Quality Control Development
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Amina Soukrati, PhD Somerville, MA - 02144
Tel: 617-***-****;514-***-****
*************@*******.**
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Amina Soukrati
Summary
Scientist with broad research experience in analytical chemistry, reformulation of existing drug, preformulation, formulation
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and drug quality control, small and pilot scale development, analytical method development and validation
Experienced with instrumentation and techniques ( DSC, DLS, LD, SEM, HPLC, TLC, GC, LC-MS, UV-Vis / Fluorescence
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Spectroscopy, IR and Raman Spectroscopy) for characterization and quantitation of drug product during production process
Proficient in the design, development and validation of HPLC analytical methods using different detectors
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( fluorescent, electrochemical, UV-Vis and evaporative detector (ELSD))
Highly experienced in dissolution study, drug release, thermal stability testing and forced degradation study for developed
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drug formulation
Efficient in synthesis and physicochemical characterization of drug nanosuspension and material polymer (hydrogel and
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microbeads polymer)
Implemented methods that meet FDA requirements, cGMP/GLP expectations and ICH guidance for new pharmaceutical
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formulation
Demonstrated high knowledge in solid chemistry, physical chemistry, polymer chemistry, electrochemistry, physical pharmacy
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Expert in liquid and solid dosage forms formulation development
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proficient in written and verbal communication skills; Self motivated, able to work independently and collaboratively ; Strong
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project management skills, including the ability to prioritize, organize, to multi_task and to meet the projects timelines; Strong
ability to seek knowledge in a specific research area
Fluently bilingual in French and English and easily integrated into team environments
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Experience
Analytical development/Quality Control (Contractor) Jan 14 – June 14
Boston Analytical, Salem, NH
Performed HPLC analytical method development, validations and method transfers for client and USP based methodologies
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Wrote validation and method transfer protocols and reports in accordance with ICH USP guidelines
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proceeded data analysis and management using LIMS
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Executed method verification and validation compliance to SOP and specification
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Wrote technical report related to assigned work in an electronic notebook
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Ensured that all work performed is performed in compliance with standard operating procedures, good manufacturing
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practices, and the regulations of the Food and Drug Administration
Participated in reviewing documentation, and documented work in a clear and organized manner
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Conferred with other chemist and client personnel regarding research, procedures performed and related results and prepared
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reports
Conducted testing of raw materials and components, in process and finished product sample in compliance with SOPs, GMP,
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and FDA regulations
Developed quantitative HPLC method for dosing solutions
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Identified and implemented methods for cost savings, improved efficiency and control
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Research Scientist Oct 09 – Mar 13
M.S. in Pharmaceutical Sciences (Pharmaceutical Technology)
Faculty of Pharmacy, Université de Montréal, Montreal, Canada
Developed new oral liquid dosage formulation from solid dosage form (Prevacid Fast Tablet) of Lansoprazole
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Evaluated chemical stability, degradation study, dissolution and content uniformity of Lansoprazole
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Developed and validated an analytical HPLC method for Lansoprazole detection
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Developed and validated an analytical HPLC method with ELSD detector (evaporative detector) for
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1-docosanol detection in standard solutions and in nanoformulations samples
• Prepared and pilot scale processing of new formulation based on docosanol nanosuspension
• Prepared and characterized a docosanol semi solid dosage form (gel) based-nanosuspension for topical use
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Amina Soukrati
Evaluated the docosanol degradation study in nanosuspension and its stability in gel form at different temperature
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Characterized docosanol nanosuspension and gel by DLS and LD for nanoparticles size measurement, by DSC for crystalline state
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study, by SEM for morphology study, by Brookfield Viscosimeter for rheological studies and by Franz Cell for the in Vitro drug
(docosanol) release study from prepared gel and commercial product (cream) through a polycarbonate membrane fixed in Franz-
cell
Research Scientist Jan 09 – Sep 09
Massachusetts College of Pharmacy, Boston, MA
Studied Indomethacin crystallization and characterized its crystals by Raman Spectroscopy, Infrared Spectroscopy and differential
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scanning calorimetry (DSC)Spectroscopy
Quantified alpha and gamma crystalline form of Indomethacin by Raman spectroscopy
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Determined the pH effect on drug solubility process
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Evaluated Indomethacin precipitation inhibition by polymer PVP-90
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Evaluated of some solid dosage form tablets by studying: hardness, friability, weight variation, disintegration and dissolution
