*

To Whom It May Concern

It is with great enthusiasm that I request my application for the chemist position. It seems that the opportunity for collaboration is great by reviewing the interests of your department. I am a permanent resident of Canada. I am currently a post doctoral fellow (visiting professor) at College of Pharmacy and Nutrition, University of Saskatchewan Canada working with Professor Jonathan Dimmock in the drug design and discovery research. The focus of my project is the design, synthesis and bioevaluation of thio adducts of 3, 5- bis (benzylidene)-4 piperidones and 4, 6-bis (benzylidene) cyclohexanones as a new class of antineoplastic agents. A summery of my achievement over the past fifteen years are as below: I have taught a variety Pharmaceutical courses such as Medicinal chemistry, Organic chemistry, General chemistry, Radio pharmacy, Radioimmunoassay, Instrumental analytical chemistry (UV, IR, 1H NMR,13C NMR, Radioimmuno assay, ELISA, Neutron Activation Analysis, Radio-HPLC, Mass and Gamma spectroscopy) and Physical and Chemical Control for pharmaceutical compounds to Pharm-D, MS and Ph.D. students. I was principle advisor of more than 30 thesis of Pharm-D and MS medicinal chemistry students and the outcomes of those researches could be published in the reputational journals. I have developed a wide range of skills and experiment in design and synthesis of anticancer agents, quality control of pharmaceutical compounds,quality control of radiopharmaceutical kits,developed new technique for the reconstitution of radiopharmaceutical kits in the nuclear medicine departments, preparation of new radiotracers for palliative therapy in bone metastasis, develop and preparation of new radiotracers for the distinction of infection from sterile inflammation lesions and the developed new formulation of radiotracer for identification of Parkinson disease by radioisotope imaging. I had a very good cooperation with Atomic 2

Energy Organization of Iran for quality control of radiotracers that were produced by the nuclear reactor and cyclotron. Please find enclosed my curriculum vitae and a list of references alongside of this letter. In addition, you will find my research and teaching statement that provide further details of the above-mentioned summary. My varied training experience, with my extensive educational background, make me an ideal candidate for the cooperation in the future. I hope that you will carefully review my application and give serious consideration to agree with my request. I look forward to hearing from you, and I thank you in advance for your consideration. Best Regards

Alireza Doroudi Pharm-D, Ph.D.

Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan. Postal Code: S7N 5C9 E-mail: ac88at@r.postjobfree.com & ac88at@r.postjobfree.com Alireza Doroudi Pharm-D, PhD (Radio pharmacy)

Drug Design and Discovery Research Group,

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College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon Saskatchewan, S7N 5C9.

E-mail: ac88at@r.postjobfree.com & ac88at@r.postjobfree.com Address

1. Canada:

Drug Design and Discovery Research Group, College Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5C9 Canada

2. Iran:

Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Postal Code: 613-***-**** Education

1. Visiting Professor:

Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon Saskatchewan, S7N 5C9, Canada 2017- 2018 The project: The design, synthesis and bioevaluation of thio adducts of 3,5- bis(benzylidene)-4 piperidones as a new class of antineoplastic agents. Main supervisor Professor Johnathan Dimmock

Supervisor Umashankar Das

2. Post doctoral fellowship:

College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon Saskatchewan, Canada 2003-2004

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The project: The design and synthesis of 2, 6-(benzylidene) cyclohexanone derivatives as a new class of anticancer agents.

Supervisor: Johnathan Dimmock

3. Ph. D Radio pharmacy:

Tehran University of Medical Sciences, Tehran, Iran 1999-2005 Tehran University of Medical Sciences.

Thesis title: The synthesis and investigation effects of antimetabolite and anticancer agents that tethered to 2, 4-dinitro phenyl amine through three carbons chain. 4. Pharm-D:

Doctor of Pharmacy, Islamic Azad University. 1987-1995 Thesis title: cis Hydroxylation of olefinic compounds by cetyl pyridinium permanganate. Scholarship: College of Pharmacy and Nutrition, University of Saskatoon, under supervision of Professor Dimmock, 2003-2004

Teaching

Organic Chemistry, Medicinal Chemistry, Physical and Chemical Controls for Pharmaceutical compounds, Radio pharmacy, Radioimmunoassay. Analytical chemistry

