Vice President Assistant

Z. Zhao

Zhijian Zhao

*** ********** *****, **********, ** 19810

Email: ***********@*****.***

302-***-****(h)

Objective

To enjoy an intellectually and creatively challenging position as an analytical chemist in

industry with the opportunity for professional growth and broadening of my skills and

experience.

Technical Skills

Expertise in method development and validation using analytical instrumentation, chemical

separation and spectroscopic methods. Extensive experience in chromatography including

HPLC/UPLC, LC/MS and GC/MS.

Highly skilled in NMR, UV-Vis, FT-IR, Karl Fisher titration, classical wet chemistry, and

quantitation.

Performed instrumental maintenance, troubleshooting, calibration, and validation.

Experience in computerized data management systems: MassLynx and ChemStation.

Proficient in Microsoft Office, Outlook, CS ChemDraw Pro, and Electronic notebook.

Good interpersonal skills, ability to work independently as well as interact effectively in team

environment, strong oral and written communication skills.

Working knowledge of GLP and FDA guidelines.

Work Experience

Senior Research Associate (12/07-Present): Merck & Co., West Point, PA

Developed and validated HPLC/UPLC, LC/MS methods to identify and separate

synthetic compounds to support HIV and Neuroscience drug discovery programs.

Performed LC/MS, GC/MS, 1-D and 2-D NMR experiments for organic molecule

structure elucidation and identification.

Applied parallels SPE (solid phase extraction) to purify libraries containing basic

nitrogen atoms.

Graduate School Experience

Research Assistant (06/94-08/97): University of Pittsburgh, PA

1

Z. Zhao

Fermented Escherichia Coli K-12 bacteria, extracted enzyme from the bacteria, incubated the

crude enzyme extracts with salicylic acid, malonyl-coenzyme A, and other co-factors to form

4-hydroxycoumarin.

Developed HPLC methods to separate the desired enzyme reaction product 4-

hydroxycoumarin from the crude enzyme reaction.

Derivatized 4-hydroxycoumarin with triisopropylsilyl chloride into silyl ether to confirm the

product by GC/MS.

Prepared the C-13 labeled salicylic acid and performed the same enzyme reaction as the non-

labeled compound and HPLC isolation, silyl ether derivatization to further confirm the

results by LC/MS.

Previous Working Experience in China

Lecturer: Analytical and Testing Center, Sichuan Normal University, Chengdu, Sichuan, PR China

Analyzed samples from different customers for structure elucidation and identification using

MS, NMR, UV-vis, FT-IR, classical wet chemistry and quantitation.

Education

M.S. Organic Chemistry, University of Pittsburgh, PA

M.S. Analytical Chemistry, Sichuan University, P.R. China

Awards

2011 Technical Achievements in Organic Chemistry Award, sponsored by the

Organic Division of the American Chemical Society, 2011

Nominated as a member of the "MRL Key R&D Awards Club" for discovery and

development of three (3) preclinical candidates, 2008

Merck Award for Excellence, Merck Research Laboratories, 2002, 2007, 2011

DuPont Central Research and Development Vice President’s Outstanding

Accomplishment Research Award, 1999

Publications

Total of seven-available upon request

References Available Upon Request

2

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