Engineering C

AYUSHI G UPTA

P hone: +91-926******* E mail: a ac3hk8@r.postjobfree.com Career O bjective

To join an organization which utilizes my knowledge of core foundation in engineering and biology and provide me with an opportunity to enhance my career and expose me to the various aspects of biomedical engineering a nd m edicine, t hereby a ccruing p ersonal a nd p rofessional s atisfaction. Academic C redentials

Integrated M .Tech ( c um l aude) B iomedical Engineering

2012-2017 IIIT-Allahabad C.G.P.I = 8 .61

XII, I .S.C 2009 SMC, A llahabad 81.60%

X, I .C.S.E 2007

SMC, A llahabad 86.40%

Internship: D epartment o f B iophysics, A IIMS, N ew D elhi ( December, 2 014 - J anuary, 2 015) Project: I dentification of inhibitors and their subsequent docking against M ycobacterium tuberculosis Thymidylate S ynthase u sing D iscovery S tudio 4 .0 Academic P rojects

● In S ilico p otential d rug t arget i dentification f or P seudomonas a eruginosa b iofilms Tools U sed: M aestro 9 .7 ( Schrodinger), U CSF C himera, N CBI B last. Description: T he aim of the project was to identify and inhibit the functioning a particular motif that l eads t o t he f ormation o f b iofilms. I t w as a chieved u sing t he m ethod o f c omputer a ided d rug design a nd d rug d iscovery.

● In S ilico d rug d esigning a gainst S taphylococcus a ureus b iofilms b y t argeting t he I ca g ene l ocus Tools U sed: R aptorX, R ampage, S chrodinger, D esmond m odule. Description: A n Ica gene operon was found to be the key to the generation of biofilms in S . aureus. Therefore, an inhibitor of the operon was found using structure based drug designing and the result was validated through the calculation of ADME properties and molecular dynamics simulation.

● Sustained d rug d elivery u sing o smotic p umps Tools U sed: M EMS F abrication T echniques.

Description: A Prototype of the osmotic pump was developed which achieved the goal of controlled drug release profile. All the materials used to develop the prototype were completely biodegradable a nd b iocompatible.

● Prototyping H RV d ata o n F PGA p latform

Tools U sed: X ilinx D esign T ools I SE 1 4.5, N exys 2 S partan, V irtex 5, V erilog. Description: A n algorithm for monitoring real-time electrocardiogram (ECG) was prototyped on FPGA platform. The FPGA chip is taken as the central microprocessor and applies structured design u sing V erilog h ardware d escription l anguage t o c ollect a nd t ransmit r eal-time E CG s ignals.

● M.Tech T hesis: B acteriocins

Tools U sed: E lectrophoresis, S pectrophotometer, G el D ock Description: Purification and characterisation of bacteriocins obtained from Lactic Acid Bacteria was done which included antimicrobial activity test and molecular mass determination of the peptide o btained.

Accomplishments

● Publication

Paper t itle: P revention o f I caA r egulated p oly N -acetyl g lucosamine f ormation i n Staphylococcus a ureus b iofilm t hrough n ew-drug l ike i nhibitors: I n s ilico a pproach a nd M D simulation s tudy

Published i n: M icrobial P athogenesis: E LSEVIER ( SCI J ournal) DOI: h ttp://dx.doi.org/10.1016/j.micpath.2017.05.025

Paper t itle: I n s ilico p otential d rug t arget i dentification f or P seudomonas a eruginosa biofilm

Published i n: C omputing f or S ustainable G lobal D evelopment ( INDIACom), 2 015 2 nd International C onference.

Publisher: I EEE

Page(s 8 63 – 8 67

Print I SBN: 9 78-9-3805-4415-1

INSPEC A ccession N umber: 1 5110176

● Chapter i n a n e dited B ook

Chapter t itle: “ M icrobial b iofilms: d evelopment, t reatment a nd p revention i n m edical i mplants” Pages o f t he m entioned c hapter: 445-451

Book t itle: “The B attle a gainst M icrobial P athogens: B asic S cience, T echnological A dvances a nd Educational P rograms”

Editor: A . M éndez-Vilas

Publisher: F ormatex R esearch C enter

Volume 1 I SBN ( 13 9 78-84-942134-6-5

Publication d ate: D ecember 2 015

● Exams Q ualified

Gate: 2 017 ( Life S ciences: B iochemistry a nd m icrobiology)

S core – 4 41

CSIR – U GC – N ET: L S – R ank 3 9 ( Life S ciences) Skill s ets a nd I nterests

● Programming S kills : C C V erilog(Basic)

● Software/ P ackages U sed: M atlab, S chrodinger, A utoDock, D iscovery S tudio, G romacs, P yMol, Chimera, X ilinx, W eka.

● Wet L ab T echniques U sed: P rotein e xtraction a nd p urification, E LISA, S DS – P AGE, Chromatography, M olecular b iology t echniques.

● Interests: D rug D esigning,Bioinformatics, M olecular B iology, D rug D elivery a nd N anostructure based d iagnostics, W riting a nd E diting r esearch a rticles.

I h ereby d eclare t hat t he i nformation g iven a bove i s c orrect t o t he b est o f m y k nowledge. Place: B engaluru

Date: 7 N ov, 2 017

(Ayushi G upta)

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