CURRICULUM VITAE

PERSONAL INFORMATION:

Name: Raphael Jay Witorsch

Born: December 12, 1941; New York City

Marital Status: Married; two children; two grandchildren

Contact Information:

Department of Physiology and Biophysics

Box 980551

School of Medicine

Medical College of Virginia

Virginia Commonwealth University

Richmond, Virginia 23298-0551

Business Phone: 804-***-****

Cell Phone: 804-***-****

e-mail: abpdfd@r.postjobfree.com

Web sites: www.witorsch.com/ray/

www.jurispro.com/RaphaelWitorsch

EDUCATION:

Yale University, New Haven, Conn., Ph.D. (Physiology), 1968

(Thesis: Evidence for acute ACTH release by extrahypothalamic mechanisms )

Yale University, New Haven, Conn., M.S. (Physiology), 1965

New York University, New York, N.Y., A.B. (Biology), 1963

POSTDOCTORAL TRAINING:

Postdoctoral Fellow in Physiology, 1968 - 1970

University of Virginia

Charlottesville, Virginia

ACADEMIC APPOINTMENTS:

Professor Emeritus of Physiology and Biophysics, 2010-present

School of Medicine

Medical College of Virginia

Virginia Commonwealth University

Richmond Virginia

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Professor of Physiology and Biophysics, 1988-2009

School of Medicine

Medical College of Virginia (MCV)

Virginia Commonwealth University (VCU)

Richmond, Virginia

Affiliate Professor of Dentistry (MCV\VCU), 1988-2009

Associate Professor of Physiology (MCV\VCU), 1979 - 1988

Assistant Professor of Physiology (MCV\VCU), 1970 - 1979

MEMBERSHIP - SCIENTIFIC, HONORARY AND PROFESSIONAL SOCIETIES:

Society of Toxicology

The Endocrine Society (Emeritus)

American Physiological Society (Emeritus)

Society for Experimental Biology and Medicine (Emeritus)

International Society for Regulatory Toxicology and Pharmacology (ISRTP)

Virginia Academy of Science

American Association for the Advancement of Science (inactive)

American Society of Andrology (inactive)

Histochemical Society (inactive)

Society of the Sigma Xi (inactive)

SPECIAL AWARDS, FELLOWSHIPS, AND OTHER HONORS:

Awards

Horace V. Stunkard Prize in Biology, New York University, 1963.

Beta Lambda Sigma, Biological Honor Society, New York University, 1963.

Delta Phi Alpha, National Honor Society for German Scholarship, 1963.

Zeta Beta Tau Fraternity, Gamma Chapter Award for Academic Achievement, New York

University, 1963.

Society of the Sigma Xi, University of Virginia, 1969.

NIH Postdoctoral Fellowship, 1969-1970.

Award for Excellence in Teaching by First Year Medical Class, MCV, 1971.

Award for Excellence in Teaching by Deans of Professional Schools, MCV, 1973.

Honorable Mention: Dr. Heinz Karger Prize Competition for an original research paper in the

area of "Cytological and histochemical approaches to the diagnosis of tumours," 1978.

Award for "Outstanding Contributions to Medical Education", First Year Medical Class, MCV,

1979.

Award for Teaching in Endocrine Course, First Year Medical Class, MCV, 1984.

Award for Best Professor of Reproduction, First Year Medical Class, MCV, 1985.

Award for Best Syllabus of the Year, First Year Medical Class, MCV, 1985.

Award for Best Professor of Endocrinology/Reproduction, First Year Medical Class, MCV,

1986.

Certificate of Appreciation in Recognition of Outstanding Service Given to the 1988 Metro

Richmond State Employees Combined Charitable Campaign, 1988.

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Acknowledgment from Endocrine Society for extra assistance with presentation of the 1989

Program and Meeting of the Society.

Faculty Member of the Year, Recognition Day Award, Physiology Graduate Student

Association, 1992-1993.

Outstanding Teacher Award for High Evaluation in M-1 Physiology Course (2001-2002), School

of Medicine, Medical College of Virginia of Virginia Commonwealth University.

Third Annual Stephen and Mary Krop Lectureship in Pharmacology, Georgetown University

Medical Center, Washington, D.C., 2002.

Outstanding Teacher Award in the Department of Physiology (2003), School of Medicine,

Medical College of Virginia of Virginia Commonwealth University.

Outstanding Teacher Award for High Evaluation in M-1 Physiology Course (2004-2005), School

of Medicine, Medical College of Virginia of Virginia Commonwealth University.

Outstanding Teacher Award for High Evaluation in M-1 Physiology Course (2006-2007), School

of Medicine, Medical College of Virginia of Virginia Commonwealth University.

