Project Manager Management

Panduranga Adulla Reddy

** ******** ***** ****, *******, MA, 02081, USA

Phone: 617-***-**** (Cell) email: ************@*****.***

Successful track record in drug discovery and development project management multiple projects in

diverse therapeutic areas in pharmaceutical/biopharmaceuticals.

Experienced scientific and project management/ Project Leader in drug discovery and development. Target

identification, Lead Generation (Fragment based lead identification, Library generation, drug design), Lead

optimization, in vitro, in vivo pharmacology, Preclinical tox studies, CMC, through IND filing.

As project manager, set objectives, make budget plans, monitor and track the progress. Arrange for Project

team meetings, write and circulate meeting minutes to the project teams. Present data to leadership

committee meetings, ensure documentation of clear action items and navigate decision making processes

and provide updates program office. Proficient in computer skills, word, excel, PowerPoint, MS project and

Gantt chart tracking etc.

Excellent in communication and coordination, negotiation, motivating internal staff and external vendors and

off shore resources (CROs) in support of time line and project deliverables.

Seasoned professional, with outstanding project planning, execution, monitoring and resource balancing

skills with ability to support multiple simultaneous projects in a matrix organizational structure. Excel at

communicating with stakeholders to provide accurate reporting and information regarding the ongoing

projects and initiatives.

Lead Strategic Alliances activity including licensing and collaborations (search evaluation of

contracts/agreements and take part along with senior management with potential partners) .

Result oriented, “can do it” attitude, in fast paced, changing, and challenging environment. Put in place clear

strategy (operational plans, explicitly stated goals and objectives) & took part in budget planning.

Ph.D. (Organic Chemistry)

Post doctoral research in synthesis and biophysical studies on peptides at CUNY, New York,

Post doctoral research in Structure Based Drug Design and synthesis of peptides and peptidomimetics, small

molecules at Kimmel Cancer Center, Thomas Jefferson University, Philadelphia.

Project Management Training:

Serono Corporate Management (2000)

Mass Biotech Council (2004)

Publications:

2

Patents [37, issued/published] and papers [35, published]

Professional Experience: Industrial

Atheon Pharmaceuticals Inc.: Project Manager,, Drug Discover & Development

Jan, 2012 Current

Privately funded Biotechnology Company focusing repurposing of old drugs for new indications through

computational and translational medicine approach.

Strategic chemistry sourcing, oversee responsibilities for external medicinal chemistry efforts, scale up and

PK/PD and in vivo efficacy studies. [Ex: academic collaborations, in vivo studies through external resources

(CRO)].

Current focus: CNS (Parkinson, new MOA), Oncology and Ophthalmology disease areas.

TargAnex Inc, ( Subject Expert Consultant): Chemistry for hit finding and Lead generation, 2011

Hetero Research Foundation (India) Scientific Advisor Portfolio Management, drug discovery and

development

Merck Research Labs: Senior Principal Scientist (Section Head), Nov.2009 Dec., 2010

Leading the multiple projects as Project Manager [lead discovery and lead optimization stages (Oncology)]

One program (Oncology) nominated for preclinical evaluation. Managed chemistry team comprised of Ph.Ds.

and M.S.

Lead Generation and Optimization, multiple targets simultaneously.

As project manager, monitor and track the progress. Arrange for Project team meetings, write and circulate

meeting minutes to the project teams. Present data to leadership committee meetings, ensure documentation

of clear action items and navigate decision making processes and provide updates program office.

Arrange for compounds made at various places/locations to central database/data center, all ADME, PK

studies by various groups, and in vivo studies for advanced compounds in appropriate animal models.

Identifying lead molecules with the project team and coordinate for large quantities of compounds through

process development group or external resources. Anticipate the project requirement in advance and act

proactively.

Worked routinely with internal and external partners and multidisciplinary drug discovery/development teams.

partners [ex: Cambridge, Boston, Kenilworth(US), Merck/Schering Plough sites and AMRI, Kalexsyn(US),

Wuxi (China) external resources].

Coordinated external resources for chemistry from AMRI and Kalexsyn in US and Wuxi in China

3

Schering Plough Research Institute: Senior Principal Scientist (Section Head), Nov.2002 Nov.2009

[Acquired by Merck)

Leading the multiple projects as Project Leader/Manager [lead discovery and lead optimization stages

(Oncology, Infectious, CNS and Inflammation disease areas)]. Two programs (Oncology) in clinical trials

(Phase I/II) and multiple programs at various preclinical stages.

Lead generation by fragment based approach and drug design. Managed chemistry team comprised of

Ph.Ds. and M.S.

