CURRICULUM VITAE

Martha K. Behnke, Ph.D.

***** ****** *** **

Mechanicsville, VA 23116

804-***-****

Education

Doctor of Philosophy, Integrative Life Sciences. 2007- 2012.

Virginia Commonwealth University, Richmond, Virginia

"Growth gone awry: investigating the role of developmental genes in

Hepatitis C induced liver cancer"

Master of Science, Biostatistics. 1991-1996.

Virginia Commonwealth University, Richmond, Virginia

"A critical review of the methods for comparing two or more cancer

staging systems."

Master of Science, Biology. 1988-1991

Virginia Commonwealth University, Richmond, Virginia

"Soil moisture salinity and growth form effects on the water relations

patterns of barrier island plants"

Bachelor of Science, Biology. 1984- 1988

Virginia Tech, Blacksburg, Virginia

Rutherford B. Hayes High School, Delaware, Ohio, 1979-1983.

Employment Experience

2010 - Genomic Statistician

Department of Surgery

Virginia Commonwealth University

Richmond, Virginia

. Perform analysis of microarray, RNAseq, and DNA methylation

data, including data quality control, normalization, and

visualization

. Provide annotation, biological context and interpretation

of experimental results

. Prepare study and grant proposals, including experimental

design and sample size analysis

. Prepare manuscripts as either primary or supporting author

2010- Biostatistics Consultant

Behnke Analytic Services

Clients:

. Living Organ Donor Network (LODN). Analysis of

longitudinal Quality of Life surveys from living kidney

donors.

. VCU Pathology Department.

1997 - Clinical Data Analyst and Transplant Database Manager

Hume-Lee Transplant Center

Virginia Commonwealth University Health System (VCUHS)

Richmond, Virginia

Biostatistician for clinical and administrative research

projects.

System administrator for networked database applications for

Vascular Access, Abdominal Transplant, Bone Marrow Transplant,

Thoracic Transplant, and Cardiology programs.

Duties include:

. Statistical analysis and reporting for internal and

external agencies including Managed Care office, Budgeting,

hospital administration, transplant surgeons and

physicians, regulatory agencies and insurance contractors.

. Assist in preparation of grant proposals and manuscripts,

including study design, sample size and power estimates,

and all aspects of statistical analysis including survival

analysis, multivariate modeling, microarray analysis and

the analysis of RNA sequencing data. Prepare manuscripts

and assist with methods and results, statistical tables and

figures, and statistical portions of discussion sections.

. Implemented a client-server departmental database on a

multi-user network.

. Development and maintenance of over 15 patient databases

for evaluation, surgery, and follow-up care for liver,

kidney, pancreas, pancreas islet cell, heart, lung, and

bone marrow transplant patients, as well as liver cancer

and vascular access patients.

. Train and Supervise staff of data entry operators

. Ongoing data quality control and internal database audits

for UNOS and CMS compliance regulations; maintain constant

readiness for unannounced regulatory site visits.

. UNet (UNOS' internet data submission software) site

administrator for VCUHS and Tissue Typing Lab.

. Technical liaison between clinical and Information

Technology staff for hardware, software, and mobile

computing issues.

. Served on several design teams for Cerner hospital

information system replacement project; team leader for

service lines design team.

1989- 1996 Statistical Consultant

Edgewood Information Services, Inc.

Columbia, Virginia

Statistical consultant and database programmer for a variety of

projects involving ecology, clinical trials, corporate

management, epidemiology, Bureau of Insurance, and health

services research

Clients have included Virginia Commonwealth University,

departments of Biology, Biostatistics, Internal Medicine, and

School of Nursing; Medical College of Virginia Hospitals

Epidemiology Unit; State Corporation Commission Bureau of

Insurance; and Veterans Administration Hospitals.

1993- 1995 Programmer/Analyst

Virginia Commonwealth University

Richmond, Virginia

Statistical programmer and database manager for the VCU site for

research grants with Massey Cancer Center.

1992 Programmer/Analyst

Medical College of Virginia Hospitals

Virginia Treatment Center for Children

Statistical consultant for Social Work and Psychiatric research

projects.

1990-1991 Laboratory Specialist

Virginia Commonwealth University

Richmond, Virginia

Synthesis and purification of oligonucleotides using DNA

synthesizers and High Performance Liquid Chromatography in the

Nucleic Acid Core Laboratory in the Department of Microbiology.

Developed new methods for quality control and purification of

nucleic acid products.