Outstanding Teacher Award for High Evaluation in M-1 Physiology Course (2007-2008), School

of Medicine, Medical College of Virginia of Virginia Commonwealth University.

Outstanding Teacher Award for High Evaluation in M-1 Physiology Course (2008-2009), School

of Medicine, Medical College of Virginia of Virginia Commonwealth University.

Faculty Teaching Excellence Award, Virginia Commonwealth University School of Medicine,

2009. (School of Medicine s highest recognition for teaching).

Recognized for teaching accomplishments by the American Physiological Society as noted in the

following article: Tipton, CM: A section devoted to profiles of renown teachers and to

the recognition and accomplishments of physiology teachers within the society, Adv

Physiol Educ 34: 163-166, 2010.

Grants

Co-Investigator, "Biochemical Correlates with Human Breast Cancer"; NIH Grant CA-17116,

May, 1975 to April 30, 1978, $145,377.

Travel Grant from Endocrine Society to attend 58th Annual Meeting of Society in San Francisco,

June, 1976.

Travel Grant from Endocrine Society to attend VI International Congress of Endocrinology,

Melbourne, Australia, February 1980.

Principal Investigator, "Prolactin Binding in Human Breast and Prostate Cancers",

Developmental Grant from NIH to MCV Cancer Center, March 1, 1979 to March 30,

1980, $3,000.

Principal Investigator, "Prolactin Binding in Normal and Neoplastic Prostate", NIH Grant CA-

23653, August 1, 1978 to July 3l, 1981, $73,245 (Direct Costs).

Principal Investigator, "Prolactin Binding in Normal and Neoplastic Prostate", NIH Grant CA-

23653, August 1, 1981 to Dec. 30, 1985, $167,732 (Direct Costs).

Principal Investigator, "Effects of oral erythrosine (FDC Red Dye No. 3) on thyroid function in

man and rats." Contract sponsored by Tri-Valley Growers of California. September 1,

1984 to December 1, 1987, $44,714.

Principal Investigator, "The role of placental lactogen in alcohol-induced intrauterine growth

retardation." Grant from the Butler Fund of the Medical College of Virginia Foundation,

January 1, 1989 to December 31, 1989, $4,053.

Principal Investigator, "The role of placental lactogen in alcohol-induced intrauterine growth

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retardation," Jeffress Research Grant, Thomas F. Jeffress and Kate Miller Jeffress

Memorial Trust, Sovran Bank, N.A., January 1, 1989 to December 31, 1990, $52,750.

Principal Investigator, "Elucidation of the antilympholytic effect of prolactin," Gustavus and

Louise Pfeiffer Research Foundation, April 1, 1991 to March 31,1992, $33,186.

Principal Investigator, "Structure-function studies of prolactin proliferative and anticytolytic

actions," Virginia Commonwealth University Grants-in-Aid, July 1, 1992 to June 30,

1993, $7,000.

Principal Investigator, "The role of p53, bcl-2, and bax in the control of apoptosis of Nb2

lymphoma cells," Grant from the A.D. Williams Fund of the Medical College of

Virginia, April 1, 1996 to December 31, 1997, $10,000.

Principal Investigator, "Mechanisms of apoptosis and anti-apoptosis," Center for Alternatives to

Animal Testing (CAAT), Johns Hopkins University School of Hygiene and Public

Health, February 1, 1998 to January 30, 1999, $5,000.

Principal Investigator, "Hormonal modulation of p53, bcl-2, and bax and apoptosis control in

Nb2 lymphoma cells," Grant from Thomas F. Jeffress and Kate Miller Jeffress Memorial

Trust, NationsBank, N.A., July 1, 1996 to June 30, 2002, $30,000.

Principal Investigator, G-screen microassay for the identification of xenoglucocorticoids, Grant

from the Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust, Bank of America,

July 1, 2003 to June 30, 2012, $45,000.

Recipient, grant associated with 2009 Faculty Teaching Excellence Award for scholarship and

education development, $3,000.

Invited Seminars and Papers, Session Chairs

Invited speaker: Symposium on Hormone Receptor Immunocytochemistry, Twenty-ninth annual

meeting of the Histochemical Society, Vancouver, B.C., April, 1978.

Invited author: September, 1979 symposium issue on genitourinary disease in the journal,

"Human Pathology".

Invited speaker: Columbia University Reproductive Endocrinology Lecture Series, June, 1980.

Invited speaker: National Prostatic Cancer Project Workshop on the Prostatic Cell. Roswell Park

Memorial Institute, Buffalo, New York, March, 1981.

Invited speaker: National Prostatic Cancer Project Conference on Prostate Cancer. A Decade of

Progress and New Horizons. Bethesda, Maryland, January, 1984.

Invited speaker: Department of Anatomy, University of Minnesota, Minneapolis, Minnesota,

February 1984.

