DENIZHAN YILMAZ

*** ********* ******* ************ *** Jersey 07840

ac9nxx@r.postjobfree.com · www.linkedin.com/in/denizhanyilmaz · 1-708-***-**** I am a Post-Doc Research Associate in Process Monitoring, Automation and Control team/ PFIZER with a background in Chemistry and Chemical and Biological Engineering. Currently, I am supporting data analysis, data driven modeling approaches and implementation of Process Analytical Technologies for real-time in situ monitoring of key process factors of cell culture systems, and eventually optimization and control of continuous upstream and downstream manufacturing operations. I have specialized in chemometric, development of kinetic and data driven modeling approaches, and model calibration and validation. I am a scientifically-driven, lifelong learner, and self-motivated team player with 7 years of research and 1 year of manufacturing and project management experience. EXPERIENCE

AUG 2018-PRESENT

ADVANCED MODELLING AND CONTROL RESEARCH ASSOCIATE, PFIZER INC. The responsibilities include supporting modeling activities, data analysis, creating required documentation, performing/organizing lab/pilot scale necessary experiments by collaborating with other groups and supervising for data sampling. AUG 2014-MAY 2018

TEACHING ASSISTANT, ILLINOIS INSTITUTE OF TECHNOLOGY (IIT) Assisted courses: Chemical Reaction Engineering, Material Energy Balances, Mathematical and Computational Methods, Heat and Mass Transfer Operations, Fluid Mechanics and tutoring for graduate and undergraduate chemical engineering courses in Academic Resource Center at IIT AUG 2012-2014

RESEARCH ASSISTANT, ILLINOIS INSTITUTE OF TECHNOLOGY (IIT) Development of kinetic model approaches to animal cell cultures and design a bioreactor simulator for monitor and control of cell culture processes DEC 2010-2012

PRODUCTION ENGINEER, CLL LABEL INC., ISTANBUL, TURKEY Managing every project and production of orders from start to finish. SEP 2007-2010

RESEARCH ASSISTANT, ISTANBUL TECHNICAL UNIVERSITY (ITU) Investigating reactive distillation column configurations, and designing temperature based inferential control structures

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EDUCATION

MAY 2018

PH.D. IN CHEMICAL AND BIOLOGICAL ENGINEERING, IIT

Research in kinetic model development for animal cell culture processes MAY 2010

M.SC. IN CHEMICAL ENGINEERING, ITU

Research in the effect of relative volatility on steady state design and temperature based inferential control of reactive distillation columns. MAY 2007

B.S. IN CHEMICAL ENGINEERING, YTU

Steady state design of reactive distillation columns and quantitative comparison of reactor/column/recycle process with reactive distillation column MAY 2006

B.S. IN CHEMISTRY, YILDIZ TECHNICAL UNIVERSITY, (YTU) Characterization of organic compounds in snail slime and making mucus-based adhesive CORE COMPETENCIES

• First Principle and Data Driven Model

Development & Validation

• Process Analytical Technology (PAT) for Real

Time Monitoring and Advanced Process

Control (APC)

• Statistical Data Analysis; Design of

Experiments (DOE)

• Unsupervised Learning (PCA, PLSR and Factor

Analysis); Deep Learning (ANN)

• System Identification, Kalman Filter

• Process Design, Optimization and Control,

Local and Global Sensitivity Analysis

• Bayesian Inference & MCMC Algorithms

• Proficient with SIMCA, PharmaMV, Minitab,

Python (Keras, NumPy, SciPy, Scikit-learn,

MatPlotLib, Pandas), MATLAB, and Microsoft

Office and familiar with JMP and R

• Knowledge of Molecular and Cell Biology

• Mammalian cell culture, Media optimization,

Bioreactor process development

• Metabolic Engineering (MFA & EFM)

• Gas chromatography–Mass spectrometry

• Liquid Chromatography (HPLC)

• Vibrational Spectroscopy (Raman, NIR, MIR, UV)

