Health Pharmacy

ISMAEEL YUNUSA

** ***** ******** ***., ******, MA 02119 857-***-**** *********@*****.***

OVERVIEW

A Health Outcomes Research professional with over eight years of experience in hospitals as a pharmacist, academia, and research organizations. Skilled at using Health care database to generate real-world evidence; health economics modeling; systematic reviews; pairwise and network meta-analysis. Known for ability to translate complex scientific concepts for laypeople, mentoring ability, and global outlook. Passionate about Patient Reported Outcomes and value propositions in Pharmaceuticals.

EDUCATION

MCPHS UNIVERSITY, Boston, MA September 2015 – March 2019 Doctor of Philosophy (Ph.D.) Candidate

Dissertation: “Evaluating the Clinical Effectiveness and Value of Pharmacological Treatments of Dementia.” ALEXANDRIA UNIVERSITY, Alexandria, Egypt September 2011 – May 2013 Doctor of Pharmacy (Pharm.D)

Dissertation: “Optimizing Pharmacotherapy in Geriatric Patients: A Pharmacist’s Role.” AHMADU BELLO UNIVERSITY, Zaria, Nigeria June 2003 – August 2010 Bachelor of Pharmacy (B. Pharm)

Project: “Quality Evaluation of Aspirin Tablets retailed in Kaduna and Zaria City in November 2008.” WORK EXPERIENCE

MCPHS UNIVERSITY, Boston, MA July 2017 – Present

Graduate Research and Teaching Assistant, Health Economics and Outcomes Research

• Conducted Systematic review and meta-analysis on Essential Tremor.

• Quantified the global burden of Essential Tremor and Identified its unmet medical needs.

• Prepared mentor-guided reports submitted to stakeholders.

• Presented findings in ISPOR conference.

• Grading exams on Health Epidemiology and Health Services and Outcomes Research courses Peer Tutoring: Tutored graduate level students on Health Epidemiology and Biostatistics, February 2016 – Present. Shire Pharmaceuticals contracting via Randstad, Lexington, MA Sept 2017 – Dec 2018

• Created, revised, and retired Standard Operating Procedures (SOP) as part of Shire-Baxalta Integration using document management systems such as Veeva and MasterControl

• Performed Gap analysis on SOPs to ensure new processes, forms and templates abide by the Shire Global Standard.

• Raised and Managed Change Controls in TrackWise 8.0 system as a change owner PHARMALEX US CORPS (formerly Degge Group Ltd), Fairfax, VA March 2017 – May 2017 Intern, Drug Safety/Pharmacoepidemiology Research

• Applied fundamental concepts: study design, biostatistics, health education, and medical communications through projects and preceptor training.

• Analyzed incidence of adverse events in drug cohorts and to evaluate signals using FAERS, WHO data

• Prepared reports to FDA in order to support Rx-to-OTC switch based on results from spontaneous adverse events analysis of FAERs and WHO databases.

• Performed comprehensive literature reviews.

• Abstracted adverse events information from over 2000 MedWatch forms of spontaneous reports.

• Developed three database profiles that were uploaded into online resource of database profiles, B.R.I.D.G.E. TO DATA (www.bridgetodata.org).

• Attended 3 FDA Advisory committee meetings as part of the Internship and learned the processes leading to the approval of new drugs. Specifically, I attended the meetings for the abuse deterrent opioid, Oxycodone

(RoxyBond), Neratinib for Her2 breast cancer, L-glutamine for sickle cell disease BRIGHAM & WOMEN'S HOSPITAL/HARVARD MEDICAL SCHOOL, Boston, MA Research Trainee – Division of General Internal Medicine and Primary Care, Department of Medicine (October 2018-Present)

• Participates in the Conservative Prescribing project. In this project, prescribers across the US are being profiled with the aim of achieving metrics for Conservative Prescribing.

• Calculated Formulary Selectivity Index to characterize how conservative prescribers are using electronic medical record data from two hospitals.