1988- 1990 Laboratory Instructor

Virginia Commonwealth University

Richmond, Virginia

Taught general biology, botany, and zoology laboratory classes

in the Department of Biology.

1985-1990 Military Police

Virginia National Guard

Society Memberships:

American Association for the Advancement of Science

American Statistical Association

SAS User's Group International

American Institute of Biological Sciences

Phi Sigma Biological Honor Society

Phi Kappa Phi Honor Society

Software expertise:

R

SAS

Microsoft Office products (Word, Excel, PowerPoint, Access)

Experienced in database design and programming structured code in a

variety of languages including PERL

Experienced in public domain analysis tools for NGS analysis including

samtools, BWA, UGene, etc.

Publications:

1. Rajesh Ramanathan MDa; Amit Sharma MDa; David D Lee MDa; Martha

Behnke PhDa; Karen Bornstein RNa; R Todd Stravitz MDa; Malcolm

Sydnor MDb; Ann Fulcher MDb; Adrian Cotterell MDa; Marc P Posner

MDa; and Robert A Fisher MDa. Multimodality Therapy and Liver

Transplantation for Hepatocellular Carcinoma: A 14-Year Prospective

Analysis of Outcomes. Submitted manuscript, Transplantation. 2013

2. Martha Behnke, Mark Reimers, Robert Fisher. Stem cell and

hepatocyte proliferation in Hepatitis C Cirrhosis transformation to

Hepatocellular Carcinoma: transplant implications. Poster

presentation, The Liver Meeting of the AASLD, Washington, DC,

November 2, 2013. Recipient of the "Presidential Poster of

Distinction" award.

3. Martha Behnke, Mark Reimers, Robert Fisher. Stem cell and

hepatocyte proliferation in Hepatitis C Cirrhosis transformation to

Hepatocellular Carcinoma: transplant implications. Annals of

Hepatology, in press December 2013.

4. Amit Sharma, Rajesh Ramanathan, Martha Behnke, Robert A Fisher,

Marc Posner. Single Pediatric Kidney Transplantation in Adult

Recipients: Comparable Outcomes With Standard-Criteria Deceased-

Donor Kidney Transplantation. Transplantation 2013 Mar 15.

5. Martha Behnke, Mark Reimers, Robert Fisher. Hepatocyte

proliferation is inhibited in Hepatitis C-induced cirrhosis and

loss of this inhibition defines a sub-type of Hepatitis C-induced

hepatocellular carcinoma with poor prognosis. Accepted abstract,

4th International Conference on Transplantomics and Biomarkers in

Organ Transplantation, March 2013.

6. Martha Behnke, Mark Reimers, Robert Fisher. Growth gone awry:

exploring the role of embryonic liver development genes in HCV

induced cirrhosis and hepatocellular carcinoma. Accepted abstract,

American Transplant Congress, December 2012.

7. Qing Ren, MD, Martha Behnke, Ph D, Todd Gehr, MD, Marc Posner, MD,

and Anne King, MD. Impact of Immunosuppression Maintenance after

Failed Kidney Transplant on Panel Reactive Antibody (PRA) for

Retransplantation, A Single Center Experience. Poster

presentation, American Transplant Congress, May 2013.

8. Dhiren Kumar MD, Anne L. King MD, Martha Behnke PhD, Marc Posner,

MD, Gaurav Gupta MD. Perioperative Blood Pressure and Kidney

Transplant Outcomes. Accepted abstract, American Transplant

Congress, December 2012.

9. Martha Behnke. Growth gone awry: exploring the role of embryonic

liver development genes in HCV induced cirrhosis and hepatocellular

carcinoma. Dissertation. November, 2012.

10. Anne L. King, Amit Sharma, Qing Ren, Martha Behnke, Pamela Kimball,

Todd W. Gehr. Preemptive plasmapheresis (PP) and CMVIg improves

survival in highly sensitized renal transplant recipients. Poster

presentation, November 2012, American Society of Nephrology.

11. Martha Behnke, Mark Reimers, Robert Fisher. Hepatitis C induced

Hepatocellular Carcinoma alters expression of genes specifically

used in embryonic liver development. Cancers 2012, 4, 945-968.

12. Amit Sharma, April Ashworth, Martha Behnke Donor Selection for

Adult- to- Adult Living Donor Liver Transplantation: Well Begun is

Half Done. Transplantation, in press.

