Assistant High School
Resume:
IVAN IOSSIFOV
IVAN IOSSIFOV, Ph.D.
* ******** **** / **** ****** Harbor, NY 11724
Telephone: +1-516-***-****
E-mail: abpig8@r.postjobfree.com
EDUCATION
**** **** ******** **********, **.D. Department of Biomedical Informatics
Advisor: Prof. Andrey Rzhetsky GPA: 4.1/4.0 (with distinction)
Thesis: Studying human disease with molecular network models derived from scientific literature
1992 1997 Sofia University, Bulgaria, BS and MS in Computer Science
Advisor: Prof. Darina Dicheva GPA: 5.9/6.0
Thesis: A method for agent-based visualization in information systems
WORK EXPERIENCE
2012 Assistant Prof., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
2008 2012 QB Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
2006 Summer Internship at Microsoft Research, Redmond, WA
2001 2004 Senior Programmer/Analyst, Department of Biomedical Informatics,
Columbia University, New York
2000 2001 Team Leader, Nemetschek LLC, Sofia, Bulgaria
1994 1999 Senior Application Developer, DISY Inc. Sofia, Bulgaria
TEACHING EXPERIENCE
2005 Teaching Assistant, Methods in Biomedical Informatics, Columbia University
2005 Teaching Assistant, Computational Biology, Columbia University
2000 Lecturer, Programming in C++, Electrical-Engineering High School, Sofia
1999 Teaching Assistant, Functional and logical programming, Sofia University
1998 Teaching Assistant, Prolog programming in AI, Sofia University
REASEARCH INTEREST
computational biology molecular networks h uman genetics human disease
applied statistical and machine learning biomedical text-mining molecular evolution
IVAN IOSSIFOV
PUBLICATIONS
1. Iossifov, I.*, Ronemus, M.*, Levy, D., Wang, Z., Hakker, I., Rosenbaum, J.,
Yamrom, B., Lee, Y., Narzisi, G., Leotta, A., Kendall, J., Grabowska, E., Ma, B.,
Marks, S., Rodgers, L., Stepansky, A., Troge, J., Andrews, P., Bekritsky, M.,
Pradhan, K., Ghiban, E., Kramer, M., Parla, J., Demeter, R., Fulton, L.L., Fulton,
R.S., Magrini, V.J., Ye, K., Darnell, J.C., Darnell, R.B., Mardis, E.R., Wilson, R.K.,
Schatz, M.C., McCombie, W.R., & Wigler, M. (2012) De Novo Gene Disruptions in
Children on the Autistic Spectrum. Neuron 74 (2) 285 *-equal contribution
2. Spector, M.S., Iossifov, I., Kritharis, A., He, C., Kolitz, J.E., Lowe, S.W., & Allen,
S.L. (2011) Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-
cell receptor chain and KIT V654A. Leukemia. doi:10.1038/leu.2011.354
3. Parla, J.S.*, Iossifov, I.*, Grabill, I., Spector, M.S., Kramer, M., & McCombie, W.R.
(2011) A comparative analysis of exome capture. Genome Biol. 12 (9) R97 *-equal
contribution
4. Gilman, S.R.*, Iossifov, I.*, Levy, D., Ronemus, M., Wigler, M., & Vitkup, D.
(2011) Rare de novo variants associated with autism implicate a large functional
network of genes involved in formation and function of synapses. Neuron 70 898 *-
equal contribution
5. Levy, D., Ronemus, M., Yamrom, B., Lee, Y.H., Leotta, A., Kendall, J., Marks, S.,
Lakshmi, B., Pai, D., Ye, K., Buja, A., Krieger, A., Yoon, S., Troge, J., Rodgers, L.,
Iossifov, I., & Wigler, M. (2011) Rare de novo and transmitted copy-number
variation in autistic spectrum disorders. Neuron 70 886
6. Iossifov, I., Rodriguez-Esteban, R., Mayzus, I., Millen, K.J., & Rzhetsky, A. (2009)
Looking at cerebellar malformations through text-mined interactomes of mice and
humans. PLoS Comput Biol. 5 (11) e1000559.