Research Trainee - Computational Neuroscience Outcomes Center, Department of Neurosurgery (October 2016

– March 2018)

• Participated in systematic reviews and meta-analyses projects to synthesize evidence that supported clinical decision making, culminating into five published articles. DIALOGUE SPECIALIST CLINICS LTD., Kaduna, Nigeria August 2013 – August 2015 Clinical Pharmacy Specialist

• Interpreted, evaluated, prepared, and dispensed medications pursuant to orders.

• Intervened to ensure safe, appropriate, and cost-effective medication use with regard to disease state, the aging processes and human developmental stages (neonate, child, adolescent, adult, and geriatric).

• Coordinated multidisciplinary periodic clinical meeting with other health care personnel on issues related to the effects and use of drugs.

• Collaborated with the health care team during clinical rounds to optimize medication therapy.

• Introduced routine vaccination services for pediatric and adult subjects. KADUNA STATE UNIVERSITY, Nigeria December 2013 – August 2015 Lecturer II (tenure track), Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences (May 2015 – August 2015)

• Lectured third year Pharmacy students in ‘Introduction to Clinical Pharmacy’ and ‘Public Health Pharmacy.’

• Introduced for the first time in the Faculty, Team-Based Learning Approach in administration of most lectures. Part-Time Lecturer (October 2014 – May 2015)

• Lectured first year Pharmacy students in PCP101 ‘Introduction to Pharmacy.’ Lecturer Assistant (December 2013 – October 2014)

• Assisted in lecturing first year Pharmacy students in ‘Introduction to Pharmacy.’ PUBLICATIONS & PRESENTATIONS

Articles in Peer-Reviewed Journals

• Yunusa I, Alsumali A, Garba AE, Regestein QR, Eguale T. Assessment of reported comparative effectiveness and safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia: a network meta-analysis. JAMA Netw Open. 2019;2(3): e190828. doi:10.1001/jamanetworkopen.2019.0828

• Fidelia I, Lamba N, Papatheodorou SI, Yunusa I, O'Neil K, Chun S, Wilson J, Maher T, Tafel I, Smith TR, Aglio LS, Mekary RA, Zaidi HA. Adult spinal deformity surgery: a systematic review of venous thromboprophylaxis and incidence of venous thromboembolic events. Neurosurg Rev. 2019 Mar 18. doi: 10.1007/s10143-019-01095-3.

• DiRisio AC, Harary M, Muskens IS, Yunusa I, Gormley WB, Aglio LS, Smith TR, Connors JM, Mekary RA, Broekman MLD. Outcomes of intraparenchymal hemorrhage after direct oral anticoagulant or vitamin K antagonist therapy: A systematic review and meta-analysis. J Clin Neurosci. 2018 Nov 21. pii: S0967-5868(18)31762-4

• Dewan MC, Rattani A, Mekary R, Glancz LJ, Yunusa I, Baticulon RE, Fieggen G, Wellons JC, Park KB, Warf BC. Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis. J Neurosurg. 2018 Apr 27:1-15.

• Robertson FC, Lepard JR, Mekary RA, Davis MC, Yunusa I, Gormley WB, Baticulon RE, Mahmud MR, Misra BK, Rattani A, Dewan MC, Park KB. Epidemiology of central nervous system infectious diseases: a meta-analysis and systematic review with implications for neurosurgeons worldwide. J Neurosurg. 2018 Jun 1:1-20.

• Simjian T, Muskens IS, Lamba N, Yunusa I, Wong K, Veronneau R, Kronenburg A, Brouwers HB, Mekary RA, Smith TR, Broekman MLD. Administration of dexamethasone and mortality in brain abscess patients: A Systematic Review and Meta-Analysis. World neurosurgery. 2018; 115:257-263.

• Mora AT, Yunusa IU, Omole VN, Jatau AI. Assessment of the Referral System at Secondary and Tertiary Health Care Facilities in Kaduna Metropolis, Nigeria. Chronicle of Medicine and Surgery 2.4 (2018): 219-225.