(UV, 1H-NMR, IR, MASS, Gamma Spectroscopy, Radio-HPLC). Work Experience

Assistant Professor: Ahvaz Jundishapur University of Medical Sciences, 2005-2015. Associate Professor: Ahvaz Jundishapur University of Medical Sciences, 2015 Member of Iranian Pharmacopeia, 2005-2008

Adviser and regulatory affair associate: Cobel Daru, 2009-2012Tehran, Iran Adviser and regulatory affair associate: Erfan Teb Pars, 2015 till now Tehran, Iran Member of committee of Import, Export and production of pharmaceutical compounds, 2013-2014

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Member of Radio pharmacy board in Iran, 2016

Editor of Acta Scientific Pharmaceutical Sciences Journal. Thesis

Adviser/Consulter

1- The evaluation of radiosensitivity of Imatinib on HT29 cell line. 2- The biological effect of Vinorelbine and ionization irradiation on HT29 cell line. 3- Synthesis and antineoplastic investigation of compounds from the attachment of nitro aniline and 5-FU due to three and five carbons chain. 4- The biological effects of Imatinib, Hydroxyurea, 5-FU and Cis-platin HT29 cell line 5- The preparation of acylation and alkylation of nitro aniline derivatives by ultrasound irradiation technique.

6- Pharmacokinetic study of labeled toxin of Iranian scorpion (Gadim) before and after labeled antisera which prepared by Razi Institute. 7- Preparation and quality control of

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Ga-Glucagon.

8- The prednisolone effect on sensitivity of

99m

Tc-MDP to discriminate simulated closed

fracture in rat model.

9- Preparation of labeled ofloxacin with

99m

Tc to detect infection lesions.

10- Labeling of UBI with

99m

Tc and comparison distribution of radio peptide with 99m

Tc-

MDP in patients with bone infection.

11- The labeling of MIBI by

99m

Tc due to ultrasound irradiation method.

12- The preparation and biological evaluation of

99m

Tc-Ofloxacin in order to discriminate

the induced infection by Escherichia coli.

13- Clinical Application of Ultrasound irradiation technique to prepare 99m

Tc-MIBI.

14- Diagnosis of induced infection by Staphylococcus aureus resistant to ciprofloxacin by 99m

Tc-MDP and

99m

Tc-Ciprofloxacin (Infecton) in the rat model.

15- The assessment of sensitivity and specificity of 99m

Tc-UBI and

99m

Tc-MDP to detect

induced infection by Staphylococcus aureus and induced sterile inflammation by carrageenan in the rat's foot.

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16- The investigation of deferoxamine on induced nephrogenic systemic fibrosis by contrast media containing gadonium in rat.

17- The investigation of efficiency of

99m

Tc-Ciprofloxacin to discriminate infection induced by Staphylococcus aureus and sterile inflammation induced by carrageenan in the rat's foot.

18- The preparation of

99m

Tc-UBI by ultrasound irradiation method.

19- The diagnosis of Parkinson by new developed formulation of 99m

Tc- Trodate

radiotracer.

20- The preparation of

188

Re-Pamideronate for palliation therapy.

21- The investigation of efficiency of

99m

Tc-Ig G radio complex to discriminate infection

induced by Staphylococcus aureus and sterile inflammation induced by carrageenan in the rat's foot.

22- The effect of Omeprazole on

99m

Tc-MDP uptake to detect the simulated closed fracture in rat model.

23- The preparation of

99m

Tc-MAG3 by Ultrasound irradiation technique.

24- The pharmacokinetic parameters of

99m

Tc-MBI which reconstituted by ultrasound

irradiation method versus boiling water bath method as an alternative method. 25- The preparation of

99m

Tc-Octerotide by ultrasound irradiation technique. 26- The evaluation of sensitivity and specificity of new developed 99m

Tc- Ceftazidime radio

complex to detect infection induced by Staphylococcus aureus and sterile inflammation induced by carrageenan in the rat model.

27- Preferentially diagnosis of infection from sterile inflammation by 99m

Tc-Ofloxacin radio

complex.

28- Synthesis, and investigation cytotoxicity and radiosensitizer effects of 2, 4 dinitro aniline tethered to chalcone derivatives.

29- The quality control of

99m

Tc-UBI radio conjugated which prepared by ultrasound irradiation technique.

30- Identification of induced septic lesion by resistant Pseudomonas aeruginosa and Acinetobacter baumannii to ceftazidime with

99m

Tc-Ceftazidime radiotracer.

