Health Project

Curriculum Vitae

Dudley Lamming, Ph.D.

Whitehead Institute for Biomedical Research

*******@**.***.***

Education and Training:

*/** ******* ************ ******, Whitehead Institute for Biomedical Research, Cambridge MA

Advisor: David M. Sabatini, M.D., Ph.D.

9/02-1/08 Ph.D., Experimental Pathology, Harvard University, Cambridge, MA

Advisor: David A. Sinclair, Ph.D.

Thesis: The regulation of lifespan by sirtuins in Saccharomyces cerevisiae

9/96-5/00 B.S., Nuclear Engineering, Massachusetts Institute of Technology, Cambridge, MA

Minor: Chemistry

Other Research Experience:

7/00-7/02 Enanta Pharmaceuticals

Associate Scientist, Discovery Biology

6/98-8/98; Technical Intern, Los Alamos National Laboratory, Nondestructive Testing

5/99-8/99 Advisor: Deborah A. Summa, Ph.D.

10/97-5/98 UROP Intern, MIT, Department of Chemical Engineering

Professional Associations:

American Aging Association, Gerontological Society of America

Academic and Professional Honors:

2011 Best Oral Presentation, American Aging Association, Raleigh, NC

2007 American Federation for Aging Research Dorothy Dillon Eweson Lecture Series travel award

2005 Albert J. Ryan Fellow

2005 Finalist, Best Student Presentation, American Aging Association Oakland, CA

2003 National Science Foundation Graduate Research Fellowship Program, Honorable Mention

1996 National Finalist, Westinghouse Science Talent Search

Publications:

Research Papers:

1. Lamming, D.W.*, Ye, L.*, Katajisto, P., Goncalves, M.D., Saitoh, M., Stevens, D.M., Davis, J.G.,

Salmon, A.B., Richardson, A., Ahima, R.S., Guertin, D.A., Sabatini, D.M., Baur, J.A. (2012).

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Science 335: 1638-1643.

2. Yilmaz, O.H., Katajisto, P., Lamming, D.W., Bakan, I., Sengupta, S., Birsoy, K., Bauer-Rowe, K.E.,

Dursun, M., Yilmaz, O., Selig., M., Nielson, P., Bhan, A., Mino-Kenudson, M., Zukerberg, L.,

Deshpande, V., Sabatini, D.M. (2012). mTORC1 in the Paneth cell niche couples intestinal stem-cell

function to calorie intake. Nature, advance online publication, doi:10.1038/nature11163

3. Robida-Stubbs, S., Glover-Cutter K., Lamming, D.W., Mizunuma, M., Narasimhan, S.D., Neumann-

Haefelin, E., Sabatini, D.M., Blackwell, T.K. (2012). TOR signaling and rapamycin influence longevity

by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metabolism 15: 713-724.

4. Medvedik, O*, Lamming, D.W.*, Kim, K.D., Sinclair, D.A. (2007). MSN2 and MSN4 link calorie

restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biology

5(10): e261.

5. Yang, H., Yang, T., Baur, J.A., Perez, E., Matsui, T., Carmona, J.J., Lamming, D.W., Souza-Pinto,

N.C., Bohr, V.A., Rosenzweig, A., de Cabo, R., Sauve, A.A., Sinclair, D.A. (2007). Nutrient-sensitive

mitochondrial NAD+ levels dictate cell survival. Cell 130(6):1095-1107.

6. Yu, M.C., Lamming, D.W., Eskin, J.A., Sinclair, D.A., and Silver, P.A. (2006) The role of protein

arginine methylation in the formation of silent chromatin. Genes Dev 20: 3249-3254.

7. Lamming, D.W.*, Latorre-Esteves, M. *, Medvedik, O.*, Wong, S.N.*, Tsang, F.A., Wang, C., Lin,

S.J., and Sinclair, D.A. (2005). HST2 mediates SIR2-independent life-span extension by calorie

restriction. Science 309: 1861-1864.

8. Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., Zipkin, R.E.,

Chung, P., Kisielewski, A., Zhang, L.L., Scherer, B., and Sinclair, D.A. (2003). Small molecule activators

of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.

9. Robinson, L.J., Roberts, W.K., Ling, T.T., Lamming, D., Sternberg, S.S., and Roepe, P.D. (1997).

Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.

Biochemistry 36:111**-*****.

Reviews:

1. Lamming, D.W., Sabatini, D.M., Baur, J.A. (2012). Pharmacologic means of extending lifespan.

Journal of Clinical and Experimental Pathology, in press.

2. Lamming, D.W. and Sabatini, D.M. (2011) A Radical Role for TOR in Longevity. Cell Metab 13(6):

617-618.

3. Lamming, D.W., Sabatini, D.M. (2010). Regulation of TOR signaling in Mammals. In M. Hall and

F. Tamanoi (Eds.), The Enzymes, Vol. 27 (pp. 21-38). Burlington: Academic Press.

4. Lamming, D.W., Wood, J.G., and Sinclair, D.A. (2004). Small molecules that regulate lifespan:

evidence for xenohormesis. Mol Microbiol 53(4): 1003-1009.

Talks and Seminars:

Brown University, May 2012, "Separable roles for mTORC1 and mTORC2 in the extension of

mammalian lifespan by rapamycin" (Invited).

Gerontological Society of America, November 2011, Rapamycin-induced hepatic insulin resistance is

mediated by mTORC2 and uncoupled from longevity.

American Aging Association, June 2011, Depletion of mTOR and mLST8 uncouples longevity from

rapamycin-induced changes in glucose homeostasis.

Cell Symposia: Metabolism and Aging, March 2011, The paradoxical effects of rapamycin on lifespan

and diabetes.

American Federation for Aging Research Symposium, October 2010, mTOR, Rapamycin, and

Longevity: A tale of two complexes.

Cold Spring Harbor Molecular Genetics of Aging, October 2008, mTOR signaling in mammalian health

and longevity.

American Aging Association Annual Meeting, June 2007, Calorie restriction and TOR signaling

converge on sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

Teaching Experience:

9/12-12/12 Instructor, Advanced Undergraduate Seminar, Massachusetts Institute of Technology

Supervisor: H. Robert Horvitz

9/03-12/03 Teaching Assistant, BCMP 200: Molecular Biology, Harvard Medical School

Instructors: Stephen Buratowski and Johannes Walter

Research Mentor to 3 undergraduate students and 1 graduate student

Feng Chen (Fall 2004 Spring 2006)

Joseph Torella (Summer 2005 Spring 2007)

Keyman Kim (Summer 2006 Summer 2007)

Mohammed Soliman (Summer 2011)

Research Support:

Completed Research Support:

F32AG032833-01A1 Dudley Lamming (PI) 12/1/08-11/30/11

NIH/NIA Ruth L. Kirschstein National Research Service Award (F32) Mammalian Target of Rapamycin

(mTOR) signaling in health and longevity. The goal of this project is to study mouse models of

decreased mTOR signaling to better understand the effects of mTOR signaling on health and longevity of

mammals. Role: PI

Mentor-Based Postdoctoral Fellow Award David Sabatini (PI) 11/01/11-03/31/12

American Diabetes Association mTOR signaling in the control of glucose homeostasis. Role:

Postdoctoral fellow

Ongoing Research Support:

Julie Martin Mid-Career Award in Aging David Sabatini (PI) 07/01/09-06/30/13

American Federation for Aging Research Mammalian Target of Rapamycin (mTOR) Signaling in Health

and Longevity. The goal of this project is to better understand the effects of decreased mTOR signaling

on mammalian health and aging. Role: Postdoctoral fellow

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