Invited speaker: Symposium on Male Reproductive Toxicology, "Use of gonadotropic hormones

and sex steroids in assessing male reproduction". Annual Meeting of the American

College of Toxicology, Fairfax, Virginia, November, 1985.

Invited speaker: "The use of gonadotropic hormone and gonadal steroids in the assessment of

male reproduction." Biology Department, James Madison University, Harrisonburg,

Virginia, January, 1986.

Invited author: "Prolactin Receptors". In Peptide Receptors, M. Kalimi and J. Hubbard, editors,

Walter de Gruyter & Co., 1987.

Invited speaker: "Environmental tobacco smoke and pulmonary function in children", Indoor Air

Pollution Advisory Group, Center for Environmental Health and Human Toxicology,

Washington, D.C., January 14, 1988.

Invited author: Immunohistochemical and biochemical studies of the prolactin-prostate

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interrelationship. In: Prolactin and Lesions in the Breast, Prostate and Uterus, H.

Nagasawa, editor, CRC Press, 1989.

Invited author: Review article entitled, "A critical analysis of the relationship between parental

smoking and pulmonary performance in children." Zeitschrift fur Das Offentliche

Gesundheitswesen, 1989.

Invited speaker: "Effects of environmental tobacco smoke on respiratory and cardiovascular

systems," Association for Research on Indoor Air, September 2, 1989, Hong Kong.

Invited speaker: "Parental smoking and respiratory health and pulmonary function in children: A

review of the literature and suggestions for future research," International Symposium on

Environmental Tobacco Smoke, McGill University, Montreal, Canada, November 4,

1989.

Invited author: Receptors, receptor regulation, membrane fluidity, and prolactin processing.

The Prostate as an Endocrine Gland. W.E. Farnsworth and R. Ablin, editors, CRC Press,

Inc. 1989.

Invited speaker: "Prolactin studies in prostate, mammary gland, and Nb2 lymphoma cells,"

Prolactin Gordon Conference, Oxnard, California, February 1, 1990.

Invited speaker: "Prolactin-glucocorticoid interactions on Nb2 lymphoma cells," R.W. Johnson

Pharmaceutical Research Institute, Raritan, New Jersey, November 30, 1990.

Invited speaker: "Prolactin-glucocorticoid interactions on Nb2 lymphoma cells,

"Neuropharmacology Branch, Department of Medical Neurosciences, Walter Reed Army

Institute of Research, Walter Reed Army Medical Center, Washington, D.C., March 15,

1991.

Invited speaker: "Apoptosis: Hormonal control and role in chemotherapeutic agent mediated

cytotoxicity," Population Council, Rockefeller University, New York, New York,

February 3, 1994.

Invited speaker: "Mechanisms of apoptosis and anti-apoptosis", Center for Alternatives to

Animal Testing (CAAT), Johns Hopkins University School of Hygiene and Public

Health, Baltimore, Maryland, February 25, 1998.

Session Chair, Apoptosis II, 37th Annual Meeting of the Society of Toxicology, Seattle,

Washington, March 3, 1998.

Invited speaker: Endocrine disruption - history, fact and fantasy of gender bending chemicals.

Third Annual Stephen and Mary Krop Lectureship in Pharmacology, Georgetown

University Medical Center, Washington, D.C., November 22, 2002.

Invited speaker: Physiological role and toxicological effects of glucocorticoids on

reproduction. Continuing Education Course The effects of non-reproductive

hormones on the reproductive system, and the implications for toxicology. Society of

Toxicology Annual Meeting, Salt Lake City, Utah, March 9, 2003.

Session Chair, Endocrine Disruptors, 45th Annual Meeting of the Society of Toxicology, San

Diego, California, March 8, 2006.

Invited speaker: "Is There a Place for a Physiologist in Toxicology. Student Day Symposium:

Life After Graduation: Stretching Your Degree to the Max. National Capital Area

Chapter, Society of Toxicology, Virginia Bio-Technology Research Park, Virginia

Commonwealth University, January 23, 2008.

Invited speaker: Keynote Presentation - "The Endocrine System: Overview and Some Issues to

Consider in Endocrine Disruption." Workshop: Conducting and Assessing the Results

of Endocrine Screening. International Society of Regulatory Toxicology and

Pharmacology (ISRTP), National Institutes of Health, Bethesda, Maryland, February 20,

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2008.

Visiting Professor of Physiology (13 lectures on endocrine/reproduction to first year medical

students), American University of the Caribbean (AUC), Cupecoy, St. Maarten,

Netherland Antilles, August 28 to September 19, 2009.

