Medical University
Resume:
Jae-Kyung Lee, Ph.D. CV
Curriculum Vitae
Jae-Kyung Lee, Ph.D.
PERSONAL INFORMATION:
Name: Jae-Kyung Lee
Address: Emory University School of Medicine
Department of Physiology
*** ******* ******, Room 605K
Atlanta, GA, 30322
*******@*****.***
404-***-**** (Office) 817-***-**** (Cell)
CITIZENSHIP: South Korea (U.S. Permanent Resident)
FAMILY: Husband, 2 sons (Younghun (8); Sungroc (3))
EDUCATION:
1997 B.S. (Biology) Kyungpook National University, South Korea
1999 M.S. (Biology) Kyungpook National University, South Korea
2005 Ph.D. (Biomedical Sciences) University of North Texas Health Science Center at Ft.
Worth, TX, Mentor: Dr. Porunelloor A. Mathew
2006 Post. doc. fellow, Department of Pathology, University of Texas Southwestern
Medical Center at Dallas, TX, Mentor: Dr. Richard Scheuermann
2008 Post. doc. fellow, Department of Physiology, University of Texas Southwestern
Medical Center at Dallas, TX, Mentor: Dr. Malu G. Tansey
ACADEMIC APPOINTMENTS:
2010-current Assistant Professor (Research-track), Department of Physiology, Emory University
School of Medicine, Atlanta, GA
2010 Instructor, Department of Physiology, University of Texas Southwestern Medical
Center at Dallas, TX
HONORS AND AWARDS:
2004 The Sigma Xi Grant-in-Aid of Research Grant Award
2005 Outstanding Graduate Student Award, Graduate School of Biomedical Science
2008 American Association of Immunology Trainee Award, Experimental Biology
2008 Postdoctoral Research Certificate, UT Southwestern Medical Center at Dallas
Invited panelist, 1st KWiSE Bio Summit Meeting, UKC
2011
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Jae-Kyung Lee, Ph.D. CV
RESEARCH SUPPORT:
Current Supports:
Source: University Research Committee, Emory University
Role: PI
Dates: 5/12-4/13
Direct Funds: $30,000
Title: Neuroprotective role of neuronal RGS10 in nigrostriatal degeneration.
Source: 1R01 NS072467-01 NIH/NINDS
Role: Co-I (50%)
PI: Dr. Malu Tansey
Dates: 9/10-7/15
Direct Funds: $1,250,000
Title: RGS10 in microglia activation and dopaminergic neuron survival.
Target Validation Grant, Michael J. Fox Foundation for Parkinson s Research
Source:
Role: Co-I (10 %)
PI: Dr. Jerry Boss
Dates: 6/11-5/13
Direct Funds: $220,000
Role of PARK18 in Parkinson s disease.
Title:
Past Extramural Support:
Target Validation Grant, Michael J. Fox Foundation for Parkinson s Research
Source:
Role: Co-PI
PI: Lee/Tansey
Dates: 6/08-5/10
Direct Funds: $250,000/yr
Title: Dopaminergic Neuroprotection by RGS10.
Past Intramural Support:
Source: 5P01 ES016731Parkinson's disease Collaborative Environmental Research Center
Pilot Grant
Role: PI (Pilot Grant)
PI: Dr. Garry Miller
Dates: 7/10-6/11
Direct Funds: $25,000
Neuroinflammation and RGS10 in Parkinson s disease.
Title:
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Jae-Kyung Lee, Ph.D. CV
Pending Supports:
Source: 1R01 NS082272-01 (Lee) NIH/NINDS,
Role: PI
Direct Funds: $1,250,000
Title: Neuroprotective role of neuronal RGS10.
Source: National Multiple Sclerosis Society Pilot Grant
Role: PI
Direct Funds: $40,000
Title: Role of RGS10 in mouse EAE.
