Computer Science Development

JOANNE LUCIANO, PHD

** ******* ****** +1-617-***-****

Belmont, Massachusetts 02478 ********@*****.***

SUMMARY OF QUALIFICATIONS

Interdisciplinary computer and life scientist with 30 years of experience in technology, research and

development. Demonstrated abilities in computational and life sciences research, design,

development, implementation, and integration. Extensive background in software engineering,

computer science, mathematical modeling, algorithm development, bioinformatics, and

computational biology and ontology development. Specialties include Artificial Intelligence,

Machine Learning, and Neural Network systems. Recent accomplishments include a leadership role

in creating a world-wide standard ontology for biological pathway data exchange. A solid record

with excellent written, oral, interpersonal skills, and enthusiasm.

PROFESSIONAL EXPERIENCE

PREDICTIVE MEDICINE, INC. (FORMERLY ORCHARD STREET SOFTWARE) Belmont, Mass. 1988 - Present

Consultant

Provide advanced technology, intellectual property, and business solutions with emphasis on

Machine Learning and Neural Network systems. Manage up to five personnel in completing

projects for selected clients:

Advanced Biological Laboratories SA Intellectual Property Consultant.

Siderean Software, Inc. Life Science Consultant. Demonstrated the impact of Seamark

semantic integration and navigation capabilities on the discovery phase of the drug

development pipeline as well as in the business/IP sphere. Published in J. Web Semantics.

Pfizer, Inc. Knowledge Management Consultant. Assisted and advised Pfizer in the area

of biological pathways and ontologies in order to identify the best synergies among

biological pathway models, knowledge structures, text mining technologies, kinase science,

and Pfizer's drug discovery process to develop the Pfizer Kinase Knowledge Base.

Beyond Genomics, Incorporated Knowledge Management Consultant. Identified

synergies between biological pathway models and knowledge structures for scientific and

intellectual property goals. Created methodology to facilitate and expedite scientific

discovery and identify new areas for Intellectual Property development.

Viveca, Incorporated Information Architect consultant. Designed solutions to streamline

Viveca s design process from initial customer contact and webpage content extraction

through to final delivery to customer. Examined process details that led to effective

technical strategies while decreasing turnaround time and reducing errors.

Pharmacia & Upjohn Analyzed Medicare claims data for evidence to support new

market. Saved the client the substantial cost and risk associated with initiating clinical trials

in new therapeutic area.

Genome Therapeutics Corporation Adapted linkage analysis software for internal use and

developed Web-based demonstration version of PathoGenome that allowed viewing on

client s system.

Eli Lilly & Company Biostatistical Consultant and SAS Programmer for long-term Prozac

study.

Millennium Pharmaceuticals, Incorporated Researched and developed computational

methods in sequence and disease analysis that included UI and database design, project

management, HTML, PERL and OPS5 programming. Enabled superior access to disease

information by researchers, and ability to identify secreted proteins of interest that served as

most viable drug candidates.

THE MITRE CORPORATION 2007 - 2009

Multi-Disciplinary Systems Engineering Lead, Bio-Onotology Expert Bedford, Massachusetts

Leading and co-developing an influenza application ontology development collaboration

with BioHealthBase and Gemina to support US Influenza research and surveillance.

JOANNE LUCIANO, PHD

Principal Investigator Founded an Ontology Evaluation research program generating

collaboration support and interest from NIST.

HARVARD MEDICAL SCHOOL / MASSACHUSETTS GENERAL HOSPITAL 2005 - 2009

Lecturer in Genetics, Boston, Massachusetts

Principal Investigator, EMPWR project, NSF funded ontology based biopathway research.

BIOPAX / MEMORIAL SLOAN KETTERING CANCER CENTER New York, New York 2002 - Present

Core Group Member and BioPathways Consortium Liaison (Core group 2002-2007)

BioPAX is a world-wide standard for the exchange of life science metadata, particularly biological

pathways data. Lead role in the creation and fostering of this community-based ontology

development initiative in OWL. Identify sources of funding and adoption of the standard by

technical, outreach, fund raising, and administrative activities.

Acquired initial and subsequently doubled Department of Energy funding (total $120,000).