Invited speaker: Keynote Presentation - The Endocrine System. Overview and Its Relevance to

EDSP Screening. (video presentation). Workshop: The Endocrine Disruptor

Screening Program: What Can Screening Results Tell Us About Potential Adverse

Endocrine Effects? International Society of Regulatory Toxicology and Pharmacology

(ISRTP), National Institutes of Health, Bethesda, Maryland, September 9, 2009.

Invited speaker: Endocrine Disruption and Personal Care Products, Environmental Workshop,

2009 Sciences Symposium. Environmental Assessment for Personal Care Products,

Personal Care Products Council, Airport Marriott Hotel, Newark, New Jersey, October

29, 2009

Invited speaker: Endocrine Disruption and Personal Care Products, Workshop: Current Issues

in Safety Assessment, 2009 Sciences Symposium. Environmental Assessment for

Personal Care Products, Personal Care Products Council, Airport Marriott Hotel,

Newark, New Jersey, October 29, 2009.

Invited speaker: Can Tier 1 Test Data Inform Priority Setting for Human Health Risk

Assessment, Workshop on Scientific Methods for Evaluating EDSP Screening Data &

Estimating Dose-Response for Endocrine Disruption, Annual Meeting of the Society for

Risk Assessment, Renaissance Baltimore Harborplace Hotel, Baltimore, Maryland,

December 6, 2009.

Visiting Professor of Physiology (10 lectures on endocrine/reproduction to first year medical

students), Trinity University School of Medicine, St. Vincent, British West Indies,

January 25 to February 5, 2010.

Invited speaker: Endocrine Disruption and Personal Care Products, Webinar: Endocrine

Disruption and Personal Care Products-Science and Regulatory Developments,

Personal Care Products Council, July 21, 2010.

Invited speaker: Endocrine Disruption and Personal Care Products, Meeting of the

International Cooperation on Consensus Regulation (ICCR) for ICCR Regulators, Invited

Regulators, and Industry, Hilton Washington, DC/Rockville Hotel and Executive Center,

Rockville, Maryland, July 11, 2012.

MAJOR COMMITTEES:

University

M-I Endocrine Curriculum, 1970-1972, 1984-1987.

M-II Endocrine Curriculum, 1970-1971.

M-II Reproduction Curriculum, 1971-1972.

Biological Seminar, Physiology Department Representative, 1971-1972.

Faculty Senate Student Affairs Committee, 1971-1972.

Physiology Department Animal Care, 1971-1972.

Dental Physiology Course, Chairman, 1972-1974, 1980.

Adrenal Section, M-I Endocrine Curriculum, Chairman, 1972-1973.

Adrenal Section, Endocrine-Reproduction Curriculum, Chairman, 1973-1974.

Graduate Committees for several Ph.D. and M.S. candidates in Physiology, Pharmacology,

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Biochemistry, Anatomy, Microbiology, 1970-present.

Physiology Department Promotions and Tenure Committee, 1975-1976.

Coordinator Medical School Orientation Program for Virginia State College premedical

students, 1975-1976.

Steering Committee, School of Medicine Self-Study, MCV, 1976.

Physiology Department Professional Education Committee, 1975-1977.

Medical School Promotions Committee (non-voting member), 1974-1977.

M-I Reproduction Curriculum, 1977-1987.

School of Basic Sciences Committee on Committees, 1979-1982.

School of Dentistry Admissions Committee, 1979-1982.

School of Dentistry Class Committee, 1979-1980.

Tenure and/or Promotions Committees for several faculty members, 1978-present.

School of Basic Sciences Faculty Committee For Self Study, 1982-1983.

Graduate Course in Endocrine Physiology, Director, 1982, 1987, 1992.

Faculty Senate, 1983-1986.

Faculty Senate Committee on Academic Programs and Research, Chairman, 1983-1985.

University Radiation Safety Committee, Subcommittee on Research Use of

Radioisotopes, 1983-1984.

Search Committee for Chairman, Department of Physiology & Biophysics, MCV, 1985.

Judging Committee, 13th Annual John C. Forbes Graduate Students Honors Day, 1985.

University Grievance and Appeals Panel, 1985-1988.

Department of Physiology Committee on Core Curriculum, 1986-1989.

Department of Physiology Committee on Affiliate Appointments, 1986-1989.

American Cancer Society Institutional Grant Review Committee, 1986-1990.

Reproduction Subject Matter Committee, MI to MIV, 1987.

School of Basic Health Sciences Committee on Dental Curriculum, 1987-1995.

School of Basic Health Sciences, School Grievance and Appeals Board, 1989-1992 (acting chair,

1990).

Judging Committee, Kinloch Nelson Honors Day, School of Medicine, 1989.

School of Medicine Student Research Committee, Medical Class of 1993, 1989-1993.

School of Medicine Appeals Committee for Students, 1990-1993, Acting Chairman, 1991-1992.

