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Scientist

Location:
Madison, Wisconsin, United States
Posted:
November 18, 2018

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Resume:

Alok Nerurkar, Ph. D.

Madison, WI

636-***-****

ac7qch@r.postjobfree.com

https://www.linkedin.com/in/aloknerurkar/

United States Permanent Resident

Curriculum Vitae

SUMMARY

■ Synthetic organic chemist with 8+ years of experience solving complex problems pertaining to design, multi-step synthesis, purification and characterization of novel organic compounds.

■ Extensive experience in optimizing synthetic methods and designing efficient routes to target molecules, methodology development, total synthesis, target-oriented library development, and rapid compound synthesis for medicinal chemistry optimization.

■ Excellent interpersonal, collaboration and communication skills with ability to work independently as well as in a multi-disciplinary team environment.

■ Demonstrated high level of productivity and effective time management skills through strategic prioritization of projects and adherence to strict deadlines in a fast-paced environment leading to 5 peer-reviewed publications and 15+ presentations at national and regional conferences.

■ Excellent leadership skills demonstrated by supervising, training and mentoring 5+ graduate and 4+ undergraduate researchers in the execution of synthetic and medicinal chemistry projects. RESEARCH EXPERIENCE

Nov 2015 – Sep 2018, Postdoctoral Research Associate, University of Wisconsin-Madison, Madison, WI Mentor: Dr. Jennifer E. Golden, Assistant Professor and Associate Director, UW-Madison Medicinal Chemistry Center, Pharmaceutical Sciences Division, School of Pharmacy, Nov 2015- Aug 2017

■ Resolved synthetic challenges in a medicinal chemistry project by developing a novel, multi-component Ugi 4CC-aza-Wittig-Intramolecular Quinazolinone rearrangement methodology for previously inaccessible and biologically active amidines.

■ Reduced time, cost and waste by 50%, and improved overall yields by 10-20% through streamlining of a 6-step, Ugi 4CC-aza-Wittig-Intramolecular Quinazolinone rearrangement sequence into a telescoped protocol for biologically relevant amidines.

■ Established structure-activity relationships (SAR) around an anti-infective sulfonamide hit compound through rational design and multi-step synthesis of 100+ analogs in less than 6 months.

■ Improved the potency by 10-folds, selectivity by 100-folds and metabolic stability by 40-folds of an anti-infective hit compound through “scaffold-hopping.”

Mentor: Dr. John Feltenberger, Assistant Director, UW Medicinal Chemistry Center, School of Pharmacy, Aug 2017- Sep 2018

■ Developed a library of type-II kinase inhibitor analogs bearing unique beta-amino acid structural motifs to enable access to new chemical space and novel Intellectual Property.

■ Piloted a one-pot parallel synthesis protocol for high-throughput generation of bis-amide kinase inhibitor libraries deploying a newly reported and highly chemoselective amide coupling reagent. Alok Nerurkar, Ph. D.

Madison, WI

636-***-****

ac7qch@r.postjobfree.com

https://www.linkedin.com/in/aloknerurkar/

United States Permanent Resident

Curriculum Vitae

Aug 2009 - Nov 2015, Graduate Research Assistant, University of Missouri - Kansas City, Kansas City, MO Mentor: Dr. Keith Buszek, Professor, Department of Chemistry

■ Identified a highly regioselective, intermolecular Diels-Alder [4+2] cycloaddition of 6,7-indolynes via a site- selective metal-halogen exchange-elimination protocol leading to total synthesis of -cis-trikentrin B, a deceptively simple, indole alkaloid natural product.

■ Investigated the electronic and steric factors responsible for the contrasteric regioselectivity in intermolecular Diels-Alder [4+2] cycloadditions of 6,7-indolynes thus gaining mechanistic insights into the reactivity profiles of 6,7-indolyne reactive intermediates.

■ Devised and executed cheaper synthetic routes by adapting Bartoli, Fischer and Leimgruber-Batcho reactions to obtain key indole starting materials, intermediates and target molecules in >10g scale quantities.

■ Executed multi-step syntheses of unique, polycyclic benzannulated indole scaffolds and libraries via 6,7- indolyne cycloaddition and cross-coupling chemistry (e.g., Negishi, Suzuki-Miyaura and Buchwald-Hartwig). Aug 2007 - June 2009, Analyst, Analytical Solutions, Mumbai, India

■ Designed and executed experiments, analyzed the experimental results and solved problems related to the development of pharmaceutical products using HPLC-UV/PDA.

■ Executed analytical method development and validation projects for different formulations, stability study samples and methods of dosage forms.

■ Participated in audits by International Organization for Standardization 9001:2000. May 2006 - Aug 2006, Summer Intern, BASF India Ltd., Mumbai, India

■ Validated synthetic routes for [EMIM]Cl and related imidazolinium ionic liquids and transferred the processes for plant-scale production.