PUBLICATIONS:
From MS Graduate Studies with Dr. S.S. Kang
1. Lee JK, Jung JC, Chun JS, Kang SS, Bang OS. (2002) Expression of p21 WAF1 is dependent on
the activation of ERK during Vitamine E-Succinate-Induced Monocytic differentiation. Mol. Cells
28: 13(1): 125-129.
From PhD Graduate Studies with Dr. P.A. Mathew (2000-2006)
2. Chuang SS, Lee JK and Mathew PA. (2003) Protein kinase C is involved in 2B4 (CD244)-
mediated cytotoxicity and AP-1 activation in NK cells. Immunology 109: 432-439.
3. Lee JK, Boles KS, Mathew PA. (2004) Molecular and functional characterization of a CS1
(CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor
tyrosine-based switch motifs. Eur. J. Immunol. 34: 2791-2799.
4. Vaidya SV, Stepp SE, McNerney ME, Lee JK, Bennett M, Lee KM, Stewart CL, Kumar V,
Mathew PA. (2005) In vivo Role of 2B4 (CD244) in Tumor Rejection as Revealed by Differential
Metastasis of B16 Melanoma Cells in 2B4-/- Mice. Journal of Immunology 174:800-807.
5. Mathew SO, Kumaresan PR, Lee JK, Huynh VT, Mathew PA. (2005) Mutational analysis of the
human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for
CD48 binding and functional activation of NK cells. Journal of Immunology 175: 1005-13.
6. Lee JK, Mathew, SO, Vaidya SV, Kumaresan PR, Mathew PA. (2007) CS1 (CRACC) induces
Proliferation and Ig Synthesis by Activated human B Lymphocytes. Journal of Immunology 179:
4672-4678.
From Postdoctoral Studies with Dr. M.G. Tansey (2006-2010)
7. Tansey MG, Frank-Cannon TC, McCoy MK, Lee JK, Martinez TN, McAlpine FE, Ruhn KA, Tran
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Jae-Kyung Lee, Ph.D. CV
TA. (2008) Neuroinflammation in Parkinson s disease: Is there sufficient evidence for mechanism-
based interventional therapy? Frontiers in Bioscience 13: 709-717.
8. Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG. (2008) Regulator of G-protein
signaling-10 (RGS10) promotes dopaminergic neuron survival via regulation of the microglial
inflammatory response. Journal of Neuroscience, 28(34):8517-28.
Lee JK, Tran T, Tansey MG. (2009) Microglia and Neuroinflammation in Parkinson s disease.
9.
Journal of Neuroimmune Pharmacology, 4:419 429. review
10. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Hong J, Das P, Golde TE, LaFerla FM, Oddo S,
Blesch A, Tansey MG. (2009) Inhibition of soluble TNF signaling in a mouse model of
Alzheimer's disease prevents early amyloid-associated neuropathology. Neurobiology of Disease,
Apr; 34 (1): 163-77.
From studies as Research Assistant Professor at Emory University (2010-current)
11. Tran T, Nguyen AD, Chang JJ, Goldberg MS, Lee JK*, Tansey MG*. (2011) Lipopolysaccharide
and Tumor Necrosis Factor regulate Parkin expression via Nuclear Factor-Kappa B. Plos One,
6(8): e23660. doi:10.1371/journal.pone.0023660. *corresponding author
12. Lee JK, Chung J, McAlpine FE, Tansey MG. (2011) Regulator of G-protein Signaling-10
negatively regulates NF-kB in microglia and neuroprotects dopaminergic neurons in
hemiparkinsonian rats. Journal of Neuroscience, 31(33):118**-*****.
13. Harms AS, Lee JK, Ruhn KM, Trevi I, Tansey MG. (2012) Regulation of Microglia Effector
o
Functions by Tumor Necrosis Factor (TNF): implications for anti-TNF therapy in the CNS. Glia
Feb; 60 (2):189-202.
14. Lee JK*, Chung J, Druey K, Tansey MG* (2012). Neuroprotective role of RGS10 in
dopaminergic neuronal through PKA/cAMP-response element binding protein (CREB) pathway.