Physiology Department Graduate Student Steering Committee, 1992-1994.

Physiology Department, Faculty Liaison with Chair, 1994-1996.

Physiology Department, Graduate Admissions Committee, 1974-1986, 1994-2008.

Physiology Department Seminar Series, Chairman, 1979; 1983-1984, 1991-1992, 1994-1995.

School of Medicine, Committee on Curriculum Renewal, Subcommittee on Women's Health,

1997.

School of Dentistry, Implementation Committee for Basic Science Curriculum for Dental

Residents, 1999-2009.

School of Medicine, Internal Review Committee, Department of Otolaryngology Residents

Programs, 2002.

School of Dentistry, D1 Class Committee, 2002-2009.

School of Dentistry, Academic Performance Committee, 2004-2009.

Department of Physiology and Biophysics, Executive Education Committee, 2008-2009.

Department of Physiology and Biophysics, Teaching Leadership Committee, 2008-2009.

School of Medicine Teaching Excellence Awards Selection Committee, 2010-2012.

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Professional

Ad Hoc Consultant, National Heart and Lung Institute Institutional Research Fellowship Grant

Application Review Committee, 1976.

Ad Hoc manuscript reviewer for Endocrinology, Endocrine Journal, Journal of the National

Cancer Institute, The Prostate, Journal of Histochemistry and Cytochemistry, Cancer

Research, Proceedings of the Society for Experimental Biology and Medicine, Science,

Journal of Andrology, Neuroendocrinology, Life Sciences, Food and Chemical

Toxicology., Experimental Cell Research, Hormone and Metabolic Research, Archives of

Biochemistry and Biophysics, Cellular and Molecular Biological Research, American

Journal of Respiratory Cell and Molecular Biology, Immunotoxicology, Agency for

Toxic Substances and Disease Registry (ATSDR). Molecular Carcinogenesis, Journal of

Toxicology and Environmental Health, Science World.

Ad Hoc book proposal reviewer for CRC Press, Wiley.

Ad Hoc Grant reviewer for National Science Foundation, National Prostatic Cancer Project,

National Institutes of Health, American Osteopathic Association, North Dakota

Experimental Program to Stimulate Competitive Research (EPSCoR), NationsBank

(Jeffress Memorial Trust), Department of Veterans Affairs, Agency for Toxic Substances

and Disease Registry (ATSDR) for Association of Minority Health Professions Schools,

Ohio Cancer Research Associates.

Special Study Section, National Institutes of Health, March 29, 1982.

Member, Indoor Air Pollution Advisory Group, Center for Environmental Health and Human

Toxicology, Washington, D.C., 1985-1988.

External Reviewer of Peer Review Panel Report entitled, "An Inquiry Into the Mechanism of

Action of FD&C Red No.3", submitted to the Commissioner of Food and Drug,

December, 1986.

Public Relations Committee, American Society of Andrology, 1985-1988.

Liason Committee, American Society of Andrology, 1987-1988.

Development Committee, Endocrine Society, 1987-1992.

Panel Member (Grant reviewer), Special Emphasis Panel (SEP), Role of Hormones and Growth

Factors in Prostate Cancer, RFA: DK-01-008, National Institute of Diabetes and

Digestive and Kidney Diseases, National Institutes of Health, August 23, 2001.

Editorial Board, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY

AND MEDICINE, 1990-1996.

Editorial Board, THE PROSTATE, 1986-2000.

Editorial Board, TOXIC SUBSTANCE MECHANISMS, 1996-2002.

Editorial Board, TOXIC MECHANISMS AND METHODS, 2002-present.

Allocations Committee, Jeffress and Gwathmey Memorial Trusts, Virginia Academy of Science

Representative, 2008-2011, Chair (2009).

Principal Editor, The Science World (TSW), Terrestrial Environmental Toxicology and TSW

Toxicology Cluster, 2009-present.

OTHER SIGNIFICANT SCHOLARLY RESEARCH OR ADMINISTRATIVE EXPERIENCE:

Graduate Students Trained

J. Travers Edwards, Jr., M.S., 1972

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(Thesis: The effects of prolactin and growth hormone on adrenal 5"-reductase in the

rat. ).

Jeanne P. Smith, M.S., 1977

(Thesis: An immunohistochemical localization of prolactin binding sites in rat ventral

prostate epithelia. ).

Robert S. Vick, Ph.D., 1986

(Thesis: Isolation and characterization of cleaved prolactin generated by target

tissue. ).

Vicky Lien Ying Wong, Ph.D., 1986

(Thesis: Proteolytic cleavage of prolactin by target tissues with special emphasis on rat

mammary gland. ).

Susan E. Fletcher, Ph.D., 1991

(Thesis: Prolactin-glucocorticoid interactions in Nb2 lymphoma cells. ).