7. Rodriguez-Esteban, R. & Iossifov, I. (2009) Figure and table mining for biomedical
research. Bioinformatics, 25 (16) 2082
8. Liu, J., Ghanim, M., Xue, L., Brown, C.D., Iossifov, I., Angeletti, C., Hua, S., N gre,
N., Ludwig, M., Stricker, T., Al-Ahmadie, H.A., Tretiakova, M., Camp, R.L., Perera-
Alberto, M., Rimm, D.L., Xu, T., Rzhetsky, A., & White, K.P. (2009) Integrated
genomic analysis of the Drosophila segmentation network leads to identification of a
highly specific biomarker for human kidney cancer. Science 323 (5918) 1218
9. Iossifov, I., Zheng, T., Baron, M., Gilliam, T. C., & Rzhetsky, A. (2008) Genetic-
linkage mapping of complex hereditary disorders to a whole-genome molecular-
interaction network. Genome Research, 18 (7) 1150
10. Cokol, M., Iossifov, I., Rodriguez-Esteban, R., & Rzhetsky, A. (2007) Response by
Cokol et al EMBO rep. 8 (9) 793
11. Cokol, M., Iossifov, I., Rodriguez-Esteban, R., & Rzhetsky, A. (2007) How many
papers should be retracted? EMBO rep. 8 (9) 793
IVAN IOSSIFOV
PUBLICATIONS (continued)
12. Rodriguez-Esteban, R., Iossifov, I., & Rzhetsky, A. (2006) Imitating manual curation
of text-mined facts in biomedicine. PLoS Comput Biol, 2 (9) e118
13. Rzhetsky, A., Iossifov, I., Loh, J.M., White, K.P. (2006) Micro-paradigms: Chains of
collective reasoning in publications about molecular interactions. Proc Natl Acad Sci
USA, 103 (13) 4940
14. Cheng, R., Juo, S.H., Loth, J.E., Nee, J., Iossifov, I., Blumenthal, R., Sharpe, L.,
Kanyas, K., Lerer, B., Lilliston, B., Smith, M., Trautman, K., Gilliam, T.C., Endicott,
J. & Baron, M. (2006) Genome-wide linkage scan in a large bipolar disorder sample
from the National Institute of Mental Health genetics initiative suggests putative loci
for bipolar disorder, psychosis, suicide, and panic disorder. Mol Psychiatry. 11 ( 3)
252
15. Cokol, M., Iossifov, I., Weinreb, C., & Rzhetsky, A. (2005) Emergent behavior of
growing knowledge about molecular interactions. Nature Biotechnology, 23 (10)
1243.
16. Rzhetsky, A., Iossifov, I., Koike, T., Krauthammer, M., Kra, P., Morris, M., Yu, H.,
Dubou, P.A., Weng, W., Wilbur, W.J., Hatzivassiloglou, V., & Friedman, C. (2005)
GeneWays: A system for extracting, analyzing, visualizing and integrating molecular
pathway data. Book chapter in Databasing the Brain: From Data to Knowledge
(Neuroinformatics), Koslow and Subramaniam (Eds).
17. Iossifov, I., Krauthammer, M., Friedman, C., Hatzivassiloglou, V., Bader, J.S.,
White, K.P., & Rzhetsky, A. (2004) Probabilistic pathway inference from noisy data
sources. Bioinformatics, 20 (8) 1205.
18. Rzhetsky, A., Iossifov, I., Koike, T., Krauthammer, M., Kra, P., Morris, M., Yu, H.,
Dubou, P.A., Weng, W., Wilbur, W.J., Hatzivassiloglou, V., & Friedman, C. (2004)
GeneWays: A system for extracting, analyzing, visualizing and integrating molecular
pathway data. Journal of Biomedical Informatics, 37 (1) 43.
19. Krauthammer, M., Kra, P., Iossifov, I., Gomez, S., Hripcsak, G., Hatzivassiloglou,
V., Friedman, C., & Rzhetsky, A. (2002) Of truth and pathways: Chasing bits of
information through myriads of articles. Bioinformatics 18 Suppl 1, S249 S257.
20. Hong, Y., Hatzivassiloglou, V., Friedman, C., Iossifov, I., & Rzhetsky, A. (2002) A
rule-based approach for automatically identifying gene and protein names in
MEDLINE abstracts. ISMB 2002, Poster 240A
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