• Omole VN, Mora AT, Yunusa IU, Audu O, Jatau AI, Gobir A. Knowledge, attitude, and perception of the referral system among tertiary health-care workers in Kaduna metropolis, Nigeria. Int J Med Sci Public Health. 2017; 6(10): 1481-1488. doi:10.5455/ijmsph.2017.0307617082017.

Articles in Peer-Reviewed Journals (Under Review)

• Ismaeel Yunusa, PharmD, Amey Ranes, BPharm. Tewodros Eguale, MD, PhD. Cost-Effectiveness of Memantine, Acetylcholinesterase Inhibitors and Memantine/Acetylcholinesterase Inhibitor Combinations in the Treatment of Moderate-to-Severe Alzheimer’s Disease.

• Farrah Pompilus, MA; Nayan Lamba, B.A.; Asad Lak, MD; Ismaeel Yunusa, PharmD; Andrella King, MS; Ihtisham Sultan, PharmD; James Amamoo, MSc; Nawaf Al-Otaibi, PhD; Mohammed Alasmari; Christian D Cerecedo-Lopez, MD; Linda Aglio, MD, MS; Ian Tafel, MD; Timothy R Smith, MD, PhD, MPH; Rania A Mekary, MS, PhD; Hasan Zaidi, MD. Minimally Invasive versus Open Surgery for the Correction of Adult Degenerative Scoliosis: A Systematic Review and Meta-Analysis.

Peer-Reviewed Presentations (Podium and/or Posters)

• Yunusa, I., Alsumali, A., Garba, A.E. and Eguale, T. Comparative safety of atypical antipsychotics used in the treatment of neuropsychiatric symptoms of dementia: A mixed treatment comparison. International Society for Pharmacoepidemiology 34th International Conference on Pharmacoepidemiology & Therapeutic Risk Management. Prague, Czech Republic, Aug 22-26, 2018. Abstract Published in: Pharmacoepidemiology and Drug Safety. 2018; 27:53-54.

• I Yunusa, T Eguale, AE Garba, A Alsumali. Risk of Death from the Use of Atypical Antipsychotic Drugs for the Treatment of Neuropyschiatric Symptoms of Dementia: A Network Meta-Analysis. ISPOR 23rd Annual International Meeting, Baltimore, MD, May 19-23, 2018. Abstract Published in: Value in Health 2018;21(1): S202.

• C Ndikumukiza, I Yunusa, T Eguale. Budget Impact Analysis of Malaria Vaccine in Children Younger than 5 Years in Rwanda: A Donor Perspective. ISPOR 23rd Annual International Meeting, Baltimore, MD, May 19-23, 2018. Abstract Published in: Value in Health 2018;21(1): S151.

• I Yunusa, C Ndikumukiza, T Eguale. Treatment Strategies in Children with Severe Sickle Cell Disease after the Introduction of L-Glutamine Powder: A Decision Analysis. ISPOR 23rd Annual International Meeting, Baltimore, MD, May 19-23, 2018. Abstract Published in: Value in Health 2018;21(1): S253.

• I Yunusa, P Abraham, A Alsumali, T Eguale. Prevalence, Disease Burden and Unmet Needs of Patients With Essential Tremor: A Systematic Review and Meta-Analysis. ISPOR 23rd Annual International Meeting, Baltimore, MD, May 19-23, 2018. Abstract Published in: Value in Health 2018;21(1): S205.

• S Mahida, I Yunusa, A Bin Sawad, A Alsumali. Systematic Assessment of Decision Analytic Models for the Cost Effectiveness of Immunosuppressive Agents Used in Kidney Transplant Patients. ISPOR 23rd Annual International Meeting, Baltimore, MD, May 19-23, 2018. Abstract Published in: Value in Health 2018;21(1): S267.

• DiRisio, A. C., Goswami, H., Shi, C., Yunusa, I., Smith, T. R., Mekary, R. A., & Broekman, M. L. P09.53 The timing of postoperative chemoradiation treatment (Stupp Protocol) after GBM resection: A systematic review. 22nd Annual Scientific Meeting and Education Day of The Society for Neuro-Oncology, November 16 – 19, 2017, San Francisco, California. Abstract Published in: Neuro-Oncology, 2017:19(3), iii82.