Neda Hashemi, M.S., 1993

(Thesis: The role of apoptosis in mediation of antineoplastic agent-induced

cytotoxicity. ).

Holly Lavoie, Ph.D., 1994

(Thesis: Investigation of intracellular signals mediating the anti-apoptotic action of

prolactin in Nb2 lymphoma cells. ).

Angelo Guanzon, M.S., 1998

(Thesis: Immunocytochemical study of apoptosis signaling in Nb2 lymphoma cells. ).

Suhas Badarinath, M.S., 1999

(Thesis: Examination of signals involved in dexamethasone induced apoptosis in Nb2

lymphoma cells. ).

Devang Patel, M.S., 1999

(Thesis: Correlation of visualized glucocorticoid receptor and apoptosis in individual

clones of Nb2 cells. ).

Rhodaline Rebano, M.S., 2000

(Thesis: Hormonal control of apoptosis and signal expression in sublines of Nb2

lymphoma cells. ).

Charlotte Cockrell, M.S., 2000

(Thesis: Functional characterization of mitogen-dependent and self perpetuating Nb2

lymphoma cell lines. ).

Elizabeth Gannon, M.S., 2001

(Thesis: Modification and analysis of prolactin dependent and glucocorticoid sensitive

Nb2 lymphoma cells. ).

Gennifer Wiltshire, M.S. 2001

(Thesis: A comparative study of signal expression in Nb2 lymphoma sublines using

immunocytochemistry. ).

John Shurm, Jr. Ph.D. 2002

(Thesis: Identification of glucocorticoid receptor mediated interactions with non-

steroidal environmental chemicals ).

Christopher Jones, M.S., 2004

(Thesis: A microassay for the detection of glucocorticoid receptor activity in non-

steroidal chemicals ).

Postdoctoral Trainees

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Mark M. Compton, Ph.D., December, 1979 to August, 1983

Jitendra R. Dave, Ph.D., December, 1981 to October, 1983

Major Teaching Assignments

MI Endocrine-Reproduction, 1970-2011.

Physiology 502, Dental Physiology, 1970-2001 (Course Director 1972-1974, 1980).

Physiology 607 (617), Graduate Endocrine Physiology/Cell Signaling, 1982 - present (taught

Fall semester of alternate years), Course Director 1984, 1988, 1992, 1996, 2000.

Physiology 361, Nursing Pathophysiology, 1985-1990 (Director, 1987).

Physiology 461, Physiology for Physical Therapists, 1989-1993..

Physiology 505, Physiology for Industrial Hygienists 1988-1993.

Associate Coordinator, First Year Medical Curriculum, MCV, 1 974-1975.

Coordinator, First Year Medical Curriculum, MCV, 1975-1977.

Member of Ad Hoc Medical Curriculum Steering Committee acting in lieu of Dean of

Curriculum, MCV, 1975-1976.

Seminar in Physiology (Director, 1979, 1983-84, 1991-92, 1994).

Review for Medical Board Examinations, National Medical School Review, University of South

Florida, Tampa, Florida, May, 1994.

Physiology 502/506, Dental and Pharmacy Physiology, Course Director, 2002-2008.

Physiology 502, Dental Physiology, Course Director, 2009.

BIBLIOGRAPHY:

Papers published (in peer reviewed journals)

Witorsch, R.J. and A. Brodish: Conditions for the reliable use of lesioned rats for the assay of

CRF in tissue extracts. Endocrinology 90:552-557, 1972.

Witorsch, R.J. and A. Brodish: Evidence for acute ACTH release by extra-hypothalamic

mechanisms. Endocrinology 90:1160-1167, 1972.

Witorsch, R.J. and J.I. Kitay: Influence of the ovary, pituitary and age on adrenal 5 alpha-

reductase activity in the rat. Endocrinology 90:1374-1379, 1972.

Witorsch, R.J. and J.I. Kitay: Pituitary hormones affecting adrenal 5 alpha-reductase activity:

ACTH, prolactin and growth hormone. Endocrinology 91:764-769, 1972.

Leftwich, E.I., R.J. Witorsch and P. Witorsch: A critical evaluation of positive end-expiratory

pressure in refractory hypoxemia. Annals of Internal Medicine 79:187-193, 1973.

Colby, H.D., R.J. Witorsch, J.L. Caffrey and J.I. Kitay: Effects of steroid suppression and

gonadectomy on adrenal 5 alpha-reductase activity and corticosterone production in rats.

Acta Endocrinologica 74:568-575, 1973.

Poland, J.L., T.D. Myers, R.J. Witorsch and R.B. Brandt: Steroid influence on cardiac glycogen.

Proc Soc Exp Biol Med 150:148-150, 1975.

