PhD graduate student

Curriculum Vitae

Name: Mamta Kaura

Academic Rank: PhD Graduate Student

Department: Chemistry, 875 Perimeter Drive MS 3025, Moscow, ID 83844-3025

University of Idaho

Expected Graduation: May 2014

Email: ********@*******.******.***

Contact# 208-***-****

Objective: Looking for an ideal position to put my knowledge and skills for effective use in

research and development

Education:

• 2000-2003: B.Sc (Hons) in Chemistry from Punjab University, CHD, India, GPA: 3.5

• 2003-2005: M.Sc (Hons) in Chemistry from Punjab University, CHD, India, GPA: 3.5

• 2008-Present: Ph.D graduate research scholar under the supervision of Associate

Professor, Patrick. J. Hrdlicka at University of Idaho, anticipated May 2014. Current

GPA: 3.70

• Thesis Title: "Novel approach for efficient targeting of single stranded RNA via

chemically modified oligonucleotides "

Research Experience:

• Independently conducted synthesis of purines and pyrimidines nucleobase modified

conformationally restricted Locked Nucleic Acids (LNAs) for targeting RNA, on large

and small scales.

• Synthesized compounds have been included in patent. Patent Title: "NUCLEOBASE-

FUNCTIONALIZED CONFORMATIONALLY RESTRICTE D NUCLEOTIDES AND

OLIGONUCLEOTIDES FOR TARGETING OF NUCLEIC ACIDS" (Patent Application

No: 201********)

. • Characterized products using multidimensional NMR techniques viz, 1H, 13C, 31P, COSY,

HSQC, DEPT and ROESY.

• Designed synthetic schemes for the synthesis of C8 purine functionalized LNAs and C5-

pyrimidine functionalized LNAs.

Skills:

• Well versed with purification techniques such as Column Chromatography,

recrystallization and precipitation

• On instrumentation, gained experience on use of DNA synthesizer, HPLC, UV vis

spectrophotometer, fluorescence spectrophotometer, pH meter, NMR-300MHz, IR, MS-

TOF

• Instructed Advanced Organic Chemistry and General Chemistry Laboratories

Short Term Jobs:

• June 2005- Dec 2005: Trainee Chemist in Process Development Lab in Ind Swift

Laboratories, India

• Feb 2006- Feb 2007: Chemistry Lecturer in Engineering College on 1 Yr contract, India

• Dec 2007- June 2008: Project Assistant, level-II in CSIO (Central Scientific

Instrumentation Organization), India

Current Teaching Experience:

• Fall 2008: Teaching Assistant for General Freshmen Laboratory

• 2009- 2010, 2010- 2012: Teaching Assistant for Advanced Organic Laboratory

• Student Evaluation (Mean: 3.6)

Award:

• Travel Award for attending Roundtable Conference On Nucleic Acids m Montreal,

Quebec, Canada, 2012

Conference Attendance:

• 2009: Donald S. Matteson Symposium, Washington State University, Pullman, WA

• 2010: ACS Norm, Washington State University, Pullman, WA

• 2010: College of Science (COS) Poster Competition, U of Idaho. Presented Poster titled

"Synthesis of C5-functionalized Tetrazole Deoxyuridines and Construction of Arrays for

Effective Targeting of Nucleic Acids"

• 2012: Roundtable Conference on Nucleic Acids, Quebec, Montreal, Canada Presented

Posted titled: "Synthesis a n d hybridization p roperties of oligonucleotides m odified with

5-(1 -aryl-1,2,3-triazol-4-yl)-2 ' -deoxyuridines "

• 2013: 9th Annual Student Research Exposition at U of I, Submitted abstract for Poster

presentation, Title: "Synthesis and Hybridization Properties of Carbohydrate-

functionalized Locked Nucleic Acids (LNAs): A New class of Antisense Oligonucleotides"

Publications:

• Mamta Kaura, Pawan Kumar and Patrick J. Hrdlicka; "Synthesis and Hybridization

Properties of Oligonucleotides Modified with 5-(1-Aryl-1,2,3-Triazol-4-yl)-2'-

Deoxyuridines" Org. Biomol. Chem., 2012, 10, 8575-8578, selected as hot article.

• Mamta Kaura, Patrick J.Hrdlicka; “Synthesis and Hybridization Properties of

Carbohydrate-functionalized Locked Nucleic Acids (LNAs): A New class of Antisense

oligonucleotides”, in preparation.

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