Manager Quality Control
Resume:
Kathy Bailey, Researcher-Resume
K ATHY BAILEY
ACADEMIC BACKGROUND CONTACT KATHY
****, **, ********** ** ************, UCLA *******@********.****.***
****, ****ytical & Light Microscopy, Woods Hole
1996, Flow Cytometry Laboratory Medicine, UCSF
RESEARCH EXPERIENCE COMPUTER SKILLS
I have conducted experiments and presented findings at meetings in several Computer Networking Certification, San
Francisco City College: UNIX, DOS,
areas of biomedical research: LANs including networking and PCs
Excel
CELL BIOLOGY: I have developed a high throughput assay for detecting PhotoShop
Indesign
unknown anabolic steroids in body fluids; I have developed and performed Dreamweaver
Prism statistical analysis
patient study assays for steroids, lipid transport, scavenger receptors, TGF, Acuity Xpress; MetaMorph; Image
analysis programs for gel, photo-
HTLV I, SK, NK, cytokeratins, oncoproteins; and have cultured and minipulated microscopy and FACS analysis); Perl
programming and Web authoring
primary retinal pigment epithelial cells, rat brain cells, bone marrow cells and
numerous eucaryotic cell lines, including T cells and B cells as required for
ADMINISTRATIVE COURSES
studies. I have prepared and characterized numerous antibodies and used
BIOCHEMISTRY 201 -INTELLECTUAL
them in immuno-histochemical studies and assays; PROPERTY
BIOSTATISTICS 183
GENETICS: I have studied the transforming ability of and performed RFLP MICRO- & MACRO- ECONOMICS
ACCOUNTING
analysis on various oncogenes; have studied the transcriptional regulation of CORPORATE DEVELOPMENT
PAM of EMF: Billing and Reporting
proteins expressed during adrenal medula development; conducted mutational PAM of EMF: Compliance
PAM of EMF: Award Set-Up
analysis of the ara operon; identified specific transposon Tn7 target insertions; PAM of EMF: Award Closeouts and FSRs
RAS Kick Start
and have cloned cDNAs and genomic DNAs of cGMP-gated channels, lectins, RAS Post Award
and oncogenes from lambda and cos libraries and/or pcr.
BIOCHEMISTRY: I have experience in purifications and analysis of proteins
INSTRUMENTATION
and protein modifications (glycosylation and phosphorylation), i.e., collagens, Molecular Devices, IMX High Thruput
lectins, oncoproteins, cytokeratins, monoclonal and polyclonal antibodies to Microscope; FLOW CYTOMETER;
ANALYTICAL AND LIGHT MICROSCOPY;
these proteins. AUTOMATED SEQUENCER, ALF;
OLIGONUCLEOTIDE SYNTHESIZER:
ADMINISTRATIVE EXPERIENCE Protocols and chemistries; COLUMN
CHROMATOGRAPHY, ion exchange,
I have been a project leader responsible for development of cancer diagnostic affinity and HPLC; Electrophoresis (2 -D
gels, westerns, etc.)
reagents (anti-oncogene, anti-HTLV and cytokeratin antibodies and immuno-
histochemistry reagents); and I validated claims of reagents and coordinated
collaborations among independent research labs and the marketing group at
Triton Biosciences.
I have coordinated all phases of laboratory build-outs for three laboratories
(molecular biology, biochemistry and diagnostics); this included ordering all
laboratory equipment, hiring and training research assistants/associates;
mentoring of post-doctoral fellows and physicians; planning and implementing
budgets; and organizing a Mac computer network and developing databases for
them.
PROFESSIONAL ACTIVITIES:
Electronic Seminars Publication and Web site manager, UCSF (1992-2000)
Editing & layout for SouthEnder quarterly newsletter (2006-2008)
Member The Association for Research in Vision and Ophthalmology
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Kathy Bailey, Researcher-Resume
EMPLOYMENT
SPECIALIST, DIABETES CENTER, UCSF
March 2010-present
I developed a sensitive and economical assay and general method for
detection of compounds with known and unknown androgen activity and
conduct pilot studies employing the assay to measure said compounds in
athletes and patients undergoing hormone replacement therapy.
SPECIALIST, OPHTHALMOLOGY DEPARTMENT, UCSF
April 1996-present
I processed images acquired by Adaptive Optics Scaning Laser
Ophthalmoscopy
[AOSOLO] and maintained a database of images of subjects' retina images for
clinical studies. I have identified scavenger receptors and investigated gene
regulation by lipid & modified lipids, i.e. oxidized-lipid uptake in human retinal
epithelial cells; and have tested drugs which modulate the uptake. Lipid and
modified lipids were used to devolop assays that simulate photoreceptor outer
segment uptake. I also identified isoforms of thyroid hormone and RXR
receptors and other genes in the trabecular meshwork which may be involved
in modulating ocular pressure observed in glaucoma and retinal degeneration
by molecular, immunohistochemical and assay analysis.
CORE MANAGER - DEPT OF NEUROLOGY, GALLO CENTER, S.F.,
CA
1994-1996
The center studies the effect of alcohol on physiology, cell biology and genes. I
managed the core facility which performed automated sequencing projects and
oligonucleotide synthesis; and engineered and prepared constructs for
expression of fusion proteins.
RESEARCH ASSOCIATE, PHYSIOLOGY &
BIOCHEMISTRY/BIOPHYSICS, UCSF
1992-1994
The lab studies signaling in the retina and retinal cell lineages. I cloned cGMP
gated ion channels in rods and cones of striped bass and expressed the wild
type channels for physiological studies.
