Organic Chemistry Data Analysis

Nour Eddine Fahmi, PhD

**** *. ******** **.

Scottsdale, AZ 85257

Phone: 434-***-****

Email: *******@*****.***

US Citizen

Summary

• Chemist with 17 years of experience in chemical R & D both in the pharmaceutical Industry and

Academia.

• Experienced in laboratory research, scale-up and technology transfer to ensure optimal product quality.

• Experienced in the design and implementation of practical and cost-saving synthetic processes.

• Inventor on four issued patents and author of twenty four publications in highly rated journals.

Professional Experience

Biodesign Institute, Arizona State University (Tempe, AZ)

- Scientist 2010 to date

• Developed strategies for the scale up synthesis of threofuranosyl nucleic acid (TNA) phosphoramidite

monomers for A, C, G, T and their corresponding triphosphates, as well as their incorporation into TNA

oligonucleotides by solid-phase synthesis.

• Designed and synthesized stereochemically pure unnatural amino acids for incorporation into proteins.

Pinnacle Pharmaceuticals, Inc. (Charlottesville, VA)

- Senior Scientist 2002-2009

• Managed all aspects of synthetic and analytical chemistry efforts (lead optimization, identification and

advancement of pre-development compounds).

• Provided leadership and management of external research and development efforts contracted to

CMOs to ensure that intermediates and finished product testing is kept up to date.

• Designed experiments and refined process steps for the manufacture of quality, stable products.

• Supervised and mentored medicinal chemists responsible for the design and synthesis of therapeutic

molecules for biological assays.

University of Virginia (Charlottesville, VA)

- Research Scientist 2001-2002

- Research Associate 1998-2001

• Participated in several projects involving synthetic organic chemistry (natural products and analogues)

and bioorganic chemistry (nucleic acids and protein engineering).

University of Hull (Hull, United Kingdom)

- Postdoctoral Research Fellow 1996-1998

• Synthesis and characterization of novel heterocycles and nucleoside analogues as antiinfective agents.

• Design, synthesis and properties of novel liquid crystal biomaterials based on carbohydrates.

Education

Université de Picardie-Jules Verne (France) Ph.D. Organic Chemistry 1996

The degree was awarded at the level of: Mention Très Honorable avec les Félicitations du Jury

(N.B. This is the highest level of award given for a PhD in France)

Title: “New synthetic routes to 4’-thionucleosides and 4’-thio-AZT”

Université de Technologie de Compiègne (France) M.Sc. Chemistry 1992

Université Ibn Tofail (Morocco) B.S. Chemistry 1991

Scholarships, Awards and Honors

1998 Awarded a prize for the most innovative work in the field of Nucleosides, Nucleotides &

Nucleic acids during the XIIIth International Round Table “Nucleosides, Nucleotides and

their Biological Applications” held in Montpellier (France).

1996-1998 Post Doctoral Fellowship at the University of Hull (U.K.) sponsored by BioChem Pharma

1995 GlaxoWellcome Scholarship, University of Hull, (UK).

1995 Doctoral Fellowship from the Picardie Region (France).

1992-1995 Doctoral Fellowship from the National Education Ministry of Morocco.

Professional Activities

Grand Awards judge for the 2013 Intel International Science and Engineering Fair in Phoenix, Arizona.

I have been invited on several occasions to review manuscripts for the following journals:

“The Journal of the American Chemical Society” 2002-2011

“Nucleosides, Nucleotides & Nucleic Acids” 2001-2002

“Journal of Biomedicine and Biotechnology” 2001-2003

Professional Affiliations

American Chemical Society (US)

Royal Society of Chemistry (UK)

Publications

25- “Therminator-Mediated Synthesis of Unbiased TNA Polymers Requires 7-Deazaguanine to Suppress

G-G Mispairing during TNA Transcription”

M. R. Dunn, A. C. Larsen, N. Fahmi, W. J. Zahurancik, M. Meyers, Z. Suo, J. C. Chaput

J. Am. Chem. Soc. 2014 (Submitted)

24- “Chemical and Biological Stability of TNA and TNA-DNA Mosaic Oligonucleotides”

K. Temburnikar, n. Fahmi, R. S. Burke, K. A. Kwasnjuk, M. T. Cancilla, J. H. Hochman, and J. C. Chaput

Nucleic Acids Res. 2014 (submitted)

23- “Probing of CD4 Binding Pocket of HIV-1 gp120 Glycoprotein Using Unnatural Phenylalanine

Analogues”

X. Yu, P. Talukder, C. Bhattacharya, N. Fahmi, J. A. Lines, L. M. Dedkova, J. LaBaer, S. M. Hecht and S.

Chen.

