DAVID ALLEN WHIPPLE
Lawrence, KS 66049 acqcws@r.postjobfree.com
SUMMARY and CAREER GOAL
Successful synthetic organic/medicinal chemist with extensive research experience in the pharmaceutical industry. Solved technical and chemical problems, developed synthetic procedures and synthesized thousands of high quality products on time. Excellent laboratory, computer and communication skills. Dedicated professional, great team player, flexible, results-oriented and self-motivated. Great lab safety record. Set up new labs. Increased productivity of others. Impacted discovery and development of medications with potential to improve people’s lives.
Performed initial synthesis of Xeljanz which is approved for rheumatoid arthritis treatment.
My goal is to continue using chemistry skills to help people.
PROFESSIONAL EXPERIENCE
Specialized Chemistry Center, University of Kansas, Lawrence, KS, 2009-2013, 2014-Present
Senior Research Assistant
Individual contributor under minimal supervision. Designed and synthesized compounds to gain structure activity relationship information for seven research projects that could increase understanding of drug addiction, cancer and malaria.
Synthesized immobilized analogs to potentially discover biomolecular target for anti-melanomia agents.
Coauthored four publications describing kappa opioid receptor, PfM18AAP enzyme or SUMO protein research.
Pfizer, Inc., Groton, CT, 1994-2009
Scientist, 2000-2009
Provided potential antibacterial drugs and immune system suppressants for biological evaluation in support of four research projects. Scaled up synthesis of more interesting compounds for further preclinical testing.
Synthesized chemical libraries and hundreds of targeted single analogs resulting in drug candidates for clinical development.
Synthesized compounds with complex structures (macrolides and monocarbams).
Scaled up preparation of potential drug candidate which was unstable to a wide variety of conditions by developing and implementing methods.
Solved synthetic problem by developing and implementing convenient synthesis of heterocyclic intermediates without which important targeted analogs could not be obtained.
Impacted the productivity of other synthetic chemists by synthesizing large amounts of several critical intermediates used by other chemists to synthesize hundreds of targeted analogs.
Raised the awareness of value in technologies by organizing and leading a team of research associates to evaluate the potential of technologies to increase the efficiency of synthesis.
Increased the productivity of new research associates by mentoring and training them.
Associate Scientist, 1994-2000
Supported three research projects by synthesizing hundreds of targeted analogs including pyrrolopyrimidines, imidazolidinones and cyclic peptides for biological evaluation.
Impacted major drug discovery by being first chemist to synthesize Xeljanz (Tofacitinib) which was approved by the FDA for treating rheumatoid arthritis.
Made improvements over initial synthesis of Xeljanz and synthesized 100 g for preclinical testing.
Sterling Winthrop, Inc., Rensselaer, NY and Collegeville, PA, 1990-1994
Research Scientist
Synthesized peptide mimetics as potential anti-inflammatory drugs for two research projects. Supported another research project by synthesizing peptides to discover novel protease substrates.
Synthesized combinatorial libraries containing thousands of peptides by using solid phase reactions and robotic equipment.
Impacted the work of all other chemists on peptide library project team. Validated development of synthetic procedures and final peptide libraries by amino acid analysis of synthetic intermediates and products.
Analyzed peptide library for potential protease substrates by sequencing enzymatic products to determine enzymatic cleavage sites.
