Scientist - Chemist
Resume:
Gregory Stoklosa
Langhorne, PA 19047
www.linkedin.com/in/gregorystoklosa
accbcs@r.postjobfree.com
Experienced SCIENTIST
A thorough knowledge of pharmaceutical principles. Able to effectively multitask assignments with a strong sense of urgency. Strong, result driven team member with effective communication skills able to interact effectively within a multidisciplinary team.
PROFESSIONAL EXPERIENCE
AMRI, Indianapolis, Indiana 2012 – 2013
Research Scientist II
* Responsible for the design, preparation, and purification of novel chemical entities for the treatment of various diseases for Lilly R&D medicinal chemistry team.
* Experience with direct interaction with the client (Lilly) & work collaboratively between different projects with Lilly & their objectives and timeframe.
* Presents quality written documentation, notebooks, methods, validation reports, data reports and summaries to the client.
* Gives effective oral presentations on my current research for the Lilly medicinal chemistry dept.
* Strong interdisciplinary interaction skills & project leadership experience within AMRI & Lilly.
* Experience in supervising research associates at AMRI.
* Shares relevant resources to team members to improve knowledge of chemistry and related lead & manage programs, to multi-task and to work and communicate effectively with colleagues, partners, contractors and management.
SANOFI, Bridgewater, New Jersey 2005 – 2012
Scientist I, Molecular Innovative Therapeutics - MIT (2010 –2012)
Scientist I, Exploratory Internal Medicine – Medicinal Chemistry (2008 –2010)
Associate Scientist, Internal Medicine – Medicinal Chemistry (2005 –2007)
* Optimization within a year culminating in the advancement of my final target into the pre-clinical trials for the PGDS inhibitor project.
* 50% of the compound in the β-Tryptase program (>60 molecules) were designed, planned & executed which directly resulted in improved physiochemical of a DC compound.
* 250 g of racemic DC candidate was synthesized in less than 3 weeks for the team which 50 g of it was transformed in an enantiopure d-Mandelic salt for the prostaglandin D2 receptor antagonist project.
* Designed and executed the synthesis of a azaindoles series with improved ADME properties that exhibited good in vivo for the β-Tryptase program.
* Inventive and innovative, self-starter comfortable and successful working in undefined area like peptidomimetic, sugar & peptide-linker chemistry.
* Leverage my analytical skills to champion the use of UPLC within medicinal chemistry department. Led the effort to automate the separation technologies at Sanofi.
* Coached & fostered professional/technical development for a summer intern student.
* Involved in the hiring committee of new chemists: hosting candidates at their interview, assisting in candidate's evaluation meeting.
www.linkedin.com/in/gregorystoklosa
accbcs@r.postjobfree.com
CHINOIN Co. Ltd, Budapest, Hungary 2008
* Volunteer amongst my peers for a scientist exchange program among my colleagues within Sanofi-Aventis Sites.
* Develop a new methodology for the synthesis of Halobenzylimidazoles analogues using readily commercially starting material to get to a wide variety of complex Halobenzylimidazoles analogues.
UNIVERSITÉ DE MONTRÉAL, Montréal, Canada 2003
Graduate teaching assistant (Chemistry Department)
BRISTOL-MYERS SQUIBB COMPANY, Candiac, Canada 2001
Analytical R&D Analyst (Pharmaceutical Research Institute)
* Develop analytical methods for HS/GC-MS & CE to characterize critical quality attributes of the drug product.
* Performed stability studies for drug product following USP protocols.
ALGORITHME PHARMA, St-Laurent, Canada 2000
Bio-Analyst (Analytical)
HONORS & AWARDS
Certificate of Merit by The Canadian Society of Chemical Technology (SCTC)
MEMBERSHIPS
The American Chemical Society (ACS)
EDUCATION
M.Sc. in Synthetic Organic Chemistry, Université de Montréal, Montréal, Canada
B.Sc. in Chemistry, Université du Québec à Montréal, Montréal, Canada
Gregory Stoklosa
800 Trenton Rd, Apt. 272
Langhorne, PA 19047
www.linkedin.com/in/gregorystoklosa
accbcs@r.postjobfree.com
ADDENDUM
PATENTS
• Harris, Keith J.; Aguiar, Joacy C.; Shum, Patrick Wai-Kwok; Zhao, Zhicheng: Poli, Gregory B.; Stoklosa, Gregory; Choi-Sledeski, Yong-Mi, Reiling Stephan, Stephany David & Gardner Charles. SUBSTITUTED PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS . US 2013/005728. (2013), 22pp.
• Harris, Keith John; Aguiar, Joacy C.; Shum, Patrick Wai-Kwok; Zhao, Zhicheng: Poli, Gregory B.; Stoklosa, Gregory T.; Choi-Sledeski, Yong-Mi & Reiling Stephan. SUBSTITUTED PYRIMIDINE AS A PROSTAGLANDIN D2 RECEPTOR ANTAGONIST. US 2013/005741. (2013), 17pp.
• Harris, Keith John; Aguiar, Joacy C.; Shum, Patrick Wai-Kwok; Zhao, Zhicheng: Poli, Gregory B.; Stoklosa, Gregory T.; Choi-Sledeski, Yong-Mi & Reiling Stephan. A SUBSTITUTED PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONIST. WO 2011/115943 A1. (2011), 41pp.
• Harris, Keith J.; Aguiar, Joacy C.; Shum, Patrick Wai-Kwok; Zhao, Zhicheng: Poli, Gregory B.; Stoklosa, Gregory; Choi-Sledeski, Yong-Mi; Reiling, Stephan; Stefany, David & Gardner, Charles. SUBSTITUTED PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONIST. WO 2011/115940 A1. (2011), 57pp.