31- The preparation of

188

Re-Residronic radio complex for palliation therapy. 32- The preparation of

188

Re-Zolidronic acid for palliation therapy.

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33- The effect of total extract of Quercus Buratti on cancer cells HT29 in radiation. 34- Synthesis of 1-(2, 4-dinitrophenyl)-5-aryl-3-oxo-1, 4-pentadiene derivatives, cytotoxicity investigation and evaluation of radiosensitizing activity of them through 2, 4-dinitrobenzyledene tethered by chalcone alkylators. Publication

1- Quail JW, Doroudi A, Das U, Dimmock JR. 1,4dimorpholinobenzene. Acta Crystallographica Section E. 2005; 61(3):693-694.

2- Quail JW, Doroudi A, Pati HN, Das U, Dimmock JR. (E, E)-2-(4- fluorophenylmethylene)-6-(4-nitrophenylmethylene)-cyclohexanone. Acta Crystallographica Section E. 2005; 61(6):1774-1776. 3- Quail JW, Doroudi A, Pati HN, Das U, Dimmock JR.

(E, E)-2-(4methylphenylmethylene)-6-(4-nitrophenylmethylene)-Cyclohexanone. Acta Crystallographica Section B. 2005; 61(6):1795-1797. 4- Das U, Doroudi A, Das S, Bandy B, Balzarini J, De Clercq E, Dimmock JR. E,E- 2-Benzylidene-6-(nitrobenzylidiene)cyclohexanones:synthesis,cytotoxicity and an examination of some of their electronic, steric and hydrophobic properties. Journal of Bioorganic Medicinal Chemistry. 2008; 16(11):6261-6268. 5- Khalaj A, Doroudi A, Ostad SN, Khoshayand R, Babai M, Adibpour N. Synthesis, aerobic cytotoxicity and radiosensitizing activity of novel 2, 4-dinitrophenylamine tethered 5- fluorouracil and Hydroxyurea. Journal of Bioorganic Medicinal Chemistry Letter. 2006; 6034-6038.

6- Khalaj A, Doroudi A, Adibpour N, Mohseni Araghi G. N-alkylation and N- Acylation of 2,4 dinitrophenyl amine by ultrasound irradiation. Asian Journal of Chemistry. 2009; 21(2):997-1001.

7- Das U, Doroudi A, Gul HI, Pati HN, Kawase M, Sakagami H, Chu Q, Stables JP, Dimmock JR. Cytotoxicity 2-benzylidene-6-

(nitrobenzylidene)Cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells.

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Journal of Bioorganic Medicinal Chemistry 2010; 18(6):2219-2224. 8- Jalilian AR, Jouiaei M, Doroudi A, Bolourinovin, Garousi J. Development of a radiolabeled glucagon compound for imaging. Nukleonica. 2010,55:219-224. 9- Jalilian AR, Jouiaei M, Doroudi A, Garousi J, Moradkhani S. Preparation and biological evaluation of radiogallium labeled glucagon for SPECT imaging. Journal of Radioanalytical Nuclear Chemistry. 2010; 285(3):551-561. 10- Jalali A, Moazen S, Babaee M, Dadashzade S, Doroudi A. The pharmacokinetics of Iranian scorpion Odonthubuthus doriae venom and the available antivenom. Journal of Venom Research.2010; 1:48-53.

11- Doroudi A*, Saadati SM, Ahmadi F, Khodayar J, Rezaee S, Heidari Kaydan H. The effect of prednisolone on the sensitivity of Technetium 99m—methylene diphosphonate (

99m

Tc-MDP) scintigraphy to detect simulated closed fracture in the rat tibia. Iranian Journal of Nuclear Medicine. 2012; 20:32-38. 12- Doroudi A*, Saadati SM, Hassanpur H, Ahmadi F, Erfani M, Rezaee S, Khodayar MJ, Samaee H, Etesami B. Preparation of

99m

Tc-MIBI complex under ultrasound

irradiation. Journal of Radioanalytical Nuclear Chemistry. 2013;298:118*-****-**- Erfani M, Doroudi A, Hadisi L, Andishmand A, Mazidi SM. Optimization condition in labeling of ofloxacin with

99m

Tc and its biological evaluation in

Staphylococcus aureus and Escherichia coli for infection imaging. Iranian Journal of Nuclear Medicine. 2013; 21:1-6.