Journal of Neurochemistry, 122 (2):333-343. *corresponding author
Lee JK*, Tansey MG. Microglia isolation from adult mouse brain. Microglia: Methods and
15.
Protocols invited book chapter (submitted). *corresponding author
16. Lee JK*, Chung J, Kannarkat G, Graham K, Tansey MG. RGS10 is essential for classical vs.
alternative activation of macrophages. *corresponding author (in preparation)
17. Kannarkat G, Choi NM, Lee JK, Cook D, Factor S, Boss JM, Tansey MG. The PARK18 SNP is
associated with altered expression and regulation of major histocompatibility complex II genes in
Parkinson s disease patients. (in preparation)
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Jae-Kyung Lee, Ph.D. CV
ABSTRACTS IN REFEREED CONFERENCE PROCEEDINGS;
1. Lee JK, Chung J, Kannakat G, Graham K, Tansey MG. RGS10 as a key regulator for the
classical vs. alternative activation of microglia and macrophages. 12th International Society of
Neuroimmunology Meeting 2012, Boston MA
2. Kannarkat G, Choi NM, Lee JK, Cook D, Factor S, Miller G, Boss JM, Tansey MG. The
PARK18 SNP is associated with altered expression and regulation of major histocompatibility
complex II genes in Parkinson s disease patients. 12th International Society of Neuroimmunology
Meeting 2012, Boston MA
3. Lee JK, Chung J, Druey K, Tansey MG (2012). RGS10 exerts a neuroprotective role through the
PKA/c-AMP response-element binding protein (CREB) pathway in dopaminergic neuron-like
cells. Program No. 659.06. Neuroscience Meeting Planner: Society for Neuroscience, New
Orleans, 2012. Online.
4. Kannarkat G, Choi NM, Lee JK, Cook D, Factor S, Boss JM, Tansey MG. The PARK18 SNP is
associated with altered expression and regulation of major histocompatibility complex II genes in
Parkinson s disease patients. Neuroscience Meeting Planner: Society for Neuroscience, New
Orleans, 2012. Online.
5. Tansey MG, Chung J, Lohr K, Kannakat G, Lee JK. RGS10 is essential for the regulation of
classical vs. alternative activation of microglia and macrophages. Program No. 667.07. 2011
Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011. Online.
6. Lee JK, Chung J, Tansey MG. Novel function of Regulator of G-protein Signaling 10 in mouse
dopaminergic neuron; direct neuroprotective role of RGS10. Program No. 321.03. 2011
Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011. Online.
7. Ramsey CP, Lee JK, Tansey MG. Studies of regulator of G-protein signaling 10 reveal distinct
biochemical properties in neuronal versus glial cell types. Program No. 554.01, 2011.
Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011. Online.
8. Lee JK, Chung J, McAlapine F, Tansey MG. Regulator of G-protein Signaling-10 negatively
regulates NF-kB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats.
US Korea Conference on Science, Technology and Entrepreneurship (UKC), Aug. 2011, Park
City, Utah.
9. Lee JK, Chung J, McAlpine FE, Tansey MG. Regulator of G-protein signaling-10 (RGS10)
regulates microglia activation in nigral neurodegenerative pathway. 4rd RGS Protein
Colloquium, April 2011, Washington DC.
10. Lee JK, Chung JG, Traveno I, Tansey MG., Mechanism of RGS10 regulation in microglia and
neuroprotective effects of RGS10 overexpression in a rat model of Parkinson s disease. Society
of Neuroscience 2010 in San Diego, CA. Session; Neuron-Glia Interactions: Response to Cell
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Jae-Kyung Lee, Ph.D. CV
Stress and Injury, 345.20, H37.