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PUBLICATIONS

Yilmaz D., Mehdizadeh, H., Navaro, D., Shehzad, A., O'Connor, M., McCormick, P., Application of Raman Spectroscopy in Monoclonal Antibody Producing Continuous Systems for Downstream Process Intensification (Proceeding)

Yilmaz D., Parulekar, S. J., Cinar, A., A Metabolic-Based Kinetic Model for Antibody Producing Cell Lines and Model Based Evaluation of Lactate Shift on Cell Culture Performance (Submitted to Journal of Biotechnology)

Yilmaz D., Parulekar, S. J., Cinar, A., A Dynamic EFM Based Model for Antibody Producing Cell Lines and Model Based Evaluation of Fed-Batch Processes (Submitted to Biochemical Engineering Journal) Yilmaz D., Parulekar, S. J., Cinar, A., A Composite Model for Antibody Producing Cell Lines with Low Glutamine Synthesize Activity (Submitted to Biotechnology Letters) Yilmaz D., Parulekar, S. J., Cinar, A., A Bioreactor Simulator for Monitoring and Controlling Antibody Producing Animal Cell Cultures (Proceeding)

Kaymak D. B., Yilmaz D., Gurer, A.Z., Inferential Temperature Control Structures for Different Types of Two-Reactant Reactive Distillation Systems, Industrial Engineering and Chemical Research, Jul 2011, Vol. 50 Issue 13, p8138-8152, 15p

Kaymak D. B., Yilmaz D., Gurer, A.Z., Effect of Relative Volatilities on Inferential Temperature Control of Reactive Distillation Columns, Industrial & Engineering Chemistry Research; Jul 2011, Vol. 50 Issue 13, p8138-8152, 15p

Kaymak D. B., Yilmaz D., Yilmaz S., Hosgor E., 2010, Quantitative Comparison of Reactor/ Column/Recycle Process with Reactive Distillation Column for Ternary Systems, 20th European Symposium on Computer Aided Process Engineering – ESCAPE20

ACADEMIC EVENTS

• A Novel Kinetic Model-Based Metabolic Flux Analysis for Antibody Producing Cell Lines, Denizhan Yilmaz, Satish J. Parulekar and Ali Cinar, 2018 AIChE Annual Meeting

• A Segregated Kinetic Model for Antibody Producing Cell Lines, Denizhan Yilmaz, Satish J. Parulekar and Ali Cinar, 2017 AIChE Annual Meeting

• A Metabolic Flux Based Dynamic Model for Antibody Producing Mammalian Cells, Denizhan Yilmaz, Satish J. Parulekar and Ali Cinar, 2016 AIChE Annual Meeting

• A Kinetic Model for Illustration of the Effect of Glutamine on the Apoptotic and Synthesis Pathways of Hybridoma Cells, Denizhan Yilmaz, Satish J. Parulekar and Ali Cinar, 2015 AIChE Annual Meeting

• Controllability of The Optimum Design for A Ternary Reactive Distillation Column, Denizhan Yilmaz and Devrim B. Kaymak, 6th Chemical Engineering Conference for Collaborative Research in Eastern Mediterranean Countries, 2010

• Quantitative Comparison of Reactive Distillation of Ternary Reactive Distillation Systems, Denizhan Yilmaz, Saliha Yilmaz, Eda Hoşgör, Devrim B. Kaymak, 9th National Chemical Engineering Congress, 2010

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SCHOLARSHIPS & PRIZES

• Pfizer W.E. Upjohn Prizes Award: Recognizes colleagues who have demonstrated above and beyond expected performance, innovation, teamwork, and leadership behaviors.

• Hamid Arastoopour Excellence in Teaching Award: Teaching Assistant of the Year for 2017 - 2018

• AIChE Student Presenter Award: Scholarship for Conference Attendance, Travel, and Accommodation

• Research Assistant Scholarship from the Food and Drug Administration grant 1U01FD005275- 01, August 2012-August 2014

• Graduate Program Scholarship from The Scientific and Technological Research Council of Turkey

(TUBITAK), Jan 2008 - Aug 2010.

MEMBERSHIPS

• Founding Member of ChBE Graduate Student Association, IIT

• American Institute of Chemical Engineers Member

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