Witorsch, R.J. and J.T. Edwards: Comparison of effects of prolactin and growth hormone on

adrenal 5 alpha-reductase in hypophysectomized rats. Proc Soc Exp Biol Med 151:689-

693, 1976.

Nolin, J.M. and R.J. Witorsch: Detection of endogenous immunoreactive prolactin and rat

mammary epithelial cells during lactation. Endocrinology 99:949-958, 1976.

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Brown, P.W., R.J. Witorsch, W.L. Banks, Jr., and W. Lawrence: A convenient method for

freezing and storage of breast cancer tissue for estrogen receptor protein assay. Arch

Surg 112:183-185, 1977.

Witorsch, R.J. and J.P. Smith: Evidence for androgen-dependent intracellular binding of

prolactin in rat ventral prostate gland. Endocrinology 101:929-928, 1977.

Witorsch, R.J.: Immunohistochemical studies of prolactin binding in sex accessory organs of the

male rat. J Histochem Cytochem 26:565-580, 1978.

Witorsch, R.J.: Immunohistochemical demonstration of intracellular prolactin binding sites

(IPBS) in R3327 rat prostatic carcinomas. Hormone Res 10:268-281, 1979.

Witorsch, R.J.: The application of immunoperoxidase methodology for the visualization of

prolactin binding sites in human prostate tissue. Human Pathology 10:521-532, 1979.

Cohen, I.K., C.W. Moncure, R.J. Witorsch and R.F. Diegelmann: Collagen synthesis in capsules

surrounding dimethylbezanthracene-induced rat breast tumors and the effect of

pretreatment with beta-aminoproponitrile. Cancer Research 39:2923-2927, 1979.

Witorsch, R.J.: Evidence for human placental lactogen immunoreactivity in rat pars distalis. J

Histochem Cytochem 28:1-9, 1980.

Witorsch, R.J: Evaluation of immunoperoxidase stained tissue sections with an electrophoresis

densitometer. J. Histochem Cytochem 30:179-182, 1982.

Witorsch, R.J.: Regional variations in the testicular dependence of prolactin binding and its

possible relationship to castration-induced involution in rat prostate gland. The Prostate

3:459-473, 1982.

Dave, J.R. and R.J. Witorsch: Increased detection of prolactin binding of rat ventral prostate

after treatment with dextran-coated charcoal: Evidence for a direct dihydrotestosterone-

prolactin interaction. Endocrinology. 111:2144-2146, 1982.

Dave, J.R. and R.J. Witorsch: Indomethacin decreases both prolactin binding and membrane

fluidity of ventral and dorso-lateral lobes of rat prostate gland. The Prostate, 4:119-128,

1983.

Compton, M.M. and R.J. Witorsch: Proteolytic fragmentation of rat prolactin by the ventral

prostate gland. The Prostate 4: 231-246, 1983.

Dave J.R. and R.J. Witorsch: Modulation of prolactin binding sites in vitro membrane fluidizers.

I. Effects on adult rat ventral prostatic membranes. Biochem Biophys Res

Communications 113:220-228, 1983.

Dave J.R. and R.J. Witorsch: Indomethacin decreases both luteinizing hormone binding and

fluidity of testicular microsomal membranes in rat. Prostaglandins, Leukotrienes and

Medicine 12:371-380, 1983.

Dave, J.R. and R.J. Witorsch: Modulation of prolactin binding sites in vitro by membrane

fluidizers. II. Age-dependent effects in rat ventral prostatic membranes. Biochim.

Biophys. Acta, 772:321-327, 1984.

Abbey, L.M. and R.J. Witorsch: Prolactin binding in normal minor salivary gland tissue. An

immunohistochemical study. Oral Surgery, Oral Medicine, and Oral Pathology. 58:682-

687, 1984.

Compton, M.M. and R.J. Witorsch: Proteolytic degradation and modification of rat prolactin by

subcellular fractions of the rat ventral prostate gland. Endocrinology, 115:476-484, 1984.

Dave, J.R. and R.J. Witorsch: Prolactin increases serum lipid fluidity and prolactin binding and

lipid fluidity of rat prostatic membranes. American J Physiol 248 (Endocrinol. Metab.

11): E687-E693, 1985.

Abbey, L.M. and R.J. Witorsch, Prolactin binding in minor salivary gland tumors. Oral Surgery,

11

Oral Medicine, and Oral Pathology 60:44-49, 1985.

Dave, J.R., R.J. Witorsch and M.Y. Kalimi: Endocrine mediated parallel changes in hepatic

glucocorticoid and prolactin receptors. Biochim Biophys Acta 845:276-282, 1985.