As project manager, monitor and track the progress. Arrange for Project team meetings, write and circulate

meeting minutes to the project teams. Present data to leadership committee meetings, ensure documentation

of clear action items and navigate decision making processes and provide updates program office.

Arrange for compounds made at various places/locations to central database/data center, all ADME, PK

studies by various groups, and in vivo studies for advanced compounds in appropriate animal models.

Identifying lead molecules with the project team and coordinate for large quantities of compounds through

process development group or external resources. Anticipate the project requirement in advance and act

proactively. Worked routinely with multi site, multidisciplinary drug discovery/development teams and external

partners [ex: Cambridge, Kenilworth, PaloAlto(US), Schering Plough sites and AMRI(US), Wuxi (China)

external resources].

Coordinated external resources for chemistry from AMRI and Kalexsyn in US and Wuxi in China

Seroo Research Institute: Principal Scientist & Group Leader: 1995 Oct.2002 . [Acquired by Merck

KGA]

Scientist, Project Manager: Built chemistry group and closely working/interacting with interdisciplinary teams

in US & across Atlantic. Managed multiple targets in diverse therapeutic areas (Small molecule and

biotherapeutics, Woman health and inflammation).

Target identification, lead generation (Fragment based) through lead optimization to clinical & preclinical

stage.

One program entered in Phase I (LHRH antagonist, modified Peptide derivative, for endometriosis and

endometrial cancer) and three programs [woman health (FSH LHRH, GnRH, GHRH agonists/antagonists,

peptidomimetics, small molecules) and inflammation/COPD (EP2/EP4 agonists] evaluated in preclinical

studies.

CD4 protein CDR3 domain peptide/ peptidomimetic inhibitors for auto immune diseases

Built and managed chemistry team (20) comprised of Ph.Ds. and M.S.

As project manager, propose and evaluate the budgets, monitor and track the progress. Arrange for Project

team meetings, write and circulate meeting minutes to the project teams. Present data to leadership

committee meetings, ensure documentation of clear action items and navigate decision making processes

and provide updates program office.

4

Arrange for compounds made at various places/locations to central database/data center, all ADME, PK

studies by various groups, and in vivo studies for advanced compounds in appropriate animal models.

Identifying lead molecules with the project team and coordinate for large quantities of compounds through

process development group or external resources. Anticipate the project requirement in advance and act

proactively.

Worked routinely with external partners and multi site, multidisciplinary drug discovery/development teams

[ex: Boston(US), Geneva(Swiss), Milan(Italy) Serono sites and OAI(UK), Syngene (India) external

resources].

Coordinated, and managed external resources for chemistry Organix in US, Evotec (OAI) in UK and Syngene

in India

Professional Experience: Academic: Teaching and Research

Kimmel Cancer Center, Thomas Jefferson University: 1993 1994

Post doctoral Visiting Scientist: Molecular modeling and design of peptides and peptidomimetic inhibitors of

CD4 protein for autoimmune diseases.

Department of Biochemistry, City University of New York: 1992 1993

Post doctoral Visiting Scientist: Biophysical studies on structure of Peptide ligands & GPCR Protein

transmembrane fragments

Osmania University: 1985 1991

Assistant/Associate Professor: Teaching and Research

Education:

Ph.D. Organic Chemistry 1984, Osmania University

Leadership Style:

Empower people to do their jobs responsibly and ensure that they take ownership, accountability and

motivated to achieve the goals and objectives.

Delegate the work to people to work with team spirit, so that they assume ownership. Encourages teamwork

and believes that team success is success of all. Recognition and pride associated with success is important.

Liaison/Project management: Working with multi disciplinary groups/Selecting CRO’s, Collaborative

Research Partners [external (academic and industrial research partners)].

Experience interpreting, coordinating in vitro and in vivo biological data and coordination with diverse groups.

Coordinate with the DMPK & in vivo biology groups to optimize the timelines for effective results

Management Training:

Change Leadership Development Academy for corporate excellence 2000

5

Negotiate to Win American Management Association 1999

Patents & Papers:

38 patents (issued, published (37) & filed (1)].Worked with a team of patent attorneys (Legal, I.P.).

[Identify the scope, writing drafts, associated all the way to the filing and prosecution]. Peer reviewed papers

published (35)

Papers/presentations published:

35 published

Computational tools/methods

Experience with computational chemistry (Tripos, Schrodinger, Accelrys, ACD, Pymol etc.) and chemo

informatics (MDL) tools. Well versed with Microsoft windows tools including project management.

Unique, Applicable Characteristics that Candidate Brings to Position

Leadership through honesty, transparency, harmony and lead by example

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