Service University
Resume:
Anton Shakhmin
University of Southern California
*** ***** ****, *** *******, CA 90089
Email: ********@***.***; Cell: 213-***-****
Education
Ph.D. in Organic/Medicinal Chemistry 2013
University of Southern California, Los Angeles, CA
Master of Science in Organic Chemistry 2006
Saint-Petersburg State University, Saint-Petersburg, Russia
Highlights
Extensive experience in synthetic organic chemistry. Developed 15+ multistep synthesis of novel
nucleotide analogues
Developed a number of effective one-step synthetic methodologies with the employment of
environmentally benign heterogeneous catalysts
Experienced in analysis and characterization of organic compounds, biomolecules, nanoparticles
Responsible for calibrating, troubleshooting and method development for HPLC/LCMS systems;
trained coworkers in operation of HPLC/LCMS
Proven success in a collaborative environment (NIH and USC Norris Comprehensive Cancer Center)
Guided/advised the research of three undergraduate/graduate students
Research Experience
August 2007 Present
Graduate Research Associate
Loker Hydrocarbon Institute, University of Southern California, Los Angeles CA with Professors
G. K. Surya Prakash and Nobel Laureate George Olah
Organic / Medicinal Chemistry
o Synthesized new chemotherapeutic anticancer agent based on 2'-deoxy-ψ-isocytidine
o Designed and synthesized novel nucleotide analogues containing bioisosteric modifications (CF2,
CF2H, Squaryl and other)
Organic/ Fluorine Chemistry
o Developed efficient synthetic methodologies and standard operating procedures for the
preparation and purification of fluorine and phosphorus containing organic compounds
o Preparation and characterization of PVP-H2O2/PVD-H2O2 complexes for selective oxidation of
sulfides and ketones
o Discovered a new one-pot synthetic procedure for preparation of polycyclic aromatic
hydrocarbons in presence of BF3 H2O, a non-oxidizing Superacid catalyst
o Functionalized surface of nanodiamonds with small organic molecules using click chemistry
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Skills
Extensive experience in:
o Characterization and separation techniques including UV–Vis, FTIR, HPLC, GCMS, LCMS,
AFM, XRD and 1H, 13C, 31P, 19F NMR
o Synthetic techniques such as Microwave-Assisted Synthesis, High pressure reactors, Air-free and
Glove box techniques
Awards
W. P. Weber Award in recognition of mentoring service and outstanding graduate research 2011
German Academic Exchange Service (DAAD) Scholarship for studying abroad 2006
Summer Research Fellowship:
o University of Southern California, CA 2005
o Bowling Green State University, OH 2004
Publications
1. Anton Shakhmin, John-Paul Jones, G. K. Surya Prakash, “Synthesis of squaryl analogues of triphosphoric
acid and computational evaluation of their chemical properties” Angew. Chem. Int. Ed. 2013 (manuscript in
preparation)
Anton Shakhmin, Yin-Wei Chang, Peter A. Jones, G. K. Surya Prakash, “Evaluation the ability of 2'-deoxy-
2.
ψ-isocytidine phosphoramidates to activate p16 Gene Silenced by DNA Methylation” J. Med. Chem., 2013
(manuscript in preparation)
3. Anton Shakhmin, John-Paul Jones, Inessa Bychinskaya, Mikhail Zibinsky, Keriann Oertell, Myron F.
Goodman, G. K. Surya Prakash, “Preparation of fluorinated nucleotide analogs stable to enzymatic hydrolysis
in RNA and DNA polymerase assays” Org. Lett., 2013 (submitted)
4. G. K. Surya Prakash, Chiradeep Panja, Anton Shakhmin, Eric Shah, Thomas Mathew and George A. Olah,
“BF3-H2O catalyzed hydroxyalkylation of aromatics with aromatic aldehydes and dicarboxaldehydes:
efficient synthesis of triarylmethanes, diarylmethylbenzaldehydes, and anthracene derivatives” J. Org. Chem.,
2009, 74(22), 8659-68.
5. G. K. Surya Prakash, Kevin E. Glinton, Anton Shakhmin, Sneha Rao, Thomas Matthew and George A.
Olah, “PVP-H2O2 and PVD-H2O2 as Solid H2O2 Equivalents: Selective Oxidation of Sulfides to Sulfoxides,
Green Chem., 2013 (manuscript in preparation)
6. G. K. Surya Prakash, Anton Shakhmin, Mikhail Zibinsky, Istv Ledneczki, Sujith Chacko and George A.
Olah, “Synthesis of monofluoroalkenes via Julia-Kocienski reaction” J. Fluor. Chem. 2010, 131(11), 1192-
1197.
7. Valerij A. Nikolaev, Alexey V. Ivanov, Anton Shakhmin, Barbara Schulze and Ludmila L. Rodina,
“Reactions of 2-diazo-1,3-dicarbonyl compounds with aromatic thioketones (superdipolarophiles)” Russ. J.
Org. Chem. 2011, 47(12), 1911-1913.
Valerij A. Nikolaev, Alexey V. Ivanov, Anton Shakhmin, Joachim Sieler and Ludmila L. Rodina,“The first
8.
examples of cycloadditions of 2-diazo-1,3-dicarbonyl compounds to aromatic thioketones” Tetrahedron Lett.
2012, 53(24), 3095-3099.
Presentations (Selected)
Anton Shakhmin and G. K. Surya Prakash, “Synthesis and biological evaluation of nonhydrolyzable
nucleotide analogs based on squaric acid” August 19-23, 2012, 244th ACS Meeting, Philadelphia (oral
presentation).
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