Manager Assistant

NAVNEET SHARMA, PhD

*** ******* ****** ***** ** Calgary, Alberta T3G 4T4

403-***-**** **********@*******.***

MEDICAL SCIENCE LIAISON

Innovative and highly motivated research scientist with over 10 years of combined experience directly contributing to advancements in pharmaceutical and biochemical/biomedical processes, with results leading to numerous publications and grants. Extensive background in laboratory protocol adherence, ensuring safety, experiment integrity, and superior quality assurance. Skilled communicator, able to prepare and present engaging biomedical / scientific discussions and presentations. Team player, collaborating with colleagues to create solutions and develop improved research / testing methods. Expertise in substrates/inhibitors, serine proteases, and novel serpins. Well-versed in Cephalosporin-C development and fermentation processes. Strong graduate-level teaching background.

Biomedical / Biochemical Research Biotechnology Business Integration

Strong Communicator University Teaching Grant Writing Pharmaceutical Development

Quality Enhancements Networking Teamwork Knowledge Translation Operational Efficiency

Peer-Reviewed Journal Publications Presentations & Seminars Scientific Information Dissemination

PROFESSIONAL EXPERIENCE

UNIVERSITY OF CALGARY Calgary, Alberta 2003-Present

Public academic research institute.

Adjunct Assistant Professor: Biochemistry & Molecular Biology 2009-Present

Teach various advanced biomedical technology and research-based classes, with 20-25 annual student intake. Concurrently perform extensive biochemical research. Deliver expert knowledge on biopharmaceutical manufacturing, regulations, and biotech analysis from business perspective. Prepare and submit research grants. Monitor student research / research proposal writing. Advanced courses taught include Clinical Trials & Bio-manufacturing and Biotechnology Business Aspects.

Research Highlights:

Studied serine proteases implantation effects on activation / inhibition of Proteinase activated receptors (PARs).

Researched protein complexes (expression, characterization, structural proteomics) by mass spectrometry (MS) employing H/D exchange.

Expanded capabilities by networking and forging alliances within the scientific community to ensure access to external laboratories and researchers.

Selected Achievements:

Pursued both research and academic/teaching achievements by embracing research as a way of life, seeking opportunities to advance knowledge and findings during evenings and weekends.

Published 5 research papers / articles in texts and renowned scientific / medical journals, including PLOS One, Vaccine, and Biochemistry & Cell Biology.

Research Associate 2003-2008

Performed extensive research in biochemistry and molecular biology. Used mouse models in studying ‘enzymatic processes of reproduction and implantation’. Conducted enzyme purification. Created method for random peptide display on bacteriophages surface, enabling various component display based on altered genetics. Taught several master’s degree Biotechnology and science-based business courses.

Research Highlights:

Identified substrates / inhibitors for different proteases and enabled research on phage display for degradome characterization, determining human kallikrein 6 substrate specificity,

Scaled up processes using bioreactors for producing recombinant proteases.

Studied characterization and function of novel serpins, as well as Implantation Serine Protease characterization, purification, enzyme kinetics, and substrate specificity determination.

Selected Achievements:

Empowered success for ~200 students by teaching graduate courses, including Proteomics, Biomedical Business Planning, and Integrated Molecular Cell Biology, Biochemistry, & Genetics, among others.

Published 10+ research papers in high impact scientific / medical journals, including PLOS One, Vaccine, Biological Chemistry, and Biochemistry & Cell Biology; presented research at numerous conferences.

NAVNEET SHARMA, PhD Page 2 403-***-**** **********@*******.***

M / S DSM ANTI-INFECTIVES INDIA LIMITED Chandigarh, India 1995-2002

Global leader in environmentally friendly anti-infective molecule development.

Senior Assistant Manager: Process Development

Key contributor to process development for Cephalosporin-C production within major fermentation facility. Performed numerous roles, including process development for Penicillin acylase production, immobilizing it onto acrylonitrile beads following purification, and using this for Penicillin-G to 7-ADCA bioconversion.

Selected Achievements:

Completed process validation and optimized raw material usage including some fermentation components by collaborating with Quality Assurance, Production, and Engineering.

