Manager Management

Kambiz Karimi

Email: *********@********.***

Address: *** **** ***** *****

City: San Mateo

State: CA

Zip: 94402

Country: USA

Phone: 650-***-****

Skill Level: Management

Salary Range: $140,000

Primary Skills/Experience:

See Resume

Educational Background:

See Resume

Job History / Details:

Kambiz Karimi

903 East Grant Place, San Mateo, CA 94402

Phone: 650-***-**** E-Mail: *********@********.***

Objective

A management position that utilizes my experience in computational biology,

software product management, biocuration management, and my educational and

research background to support the next generation of informatics solutions for analysis of large-scale biological data

Experience

Ingenuity Systems

Content Acquisition Manager / Curation Manager Mar 2006 - Present

Knowledge Acquisition Team

* Management of full-time and consulting scientists in the literature curation team

- Worked closely with the team to optimize Ingenuity's curation protocols, processes, software tools and workflows in order to ensure cost-efficient coverage of biological content in key areas (E.g. pharmacogenomics, mutations/SNPs, microRNA)

- Prioritized curation projects based on content product roadmap and customer feedback

* Management of biological pathway curation team

- Authored Ingenuity's Canonical Pathway Curation and QC Protocol, and worked with the software engineering team to develop Ingenuity's Pathway Editor tool based on protocol requirements

- Led the pathway curation team to develop a library of ~600 signaling and metabolic pathways

* Development of a new Curation Protocol for capturing variant-to-disease relationships in support of Ingenuity's new Variant Analysis application

- The curated findings enable Variant Analysis software to identify potential disease-causing mutations in a patient's whole genome sequence data

* Development of a new Curation Protocol for pharmacogenomics content

- Led comprehensive curation of published pharmacogenomics studies linking genomic variants to drug response, efficacy, toxicity and metabolism

* Assisted with development of a new NLP-based finding extraction workflow for automated extraction of findings from Medline abstracts

- Natural Language Processing aided finding extraction has helped to increase breadth of journal coverage while reducing content latency in Ingenuity's applications

* Licensing of biological content from 3rd party databases

- Approximately 2 million biological relationships imported into knowledge base from protein interaction databases, microRNA targeting databases, biomarker, metabolite, drug and disease databases, toxicity databases, as well as clinical trial registries

* Development of key relationships with major publishers for access to literature content

* Support of Sales, Marketing, Product Management, and Customer Support teams with content and product related inquiries

Ingenuity Systems

Content Product Manager Jan 2007 - June 2009

Product Management Team

* Content Product Management for IPA, Ingenuity's flagship pathways analysis software solution

- Helped increase IPA utilization and adoption by developing feature requirements for display of new content based on customer needs and internal roadmap requirements

- Worked with software engineering, computational biology and product management teams to integrate new types of content and functionality in IPA

- Represented Ingenuity at conferences, workshops and customer visits

- Coordinated scientific evaluation of new IPA features and content

Ingenuity Systems

Senior Biology Knowledge Base Modeler / Ontology Engineer July 2001 - Feb 2006

Ontology Modeling group

* Development of Ingenuity's proprietary ontology and synonym library, the world's largest biological ontology and the foundation of Ingenuity's knowledge base

* Structuring of curated literature findings according to semantic guidelines

* Development of computable signaling and metabolic pathway models

* Design of knowledge base models for storage of literature findings

* Development of scripts and SQL-type queries to write to and retrieve information from the Ingenuity knowledge base

* Reporting and fixing of knowledge base-related bugs

University of Virginia

Postdoctoral Research Associate July 1997 - June 2001

Department of Otolaryngology - Head and Neck Surgery

* Research in developmental otology and sensory hearing cell regeneration, with emphasis on the molecular mechanisms

that regulate cell proliferation and differentiation in the inner ear sensory epithelia

Albany Medical College

Doctoral Candidate Aug 1992 - May 1997

* Dissertation research in the study of intracellular signaling pathways involved in IgG-mediated phagocytosis,

with emphasis on the role of protein kinases, phospholipases, and bioactive lipid messengers

Education

* Ph.D. (Cell Biology and Physiology), 1997, Albany Medical College, Albany, NY

* M.S. (Cell Biology and Physiology), 1996, Albany Medical College, Albany, NY

* B.S. (Biomedical Engineering), 1992, Rensselaer Polytechnic Institute, Troy, NY

* B.A. (Physics), 1991, Knox College, Galesburg, IL

Honors

* NIH Postdoctoral Fellowship in Neural and Behavioral Development Research Training, 2000

* NIH Predoctoral Fellowship in Cardiovascular Disease Research Training, 1996

* Graduate Studies Program Award in Recognition of Excellence in Research, 1995

Publications

Sage C, Huang M, Karimi K, Gutierrez G, Vollrath MA, Zhang DS, Garcia-Anoveros J,Hinds

PW, Corwin JT, Corey DP, Chen ZY. Proliferation of Functional Hair Cells in Vivo in the

Absence of the Retinoblastoma Protein. Science 307:1114-8, 2005

Karimi K, Gemmill TR, Lennartz MR. Protein kinase C and a calcium-independent

phospholipase are required for IgG-mediated phagocytosis by Mono-Mac-6 cells.

Journal of Leukocyte Biology 65: 854-862, 1999

Karimi K, Lennartz MR. Mitogen-activated protein (MAP) kinase is activated during

IgG-mediated phagocytosis, but is not required for target ingestion. Inflammation 22: 67-82, 1998

Karimi K, Lennartz MR. Protein kinase C activation precedes arachidonic acid release during

IgG-mediated phagocytosis. Journal of Immunology 155: 5786-5794, 1995.

Karimi K, Karaoli T, Whitley MZ, Byrne MC, Corwin JT. Spatiotemporal maturation of rat

cochlear and vestibular hair cells correlates with transient expression of tumor

suppressor p57Kip2. Mechanisms of Development. Prepared for submission.

Contact this candidate