EDUCATION
MS, Master of Science, Medicinal Chemistry, 1990
Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
Thesis: Synthesis and Evaluation of Potential Mechanism-based Inhibitors of Dihydroxy Acid
Dehydratase. Research Advisor: Dr. Richard B. Westkaemper
BS, Bachelor of Science, Chemistry, 1984, minors in Biology and Mathematics
James Madison University, Harrisonburg, VA
PROFESSIONAL AWARDS and AFFILIATION
Safest Lab in Department Recognition, Pfizer Individual Performance Awards 2008 (2), 2006
Pfizer Team Award 2008, Pfizer Department Teamwork Award 2004-2005
Sterling Winthrop Vision and Accomplishment Award 1992
American Chemical Society Member since 1983
LABORATORY SKILLS
Multi-step synthesis, moisture and air sensitive reagents, 5 mg-200 g reactions, heterocyles, sugars, peptides, stereoselective reactions, microwave reactors, Biotage and Isco flash chromatography, Shimadzu preparative HPLC, Genevac evaporator, lyophilizer, NMR, LCMS, GCMS, IR, analytical HPLC, polarimeter, amino acid analyzer and protein sequencer
COMPUTER SKILLS
E-Notebook for Chemistry, Inventory, ChemDraw, Isis, SciFinder, CrossFire Beilstein, PubChem, Outlook, Excel, Word and PowerPoint
SCIENTIFIC COMMUNICATION SKILLS
Presented and hosted seminars, wrote internal chemistry papers and reports, assisted with preparation of publications and patent applications, presented posters, organized research project chemistry meetings and discussed organic chemistry with consultants and contracted synthetic chemists
PUBLICATIONS and PATENTS
Alontaga, A. Y.; et al. Design of High Throughput Screening Assays and Identification of SUMO-1 Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface. ACS Combinatorial Science 2015, Just Accepted Manuscript, available at http://pubs.acs.org, DOI:10.1021/co5001816.
Frankowski, K. J.; et al. Potency Enhancement of the -Opioid Receptor Antagonist Probe ML140 through Sulfonamide Constraint Utilizing a Tetrahydraisoquinoline Motif. Bioorg. Med. Chem. 2015, http://dx.doi.org/10.1016/j.bmc.2014.12.033.
Spicer, T.; et al. Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18
Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening. J. Biomol.
Screen. 2014, 19, 1107-1115.
Frankowski, K. J.; et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist
Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem. Neurosci. 2012, 3, 221-236.
Flanagan, M. E.; et al. Preparation, Gram-Negative Antibacterial Activity and Hydrolytic Stability of
Novel Siderophore-Conjugated Monocarbam Diols. ACS Med. Chem. Lett. 2011, 2, 385-390.
Flanagan, M. E.; et al. Discovery of CP-690550: A Potent and Selective Janus Kinase (JAK) Inhibitor
for the Treatment of Autoimmune Diseases and Organ Transplant Rejection. J. Med. Chem. 2010, 53,
8468-8484.
Magee, T. V.; et al. Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug
Resistant Community-Acquired Respiratory Tract Infections. J. Med. Chem. 2009, 52, 7446-7457.
Changelian, P. S.; et al. The Specificty of JAK3 Kinase Inhibitors. Blood 2008, 111, 2155-2157.
Changelian, P. S.; et al. Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3
Inhibitor. Science 2003, 302, 875-878.
Ripin, D. H. B.; et al. Development of a Scaleable Route for the Production of cis-N-Benzyl-3-
methylamino-4-methylpiperidine. Org. Process Res. Dev. 2003, 7, 115-120.
Linde, R. G., II; et al. Cyclic Homopentapeptides. 3. Synthetic Modifications to the Capreomycins and
Tuberactinomycins: Compounds with Activity Against Methicillin-Resistant Staphylococcus
Aureus and Vancomycin-Resistant Enterococci. Bioorg. Med. Chem. Lett. 1997, 7, 1149-1152.
Dirlam, J. P.; et al. Cyclic Homopentapeptides. 1. Analogs of Tuberactinomycins and Capreomycin
with Activity Against Vancomycin-Resistant Enterococci and Pasteurella. Bioorg. Med. Chem. Lett.
1997, 7, 1139-1144.
Dolle, R. E.; et al. Preparation of Peptidyl Heteroaryloxymethyl Ketones as Interleukin-1
Converting Enzyme Inhibitors. U. S. Patent 5585357, 1996.