Increased plant productivity by leading process development section of Cephalosporin-C, including process control and improvement, with full outcome accountability.

Established Cephalosporin-C production at 10000 x 7 liters scale with exceptional quality and quantity, introduced ‘Scavenger Column’ in downstream processing

M / S MAX-GB LIMITED, INDIA Chandigarh, India 1993-1995

Pharmaceutical company specializing in semi-synthetic penicillin & intermediates production.

Assistant Manager: Research & Development

Collaborated on Cephalosporin C fermentation development. Achieved shake flask level (0.5-3 liter) and lab fermenter level (10 liter). Optimized downstream processing components, including microfiltration, absorption chromatography, de-colorization chromatography, reverse osmosis concentration, crystallization, and drying. Designed analytical method for determining Cephalosporin-C content and impurities by HPLC.

Selected Achievements:

Developed biocatalysis process for Cephalosporin-C conversion into 7-ACA via M/S Boehringer technology.

Escalated Cephalosporin-C production process from R & D to pilot scale (~3K liters) and subsequently industrial scale by successfully accomplishing all assigned tasks.

EDUCATION

Doctor of Philosophy in Molecular Biology & Biochemistry

Research: Indian Institute of Integrated Medicine (CSIR) Jammu, India

Degree: School of Life Sciences Amritsar, India

Master of Science in Molecular Biology & Biochemistry

School of Life Sciences Amritsar, India

Executive Master of Business Administration in Innovative Technology

University of Fredericton Fredericton, Canada

Bachelor of Science in Botany, Zoology, & Chemistry

DAV College Jalandhar, India

ADDITIONAL PROFESSIONAL DEVELOPMENT

Faculty Teaching Certificate Instructional Skills Intellectual Property

RECENT RESEARCH PUBLICATIONS

Implantation Serine Proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via Proteinase Activated Receptors; Biochemistry and Cell Biology (2013)

Strypsin 1; Handbook of Proteolytic Enzymes (2013)

Implantation Serine Proteinases-Structure, Function and Evolution; Serine Proteases (2012)

Full details for these and additional publications available on request.

TECHNICAL SKILLS

Microsoft Office (Word / Excel / PowerPoint / Outlook) Windows Mac

PROFESSIONAL MEMBERSHIPS

International Proteolysis Society (IPS) Canadian Society for Molecular Biosciences (CSMB)

OTHER LANGUAGE SKILLS

Punjabi Hindi

NAVNEET SHARMA, PhD

192 Citadel Meadow Close NW Calgary, Alberta T3G 4T4

403-***-**** **********@*******.***

Dear Sir / Dear Madam:

With over 10 years of combined experience in biomedical and pharmaceutical research, I now seek to bring my biotechnological business expertise to your company. A skilled communicator, I excel at delivering clear and engaging presentations, meetings, trainings, and seminars. My background in planning and executing large-scale clinical studies and process improvements have given me in-depth familiarity in policy and procedural development, including making proactive changes leading to maximized efficiencies and improved overall integrity to experimentation results. Well-versed in both clinical and business aspects of biotechnology, I am confident my research and scientific abilities can make me a valued asset to your organization.

My roles have ranged from Research & Development Assistant Manager to Biochemistry & Molecular Biology Adjunct Assistant Professor. I have a wide-ranging background spanning drug industry processes, university teaching, and advanced research. A sample of my key contributions include:

Increasing plant productivity by leading process development section of Cephalosporin-C, including process control and improvement, with full outcome accountability.

Empowering success for ~200 students by teaching graduate courses, including Proteomics, Biomedical Business Planning, and Integrated Molecular Cell Biology, Biochemistry, & Genetics, among others.

Identifying substrates / inhibitors for different proteases and enabled research on phage display for degradome characterization, determining human kallikrein 6 substrate specificity,

Studying characterization and function of novel serpins, as well as Implantation Serine Protease characterization, purification, enzyme kinetics, and substrate specificity determination.

A more detailed presentation of my professional background can be found in the enclosed resume. I have included my contact information and I would welcome the opportunity to discuss my qualifications with you. Thank you for your consideration, and I look forward to your response.

Sincerely,

Navneet Sharma, PhD

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