Bioorg. Med. Chem. Lett. 2014, 24, 5699-5703

22- “Fluorescent Biphenyl Derivatives of Phenylalanine Suitable for Protein Modification”

S. Chen, N. Fahmi, L. Wang, C. Bhattacharya, S. J. Benkovic and S. M. Hecht.

Biochemistry 2013, 52(47), 8580-8589.

21- "Detection of DHFR Conformational Change by FRET Using Two Fluorescent Amino Acids"

S. Chen, N. Fahmi, L. Wang, C. Bhattacharya, S. J. Benkovic and S. M. Hecht.

J. Am. Chem. Soc. 2013, 135(35), 129**-*****.

20- "Two Pyrenylalanines in Dihydrofolate Reductase Form an Eximer Enabling the Study of Protein

Function"

S. Chen, L. Wang, N. Fahmi, S. J. Benkovic and S. M. Hecht.

J. Am. Chem. Soc. 2012, 134(46), 188**-*****.

19- "Synthesis of pdCpAs and Transfer RNAs Activated with Thiothreonine and Derivatives"

S. Chen, N. Fahmi, R. C. Nangreave, Y. Mehellou and S. M. Hecht.

Bioorg. Med. Chem. 2012, 20 (8), 2679–2689.

18- "β -puromycin Selection of Modified Ribosomes for in-vitro Incorporation of β-amino acids"

L. Dedkova, N. Fahmi, R. Paul, M. Del Rosario, G. Feder and S. M. Hecht.

Biochemistry 2012, 51(1), 401–415.

17- "Inhibition of S. aureus α-Hemolysin and Anthrax Lethal Toxin by β-Cyclodextrin Derivatives"

V. A. Karginov, E. M. Nestorovich, F. Schmidtmann, T. M. Robinson, A. Yohannes, N. Fahmi, S. M.

Berzukov and S. M. Hecht.

Bioorg. Med. Chem. 2007, 15 (16), 5424–5431.

16- "Site Specific Incorporation of Glycosylated Serine and Tyrosine Derivatives into Proteins"

N. Fahmi, L. Dedkova, B. Wang, S. Golovine and S. M. Hecht.

J. Am. Chem. Soc. 2007, 129, 3586–3597.

15- "Construction of modified ribosome for Incorporation of D-amino acids into proteins"

L. M. Dedkova, N. Fahmi, S. Y. Golovine and S. M. Hecht.

Biochemistry 2006, 45, 15541–15551.

14- "Search for Cyclodextrin-Based Inhibitors of Anthrax Toxins: Synthesis, Structural Features, and

Relative Activities"

V. A. Karginov, E. M. Nestorovich, A. Yohannes, T. M. Robinson, N. Fahmi, F. Schmidtmann, S. M. Hecht

and S. M. Bezrukov.

Antimicrobial Agents Chemotherapy 2006, 50, 3740–3753.

13- "β -Cyclodextrin Derivatives that Inhibit Anthrax Lethal Toxin"

V. A. Karginov, A. Yohannes, T. M. Robinson, N. Fahmi, K. Alibek and S. M. Hecht.

Bioorg. Med. Chem. 2006, 14 (1),33–40.

12- "Enhanced D-Amino Acid Incorporation Into protein by Modified Ribosome"

L. Dedkova, N. Fahmi, S. Y. Golovine and S. M. Hecht.

J. Am. Chem. Soc. 2003, 125, 6616–6617.

11- "Total Synthesis of Deamido Bleomycin A2, the Major Catabolite of the Antitumor Agent Bleomycin"

Y. Zou, N. Fahmi, C. Vialas, G. M. Miller and S. M. Hecht.

J. Am. Chem. Soc. 2002, 124, 9476–9488.

10- “Studies Towards the Site Specific Incorporation of Sugars Into Proteins: Synthesis of Glycosylated

Aminoacyl-tRNAs”

N. Fahmi, S. Golovine, B. Wang and S. M. Hecht.

Carbohydr. Res. 2001, 330 (2), 149–164.

