Project Research

Gajanan Inamdar

Excellent, motivated, energetic and intuitive, synthetic organic &

medicinal chemist and drug discovery scientist.

**** ********* ** ***# * Fort Collins CO 80521

***********@*****.*** - 970-***-****

Objectives

• My core competencies are drug designing (pharmaceutical), synthetic

organic and medicinal chemistry, multi-step synthesis, analytical

chemistry which especially spectroscopy liquid and gas chromatography.

Pharmacist by training, I have compelling knowledge in pharmacology

and an understanding of molecular biology. One of my important strength

is literature search, information digging and communication. I have

efficaciously managed a project and a small group of scientists in the

capacity of a project leader, extensively worked for design and synthesis

of various heterocycles and steroids.

• Demonstrated compelling understanding of the drug discovery process,

especially anti-inflammatory & anti-cancer research,

• Experienced in chemistry lab start-up & strong experience of working for

contract research & pharmaceutical companies and academic set-up,

• I have always believed in quality and ethical scientific approach for

effective drug discovery research and lead a team of young scientist and

help them find their career path.

Accomplishments

• Successfully designed, synthesized and characterized novel tri-substituted

thiazole based adenosine receptor antagonist and accomplished one of the

potent ligands for the A2A and A2B receptor sub-type.

• Successfully managed and led a kinase based project revolving around

constructing various 3-amino-1,2,4-benzotriazines, qunoxalins and the

mono and di oxides. My responsiblities apart from managing a small

group of scientist, involved scheme design, molecule design and synthesis

of about 100 compounds for a UK based pharmaceutical. My motivation

and hard work was instrumental in trouble shooting synthetic flaws with

the help of MS, NMR and LCMS and convincing the client. Thus earning

valuable business recommendation and increased the number of FTE's for

the project.

• Setting up a chemistry laboratory at the Department of Pharmacology,

Penn State University College of Medicine, I successfully designed,

synthesized and characterized triterpenoid derivatives as potential and

selective anti-melanoma compounds. The success was rewarded with

filling of 2 US patent (one granted). The most successful molecule is

placed in pre-/clinical trials.

• Actively led and managed the drug modification team which listed natural

products like taxols and other FDA-approved drugs like imatinib, sidenafil,

gemcitabine, thalidomide and pomalidomide. The modification were able to

greatly enhance either solubility, modify PK/PD, avoiding early first pass

metabolism or evading P-glycoprotein.

Experiences Research Scientist Sphaera Pharma

2/2012 - 4/2014

• Lead the Drug Modification group and manage 2 research chemists.

• Research different generally recognized as safe (GRAS) chemicals and

reagents.

• Secondly use GRAS reagents to construct drug motifs that can be

biologically cleaved and modify then suitably for their use in quaternize

(modified) drugs.

• Modification of existing FDA approved drugs, to synthesize new

derivatives that would act a pro-drugs. The aim of this research was to

modify either of the following, solubility, PK/PD profile, absorption,

obscure form first pass metabolism and P-glycoprotein 1

• The modifications also helped in effective formulations and drug re-

purposing (for other pharmacological action than it is labeled for).

• I was actively involved in design, synthesis and purification of 11beta-

hydroxy pregnenolone derivatives. The purpose of this project was to

develop steroidal compounds that closely matched the 3D molecular

structure of epichatechin. The final outcome would be activation of 5'

adenosine monophosphate-activated protein kinase to ameliorates

muscular distrophy.

Post-doctoral research scholar Penn State Hershey College of Medicine

8/2009 - 5/2011

Set-up and start a fully operation synthetic organic and medicinal chemistry

lab. Design, synthesize, elucidate and pharmacological evaluation of a

triterpenoid based anti-melanoma compounds. High-through-put screening

of compound library for synergy studies. Cell culture and cell based assays

Scientist-I Oxygen Healthcare

10/2007 - 7/2009

Lead kinase based project, design and synthesize kinase based anti-cancer

compounds for a UK based pharmaceutical company. Develop experience

in

multi-step synthesis from mg to g scale (10 mg to10g), Synthesize, purify,

and characterize intermediates and compound. Manage 3 synthetic organic

chemist at research associate level. To work with cross-functional scientific

and research teams. Conduct meetings and communication with client and

report the plan and status of the project Decisive trouble shooting of

reaction schemes & conditions.

Research Assistant Sun Pharma Advanced Research Centre

4/2002 - 5/2003

My priorities were to enhance skills in the areas of stability study, method

validation, and documentation using various analytical instruments. This

included extensive use of liquid & gas chromatography along with

dissolution apparatus. Developed methods for determination of the level of

nitrosoamines in the rubber enclosures. SOP and report preparation and

documentation.

Research Officer Zydus Cadila Healthcare

3/2001 - 4/2002

My primary responsibilities were to get rigorously trained in conducting

stability studies using dissolution apparatus and HPLC with report

generation and documentation. The stability studies were carried out on

formulations that were aimed for regulatory markets.

Educations

Doctorate - Chemistry (Synthetic organic and medicinal chemistry)

B V Patel Pharmaceutical Education and Research Development (PERD)

Centre, 2007

Master - Pharmaceutical Chemistry

KLE's College of Pharmacy, 2000

Bachelor - Pharmacy Education

MM's College of Pharmacy, 1998

Skills

Project Management, Team Lead, Synthetic Chromatography, Pro-drugs,

Organic Chemistry, Medicinal Chemistry, Drug

Nuclear magnetic resonance,

Design, Pharmacology, Analytical Chemistry,

Communication, Trouble shooting, Literature Mass spectroscopy

Search, Purification,

References

Dr Kamala Vasu - +919*********, ******@*****.***

Dr Manish Nivsarkar - +917*********, ********@**********.***

Dr Nehal Sheth - +912*********, *********@*****.***

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