKILLS

Lab Instrument/Platforms/Skills: HPLC, ICP-MS, 1H-NMR, dry and wet lab skills

Statistical Software: Excel, SPSS, SAS, STATA, R

Microsoft word, EndNote, PowerPoint, Microsoft Excel

Scientific writing and manuscript preparation.

Grant proposal writing and preparation.

Fieldwork investigation

LANGUAGE

Mandarin and English: Excellent in speaking, writing and reading. Taiwanese: Fluent in speaking.

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