13. Amit Sharma, Todd L. Teigeler, Martha Behnke, Adrian Cotterell,

Robert Fisher, Anne King, Todd W.B. Gehr and Marc Posner. The mode

of pre-transplant dialysis does not affect post-renal transplant

outcomes in African Americans. Journal of Transplantation, 2012;

2012:303596.

14. Amit Sharma, Martha Behnke et al. Pediatric single and en bloc

kidney transplantation in adult recipients: single center

experience. Oral presentation June 2012, American Transplant

Congress

15. Julie Ann Linatoc, Qing Ren, Martha Behnke, Amit Sharma, Marc

Posner, Todd Gehr, Anne King. The effect of Hepatitis C Virus (HCV)

infection on the outcome of highly sensitized kidney transplant

recipients in the modern immunosuppression era. Oral presentation

June 2012, American Transplant Congress

16. Muhammad Saim, Martha Behnke, Anne King, Qing Ren, Marc Posner.

Preliminary outcomes for list paired exchange recipients. Poster

presentation June 2012, American Transplant Congress

17. Amit Sharma, Christine Dao, Martha Behnke, Sonia Taneja, Robert

Fisher, Evelyne Goudreau, Anne King, Marc Posner. Transplant

outcomes in patients with pre-transplant coronary re-

vascularization: What should we expect? Oral presentation June

2012, American Transplant Congress.

18. Martha Behnke, Robert Fisher, Mark Reimers. Knowledge-driven

analysis identifies novel developmental genes that contribute to

Hepatitis-c induced hepatocellular carcinoma. Poster presentation,

March 2012, 3rd International Conference on Transplantomics and

Biomarkers in Organ Transplantation.

19. Amanda Hall, Martha Behnke, et al. Living Kidney Donors' Quality of

Life: the Impact of Recipient Outcomes. Submitted to American

Journal of Transplantation November 2011.

20. Amit Sharma, Martha Behnke et al. Peritoneal dialysis and renal

transplant outcomes in African-Americans. Submitted to Peritoneal

Dialysis International November 2011.

21. Robert Fisher, Martha Behnke, Mark Reimers. How can genomics be

used to monitor and predict outcomes after liver transplantation

for HCC? Oral presentation, The Liver Meeting of the AASLD,

November 2011 (San Francisco, CA)

22. Robert A. Fisher, Douglas M. Heuman, Ann M. Harper, Martha K.

Behnke, Alastair D. Smith, Mark W. Russo, Steven Zacks, John W.

McGillicuddy, James Eason, Michael K. Porayko, Patrick Northup,

Michael R. Marvin, Johnathan Hundley, Satheesh Nair. Region 11 MELD

Na Exception Prospective Study. 2011. Annals of Hepatology, 2012

11(10):62-67.

23. Martha Behnke, Mark Reimers, Robert Fisher. Knowledge-driven

analysis identifies novel developmental growth factors involved in

Hepatitis C - induced Hepatocellular Carcinoma. Poster

presentation, Systems Biology Summit June 2011 (Richmond, Virginia)

24. Amit Sharma, MD, Anne King, MD, Adrian Cotterell, MD, Daniel Maluf,

MD, Martha Behnke, Robert Fisher, MD, Marc Posner, MD. Renal

Transplantation Outcomes in Patients with Pre-transplant Cardiac

Interventions: Hope for the Best, Prepare for the Worst. Oral

presentation, American Transplant Congress 2011.

25. Martha Behnke, MS, Valeria Mas, PhD, Mark Reimers, PhD, Robert

Fisher, MD. Molecular Events in the Progression of Hepatitis C

(HCV) Induced Hepatocellular Carcinoma (HCC): Impact of Data

Normalization in the Analysis of Affymetrix Microarray Chips.

American Transplant Congress 2010. poster presentation May 2010

26. Amit Sharma MD, Daniel G Maluf MD, Martha Behnke, Adrian H

Cotterell MD, Robert A Fisher MD, Marc P Posner MD. Hume-Lee

Transplant Center, Department of Surgery, Virginia Commonwealth

University, Richmond. Outcomes after dual and pediatric en bloc

kidney transplantation: single center experience. American

Transplant Congress 2010. poster presentation May 2010

27. Amit Sharma MD, Adrian H Cotterell MD, Martha Behnke, Daniel G

Maluf MD, Robert A Fisher MD, Marc P Posner MD. Pre-transplant

peritoneal dialysis is not associated with an increased risk of

post-renal transplant thrombotic or infectious complications.