9- "Stereoisomeric Pyrimidine Nucleoside Analogues Based on the 1,3-Dihydrobenzo[c]furan Core"

D. F. Ewing, N. Fahmi, C. Len, D. F. Ewing, G. Mackenzie and A. Pranzo.

J. Chem. Soc. Perkin Trans I 2000, 3561–3565.

8- "Synthesis of Nucleoside Analogues Incorporating the 3-Hydroxymethylphenyl Glycone, a New

Approach to Conformationally Restricted Systems for Enzyme Inhibition"

D. F. Ewing, N. Fahmi and G. Mackenzie.

Collection Symposium Series (Chemistry of Nucleic Acids Components) 1999, 2, 277–280.

7- "Nucleoside Analogues with a Novel Glycone Based on the Benzo [c]furan Moiety"

D. F. Ewing, N. Fahmi, C. Len, G. Mackenzie, G. Ronco P. Villa and G. Shaw.

Nucleosides & Nucleotides 1999, 18 (11-12), 2613–2630.

6- "Configuration and Conformational Studies of Nucleoside Analogues Based on the Benzo[c]furan

Core"

D. F. Ewing, N. Fahmi, Mackenzie and A. Pranzo.

Nucleosides & Nucleotides 1999, 18 (4-5), 627–632.

5- "Simple and Stereoselective Syntheses of Nucleoside Analogues with a Benzo[c]furan Glycone Moiety"

D. F. Ewing, N. Fahmi, Mackenzie and A. Pranzo.

Nucleosides & Nucleotides 1999, 18 (4–5), 559–563.

4- "Synthesis and Configurational Assignmemt of 3-Substituted 2-deoxy-4-thio-D-ribofuranose

Derivatives"

H. Ait-Sir, N. Fahmi, D. F. Ewing, G. Goethals, G. Mackenzie, T. Bougrine, G. Ronco and P. Villa.

J. Chem. Soc. Perkin Trans I 1996, 1665–1671.

3- "Synthesis of 2-Deoxy-4-Thio-D-Ribofuranose and its 3-Azido Analogue from L-Arabinose;

Intermediate in the Synthesis of 4’-Thiodeoxynucleosides"

H. Ait-Sir, D.F. Ewing, N. Fahmi, G. Goethals, G. Mackenzie, G. Ronco and P. Villa.

Nucleosides & Nucleotides 1995, 12 (3-5), 359–362.

2- "An Alternative Strategy for the Synthesis of 3’-Azido-2’,3’-Dideoxy-4’-Thionucleosides Starting From

D-Xylose"

T. Bougrine, N. Fahmi, D. F. Ewing, G. Mackenzie, G. Ronco and P. Villa.

Carbohydr. Res. 1995, 267, 203–215.

1- "Electrospray Tandem Mass Spectrometry of 3’-Azido-3’-deoxy-thymidine (AZT) and a Novel Series of

of 3’-Azido-2’.3’-dideoxy-4’-thio-5-halogenouridines and Their Respective α Anomers"

J. Banoub, E. Gentil, T. Bougrine, N. Fahmi, G. Mackenzie, G. Ronco and P. Villa.

Spectroscopy 1994, 12, 69–83.

Patents

1- "Preparation of Phenazopyridine Conjugates, Especially Phenazopyridine Carbamates, Aminoacyl and

Peptidyl Phenazopyridines with Increased Bioavailability and Reduced Side Effects"

S. M. Hecht, N. Fahmi, S. Roy and G. Bonneville, PCT Int. Appl. WO 2010/071878.

2- "Cyclodextrin Drivatives as Potentiators for Antibiotics"

S. M. Hecht, N. Fahmi, L. Dedkova, S. Bera and R. Kolanos. PCT Int. Appl. WO 2009/058327.

3- "β-cyclodextrin derivatives and their use against anthrax lethal toxin"

V. Karginov, S. M. Hecht, N. Fahmi and K. Alibek. PCT Int. Appl. WO 2006/001844

4- " β -cyclodextrin derivatives as antibacterial agents"

N. Fahmi, F. Schmidtmann and S. M. Hecht. PCT Int. Appl. WO 2006/083678

Additional Information

Languages:

Fluent in English, French and Arabic (speaking and writing)

Teaching Duties

I have undertaken teaching and supervision duties both at the University of Picardie (France), University

of Hull (UK) and Arizona State University (US)

• Laboratory demonstrating

• Final year project student supervision

• Advanced organic chemistry courses

Skills and Expertise

Organic Chemistry, Medicinal Chemistry, Process Chemistry, Bioconjugation, Analytical Chemistry, Drug

Discovery, Research and Development, Data Analysis, Analytical Techniques (NMR, MS, IR, LC-MS,

HPLC, chromatography, UV-Vis, Fluorescence), Scientific Software, patent analysis

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