11. Lee JK, McCoy MK, Harms AS, Keefer E, Ruhn K, Tansey MG., Mechanism of Regulator of G-
protein Signaling 10 in regulating microglia activation and DA neuron survival in the ventral
midbrain. Society of Neuroscience 2008 in Washington, D.C. Session; Neuroinflammation and
Neurodegeneration II, DD27.
12. Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, and Tansey MG. Regulator of G-protein
signaling (RGS10) regulates microglial response to chronic inflammatory stimuli and impacts
dopaminergic neuron survival. 3rd RGS Protein Colloquium April 2008, San Diego, CA.
13. Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, and Tansey MG. Regulator of G-protein
signaling (RGS10) regulates microglial response to chronic inflammatory stimuli and impacts
dopaminergic neuron survival. Experimental Biology 2008, American Association of
Immunologists, April 2008, San Diego, CA.
14. Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG. Regulator of G-protein
Signaling (RGS10) promotes dopaminergic neuron survival via regulation of the microglial
inflammatory response. 5th Annual Postdoctoral Symposium & Poster Session, December, 2007,
Dallas, Texas.
15. Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG. Regulator of G-protein
Signaling (RGS10) promotes dopaminergic neuron survival via regulation of the microglial
inflammatory response. Society of Neuroscience, Nov. 2007, San Diego, CA. Poster #605.10.
16. Sinha SK, Lee J, Bai X, Lee JK, Liu S, Scheuermann RH. CKLFSF8-A novel component of the
antigen processing and presentation pathway revealed by microarray analysis following B cell
antigen receptor (BCR) stimulation. American Association of Immunologists, May 2006, Boston,
MA. Poster #B128.
17. Lee JK, Lee JA, Sinha SK, Liu S, Bai X and Scheuermann RH. Functional study to evaluate
Candidate Molecules involving Antigen Processing and Presentation Pathway following B cells
antigen receptor (BCR) stimulation. The University of Texas Southwestern Medical Center at
Dallas, Laboratory of Molecular Pathology Annual Scientific Retreat, February, 2006, Dallas,
TX.
18. Lee JK, Lee JA, Scheuermann RH. Functional study to evaluate Candidate Molecules involving
Antigen Processing and Presentation Pathway following B cells antigen receptor (BCR)
stimulation. The University of Texas Southwestern Medical Center at Dallas, Third Annual
Postdoctoral Symposium & Poster Session, December, 2005, Dallas, Texas.
19. Lee JK and Mathew PA. Characterization of a Novel Receptor CS1 (CRACC) in Human B-
Lymphocytes. Research appreciation Day, April, 2005, Fort Worth, Texas.
20. Lee JK, Boles KS and Mathew PA. Characterization of a novel CS1 splice variant in human NK
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Jae-Kyung Lee, Ph.D. CV
cells. Experimental Biology 2004, American Association of Immunologists, April, 2004,
Washington DC.
21. Lee JK and Mathew PA. Characterization of a Novel Receptor CS1 in Human Lymphocytes.
Research appreciation Day, April 2, 2004, Fort Worth, Texas.
22. Lee JK, Kumaresan PR, Boles KS and Mathew PA. Molecular characterization of a novel CS1
splice variant in human NK cells. American Association of Immunologists 90th Anniversary
Annual Meeting, May, 2003, Denver, Colorado.
23. Vaidya S, Stepp S, Lee JK, Stewart C, Bennett M, Kumar V and Mathew PA. In vivo role of 2B4
in tumor rejection as revealed by differential metastasis of B16 melanoma in 2B4 deficient male
and female mice. American Association of Immunologists 90th Anniversary Annual Meeting, May,
2003, Denver, Colorado.
RESEARCH PRESENTATIONS:
2012
Invited Speaker, Korean-American Women in Science and Engineering, East Chapter Annual
Conference 2012, Dec. 8th. Hosted by Dr. Sunyoung Cho, title: Role of Neuroinflammation in
Neurodegenerative diseases.
Invited Speaker, Rutgers University, Department of Cell Biology and Neuroscience, Mar. 28th.