American Transplant Congress 2010. poster presentation May 2010

28. William Andrew Hackworth, MD1, Mitchell L Shiffman, MD1, Richard K

Sterling, MD1, Martha K Behnke, MS1, Douglas M Heuman, MD1,

Velimir A Luketic, MD1, Michael Fuchs, MD1, Jasmohan Bajaj, MD1 and

R Todd Stravitz, MD. Long-Term Cause of Death in Liver Transplant

Recipients with and without Hepatitis C. American Transplant

Congress 2010. poster presentation May 2010

29. Daniel G Maluf, MD, Martha Behnke, MS, Adrian H Cotterell, MD, Amit

Sharma, MD, MPhil, Robert A Fisher, MD, Sorabh Kapoor, MD, Valeria

R Mas, PhD, Todd W Gehr, MD, Anne L King, MD and Marc P Posner,

MD.THE USAGE OF HEPATITIS C POSITIVE GRAFTS PROVIDE SURVIVAL

BENEFIT IN RENAL TRANSPLANTATION. American Transplant Congress

2010. oral presentation May 2010.

30. Carl, DE, Grossman C, Behnke M, Sessler CN, Gehr TW. Effect of

timing of dialysis on mortality in critically ill, septic patients

with acute renal failure. Hemodial Int. 2010 Jan; 14(1):11-17.

31. Fisher RA, Cotterell AH, Maluf DG, Stravitz RT, Ashworth A,

Nakatsuka M, Sterling RK, Luketic VA, Behnke MK, Posner MP. Adult

living donor versus deceased donor liver transplantation: a 10-year

prospective single center experience. Ann Hepatol. 2009 Oct-Dec;

8(4):298-307.

32. Smith JO, Shiffman ML, Behnke M, Stravitz RT, Luketic VA, Sanyal

AJ, Heuman DM, Fisher RA, Cotterell AH, Maluf DG, Posner MP,

Sterling RK. Incidence of prolonged length of stay after

orthotopic liver transplantation and its influence on outcomes.

Liver Transpl. 2009 Mar;15(3):273-279.

33. Nakatsuka, M, AD Colquhoun, M Behnke, RA Fisher, MP Posner.

Transplant Nephrectomy. E-Poster: XXII International Congress 2008

of the Transplantation Society, Syndey, Australia. August, 2008.

34. Maluf, Daniel G.; Fisher, Robert A.; Mas, Luciana A.; Cotterell,

Adrian H. ; Mas, Valeria R.; Stravitz, Richard T.; Behnke, Martha

K.; Posner, Marc P. Effectivness of the Use of Rabbit Anti-

Thymoglobulin for the Treatment of Acute Cellular Rejection in

Liver Transplantation: Poster Board #-Session: P204-III: Abstract#

1557. American Journal of Transplantation. 7 Supplement 2:547-548,

May 2007.

35. Tripathi, Shreyank, Pamela M. Kimball, Anne L. King, Eric M.

Gibney, Martha K. Behnke, Marc P. Posner, Daniel G. Maluf.

Treatment with plasmapheresis and immunoglobulin for the treatment

of highly sensitized patients post-kidney transplantation: poster

board #- Session P98-I: Abstract #762. American Journal of

Transplantation. 7 Supplement 2:344, May, 2007.

36. Daniel G Maluf, Robert A Fisher, Arnold D Salzberg, Adrian H

Cotterell, Martha K Behnke, and Marc P Posner. Financial impact

of using extended criteria donors in liver transplantation: a

single center experience. Accepted for publication 2007.

37. Daniel G Maluf, Robert A Fisher, Anne L King, Eric M Gibney,

Valeria R Mas, Adrian H Cotterell, Mitchell L Shiffman, Richard K

Sterling, Martha Behnke, Marc P Posner. Hepatitis C Virus

infection and kidney transplantation: Predictors of patient and

graft survival. Transplantation. 2007. 83(7):853-857. April 15,

2007.

38. Daniel G Maluf, Robert A Fisher, Anne L King, Eric M Gibney,

Valeria R Mas, Adrian H Cotterell, Richard T Stravitz, Richard K

Sterling, Mitchell L Shiffman, Martha Behnke, Marc P Posner.

Predictors of patient and graft survival on HCV patients undergoing

kidney transplantation. Abstract presented at the 2006 World

Transplant Conference, Boston, MA

39. Jenny Smith, Martha Behnke, R Todd Stravitz, Mitchell Shiffman,

Velimir Luketic, Arun Sanyal, Robert Fisher, Adrian Cotterell,

Daniel Maluf, Marc Posner, Richard Sterling. Factors associated

with prolonged length of stay (PLOS) after orthotopic liver

transplantation and the impact of PLOS on survival. 2006. Abstract

#90. American Journal of Transplantaion. 6 Suppl.2:96-97.

