GUIXUE BU

* ***** ****, *******, ** ***** 978-***-**** aca160@r.postjobfree.com

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(Visa Status: Permanent Resident)

SUMMARY OF QUALIFICATIONS

Experienced Biomedical Engineer/Scientist with specialties in systems design, algorithm & software

development, and signal and image analysis. Track record of delivering within aggressive timelines quality

solutions and data to meet the demands of various biomedical applications. Expertise and skills include:

Extensive hands-on experience in hardware/software development and validation, biomedical signal

and image processing and analysis.

Proficient with algorithm development and software prototyping for signal & image analysis.

Solid background in electronics and electrical/optical sensing technologies with experience in

embedded systems design and implementation, systems integration, verification and validation.

Strong problem solving skills with experience in maintaining and troubleshooting complex systems.

Broad knowledge of life science with good understanding of medical devices/systems, diagnostic

technologies, and device-based therapies.

Knowledge of regulatory standards and directives for medical devices/systems.

TECHNICAL SKILLS

Computer Skills

Operating Systems and Platform: Windows NT/2000/XP/7/8, Linux, Microsoft Visual Studio.

Programming Languages: C/C++, Matlab, LabVIEW, LabWindows/CVI, IDL, TI DSP Embedded C.

Software Engineering: familiar with Software design, construction, testing processes; team work

experience in software development.

Hardware Skills

Electronics: circuits design, verification & validation; electric & opto-electronic sensing technologies.

Systems: microprocessors and interface technologies; AD/DA convertors; development tool kits; systems

integration; familiar with clinical diagnostic, monitoring, and therapeutic devices/systems.

Preclinical & Clinical Research Skills

Diseases and Models: familiar with cardiovascular diseases & cancers, imaging biomarkers for clinical

assessment and prognosis, and preclinical in vivo and in vitro models.

Laboratory Techniques: various in vivo and in vitro assays and technologies including imaging, rodent

handling (anesthetizing, dosing, tissue collection), sample preparation, primary cell isolation and culture.

PROFESSIONAL EXPERIENCE

December 2010 – November 2013, Senior Scientist, Research and Development, Pfizer Inc.

Collaborated with colleagues across Pfizer as a member of a cross-functional and highly collaborative

multidisciplinary team to design studies and to provide preclinical in vivo and ex vivo imaging support.

Developed imaging protocols, image analysis algorithms and software tools for biomedical signal and

image processing and analysis.

Designed imaging experiments and conducted laboratory research on multiple platforms.

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Managed a microscopy laboratory housing an advanced multiphoton microscope. Performed

troubleshooting as needed and routine quality assurance tests.

August 2008 – December 2010, Research Data Analyst, Indiana University School of Medicine

Developed software tools and analyzed DCE-MRI images from clinical trials in collaboration with

radiologists and oncologists.

Developed modules for generating maximum intensity projection (MIP) animations of 3D images in

Image Visualization and Analysis (IVA, custom software developed at Indiana University).

Investigated compartment models and curve fitting algorithms for analyzing 3D/4D dynamic molecular

imaging data (PET and MRI).

Analyzed static and dynamic preclinical PET/CT images from studies including targeted therapies for

plexiform neurofibromas, nanoparticle drug delivery, and new PET tracers.

Performed routine quality control and troubleshooting of clinical (Siemens HR+ PET, Biograph 64

PET/CT) and preclinical (IndyPET III) scanners.

January 2003 – July 2008, Research Assistant, Purdue University

Designed, implemented, and validated hardware & software to support cardiac electrophysiology

research with optical microscopy, electrode array recording, and standard electrocardiogram (ECG).

Researched & developed optical microscopy techniques and signal enhancement algorithms for

quantitative measurement of bioelectrical signals with applications to heart & neuroscience research.

Tested, characterized, and validated novel voltage-sensitive fluorescent probes for heart research.

Developed models of ventricular depolarization and simulated body surface ECG map with realistic

human torso model.

Conducted experiment and computational model studies to identify arrhythmogenesis mechanisms and to

link genetic mutation to changes in cardiac action potentials and abnormalities in ECG.

HONORS

2008 Purdue Graduate Student Government (PGSG) Travel Grant, Purdue University.

2007 Purdue Incentive Grant, the Graduate School, Purdue University.

2003 SCIRun/BioPSE Workshop Scholarship, SCI Institute, University of Utah.

2003 GSO Award, Graduate Office, Indiana University Purdue University Indianapolis.

EDUCATION

Purdue University, West Lafayette, IN

PhD, Biomedical Engineering, 2008

Purdue University, Indianapolis, IN

MS, Biomedical Engineering, 2004

Jinan University, Guangzhou, China

MS, Optics, 1996

Tsinghua University, Beijing, China

BE, Biomedical Engineering and Instrumentation, 1993

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