Selected Prot g as the critical tool for on-time delivery the initial release.

Assembled a worldwide network of stakeholders and contributors to this emerging standard.

BIOPATHWAYS CONSORTIUM (BPC) International Consortium 2001 - Present

Co-Organizer/Steering Committee

Co-Organizer for the BPC, an organization fostering scientific development through understanding

of biological pathways. Grant proposal writing for funding various activities of Consortium.

Responsible for maintaining Website facilitating worldwide communications among life

sciences community. Negotiated with Web design firm that led to $6,000 savings.

Co-developing a pathway genome databases for Prochlorococcus Marinus, a marine

photosynthetic bacteria in George Church s lab at Harvard Medical School.

MOLECULAR MINING CORPORATION Boston, Massachusetts 2001 - 2002

Director of Business Development

Directed business initiatives for life science data mining company. Initiated and supported

collaborations with pharmaceutical, biotechnology and academic clientele.

Spearheaded company drive for involvement in high-throughput analysis and pharma-

biotech integration projects while expanding client offerings. Developed broad strategic

concept for pharmaceutical partners.

3RD MILLENNIUM, INCORPORATED Cambridge, Massachusetts 2000 - 2001

Senior Scientist, BioPathways

Senior Scientist on NIST grant to develop next generation integrated information infrastructure for

pharmaceutical and biotech research.

Expertly developed demo of hypothesis-driven visualization system using Huntington s

Disease as model. Effectively researched and captured information for display of disease

mechanisms and manifestations that served as research planning tool for biopathways.

GENOME THERAPEUTICS CORPORATION Waltham, Massachusetts 1999

Assistant Director, Bioinformatics

Assistant Director for oldest and only biotechnology firm funded by government for Human

Genome Project.

Created vision and standards that drove bioinformatics operation and set up academic

research alliance to utilize and develop novel approaches to drug target screening for

pathological genetics, functional genomics and pharmacogenomics.

Established and led 16-person multidisciplinary team that successfully completed GTC s

corporate-wide Y2K Readiness Program two months ahead of aggressive schedule.

LUCIANO & HILLER, INCORPORATED Belmont, Massachusetts 1982 - 1988

President

President and Owner of consultancy serving Greater Boston s technology and business systems

marketplace.

7/2009

JOANNE LUCIANO, PHD

Served Lotus Development Corporation by leading strategic testing effort for Metro

personal information manager product. Developed automated regression compatibility test

for Metro Kernel.

EDUCATION AND FELLOWSHIPS

HARVARD MEDICAL SCHOOL/MASSACHUSETTS GENERAL HOSPITAL 1996 2005

Research in Outcome Prediction, Modeling Depression Recovery and Pharmacogenomics

Research Fellow Psychiatry Department Joint Appointment

o Neural Systems Group (1996-1999)

o Depression Research Program (1999-2005)

Faculty - Institute of Cybermedicine (2000-2002).

BOSTON UNIVERSITY Boston, Massachusetts

PhD in Cognitive and Neural Systems 1996

Dissertation Title Neural Network Modeling of Unipolar Depression:

Patterns of Recovery and Prediction of Outcome

Master of Science Degree in Computer Science 1987

Bachelor of Science Degree in Computer Science (Cum Laude) 1982

PATENTS, PROFESSIONAL ACHIEVEMENTS & AFFILIATIONS

Automated Treatment Selection Method (Patent Number 6,063,028 Issued 5/16/00)

Method for Predicting the Therapeutic Outcome of a Treatment

(Patent Number 6,317,731 Issued 11013/01)

International Neural Society, International Society for Computational Biology, ACM,

IEEE & IEEE Computer Society

APPOINTMENTS

Faculty & Harvard Medical School, Department of Genetics, Lecturer (2005-2009)

Research Boston University, Metropolitan College, Computer Science Instructor (2005)

Boston University, Behavioral Pharmacology, Research Associate (1991-1992)

Harvard Medical School, Faculty, Institute of Cybermedicine (2000-2002)

Advisory Boston University, Dean s Advisory Board, Metropolitan College (2003-present)

Boards International Society for Computational Biology, Finance Committee (2002-2005)

International Society for Computational Biology, Publications Committee (2007-2008)

7/2009

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