• Choi-Sledeski, Yong-Mi; Liang, Guyan; Nieduzak, Thaddeus R.; Poli, Gregory B.; Shum, Patrick Wai-Kwok; Stoklosa, Gregory T. & Zhao, Zhicheng. INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS. WO 2011/079102 A1. (2011), 396pp.
• Choi-Sledeski, Yong-Mi; Nieduzak, Thaddeus R.; Poli, Gregory B.; Shum, Patrick Wai-Kwok; Stoklosa, Gregory T. & Zhao, Zhicheng. DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-1H-INDOL-3-YL]-METHANONES DISUBSTITUEES. WO 2011/078984 A1. (2011), 93pp.
• Choi-Sledeski, Yong-Mi; Gardner, Charles; Liang, Guyan; Poli, Gregory Bernard; Shum, Patrick Wai-Kwok; Stoklosa, Gregory T. & Zhao, Zhicheng. DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-1H-INDOL-3-YL]-METHANONES DISUBSTITUEES. WO 2011/022449 A1. (2011), 126pp.
• Choi-Sledeski, Yong-Mi; Gardner, Charles; Liang, Guyan; Poli, Gregory Bernard; Shum, Patrick Wai-Kwok; Stoklosa, Gregory T. et Zhao, Zhicheng. [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-1H-INDOL-3-YL]-METHANONES DISUBSTITUEES. FR 2 955 324 – A1. (2010), 122pp.
• Aldous, Suzanne C.; Fennie, Michael W.; Jiang, John Z.; John, Stanly; Mu, Lan; Pedgrift, Brian; Pribish, James R.; Rauckman, Barbara; Sabol, Jeffrey S.; Stoklosa, Grzegorz T.; Thurairatnam, Sukanthini; Vandeusen, Christopher L. Pyrimidine hydrazide compounds as PGDS inhibitors. WO 2008/121670 A1. (2008), 258pp.
PUBLICATIONS/POSTERS
• Guyan Liang, Yong Mi Choi-Sledeski, Gregory Poli, Xin Chen, Patrick Shum, Anne Minnich,
Qingping Wang, Joseph Tsay, Keith Sides, Jennifer Cairns, Gregory Stoklosa, Thaddeus Nieduzak,
Zhicheng Zhao, Jie Wang, Roy J. Vaz «A conformationally constrained inhibitor with an enhanced potency for -tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO)» Bioorganic & Medicinal Chemistry Letters, 2010, 20, 6721–6724.
• Lebel, H., Davi, M., Stoklosa, G. T. «Transition-Metal-Catalyzed Chemoselective Methylenation of Dicarbonyl Substrates» Journal of Organic Chemistry, 2008, 73, 6828-6830.
www.linkedin.com/in/gregorystoklosa
accbcs@r.postjobfree.com
• Gregory T. Stoklosa, Hélène Lebel. "Study on the Chemoselectivity of the Rhodium-Catalyzed Methylenation" 87th Canadian Chemistry Conference and Exhibition. London, Canada, May 29-June 1, 2004.
• Gregory T. Stoklosa, Hélène Lebel. "Study on the Chemoselectivity of the Rhodium-Catalyzed Methylenation" 1st Symposium of the Graduates Students of Chemistry of Université de Montréal. Montréal, Canada, March 23, 2004.
• Gregory T. Stoklosa, Hélène Lebel. "Study on the Chemoselectivity of the Rhodium-Catalyzed Methylenation" 14th Annual Québec-Ontario Minisymposium on Bio-organic and Synthetic Chemistry. Montréal, Canada, December 5-7, 2003.
CONFERENCES/COURSES
• Project Management™ A practical Approach A two-Day Workshop given by FranklinCovey, Bridgewater, NJ.
• Short Course in Heterocyclic Chemistry given by Prof. Gordon W. Gribble (Dartmouth College) Sanofi-Aventis, Bridgewater, NJ.
• ACS Pharmacokinetics-Pharmacodynamics Webcourse - Pharmacokinetics and Pharmacodynamics for Chemists given by Terry Kenakin (GlaxoSmithKline Research and Development,) Research Triangle Park, NC.
• An Overview of Organic Fluorine Chemistry given by Prof. William Dolbier (University of Florida) Sanofi-Aventis, Bridgewater, NJ.
• Writing Reasonable Organic Reaction Mechanisms given by Prof. Robert B. Grossman (University of Kentucky) Sanofi-Aventis, Bridgewater, NJ.
• Sanofi-Aventis Visions in Chemistry (VIC) Symposium, Raritan Valley Community College, North Branch, NJ.
• CAALS-2008 – Chemistry as a Life Science Symposium XIV, The Paul Robeson Campus Center, Rutgers, The State University, Newark, NJ.
• Organometallic Chemistry and its Application to Organic Synthesis, presented by Prof. Stephen L. Buchwald (Massachusetts Institute of Technology, MA) & Prof. Eric N. Jacobsen (Harvard University, Cambridge, MA) Sanofi-Aventis, Bridgewater, NJ.
• Residential School on Medicinal Chemistry, Chemistry and biology in drug discovery 2007, Drew University, Madison, NJ.
• Sanofi-Aventis Visions in Chemistry (VIC) Symposium, Bridgewater Marriott Hotel, Bridgewater, NJ.
• Metalation and Transition Metal Catalyzed Methods and Strategies in Aromatic and Heteroaromatic Synthesis given by Prof. Victor Snieckus (Queen’s University, Kingston, ON) Sanofi-Aventis, Bridgewater, NJ.
• Sanofi-Aventis Visions in Chemistry (VIC) Symposium, Raritan Valley Community College, North Branch, NJ.
• Managing Your Professional Development, given by Blessing/White, Inc. Bridgewater, NJ.
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