Assistant Years Experience

Himabindu Anumala

**** ******* **, *******, **-**538

E-mail: ************@*****.*** Phone: 510-***-****

Highly expertise and results-driven research associate with 3+ years experience in

medicinal chemistry and organic synthesis. Accustomed with pharmaceutical,

pharmacological and biotechnology based techniques and drug discovery areas.

TECHNICAL SKILLS

Highly conversant with modern synthetic and analytical instrumentation such as

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NMR Spectrometer, FTIR, HPLC, GCMS, Rotovapor, UV-VIS, Raman

Spectroscopy, Column Chromatographic techniques, Microwave assisted

techniques and differential thermal analysis.

Analysis of vitamins, steroids alkaloids, antibiotics and synthetic drugs by different

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analytical techniques such as flouirmetry, nephlometry, turbidometry, poteniometry,

polarography, electrophoresis, RIA, ELISA.

Analgesiometers, Manometers, Starling Artificial Respiratory pump and performed

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techniques like Syme’s technique, organ bath, mounting procedures in invitro

measurements as part of my undergraduate pharmacology laboratory experiments.

PROFESSIONAL SUMMARY

Eastern Michigan University Lab, Ypsilanti, Michigan

Research Assistant, Department of Chemistry May 2011-July 2013

• Research program focuses on Design and synthesis of small molecule inhibitors of

plasminogen activator inhibitors (PAI-1) and their biological evaluation.

• Over 40 novel compounds including the most potent known inhibitors of PAI-1 were

synthesized, and the compounds show significant activity both in vitro and in vivo.

• Developed skills in standard techniques of synthetic organic chemistry for isolation,

purification, multi-step organic synthesis, and structural elucidation of bioactive

molecules with special emphasis on Structure Activity Relationship (SAR)

development and improving drug-like properties.

• Supervised few under-graduates for their research for running most sensitive

reactions, handling instruments.

Eastern Michigan University Lab, Ypsilanti, Michigan

Graduate Teaching Assistant, Department of Chemistry May 2011-July 2013

• Instructed, monitored and evaluated class of 40 undergraduate students of all levels

in the practical labs of

• Chem 118 – Fundamentals of Chemistry Laboratory

• Chem 120 – Fundamentals of Organic and Biochemistry

• Chem 122 – General Chemistry

• Chem 271 & 373 – Organic Chemistry Laboratory

• Tutored and assisted nursing students individually or in small groups to help them

master the assignments and reinforce learning chemistry concepts.

Aurobindo Pharma Ltd, India

Chemist May 2010- November 2010

• Formulation and evaluation of pharmaceutical drugs by using HPLC, GCMS and by

different analytical techniques.

• Accustomed with technical writing, documentation, organization, literature searches,

laboratory notebook, assay validation guidelines and GLP regulations.

Kakatiya University Lab, Warangal, India

Research Assistant, Department of Pharmacology January 2009- May 2010

• Research program focuses on Synthesis and Pharmacological screening of new

Isatin Derivatives.

• Handled animal models for testing the biological activity of Isatin derivatives, such as

Paw Edema test.

• Studied the effect of hepatic microsomal enzyme inhibitors and inducers on the

phenobarbitone sleeping time on mice, employed different routes of administration of

drugs.

LABORATORY SKILLS

Adept in invitro evaluation of agonists, antagonists, electrolytes on receptors and on

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different isolated tissues preparations.

Worked extensively on recording of dose response curve (Cumulative and non-

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cumulative), ED50 measurement of drugs in different tissues of various animal

models.

Performed microbiological assay of antibiotics by agar diffusion and turbidometric

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methods, detection of antibiotics by bioautography technique, immobilization of

enzymes (gel entrapment), and sterilization by moist, dry, filtration, radiation and

gases.

Hands on experience in isolation, maintenance of pure cultures by different methods

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(streak plate method), different staining techniques, and enumeration of bacteria by

pour plate and direct microscopic count, knowledge of flowcytometry methods.

Well-versed with fundamentals of serology, neutralization, complexation,

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opsonization, lattice theory and complement fixation.

