Senior Scientist, polymer, organic chemistry, analytical chemistry

Alexander Marin, Ph.D.

857-***-**** (cell)

***********@*******.***

OBJECTIVE

Research and Development position in biotechnology

SUMMARY of qualificationS

. Extensive R&D experience in biotech industry

. In-depth knowledge in organic synthesis and purification, polymer

synthesis and modification

. Strong expertise in analytical and physical chemistry, including various

instrumental techniques: HPLC, GPC-MALLS, GC, CE, GC MS, DLS, SLS, DSC,

FTIR, UV-Vis, fluorescence spectroscopy, NMR, EPR

. Strong background in biopolymers and drug delivery using biopolymers

. Expertise in intradermal vaccine/drug delivery

. Scientific leadership in private and academic sectors

. Project management experience (supervised teams of Ph.D, MS, and BS

researchers)

. Track record of innovations: 14 US issued and pending patents, 16 foreign

patents

. Publications: 115 technical papers in peer reviewed US and international

journals, and book chapters

. Invited speaker to numerous international conferences

. Excellent communication and interpersonal skills

PROFESSIONAL EXPERIENCE

Apogee Technology Inc., Norwood, MA

Principal Scientist (06.2006-02. 2013)

. Responsible for R&D of intradermal vaccine/drug delivery systems,

including experimental design, formulation and analytical work

. Developed an efficient method for increasing stability of proteins in

liquid and solid state

. Developed a new method for controlled release of drugs from microneedles

. Developed and optimized the coating process of microneedles

. Set up a new laboratory to perform formulation/analytical work

. Supervise a team of MS and BS researchers

Parallel Solutions Inc., Cambridge, MA

Program Manager (2002-2006)

Head of Chemical Laboratory, responsible for organic synthesis and

analytical work

Supervised a team of MS, BS researchers; prepared technical reports and

scientific papers

Research & Methods Development

. Generated combinatorial libraries of 300 novel biologically active

polymers for drug delivery applications

. Studied correlation between formation of non-covalent antigen-polymer

complexes and immunostimulanting activity.

. Investigated biopolymer-protein interactions using HPLC-MALLS

. Analyzed and characterized polyphosphazenes, their degradation products,

and potential impurities

. Developed a single-step substitution synthesis of sulfonated

polyphosphazenes using "non-covalent protection"

. Synthesized new biodegradable polyphosphazenes for drug-eluting stents

University of Utah, Bioengineering Department, Salt Lake City, UT

Research Associate (1999-2002)

Carried out study on drug release from polymer vesicles. Set up a new

laboratory including chemistry and cell biology facilities. Supervised a

team of researchers (PhD and graduate students).

Research & Methods Development

. Developed ultrasound activated method for drug delivery to cancer cells

using polymeric micelles

. Conducted study on drug interaction with cell components and viable

cells, intracellular drug trafficking and cell killing

. Analyzed doxorubicin released from polymer micelles under ultrasound

University of Ancona, Department of Material Sciences, Ancona, Italy

Visiting Professor (1992-1999)

Conducted study on polymer degradation and stabilization, presented

lectures on physical chemistry of polymers for staff and graduate students.

Research & Methods Development

. Synthesized new aromatic amines and nitroxides as thermal stabilizers for

polyolefins

. Developed a novel method of spin labeling of polymer chain to study

macromolecular motion

. Developed a method to investigate charge-transfer complexes in a polymer

matrix

. Conducted research on diffusion, solubility and loss of high molecular

weight triazinic stabilizers in polyolefins

. Identified the role of cell wall components in metal uptake by fungi

. Studied the mechanism of interaction between aminoxyl radicals and

phosphites during polymer oxidation

Institute of Chemical Physics Russian Academy of Sciences, Moscow, Russia

Scientist, Senior Scientist (1985-1992)

Head of polymer additive research group, supervised Ph.D. scientists and

Ph.D graduates

Research & Methods Development

. Developed and experimentally validated a theory for dissolution of

additives in polymers

. Investigated kinetics of mono- and bimolecular chemical reactions in

polymers based on non-uniform additive distribution

. Developed accelerated testing method to evaluate the antioxidative

stability of polymers

. Developed a new stabilizer package to suppress yellowing of plasticized

poly(vinyl butyral)

. Identified the mechanism of stabilization of gossipol and gossipol resins

. Conducted study on sorption of ions and organic compounds by

biopolymers: (cellulose, chitin, chitosan, biomass of microorganisms);

invented new sorbents for water purification from heavy and radioactive

metals

. Developed efficient and inexpensive method of fruit juice purification,

based on natural biopolymers

EDUCATION

Dr.Sc., Ph.D., Polymer Chemistry, Institute of Chemical Physics, Russian

Academy of Sciences, Moscow, Russia

MS, Physical Chemistry, State University of Nizhny Novgorod, Nizhny

Novgorod, Russia

LIST OF RECENT PUBLICATIONS

Papers

1. A. Marin, A.K. Andrianov. Carboxymethylcellulose-Chitosan coated

microneedles with modulated hydration properties. J. Appl. Polymer. Sci.

121(1):395-401 (2011).

2. A.K. Andrianov, D.P. Decollibus, A. Marin, A. Webb, Y. Griffin, R.J.

Webby. PCPP-formulated H5N1 influenza vaccine displays improved stability

and dose-sparing effect in lethal challenge studies. J. Pharm. Sci. 100

(4): 1436-1443 (2011).

3. D.P. Decollibus, A., Marin, A.K. Andrianov. Effect of environmental

factors on hydrolytic degradation of water-soluble polyphosphazene

polyelectrolyte in aqueous solutions. Biomacromolecules. 11(8):2033-8

(2010).

