Matthew B. Smith

** ******** ***** ****, ********** of Physics.

Bethlehem, PA. 18015

610-***-**** - abqj6d@r.postjobfree.com

Current Research

Modeling the dynamics of proteins using data collected from single-molecule

speckle microscopy experiments. Developing and implementing tools to analyze

fluorescent images of live cells.

Education

2007-2012,

Maintaining 3.8 GPA in Ph. D. Physics Lehigh University.

(Expected graduation September 2012)

2004-2006, B.S. Physics, Summa Cum Laude. California State University Chico.1997-2002, B.S. Mechanical Engineering, California State University Chico.

Achievements

2011 Attended the 61st Lindau Nobel Laureate Meeting, Lindau Germany.

2008 Yoshida Travel Award (Department of Physics, Lehigh University)

2007-2009 GAAN Fellowship (Grant from the U.S. department of Education

to Lehigh University Department of Physics) which required a teaching assignment.

2002-2004 Completed Peace Corps two year service in The Gambia, West Africa.

teaching math and science to students grades 7-9.

Publications

"Model of Actin Turnover in the Lamellipodium Suggests Remodeling through Slowly Diffusing Oligomers."

Matthew B. Smith, Naoki Watanabe, Dimitrios Vavylonis *In preparation*

"Interactive, Computer-Assisted Tracking of Speckle

Trajectories in Fluorescence Microscopy: Application to

Actin Polymerization and Membrane Fusion," Matthew B. Smith,

Erdem Karatekin, Andrea Gohlke, Hiroaki Mizuno, Naoki Watanabe,

and Dimitrios Vavylonis, Biophys J. 2011.

"Segmentation and Tracking of Cytoskeletal Filaments using Open Active Contours,"

M. B. Smith, H. Li, T. Shen, X. Huang, E. Yusuf, and D. Vavylonis, Cytoskeleton 2010.

"Automated Actin Filament Segmentation, Tracking, and Tip Elongation Measurements

based on Open Active Contour Models," H. Li, T. Shen, M. B. Smith, I. Fujiwara,

D. Vavylonis, and X. Huang, In Proc. of the IEEE International Symposium on Biomedical Imaging:

From Nano to Macro, Boston, 2009.

Open Source Software from Publications

Speckle TrackerJ, for tracking point-like particles in 2D images.

http://athena.physics.lehigh.edu/speckletrackerj

JFilaments, for tracking filament structures in 2D and 3D images.

http://athena.physics.lehigh.edu/jfilament

Conferences

"Model of actin turnover and the role of slowly diffusing oligomers in the lamellipodium,"

Matthew B. Smith and Dimitrios Vavylonis, Biophysical Society Annual Meeting 2012, San Diego, CA.

"Model of Actin Turnover in the Lamellipodium that Reconciles Prior Experiment Results,"

(poster presentation, Matthew B. Smith, Naoki Watanabe, and Dimitrios Vavylonis)

2011 American Society for Cell Biology Annual Meeting, Denver, CO.

"Segmentation and Tracking of Cytoskeletal Filaments using Open Active Contours."

(poster presentation, M. B. Smith, H. Li, T. Shen, X. Huang, E. Yusuf, D. Vavylonis).

2010 American Society for Cell Biology Annual Meeting, Philadelphia, PA.

"Turnover Dynamics of Diffuse Actin and Regulators at the Leading edge", (oral presentation,

Matthew B. Smith, Naoki Watanabe and Dimitrios Vavylonis). 2010 Biophysical Society Annual

Meeting, San Francisco, CA.

"Segmentation and Tracking of Cytoskeletal Filaments using Open Active Contours."

(poster presentation, M. B. Smith, H. Li, T. Shen, X. Huang, E. Yusuf, D. Vavylonis).

The Cellular Cytoskeleton workshop, Pingree Park, CO. 2010.

"Actin Filament Segmentation and Tracking using Active Contours,(poster presentation,"

M. B. Smith, D. Vavylonis, T. Shen, H. Li, X. Huang, M. Fedorka, A. Ruby, L. Vasko).

2009 Computational Science and Engineering/HPC Workshop, Lehigh University, Bethlehem, PA.

"Mechanisms of large length fluctuations during actin filament growth," (poster presentation

Matthew B. Smith, Dimitrios Vavylonis). 2009 Biophysical Society Annual Meeting, Boston, MA.

"Turnover dynamics of diffuse actin and regulators at the leading edge," (poster presentation,

Matthew B. Smith, Naoki Watanabe and Dimitrios Vavylonis).

2009 American Society for Cell Biology Annual Meeting, San Diego, CA.

"Mechanisms of large length Fluctuations during actin Filament growth," (oral presentation,

Matthew B. Smith, Dimitrios Vavylonis).

2009 The American Physical Society March Meeting, Pittsburgh, PA.

"The effect of cooperative polymerization kinetics in actin filament elongation rate and

length fluctuations," (poster presentation, M.B. Smith and D. Vavylonis).

2009 Lehigh University Research Symposium.

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