Data Analysis
Resume:
Jie Liu
ac1uao@r.postjobfree.com
**E *0th Ave. Apt 6 San Mateo, CA 94403 213-***-**** WORKING EXPERIENCE
Gilead Sciences Inc. Foster City, CA
Biostatistician in Hematology/Oncology Group Jan 2017- Present Study statistician for two Phase 1b clinical trials to evaluate the safety and efficacy of study drug in cancer patients
Contributed to the sections of protocols that require statistical input
Developed statistical analysis plans (SAPs), table, listing and figure (TLF) shells
Worked with statistical programmers to complete statistical analysis
Participated in department and cross-functional meetings Played a key role in a Phase 3 study in patients with advanced gastric or gastroesophageal junction adenocarcinoma
Validated futility boundary based on conditional and predictive power
Event projection for futility interim analysis
Explored potential delayed treatment effect through intensive simulations
Computed cumulative incidence rate for Venous thromboembolism (VTE)
Reviewed TFLs and validated key results
BioMarin Pharmaceutical Inc. Brisbane, CA
Intern May -Aug. 2016
Design and analysis for a Phase 3 study of Pegvaliase for Phenylketonuria (PKU)
Help to determine the secondary endpoints by thorough literature reviews
Analyze data from a Phase 3 randomized discontinuation design and participate in the preparation of FDA submissions
USC Norris Comprehensive Cancer Center Los Angeles, CA Research Assistant Aug. -Dec. 2015
Evaluation of the effect of Adriamycin on survival in patients with hepatoblastoma
Investigated the methods of treatment assignment and trial size calculation
Conducted interim analysis including effectiveness and futility monitoring EDUCATION
University of Southern California Los Angeles, CA
Ph.D. in Biostatistics GPA: 3.9/4.0 Aug. 2012- Dec. 2016 Dissertation: Statistical Analysis of High-throughput Genomic Data
Evaluated and compared processing methods for Infinium HumanMethylation450 BeadChip data
Presented the results in International Chinese Statistical Association (ICSA) conference as an invited speaker
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Proposed a novel Lasso variant to improve prediction of disease subtypes in multiple high-dimensional genomic data integration
Explored the performance of Lasso variant in both intensive simulation settings and real cancer data sets
Nankai University Tianjin, China
B.M, M.S, Clinical Medicine (7-year-program) Sept. 2005 - June 2012 GPA: 88.9/100 (3.8/4.0), top 5% ranking
SKILLS AND TECHNIQUES
Statistical and analytical software including SAS, R, EAST, PASS, Python, S-Plus, and STATA
Statistical analyses including linear and logistic regression analysis, longitudinal analysis, survival analysis, and multivariate analysis
Statistical modeling (generalized and linear mixed models)
Strategies in treatment allocations, calculation of sample size and power
Bayesian analysis, adaptive designs, and biomarker analysis
Experimental design, statistical graphics, clustering analysis, and multiple testing
UNIX environment, high performance computing
HONORS AND AWARDS
EDGE & APD Fellowship, granted by USC Graduate School, supported travel accommodations and conference fees for SQG Conference in Seattle, 2013 CSST Scholarship, granted by UCLA to support the summer research program, 2011 National Scholarship, the highest honor granted by the Ministry of Education of People’s Republic of China, 2008
Tianjin Government Scholarship, the highest honor granted by Tianjin Government, 2007
PUBLICATIONS AND ABSTRACTS
Liu J, Siegmund KD. An evaluation of processing methods for HumanMethylation450 BeadChip data. BMC Genomics (2016) 17:469. (Methodology Article) Liu J, Chopra S, Nichols PW, Liang GN, Sigmund KD. Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers. Oncotarget
(2016) (Clinical Research Paper)
Liu J, Siegmund KD, Lewinger JP. Multi- tuning parameter Lasso Regression for Sample Classification. Abstracts of Papers, Joint Statistical Meetings, Chicago, Illinois, 2016 Liu J, Siegmund KD. An evaluation of processing methods for HumanMethylation450 BeadChip data. Abstracts of Papers, ICSA/Graybill Conference, Fort Collins, CO, June 2015. Abstract and Presentation 54
Liu J, Gao CJ. B cells and graft-versus-host disease. Chinese Journal of Hematology, 2012, 33(8): 679-82
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