14- Erfani M, Doroudi A, Hadisi L, Andishmand A, Mirshojaei SF, Shaffiei M.99m Tc-tricarbonyl labeling of ofloxacin and its biological evaluation in Staphylococcus aurous as an infection imaging agent. Journal Labeled Compounds and Radiopharmaceuticals. 2013; 56(12):627-631.

15- Doroudi A*, Saadati SM, Ahmadi F, Kiasat A, Khodayar MJ, Meghdadi H, Rezaee S. The sensitivity of 99mTc-Ciprofloxacin (Infecton) scintigraphy imaging to detect infection lesions induced by Staphylococcus aureus susceptible or resistant to ciprofloxacin antibiotic in rat's foot. IOSR Journal of Pharmacy. 2014; 4(12):10-15.

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16- Doroudi A*, Erfani M, Damavandi Kamali K, Saadati SM, Ahmadi F, Kiasat A, Khodayar MJ, Meghdadi H. Sensitivity and specificity of 99mTc-UBI29-41 and 67Ga- Citrate scintigraphy imaging to discriminate infection lesion induced by Staphylococcus aureus and sterile inflammation lesion induced by carrageenan in rat's foot. IOSR Journal of Pharmacy.2014; 4(11):37-43.

17- Erfani M, Doroudi A, Dinari MA, Shirmardi SP. Preparation of a rhenium -188 labeled bisphosphonate for bone pain palliation therapy. Journal of Radioanalytical Nuclear Chemistry. 2015; 303:3813-3817

18-Doroudi A*, Erfani M, Norouzi B, Saadati M, Kiasat A, Ahmadi F, Etesami B, Baghersad MH. Clinical application of ultrasound for preparation of 99m

Tc-Sestamibi

complex. Annals Nuclear Medicine. 2015; 29:295-301. 19- Doroudi A*, Erfani M, Kooshki F, Saadati SM, Ahmadi F, Kiasat A, Khodayar MJ, Etesami B, Meghdadi H. Efficacy of

99m

Tc-Ciprofloxacin and

67

Ga-Citrate

scintigraphy to discriminate infection foci induced by Staphylococcus aureus from sterile inflammation induced by Carrageenan in rat. Iranian Journal of Nuclear Medicine. 2015; 23:96-102.

20-Doroudi A*, Samaee H, Saadati SM, Ahmadi F, Kiasat A, Erfani M. Clinical evaluation of

99m

Tc-MDP three phase bone scan and

99m

Tc-UBI29-41 scintigraphy

imaging in preferentially detection infection from sterile inflammation among diabetic patients with suspected foot infection. IOSR Journal of Pharmacy. 2015; 5(2):20-26. 21-Doroudi A*, Erfani M, Mousavinia SM. The radiosensitivity effect of Hydroxyurea on HT29 cell line. IOSR Journal of Pharmacy. 2015; 5(4):40-43 22-Doroudi A*, Erfani M, Zaheri M, Saadati SM, Ahmadi F, Kiasat A, Etesami B, Meghdadi H, Rezaee R. Preparation of

99m

Tc-UBI complex samples under ultrasound

irradiation technique. International Journal of Current Research. 2015; 7:217**-*****. 23- Erfani M, Sharifzadeh S, Doroudi A, Shafiei. Labeling and evaluation of 99m

Tc-

tricarbonylmeloxicam as a preferential COX-2 inhibitor for inflammation imaging. Journal of Labeled Compounds and Radiopharmaceuticals. 2016; 59: 284-290. 10

24-Doroudi A*, Saraji F, Erfani M, Saadati SM, Kiasat A, Ahmadi F, Etesami B. The stability of

99m

Tc-MIBI (Sestamibi) complex samples which prepared under ultrasound irradiation technique versus boiling water method. Journal of Applied Pharmaceutical Science. 2016; 6(11): 126-134.

25-Erfani M, Rahmani N, Doroudi A, Shafiei M. Preparation and evaluation of rhenium-188- pamidronate as a palliative treatment in bone metastasis. Journal of Nuclear Medicine and Biology. 2017; 49:1-7.