40. Maluf DG, Stravitz RT, Cotterell AH, Posner MP, Nakatsuka M,

Sterling RD, Luketic VA, Shiffman ML, Ham JM, Marcos A, Behnke MK,

Fisher RA. Adult living donor versus deceased donor liver

transplantation: a 6-year single center experience. Am J

Transplant. 2005 Jan;5(1):149-56.

41. Arnold D. Salzberg, M.D., Daniel G. Maluf, M.D., Robert A. Fisher,

M.D., Adrian H. Cotterell, M.D., Martha K. Behnke, M.S., Marc P.

Posner, M.D. "Institutional Financial Impact of Using Extended

Criteria Donors in Liver Transplantation in the Meld Era".

Virginia Chapter, American College of Surgeons and Virginia

Surgical Society. 2007 Annual meeting; Poster presentation.

42. Ham, J.M., R.A. Fisher, M. Behnke, P. Descutner, A.H. Cotterell, S.

Dawson and M.P. Posner. Charge comparisons of living donor right

lobe liver transplantation versus cadaver donor liver

transplantation. Transplant 2001, The Joint American Transplant

Meeting, Chicago, IL. May, 2001. Am. J. Transplant. 1(1): 318,

2001. Abstract; Poster

Presentation.

43. Sterling, R.K., M.E. Lawrence, M.K. Behnke, M.L. Shiffman, V.A.

Luketic, R.T. Stravitz, A.J. Sanyal, R.A. Fisher, A.H. Cotterell,

S. Dawson, M.P. Posner. Predictors of mortality in patients with

prolonged length of stay after liver transplantation. Transplant

2002, American Transplant Congress, Washington, DC. April, 2002.

Am. J. Transplant. 2 (3): 299. 2002.

44. Ham JM, Fisher RA, Behnke M, Cotterell AH, Dawson III S, Marcos A

and Posner MP. Liver donor adult right lobe liver transplants.

Abstract, poster presentation. Am Journal of Transplantation: 1

(1): Ab #714; p 315, 2001.

45. Hegab AM, Kirtland M, Shiffman ML, Luketic CA, Sterling RK, Sanyal

AJ, Fisher RA, Ham JM, Marcos A, Posner MP. Natural History of HCV

Following Liver Transplantation (OLT): Identification Of Patients

At High Risk For Disease Progression. Transplantation 69 (8) S313,

2000.

46. Hegab, AM, Kirtland, M, Shiffman, ML, Luketic, VA Sterling, RK,

Sanyal, AJ, Fisher, RA, Ham, JM, Marcos, A, Posner, MP. Natural

History of HCV Following Liver Transplantation: Identification of

Patients at High Risk for Disease Progression. Transplantation,

Vol. 69, No. 8, p S313, April 27, 2000. Poster at First Joint

Annual Meeting, of the ASTS and AST, Chicago, May 2000.

47. Whittemore, Martha. 1996. A critical review of the methods for

comparing two or more cancer staging systems. Master's thesis.

48. Desch, CD, L Penberthy, CJ Newschaffer, BE Hillner, M Whittemore, D

McClish, TJ Smith, SM Retchin. 1996. Factors that determine the

treatment for local and regional prostate cancer. Medical Care.

34(2): 152-162.

49. McClish, D, L Penberthy, M Whittemore, CJ Newschaffer, D Woolard,

CD Desch, SM Retchin. 1996. Ability of Medicare Claims Data and

Cancer Registries to Identify Cancer Cases and Treatment.

50. Newschaffer, CJ, L Penberthy, CD Desch, SM Retchin, M Whittemore.

1996. The effect of age and comorbity in the treatment of elderly

women with nonmetastatic breast cancer. Archives of Internal

Medicine. 156(1): 85-90.

51. Whittemore, Martha. 1994. The linkage of Virginia income tax

returns data to Medicare and the Virginia Cancer Registry. Paper

presentation at Linkage of Central Cancer Registries with Secondary

Databases Conference. Richmond, Virginia.

52. Whittemore, MK, DR Young. 1990. Soil moisture salinity and growth

form effects on the water relations patterns of barrier island

plants. American Journal of Botany. 77(6 Suppl): 64-65

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