• Jose Paredes, Liu C, Yunusa I, Ndikumukiza C, Enrique Seoane. Price analysis of oral antidepressant drugs with generic competition marketed in the US (1988-2015). ISPOR 21st Annual International Meeting, Washington, DC, May 24, 2016. Abstract Published in: Value in Health 2016;19(3): A188. HONORS AND AWARDS

• International Society for Pharmacoepidemiology (ISPE) Scholarship to attend the 34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management, Prague, Czech Republic, August 22-26, 2018.

• Epidemiology and Population Health Summer Institute (EPIC) 2018 Scholarship for Propensity Score Matching Course, Columbia University Mailman School of Public Health, New York, NY.

• Certificate of Honor in Recognition of remarkable participation in Community Development Service, Medical and Health Services Group, National Youth Service Corps, Nigeria, 2014. ADDITIONAL INFORMATION

Continuing Education

• Propensity Score Matching - Epidemiology and Population Health Summer Institute, Columbia University Mailman School of Public Health June 1-30th, 2018, New York, NY.

• Survival Analysis - Epidemiology and Population Health Summer Institute, Columbia University Mailman School of Public Health June 15-16th, 2018, New York, NY.

• Decision Modeling Using R Workshop - The Child Health Evaluative Sciences (CHES) department of the Hospital for Sick Children and the THETA collaborative. Peter Gilgan Centre for Research and Learning, Toronto, Canada. April 4th – 6th, 2018

• Advanced Decision Modeling for Health Economic Evaluations -Short course, International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 22nd Annual Meeting May 20th, 2018, Boston, MA.

• Value of Information: Active Learning, Modeling Tools and Applications -Short course, International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 23rd Annual Meeting, May 19th, 2018, Boston, MA.

• Causal Inference and Big Data - Causal Inference and Big Data Summer Institute, Center for Clinical Epidemiology & Biostatistics, Perelman School of Medicine, University of Pennsylvania July 24-27, 2017, Philadelphia, PA.

• Network Meta-analysis - Epidemiology and Population Health Summer Institute, Columbia University Mailman School of Public Health June 15-16th, 2017, New York, NY.

• Bayesian Analysis - Overview and Application-Short course, International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 22nd Annual Meeting May 20th, 2017, Boston, MA.

• Budget Impact Analysis - Short course, International Society for Pharmacoeconomics and Outcomes Research

(ISPOR) 22nd Annual Meeting May 21st, 2017, Boston, MA.

• Biologics and Biosimilars: An Integrated Overview of Product Development, Pharmaceutical Education and Research Institute Inc., Fairfax, VA, April 27-28, 2017.

• Protecting Human Research Participants, National Institutes of Health (NIH) Office if Extramural Research, Bethesda, MD, May 19th, 2017.

• Evidence-based Medical Practice at Alexandria Regional Centre for Women’s Health and Development, Alexandria, Egypt in collaboration with Oxford University Centre for Evidence-based Medicine from the 4th to 7th December 2011

Additional Experience

• Intern Pharmacist, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria, November 2010– November 2011.

Peer Reviewer of Journal Articles (Verifiable on: Publons: https://publons.com/researcher/1466378/ismaeel-yunusa/)

• Journal of Pharmaceutical Health Services Research Nov 2018-present

• Journal of Comparative Effectiveness Research Nov 2018-present

• Value in Health Regional Nov 2018-present

• Complementary Therapies in Clinical Practice Nov 2018-present Professional Memberships

• International Society for Pharmacoeconomics and Outcomes Research (ISPOR)

• International Society for Pharmacoepidemiology (ISPE)

• Pharmaceutical Society of Nigeria

Software Skills/Proficiency

• Proficient in Microsoft Excel, Outlook, SPSS, SAS, STATA, R, Comprehensive Meta-analysis (CMA), WinBUGS, TreeAge Pro and heRo3.

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