Preparation and evaluation of solid dosage forms such as compressed tablets, hard

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and soft capsules, coating (sugar, film, press & enteric coating methods) and

granulation.

Proficient in methods adopted for control releases in various drug delivery systems

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(sustained, transdermal, GRD), microencapsulation techniques, and determined the

disintegration of tablets.

Designed bioavailability, bioequivalence studies and interpretation of their results,

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invitro dissolution studies, Protein binding studies (equilibrium dialysis method,

drug–drug interaction at protein binding sites).

Formulation and evaluation of cosmetic products (lotions, creams, dusting powders,

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lipsticks), coloring agents, preservatives, antioxidants and perfumes used in

cosmetics.

Instructed, monitored and evaluated the grades of undergraduate students and even

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tutored individually or in small groups to help them master the assignments and

reinforce learning chemistry and biochemistry concepts.

EDUCATION

Master of Science in Chemistry

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Eastern Michigan University, Ypsilanti, MI, USA January 2011-July 2013

Research Advisor: Dr. Cory Emal

Related Coursework: Advanced Organic Chemistry & Spectroscopy, Cell Signaling

and Neurochemistry.

Bachelor of Science in Pharmacy

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Kakatiya University, Warangal, India October 2006-May 2010

Related Coursework: Pharmacology & Toxicology, Medicinal Chemistry,

Pharmaceutical Analytical Chemistry, Hospital and Clinical Pharmacy, Microbiology

and Immunology, Biopharmaceutics and Pharmacokinetics, Pharmaceutical

Biotechnology, Pharmaceutical Technology, Pharmacognosy, Cosmetic Technology.

Certification on Drug Discovery Modules

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NIPER & IICT, India October 2010-November 2010

Overview on Drug Discovery and Development

Dosage Form Development & Novel Drug Delivery Systems.

Pre-Clinical Phase & Toxicology Evaluation.

Awards & Affiliations

• Aug 2011-June 2013 Graduate Assistantship, Eastern Michigan University

May 2011-July 2013 Research Assistantship, Eastern Michigan University

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EMU Success Scholarship

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Member of American Chemical Society

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Member of Indian Pharmaceutical Association & Congress

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Presentations

• Anumala, H.; Guntaka, N.S.; Weerakoon, D.A.; Vaghela,C.; Lisi, J. M.;Warnock, M.;

Lawrence, D. A.: Emal, C. D. Design, and synthesis of novel heterocycle-based

inhibitors of plasminogen activator inhibitor-1. 245th American Chemical Society

National Meeting and Exposition, New Orleans, LA – 04/07/2013

• Anumala, H.; Lisi, J. M.; El-Ayache, N. C.; Warnock, M.; Lawrence, D. A.: Emal, C.

D. Design, synthesis, and evaluation of non-symmetric small molecules for the

enhanced inhibition of plasminogen activator inhibitor-1. Central Regional Meeting of

the American Chemical Society, Dearborn, MI – 6/6/2012.

• Anumala, H.; Lisi, J. M.; El-Ayache, N. C.; Warnock, M.; Lawrence, D. A.: Emal, C.

D. Design, synthesis, and evaluation of non-symmetric small molecules for the

enhanced inhibition of plasminogen activator inhibitor-1. Graduate Research Fair,

Eastern Michigan University, Ypsilanti, MI – 03/26/2012.

• Anumala, H., Sreeram, D., Rajpal, K., Ravi, K. Synthesis and Pharmacological

screening of new Isatin Derivatives. Indian Pharmaceutical Congress, Ahemedabad,

India – 12/11/2009.

• Anumala, H., Krishnamaneni, R., Akavaram, S., Basker, C. A review on Solid Lipid

Nanoparticles. Indian Pharmaceutical Association, Bangalore, India – 07/10/2009.

• Anumala, H., Koutam, J., Munjam, S. Role of Biotechnology in Medicinal plants.

International conference on Plant Biotechnology and Molecular Biology, Kakatiya

University, India – 08/17/2008.

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