EDUCATION

2009-2015, Ph.D., Organic Chemistry, University of Missouri - Kansas City, Advisor: Dr. Keith Buszek Thesis title: “Part I. Investigations into the Remarkable Regioselectivity of 6,7-Indole Aryne Cycloadditions with 2- Substituted Furans. Part II. The Regioselective Metal-Halogen Exchange Studies of Polybromoindole Scaffolds and their Applications to Natural Products Total Synthesis, Library Development and Targeted Drug Design.” 2005-2007, M.S., Organic Chemistry, University of Mumbai SKILLS, SOFTWARE & INSTRUMENTATION

Synthetic Methodology

Microwave Synthesis

Library Synthesis

Multi-Step Synthesis

SAR Optimization

Parallel Synthesis

Air- and Moisture Sensitive Reactions

Complex Small Molecule Synthesis

Chemical Databases LC/MS, HPLC, MS IR, UV-VIS, NMR Column Chromatography ChemDraw Scifinder MestreNova Microsoft Office Suite Alok Nerurkar, Ph. D.

Madison, WI

636-***-****

ac7qch@r.postjobfree.com

https://www.linkedin.com/in/aloknerurkar/

United States Permanent Resident

Curriculum Vitae

PEER REVIEWED PUBLICATIONS

■ Nerurkar, A.; Jaffett, V.; Cao, X.; Golden, J. E. “Facile Synthesis of Novel Amidobenzamidines via an Intramolecular Rearrangement of Substituted Quinazolinones”, 2018, Manuscript in Preparation.

■ Nerurkar, A.; Buszek K. R. “Regioselective Cycloadditions of Indole-Arynes Derived from Tribromoindoles and their Applications in Library Development”, J. Org. Chem., 2018, Submitted.

■ Buszek, K. R.; Brassfield, H. A.; Brown, N.; Chandrasoma, N.; Luo, D.; Maina, L. W.; Nerurkar, A.; Pathmanatha, S.; Suarez, S. “Total Synthesis of the Trikentrins and Herbindoles. 6,7-Annulated Indole Alkaloids via Intermolecular Indole Aryne Cycloaddition”, in Strategies and Tactics in Organic Synthesis, 2018, Invited- Manuscript in Preparation.

■ Nerurkar, A.; Chandrasoma, N.; Maina, L.; Brassfield, A.; Luo, D.; Brown N.; Buszek K. R. “Further Investigations into the Regioselectivity of 6,7-Indole Aryne Cycloadditions with 2-Substituted Furans; Remarkable Contrasteric Preference Depends on Pyrrole and Benzene Ring Substitution”, Synthesis, 2013, 45, 1843-1852.

■ Chandrasoma, N.; Brown N.; Brassfield, A.; Nerurkar, A.; Suarez, S.; Buszek K. R. “Total Synthesis of -cis- Trikentrin B via Intermolecular 6,7-Indole Aryne Cycloaddition and Stille Cross-Coupling." Tetrahedron Lett. 2013, 54, 913-917.

PRESENTATIONS (selected – 5 of 19)

■ Nerurkar, A.; Buszek. K. R. "Tribromoindoles as Versatile Intermediates for Regioselective Metal-Halogen Exchange, Indole-Aryne Formation, and Further Reactions: Synthesis and Reactions of 4,5,6- and 4,5,7- Tribromoindoles.” 51st American Chemical Society Midwest Regional Meeting, St. Joseph, MO, October 21-24, 2015 (Abstract: MWRM 247 - Poster)

■ Nerurkar, A.; Chandrasoma, N.; Maina, L.; Brassfield, A.; Luo, D.; Brown, N.; Buszek. K. R. "Further Investigations into the Regioselectivity of 6,7-Indole Aryne Cycloadditions with 2-Substituted Furans: Remarkable Contrasteric Preference Depends on Pyrrole and Benzene Ring Substitution.” 49th American Chemical Society Midwest Regional Meeting, Columbia, MO, November 12-15, 2014 (Abstract: MWRM 428 - Poster)

■ Nerurkar, A.; Chandrasoma, N.; Maina, L.; Brassfield, A.; Luo, D.; Brown, N.; Buszek. K. R. "Further Investigations into the Regioselectivity of 6,7-Indole Aryne Cycloadditions with 2-Substituted Furans: Remarkable Contrasteric Preference Depends on Pyrrole and Benzene Ring Substitution.” 247th American Chemical Society National Meeting, Dallas, TX, March 16-20, 2014. (Abstract: ORGN 65 - Oral)

■ Nerurkar, A.; Chandrasoma, N.; Maina, L.; Brassfield, A.; Luo, D.; Brown, N.; Buszek. K. R. "Further Investigations into the Regioselectivity of 6,7-Indole Aryne Cycloadditions with 2-Substituted Furans: Remarkable Contrasteric Preference Depends on Pyrrole and Benzene Ring Substitution." 48th American Chemical Society Midwest Regional Meeting, Springfield, MO, October 16-19, 2013. (Abstract: MWRM 166 - Oral)

■ Nerurkar, A.; Brown, N.; Luo, D.; Brassfield, A.; Chandrasoma, N.; Maina, L. W.; DeCapo, J.; Suarez, S.; Kaye, B.; Drossos, P.; Pathmanathan, S.; Robinson, J.; Adair, T.; Buszek, K. R. "Practical Synthetic Routes to Polyhaloindole Scaffolds: Versatile Platforms for the Total Synthesis of Complex Natural Products and for the Construction of Novel Annulated Indole Libraries." 245th American Chemical Society National Meeting & Exposition, New Orleans, LA, April 7-11, 2013. (Abstract: ORGN 931 - Poster)



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