Singh, J.; et al. Application of Genetic Algorithms to Combinatorial Synthesis: A Computational
Approach to Lead Identification and Lead Optimization. J. Am. Chem. Soc. 1996, 118, 1669-1676.
Dolle, R. E.; et al. Aspartyl Diphenylphosphinyl)oxy)methyl Ketones as Novel Inhibitors of
Interleukin-1 Converting Enzyme. Utility of the Diphenylphosphinic Acid Leaving Group for the
Inhibition of Cysteine Proteases. J. Med. Chem. 1995, 38, 220-222.
Singh, J.; et al. Validation of Screening Immobilized Peptide Libraries for Discovery of Protease
Substrates. J. Med. Chem. 1995, 38, 217-219.
Dolle, R. E.; et al. Preparation of -Heteroaryloxymethyl Ketone Peptide Derivatives as Interleukin-1
Converting Enzyme Inhibitors. Eur. Patent 0644198 A1, 1995.
Singh, J.; et al. Relationship between Structure and Bioavailability in a Series of Hydroxamate Based
Metalloprotease Inhibitors. Bioorg. Med. Chem. Lett. 1995, 5, 337-342.
KEY WORDS
Lead Generation Non-Clinical Development Senior Associate Scientist
Complex Projects Complex Scientific Data Multidisciplinary Project Team
Laboratory Projects Complex Experiments Synthetic Organic Chemistry
Synthesis Design Mechanistic Chemistry Structure Activity Determination
Scientific Data Industrial Experience Synthesis Development
Submission Synthetic Route Design Method Development
Report Medicinal Chemistry Synthetic Methodology
Interpret Synthetic Chemistry Lead Optimization
Purification Organic Chemistry New Chemical Entities
Characterization Chemical Identification Synthesis Discovery
Analogs Parallel Synthesis Process Development
Targets Chemical Libraries Biologically Active Compounds
Small Molecules Targeted Products Develop methodology
Novel Products Organic Molecules Mechanistic Organic Chemistry
Scale-up Organic Compounds Proton Nuclear Magnetic Resonance
Purification Process Chemistry Carbon Nuclear Magnetic Resonance
Biochemistry Laboratory Automation Reverse Phase Chromatography
Drug Discovery Laboratory Instruments Flash Chromatography
Drug Design Laboratory Equipment Analytical Chromatography
Lab Safety Chemical Processes Preparative Chromatography
Mechanism Mass Spectrometer Thin Layer Chromatography
Flexible Lead compounds Column Chromatography
Spectroscopy Recrystallization Normal Phase Chromatography
New Leads Distillation Reaction Optimization
Hits Gas Chromatography Separation Methods
Infrared Drug Substances Synthetic Organic Chemist
Drug-like Synthetic Problems Method Validation
Application Analytical Techniques Experimental Protocols
Staff Chemist Biological Testing Instrumental Techniques
Bench Chemist Research Chemist Heteroaromatic Compounds
Problem Solver Chemistry Associate Active Pharmaceutical Intermediates
Expert Synthetic Chemist Physical Organic Chemistry
Process Problems Medicinal Chemist Biophysical Properties
Implementation Research Assistant Lead Optimization
Characterization Synthetic Reactions Continuous Improvement
Isolate Products Monitor Reactions Interdisciplinary Team
Bench Experience Research Associate Laboratory Experience
Research Scientist Laboratory Techniques Automation Techniques
Research Team Aromatic Compounds Combinatorial Libraries
Input Synthetic Techniques Chemical Library Design
Target Design Target Molecules Cross-referenced Data Files
Efficacy Physical Properties State-of-the-art Techniques
Collaboration Target Compounds Microwave-assisted Synthesis
Adaptable Compound Design Written Communication
Innovative Lead Identification Verbal Communication
Propose Scientific Reports High-throughput Screening
Document Patent Applications Laboratory Experiments
FTIR Literature Searching Scientific Publications
Collaborate Experimental Data Electronic Library Resources
Contribute Problem-solving Safe Laboratory Environment
