Bioanalytical, HPLC, LC-MS/MS, In-vitro metabolism

CHALLAGUNDLA MURALIKRISHNA

M.S. (Pharm.) Pharmaceutics,

NIPER RaeBareli – 229 010.

Mobile: +91-860*-******, +91-958*-******(A.P).

Email: ******************@****.***

Objective

An opportunity to apply my learning and looking for growing career path which

satisfy my intellect and skills to stretch my ability and integrating my efforts for working

towards the organization’s goal.

Educational Qualifications

Academic Marks

Course Board/University Institution year M.S. (Pharm.) NIPER NIPER, Raebareli 2012-Current 8 CGPA

Acharya Nagarjuna Sims College of Pharmacy

B.Pharm University Guntur, A.P. 2008-2012 79.83%

Board of Intermediate Sri Prathibha Junior College

Class XII Education Ongole, A.P. 2006-2008 86.1%

Board of Secondary Z.P.High School, Marella

Class X Education A.P. 2005-2006 81.5%

Achievements

Qualified GPAT 2012 Exam with all India 797th rank

Qualified NIPER-JEE 2012 Exam with all India 347th rank

Qualified PGCET with State 27th rank

Successfully completed the course “General Course on Intellectual Property” WIPO in

2012

Strengths

• Patience, hardworking, good team player, honest and loyal, quick learner

• Ready to take up responsibilities with ease and ability to work effectively under stressful

environment

Project Undertaken

Project Title: “Bioanalytical method development and validation of prospective anti-

malarial compound and its application to preclinical pharmacokinetic study”.

Project Supervi sor: Dr.Wahajuddin

Project summar y: Accurate quantitative analysis is one of the most integral parts of

pharmacokinetic studies. The objective of the project is to develop and validate a sensitive,

selective, precise and accurate bioanalytical method for quantification of the prospective

anti-malarial compound in biological matrices. Method development and validation will be

carried out as per USFDA guidelines, using LC-MS as the bioanalytical technique of choice

due to its better sensitivity and selectivity. This validated method will be used to analyze the

test samples of preclinical pharmacokinetic studies and in-vitro metabolism studies.

Duration: 1 Year

Skill Set

• Experienced in performing in vitro metabolic stability with liver microsomes, in vitro

plasma stability, plasma protein binding, CYP reaction phenotyping, drug-drug

interactions

• Efficient in performing in vivo experiments in various species (Rat, Mice and Rabbit) through

different administration routes

• Acquainted with bioanalytical method development and validation, pharmacokinetic and

dynamic data analysis using winnonlin 5.1 and preclinical formulation for PK studies

• Knowledge of application softwares like GraphPad Prism®, SigmaPlot®, and SigmaStat ®

• Appreciable understanding of concepts related to Intellectual Properties and Regulatory

Affairs

• spectrometry, Automated tablet compression machine, Dissolution apparatus,

Disintegration test apparatus, Cone and Plate Viscometer, Roche f riabilator, Sonicator,

Homogenizer, Freeze dryer, Rota evaporator and Ultra-centrifuge

• Knowledge in literature search and data retrieval using various scientific search engines

like Science direct, Google scholar, Scifinder, Scopus, and PubMed

• Well versed with the use of analytical instruments and techniques like LC-MS/MS,

HPLC methods

Presentations/ Training

• Participated in 5th NIPER (RBL)-CDRI Symposium on “Chemical and Biological Approaches

in Drug Development & Delivery Strategies” at CDRI, Lucknow (21st-23rd March, 2013)

• Participated in “PK/PD Workshop Using Phoenix – WinNonlin, NLME and IVIVC”

held at Pharmacokinetics & Metabolism Division, CSIR-Central Drug Research

Institute, Lucknow during 4th- 6th December, 2013

• Participated in 6th NIPER (RBL)-CDRI Symposium on “Current Scenario in Drug Discovery

and Development” at CDRI, Lucknow (20th-22nd February, 2014)

Personal Profile

Name : Ch. Muralikrishna

Father’s Name : Ch. Yedukondalu

Date of Birth : 12-June-1991

Marital Status : Unmarried

Languages Known : English, Hindi and Telugu

Nationality : Indian

Permanent Address : 1-102A, Marella, Mundlamuru Md,

Prakasam Dist., AndhraPradesh-523201.

Declaration

I hereby declare that the information furnished above is true to the best of my knowledge.

(Ch.Muralikrishna)

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