RESEARCH ASSOCIATE/LAB MANAGER, NEUROSURGERY/BRAIN
TUMOR RESEARCH CENTER, UCSF
1990-1991
The lab studied gene regulation in neural development, astrocyte function and
genetics. I investigated gene regulatory sequences in the adrenal medulla and
managed all aspects of the laboratory. Experimental proposals, journal clubs
and results were prepared and presented regularly.
RESEARCH ASSOCIATE/LAB MANAGER - PSYCHIATRY, UCSF
1986-1990
The lab focused on the characterization and function of lectins. I investigated
the role of endogenous lectins in vertebrate tissues and performed the
biochemistry and molecular biology required for the study. I managed the
administrative and operational aspects of the lab.
DIAGNOSTICS PROJECT LEADER - TRITON BIOSCIENCES, INC,
ALAMEDA, CA
1984-1986
Our group developed cancer diagnostics and clinical assays. I was project
leader for cancer diagnostics reagents. I collaborated with research and
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Kathy Bailey, Researcher-Resume
business teams to transfer and develop research reagents. I established and
wrote upprocedures and protocols for patents, clinical trials, quality control.
Reagents/assays included cytokeratin antibodies/assays, HTLV I
antibodies/assays, anti-oncogene and anti-TGF antibodies/assays.
RESEARCH ASSOCIATE/LAB MANAGER -
HEMATOLOGY/ONCOLOGY, UCLA
1982-1985
The lab was involved in investigating cancer diagnostics. I investigated
potential cancer diagnostics,i.e., oncogene protein assays (using RIPA and IEF
gels), performed RFLP's and TGF assays for Triton Biosciences, generated
and characterized anti-oncogene antibodies and generated oncogene
constructs for transfecting cells.
RESEARCH ASSOCIATE - IMMUNOLOGY & MICROBIOLOGY,
UCLA
1980-1982
I assisted in the development of immunological assays for patient studies,
performed immunofluorescence typing of lymphocytes, monitoring
immunological response by ADCC/SK, PHA, specific radioimmunoassay and B
cell plaque assay in a clinical laboratory setting. Isolated cells from patient
sample and monitored blood cell types and counts manually and with cell
sorting techniques.
PUBLICATIONS:
Ishida, BY, Keith G Duncan, Kathy R Bailey, John P Kane, and Daniel M
Schwartz, "High Density Lipoprotein - mediated lipid efflux from retinal
pigmented epithelial; Cells in Culture"; BJOPHTHALMOL/2005/08576.
Brian Y. Ishida, Kathy R. Bailey, Keith G. Duncan, Robert J. Chalkley, A.L.
Burlingame, John Kane, Daniel M. Schwartz, "Regulated Expression of
Apolipoprotein E by Human Retinal Pigment Epithelial Cells", Journal of
Lipid Research, 16 October.
Bailey, K.R., B.Y. Ishida, K.G. Duncan, J.P. Kane, D.M. Schwartz. 2003,
Apolipoprotein E Containing High Density Lipoproteins can Function as
Preferential Acceptors for Retinal Pigment Epithelium Cell Digested Photo
Receptor Outer Segment Lipids, Association for Research in Vision and
Ophthalmology (ARVO) Annual Meeting. Abstract #477.
Stewart, J.M., K.R. Bailey, K.G. Duncan, J.P. Kane, D.M. Schwartz. 2003.
Expression of Reverse Cholesterol Transport Proteins SR-B1, SR-BII and
ABCA1 in the Human Retinal Pigment Epithelium, Association for Research
in Vision and Ophthalmology (ARVO) Annual Meeting. Abstract #1711.
Keith G. Duncan, Kathy Bailey, John P. Kane and Daniel M. Schwartz,
Biochemical and Biophysical Research Communications (March 2001)
Keith G. Duncan, Michele D. Jumper, Ralff C.J. Ribeiro, Kathy R. Bailey, Paul
M. Yen, Akira Sugawara, Ashmi Patel, Robert Stern, William W. Chin John
D.Baxter and Daniel M. Schwartz, "Human Trabecular Meshwork Cells: A
Thyroid Hormone Target Tissue." Graefe's Archive of Clinical and
Experimental Ophthalmology 1999:237:231-240.
K.G. Duncan, K.R. Bailey, J.D. Baxter and D.M. Schwartz. "The Human
Retinal Pigment Epithelium: A Target Tissue for Thyroid Hormones."
Ophthalmic Research 1999:31:399-406.
PATENT(S):
(1) U.S. Patent Application No.: 10/313,641. TREATMENTS FOR AGE-
RELATED MACULAR DEGENERATION (AMD). Dec 6, 2002; (2) U.S. Patent
Application No.: U.S. Continuation-in-Part Patent Application No.: . METHODS
TO INCREASE REVERSE CHOLESTEROL TRANSPORT IN THE RETINAL
PIGMENT EPITHELIUM (RPE) AND BRUCH S MEMBRANE (BM), March 5,
2004; (3) Divisional Patent Application No. : . TREATMENT FOR DARK
ADAPTATION. February 9, 2005.
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Kathy Bailey, Researcher-Resume
1 November 2009
file C /Users/Kathy/Documents/Web/KRB%20resume/KRB_resume_v6.html[6/12/2011 8:43:39 PM]
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