Team Leader University

Chen Liu

*** **** ******** ***,***,Winston Salem, NC 27109 *****@***.***

EDUCATION

Wake Forest University, Department of Physics, Winston-Salem, NC

Ph.D., Physics (Specialty in Biophysics) Aug 2013

Wake Forest University, Schools of Business, Winston-Salem, NC

Master of Business Administration Aug 2013

Bowling Green State University, Bowling Green, OH

Master of Science in Physics, GPA: 3.9 Aug 2009

Thesis: A numerical and analytical study of phonation threshold pressure

and experiments with a physical model of the vocal fold mucosa

East China University of Science and Technology, Shanghai, China

Bachelor of Science in Physics, GPA: 3.3 Jun 2007

Thesis: A numerical calculation of the state energy of fractional quantum

hall effect in the Haldane s model

RESEARCH EXPERIENCE

Simulations of chemical and biological reactions of reactive oxygen species in cellular mechanism

Used computational modeling to solve biologically relevant differential equations.

The effect of microparticles (MPs) on Nitric Oxide (NO)-mediated vasodilation with and without intravascular flow on rat mesenteries in myograph

Conducted on single arteriole blood vessels examining vasodilation.

Plasma NO-scavenging activity

Examined NO-scavenging activity of plasma derived from various ages of banked blood on a NO analyzer

Simulations of NO uptake by red blood cells (RBC) and by MPs derived from red cells

Confirmed extracellular diffusion of NO limits NO uptake rate and discovered microparticle encapsulated Hemoglobin (MP-HbA) reduce NO bioactivity significantly on a COMSOL model

Stopped-flow absorption measurements of NO uptake by red blood cells under oxygenated and deoxygenated conditions with a viscous or non-viscous buffer

Demonstrated the viscosity of the buffer had a substantial effect on external diffusion using millisecond-resolved kinetics

Kinetics of Nitric Oxide reactivity with MP-HbA

Discovered MP-HbA scavenges NO 2.5 to 3 times slower than free HbA but 1000 times faster than RBC-HbA by using fast time-resolved flash photolysis technique

PUBLICATIONS Donadee C., Raat N. J.H., Kanias T., Tejero J., Lee J. S., Kelley E. E., Zhao X., Liu C., Reynolds H., Azarov I., Frizzell S., Meyer E. M., Donnenberg A. D., Qu L., Triulzi D., Kim-Shapiro D. B., Gladwin M. T., Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion. Circulation, 2011. 124(4): p. 465-476. Azarov I., Liu C., Reynolds H., Tsekouras Z., Lee J.S., Gladwin M. T., and Kim-Shapiro D. B., Mechanisms of Slower Nitric Oxide Uptake by Red Blood Cells and Other Hemoglobin-containing Vesicles. Journal of Biological Chemistry, 2011. 286(38): p. 335**-*****. (co-author)Azarov I., Liu C., Reynolds H., Lee J.S., Donadee C.,Raat H., Gladwin M. T., and Kim-Shapiro D. B., Kinetics of Nitric Oxide reactivity with Micro Vesicle-Encapsulated Hemoglobin. Free Radical Biology and Medicine, 2010. 49: p. S108-S108. (Abstract)

LEADERSHIP Team Leader - MIT-CHIEF Business Plan Contest, Pitch to China Jul 2012President - Chinese Students and Scholars Association, WFU May 2011 - May 2012Director - Public Relations Department of CSSA, BGSU Aug 2007 - Aug 2008President - Physics Club, ECUST Sep 2005 - Jul 2006

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