26-Doroudi A*, Kiasat A, Saadi M, Saadati SM, Ahmadi F, Etesami B, Khodayar MJ, Erfani M. The evaluation of sensitivity and specificity of new developed 99m

Tc-

Ofloxacin radiotracer to discriminate induced infection by Staphylococcus aureus and induced sterile inflammation by carrageenan in rat's foot. International Journal of Pharmaceutical Sciences and Research. 2017; 8(4):1000-1008. 27-Doroudi A*, Ahmadi F, Moradpour SA, Khodayar MJ, Saadati SM, Kiasat A, Etesami B, Erfani M. The evaluation of omeprazole effect on the sensitivity of 99m

Tc-

MDP bone-seeking to detect simulated closed fracture in the rat's foot. Iranian Journal of Nuclear Medicine. 2017; 25(2):92-97.

28.Erfani M, Tabatabaei M, Doroudi A, Shafiei M. Radiolabeling of zoledronic acid with

188

Re as a new palliative agent radiotracer in treatment of bone tumors. Journal of Radioanalytical Nuclear Chemistry. 2018; 316(2):491-500. 29- Doroudi A*, Rezaee E, Saadati SM, Kiasat A, Ahmadi F, Etesami B, Erfani M. The role of sonication for the preparation of infection-seeking radiotracer sample versus the standard method. Research Journal of Pharmacy and Technology. 2018; 11(3):987-995.

30- Doroudi A*, Ghasemi Falavarjani S, Khodayar MJ, Ahmadi F, Saadati SM, Kiasat A, Etesami B, Etesami B. The preparation of

99m

Tc-MAG3 radiotracer by ultrasound.

International Journal of Pharm Tech Research. 2018; 11(2):156-167. 31- Heidari Kaydan S, Doroudi A*, Ahmadi F, Khodayar MJ, Erfani M. The sensitivity and specificity of

99m

Tc-IgG radiotracer to differentiate infection lesions induced by Staphylococcus aureus and sterile inflammation lesions induced by carrageenan assay in rat's foot. Electronic Physician Journal. 2018; 10(6): 6965-6973. 11

32- Saadati SM, Kiasat A, Mousavinia M, Ahmadi F, Ahadi R, Rafie S, Etesami B, Erfani M, Doroudi A*. Clinical evaluation of new formulation of 99m

Tc-TRODAT-1

for SPECT imaging in Parkinson patients and volunteer subjects. International Journal of Pharmaceutical Sciences and Research.2018; 9(8):3281-3290. 33- Doroudi A*, Zarei Ahmadi A, Mohammadi R, Hashemitabar M, Tahmasebi Birgani J, Hoseini-Ghahfarokhi. Synthesis, in vitro evaluation of cytotoxicity and radiosensitizer activity of novel 2-(2, 4-dinitrobenzylidene) cyclohexanone derivatives against the radioresistant HT29 cell line under aerobic condition. Iranian Journal of Nuclear Medicine. Accepted.

34- Doroudi A*, Hemmati M, Saadati SM, Kiasat A, Ahmadi F, Etesami B, Khodayar MJ, Erfani M. The application of ultrasound irradiation as an alternative method for the preparation of 99mTc-Octreotide radio complex. International Journal of Pharmaceutical Sciences and Research. Accepted. 35- Doroudi A, Das U, Zhu J, Dimmock J. Structure of 2-[phenylethylthio) methyl] cyclohexanone: a candidate prodrug of the cytotoxin E-2-benzylidenecyclohexanone.

. Acta Crystallography Sect E. Submitted

Abstract

1- Synthesis new radiosensitizer compounds and biological effects on the HT29 cell line. Poster presentation. 2007, Antalya, Turkey

2- The biological effects of imatinib and 4 Gy ionizing irradiation on HT29 cell line. Poster presentation, 2009, Ankara, Turkey.

3- Biological effect of imatinib with 5-FU, Hydroxyurea and cis-platin on Human colon tumor cell line HT29. Poster presentation, 2009, Ankara, Turkey. 12

4- New technique for preparation of

99m

Tc-MIBI. 2015, Oral presentation, Toronto,

Canada

5- The application of ultrasound irradiation technique for the reconstitution of radiopharmaceutical kits. Oral presentation, 2016, Toronto, Canada. References:

1- Professor Johnathan Dimmock:

Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon Saskatchewan, S7N 5C9, Canada. E-mail Address: ac88at@r.postjobfree.com

2- Dr Umashankar Das:

Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon Saskatchewan, S7N 5C9, Canada. E-mail Address: ac88at@r.postjobfree.com

3- Professor Seyed Nasser Ostad:

Toxicology& Pharmacology Department, Tehran University of Medical Sciences, Tehran, Iran.

E-mail Address: ac88at@r.postjobfree.com

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