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Postdoctoral Research Fellow May 05 – Dec
07
Northeastern University, Boston MA
Performed radiochemical synthesis and HPLC purification of radiotracer such as agonist and antagonist of CB1, CB2 cannabinoid
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receptors
Quantified the level of radio-labeled compounds (3H or 125I) in radiotracers
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Performed tail intravenous injection and peritoneal injection of radiotracer to mice followed by dissection/ micro dissections of
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mouse brain and organs
Worked with radiotracer to determine drug metabolism and the uptake of its drug in different 5 regions of the brain, in blood and in
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nine different organs of mice
Designed, developed and validated an analytical method for Glutathione detection in Biological cells using HPLC with
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fluorescence detection and mass spectroscopy
Performed micro-dissection of rat brain
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Did protein assay for quantification of proteins in rat brain
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Developed and validated an analytical HPLC method with electrochemical detector for catecholamine’s detection (such as
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dopamine and norepinephrine) in rat brain
Analytical Chemist Jan 04 – Apr 05
Acti Lab Pharma, Montreal, Canada
Performed analytical chemistry assays based on new and existing methodologies, operated analytical instrumentation such as
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HPLC, GC, and LC/ MS
• Provided technical report with interpretation of test results
• Developed, established, and validated analytical testing methodology used to control raw materials, production intermediates, and
final products in cosmetic and pharmaceutical field
Teaching Assistant Jan 02 – Dec 03
Department of Chemistry, Université Libre de Bruxelles, Brussels, Belgium
Prepared syllabus, designed experiments, taught prelab and lead a group of 20 undergraduate and graduate students in lab classes
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for analytical chemistry laboratory and material polymer chemistry laboratory
• Mentored and guided a group of 30 undergraduate students for general chemistry laboratory class
• Lead section meeting and tutored students in lectured classes for general chemistry, analytical chemistry and macromolecular
chemistry
Graduate student; PhD Candidate Jan 97 – May 01
Macromolecular Chemistry Laboratory/ Department of Chemistry
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Amina Soukrati
Université Libre de Bruxelles, Brussels, Belgium
Dissertation topic: Photochemistry, Photophysics and Enzyme Immobilization in Hydrogels
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Synthesized and studied properties of ionic and nonionic hydrogels based Polymers
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Studied controlled free radical polymerization of acrylamide monomer crosslinked by methylene bis’ acrylamide for hydrogels
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membrane which is initiated by three different methods: using thermally decomposable initiators
(sodium persulfate Na2S2O8), photoinitiators like sodium anthraquinone sulfonate or gamma radiation
Synthesized hydrogels in membrane shape or microbeads form
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Developed an enzyme biosensor by immobilization of glucose oxydase in hydrogel microbeads
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Developed a reused heterogeneous photosensitizer and photocatalyst by ionic exchange fixation in cationic hydrogel
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Studied hydrogel microenvironment by fixation of fluorescent probe
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Graduate student: Master study Sep 95 – Nov 96
Bioelectrochemistry& instrumental analysis laboratory, Pharmacy Institute
Université Libre de Bruxelles, Brussels, Belgium
Dissertation topic: Amperometric detection of hydrogen peroxide on gold electrode
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Studied the electrochemical behavior of hydrogen peroxide at modified and non modified gold electrode
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Proceeded to a platinum layer deposit on gold electrode after its modification for hydrogen peroxide detection in interference of
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ascorbic acid
Education
Master in Pharmaceutical Sciences, Université de Montréal, Montreal, Canada, 2009-2013
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PhD Sciences; Chemistry, Université Libre de Bruxelles, Brussels, Belgium 1997-2001
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Master of Sciences in Applied Chemistry (Hons.), Université Libre de Bruxelles, Brussels,
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Belgium, 1995-1996
• Bachelor of Sciences; Chemistry, Université Chouaïb Doukali, El Jadida, Morocco 1993
Scientific guest lectures and Publications
Development and characterization of a docosanol nanosuspension and a semi solid topical formulation for HSV viral treatment (in
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preparation for patent work and publications 2014-2015). A.Soukrati and Grégoire Leclair.
• Quality evaluation of extemporaneous delayed-release liquid formulations of lansoprazole. American Journal of health-system
pharmacy, 2011 Nov 1: 68 (21): 2069-74. A. Melkoumov, A.Soukrati & al.
• Evaluation of the in vivo receptors occupancy using radiolabeled agonist and antagonist of cannabinoid receptors (in
preparation for patent work). S.John Gatley and A.Soukrati.
• Re-examination of the dopamine hypothesis concerning longterm neurological effects of HZE radiation ( Grant report ) S.John
Gatley, A. Soukrati and al.
• Fabrication of specify glucose electrode by enzyme immobilization in hydrogels. A.Soukrati. Electrochemistry journeys 01,
Marrakech, Morocco.
• Investigation of polyacrylamide hydrogels using 1-anilinonaphtalene 8-sulfonate (ANS) as fluorescent probe: 2000. G.
Geuskens and A. Soukrati. European polymer journal 36, 1537-1546.
• Photochemistry and photophysics in hydrogels: May 1999. A. Soukrati. Belgian polymer group.
• Amperometric detection of H2O2 on gold electrode: 1996. Soukrati. M.Sc. Dissertation, Université Libre de Bruxelles,
Belgium.
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Amina Soukrati
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