Hosted by Dr. Kerl Herrup, title: Novel function of RGS10 in Neuroinflammation and models of
Parkinson s disease.
Seminar Speaker, Emory University, Center for Neurodegenerative Diseases, Feb. 23rd, title: Role
of RGS10 in neuroinflammation and models of Parkinson s disease.
Seminar Speaker, Emory University, Transporters Workers Union Seminar, Feb. 17th, title: Role of
RGS10 in neuroinflammation and models of Parkinson s disease.
2011
Symposium Speaker, Society for Neuroscience, Washington D. C., Nov. 14th, title: Novel function
of RGS10 in mouse dopaminergic neuron; direct neuroprotective role of RGS10.
Seminar Speaker, Emory University School of Medicine, Department of Physiology, Oct. 13th,
title: RGS10 negatively regulates NF- B in microglia and neuroprotects dopaminergic Neurons in
hemiparkinsonian rats.
Symposium Speaker, US Korea Conference on Science (UKC2011), Technology and
Entrepreneurship, Aug. 11th, title: RGS10 negatively regulates NF- B in microglia and
neuroprotects dopaminergic Neurons in Hemiparkinsonian Rats.
2008
Symposium Speaker, Experimental Biology 2008, American Association of Immunologists, Apr.
7th, title: Regulator of G-protein signaling (RGS) 10 regulates microglial response to chronic
inflammatory stimuli and impacts dopaminergic neuron survival.
2004
Symposium Speaker, Research Appreciation Day, University of North Texas Health Science Center,
Apr. 9th, title: Characterization fo a Novel Receptor CS1 (CRACC) in Human Lymphocytes.
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Jae-Kyung Lee, Ph.D. CV
ACTIVITIES AND SERVICES:
Professional Society:
Society for Neuroscience (Member) (2005-present)
American Association of Immunologists (Member) (2002-present)
International Society of Neuroimmunology (Member) (2010-present)
Korean-American Scientists and Engineers Association (Member) (2010-present)
Korean-American Women in Science and Engineering (Member) (2010-present)
Sigma Xi, The scientific research society (Associate Member) (2004-2009)
Society of Experimental Biology (Student member) (2000-2001)
National Service:
Journal Reviewer:
Journal of Neuroscience (2009-present)
Journal of Neuroinflammation (2010-present)
Neuroimmune Modulation (2010-present)
British Journal of Pharmacology (2011-present)
Journal of Neurochemistry (2010-present)
Neuroscience (2010-present)
Plos One (2010-present)
Journal of Neuroscience Research (2012-present)
TEACHING EXPERIENCES:
Teaching graduate students at UT Southwestern Medical Center: Bruno Britto, Carly Hale, Ankur Patel,
Emi Sei, Robert Orchard, and Randy Parker, Group Problem Solving (GPS) Postdoc Leader, Fall 2008,
Graduate School of UT Southwestern Medical School, my group was graded the highest score in the
class.
Supervising Dr. Tansey s laboratory at UT Southwestern Medical Center (2009-2010)
Laura Alto, Ph.D., Post-doc
Yelenis Marie, Ph.D., Post-doc
Thi Tran, Ph.D. Candidate
Terina Martinez, Ph.D. Candidate
Ashley Harms, Ph.D. Candidate
Kelly Ruhn, Lab manager, Research technician
Issacc Trevi Research technician
o,
Research Supervising:
Adebimpe Kasumu, Ph.D. student, UT Southwestern Medical School, Fall 2008
Anna Miller, Ph.D. student, UT Southwestern Medical School, Fall 2008
Anju Sreelatha, Green undergrad. fellow, UT Southwestern Medical School, Spring 2009
Constance Harrell, MD/Ph.D. Student, Emory University, Spring 2011
Kelly Lohr, Ph.D. Student, Neuroscience program, Emory University, Spring 2011
George Kannakat, MD/Ph.D. Student, Emory University, Spring 2011
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