Independent Research Program Statistical Data Analysis
Team oriented Conduct Reactions Industrial Setting
Expertise Set up Reactions Execute Experiments
Hands-on Plan Synthesis Team Environment
Prepare Self Starter Strong Work Ethic
Integrity Committed Interpersonal Skills
Honest Responsible Knowledgeable
Performs Experienced Understanding
Efficient Confident Laboratory Notebook
Planning Multi-tasking Novel Inhibitors
Modify Performance Pharmaceuticals
Results Technology Nutritional Supplements
Ideas Hypotheses Synthetic Pathway Design
SAR Sub-libraries Project Goals
DMPK Inventions Milligram Scale
API Research Team Multigram Scale
UV Organized Robotic Equipment
LC-MS Analytical Data Pharmaceutical Industry R&D
Oral Reports Isolating Products Carry Out Synthetic Reactions
Group Meetings Characterize Products Standard Practices of Lab Safety
Library Searches Submit Compounds Written Progress Reports
Novel Analogs Biological Evaluation Plan Efficient Use of Time
Strong Ethics e-Library Resources Follow Established Priorities
Research-driven Designing Synthesis Interpret Analytical Data
Biology Executing Synthesis Cross-Referenced Files of Data
Knowledge Proprietary Analogs Diversified Experiences
New Analogs Pharmaceutical Company Improving Human Health
New Molecules Exploratory Chemistry Identify Synthetic Pathways
Lead Op Chemical Tools Formulation Requirements
IP Documents Process Robustness Strategic Process Development
Pharm R&D Cost Effectiveness New Drug Products
GC-MS Chemical Development Active Pharmaceutical Ingredient
Process Safety Pharmaceutical Division New Synthetic Methodologies
Product Quality Solid-phase Synthesis Solution-phase Synthesis
Sub-libraries Elemental Analysis Mass Spectroscopy
Discipline Crystallization Efficient Synthesis Routes
TLC Microwave Synthesis Target Molecules
Plan Techniques Structure-activity Relationship Studies
Conceive Characterizing Structure-activity Relationships
Isolating Synthetic Methods Design Laboratory Experiments
Develop Record of Ideas Detailed Laboratory Notebooks
Maintain Pharmacokinetics Specified Therapy Targets
Apply Chemistry Literature Effective Synthesis Routes
Utilize Achieve Molecule Design Goals
Water-soluble Highly Motivated Established Drug Discovery Team
Operation Routine Maintenance Organic Chemistry Techniques
Carbohydrates Reaction Mechanisms Laboratory Instrumentation
Record Keeping Troubleshooting Discovery Chemistry
Portfolio Lead Identification Novel Chemical Entities
Document Preclinical Candidates Metabolite Synthesis
Pharmacology Presentation Skills Improved Synthetic Strategies
Biochemistry Literature Searches Fundamental Concepts
NMR Analytical Chemistry Search
Scientific Literature LC
LCMS Automated Column
Motivated Talented Team-oriented
Key contributor Independently Minimal Supervision
Present Reaction mechanisms Pharmacologically active
Multi-step Total synthesis Database searching
Literature Reaction precedents Structural identification
Methods External visibility Peer reviewed journals
Publications Presentations External chemistry conferences
Patents External chemistry Internal chemistry meetings
IR Science community Spectral interpretation
MS Assign structure Spectroscopic
Solve Execute Computer searching
Peptide chemistry Bioconjugation Solid-phase synthesis
Proteins Mass spectrometry Hydrophilic polymers
Molecular modeling Process research Process development
Novel routes Practical routes Therapeutic targets
Enthusiastic Productive Spectral interpretation
Functional Spectral analysis Chemical literature
Ascertain Viable approaches New reaction discovery
Total synthesis Reaction Mechanism Synthetic method development
Goal-oriented Scientific accomplishment Peer-reviewed publications