4. A. Marin, D.P. Decollibus, A.K. Andrianov. Protein stabilization in

aqueous solutions of polyphosphazene polyelectrolyte and non-ionic

surfactants. Biomacromolecules. 11(9):2268-73. (2010).

5. A.K. Andrianov, A.P. Marin, D.P. DeCollibus. Microneedles with intrinsic

immunoadjuvant properties: microfabrication, protein Stability, and

modulated release. Pharm. Res. 28(1):58-65 (2010).

6. A.K. Andrianov, D.P. DeCollibus, H.A. Gillis, H.H. Kha, A. Marin, M.R.

Prausnitz, L. A. Babiuk, H.Townsend, G. Mutwiri.

Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for

intradermal immunization. PNAS, 106,189**-***** (2009).

7. A.K. Andrianov, A. Marin, P. Peterson, J. Chen. Fluorinated

polyphosphazene polyelectrolytes. Journal Appl. Polymer Sci.103(1):53-58

(2007).

8. A.K. Andrianov, A. Marin. Degradation of Polyaminophosphazenes: Effects

of hydrolytic environment and polymer processing Biomacromolecules, 7

(5), 1581-1586 (2006).

9. A. Andrianov, A. Marin, Jianping Chen. Synthesis, properties, and

biological activity of

poly[di(sodiumcarboxylatoethylphenoxy)phosphazene]. Biomacromolecules, 7,

394-399. (2006).

10. A. Andrianov, A. Marin, B. Roberts. Polyphosphazene polyelectrolytes: A

link between the formation of noncovalent complexes with antigenic

proteins and immunostimulanting activity. Biomacromolecules. 6(3); 1375-

1379 (2005).

11. A. K. Andrianov, A. Marin, P. Peterson. Water-soluble biodegradable

polyphosphazenes containing N-Ethylpyrrolidone Groups. Macromolecules,

38 (19), 7972-7976 (2005).

12. A. Andrianov, A. Marin, J. Chen, J. Sargent, N. Corbet. Novel route to

sulfonated polyphosphazenes: Single-step synthesis using "non-covalent

protection" of sulfonic acid functionality. Macromolecules. 37(11), 4075

- 4080 (2004).

13. A.K. Andrianov, A. Marin, J.R. Sargent, J. Chen. Synthesis of

polyphosphazenes with sulfonic acid functionalities using noncovalent

protection methods. Polymer Preprint.;44(1):724-725 (2003).

14. A. Andrianov, A. Marin, B. Roberts. Polyphosphazene polyelectrolytes: A

link between the formation of noncovalent complexes with antigenic

proteins and immunostimulanting activity. Biomacromolecules. 6, (2005).

15. A. Andrianov, A. Marin, Jianping Chen, J. Sargent, N. Corbet. Novel

Route to sulfonated polyphosphazenes: Single-step synthesis using "non-

covalent protection" of sulfonic acid functionality. Macromolecules.

37(11) 4075 - 4080 (2004).

16. A. Andrianov, A. Marin, J.R. Sargent, J. Chen. Synthesis of

polyphosphazenes with sulfonic acid functionalities using non-covalent

protection methods. Polymer Preprints, 44(1), 724 (2003).

17. A. Marin, L. Greci, P. Dubs. Physical behavior of 3-aryl-benzofuran-2-

ones (Irganox HP-136) in polypropylene. Polym. Degrad. Stab. 78(2), 263-

267 (2002).

18. A. Marin, L. Greci, P. Dubs. Antioxidative activity of 3-aryl-

benzofuran-2-ones (Irganox HP-136) in polypropylene. Polym. Degrad. Stab.

76(3), 489-494 (2002).

19. A. Marin, H. Sun, G.A. Husseini, W.G. Pitt, D.A. Christensen, N.Y.

Rapoport. Drug delivery in pluronic micells: effect of high-frequency

ultrasound on drug release from micelles and intracellular uptake. J.

Control. Release. 84(1-2), 39-47 (2002).

20. N. Rapoport, A. Marin, Y. Luo, G.D. Prestwich, M.D. Muniruzzaman.

Intracellular uptake and trafficking of Pluronic micelles in drug

sensitive and MDR cells: effect on the intracellular drug localization.

J. Pharm. Sci. 91(1), 157-170 (2002).

21. A. Marin, M. Muniruzzaman, N. Rapoport Mechanism of the ultrasonic

activation of micellar drug delivery. J. Control. Release. 75(1-2), 69-81

(2001).

22. N. Rapoport, A. Marin, M. Muniruzzaman. Micellar drug delivery to drug

resistant cells using ultrasonic activation. Polymeric Materials:

Science & Engineering., 84, 970-971 (2001).

23. A. Marin, M. Muniruzzaman, N. Rapoport. Acoustic activation of drug

delivery from polymeric micelles: effect of pulsed ultrasound. J.

Control. Release. 71(3), 239-249 (2001).

24. N. Rapoport, A.P. Marin, A. A. Timoshin. Effect of a polymeric

surfactant on electron transport in HL-60 cells. Arch. Bioch. Bioph. 384

(2000).

25. A.P. Mar'in, M. Bonora, L. Greci. Washing out of oligomeric triazinic

hindered amine from polypropylene. Appl. Polym. Sci., 78, 2158-2165

(2000).

26. A. P. Mar'in, V. Borzatta, M. Bonora, L. Greci. Solubility of high

molecular weight, sterically hindered amines in polypropylene. J. Appl.

Polym.Sci., 75 (7), 883-889 (2000).

27. A. P. Mar'in, V. Borzatta, M. Bonora, L. Greci. Diffusion of high

molecular weight, sterically hindered amines in polypropylene. J. Appl.

Polym.Sci., 75 (7) 890-896 (2000).

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