Dave, J.R., R.J. Krieg, Jr., and R.J. Witorsch: Modulation of prolactin binding sites in vitro by

membrane fluidizers. III. Effects on male prostatic and female hepatic membrane in

alcohol-fed rats. Biochim Biophys Acta 816: 313-320, 1985.

Witorsch, R.J., R.S. Vick, L.M. Abbey and M.J. Wilson: A systematic study of age-dependent

changes in prostatic morphology and prolactin binding of ACI rats. The Prostate 7:327-

344, 1985.

Dave, J.R. and R.J. Witorsch: Modulation of prolactin binding sites in vitro by membrane

fluidizers. IV. Differential effects on plasma membrane and Golgi fractions of male

prostate and female liver in the rat. Biochem Biophys Res Commun134: 1122-1128,

1986.

Wong, V.L.Y., M.M. Compton, and R.J. Witorsch: Proteolytic modification of rat prolactin by

subcellular fractions of the lactating rat mammary gland. Biochim Biophys Acta 81: 167-

174, 1986.

Vick, R.S., V. Wong, and R.J. Witorsch: Biological, immunological, and biochemical

characterization of cleaved prolactin generated by lactating mammary gland. Biochim.

Biophys. Acta. 931: 196-204, 1987.

Gardner, D.F., R.D. Utiger, S.L. Schwartz, P. Witorsch, Meyers, B., L.E. Braverman, and R.J.

Witorsch: Effects of Oral Erythrosine (2',4',5',7'-Tetraiodofluorescein) on thyroid

function in normal men. Toxicology and Applied Pharmacology 91: 299-304, 1987.

Witorsch, R.J.: Moderate alcohol consumption and increased incidence of breast cancer in

women. New England J. Med. 317: 1288, 1987 (letter to the editor).

Paul, T., B. Meyers, R.J. Witorsch, S. Pino, S. Chipkin, S.H. Ingbar, and L.E. Braverman: The

effect of small increases in dietary iodine on thyroid function in euthyroid subjects.

Metabolism 37: 121-124, 1988.

Witorsch, R.J., and P. Witorsch: A critical analysis of the relationship between parental smoking

and pulmonary performance in children. Zeitschrift fur Das Offentliche

Gesundheitswesen. 51: 78-83, 1989.

Jennings, A.S., S.L. Schwartz, P. Witorsch,, D.F. Gardner, and R.J. Witorsch: Effects of oral

erythrosine (2',4',5',7'-tetraiodofluorescein) on the pituitary-thyroid axis in rats.

Toxicology and Applied Pharmacology. 103: 549-556, 1990.

Hood, R.D., J.M. Wu, R.J. Witorsch, and P. Witorsch: Environmental tobacco smoke exposure

and respiratory health in children: An updated critical review and analysis of the

epidemiological literature. Indoor Environment 1: 9-35, 1992.

Witorsch, P., and R.J. Witorsch, Analysis of potential confounding variables in epidemiologic

studies of parental/household smoking and respiratory health in pre-school children.

Indoor Environment 2: 71-91, 1993.

Fletcher-Chiappini, S.E., M.M. Compton, H.A. LaVoie, E.B. Day, and R.J. Witorsch:

Glucocorticoid-prolactin interactions in Nb2 lymphoma cells: Antiproliferative versus

anticytolytic effects. Proc. Soc. Exptl. Biol. Med. 202: 345-352, 1993.

Witorsch, R.J.. E.B. Day, H.A. LaVoie, N. Hashemi, and J.K. Taylor: Comparison of

glucocorticoid - induced effects in prolactin dependent and autonomous rat Nb2

lymphoma cells. Proc. Soc. Exptl. Biol. Med. 203: 454-460, 1993.

LaVoie, H.A. and R.J. Witorsch: Investigation of intracellular signals mediating the anti-

apoptotic action of prolactin in Nb2 lymphoma cells. Proc. Soc. Exptl. Biol. 209: 257-

12

269, 1995.

Witorsch, R..J.: Toxic effects on the seminiferous epithelium and Sertoli cell. Toxic Substance

Mechanisms 15: 195-218, 1996 (review).

Witorsch R..J. and P. Witorsch: Environmental tobacco smoke and birthweight of offspring: A

critical review and analysis of the epidemiological literature. Indoor + Built Environment

5:219-231, 1996.

Witorsch R..J.: Letter to the Editor (Prolactin, anti-angiogenesis, and the prostate) The Prostate

34: 302, 1998.

Witorsch R..J. and P. Witorsch: Environmental tobacco smoke and respiratory health in children:

A critical review and analysis of the literature from 1969 to 1998. Indoor + Built

Environment 9: 246-264, 2000.

Witorsch R..J.: Endocrine disruption: a critical review of environmental estrogens from a

mechanistic perspective. Toxic Substance Mechanisms 19: 53-78, 2000.

Witorsch R..J..: Low dose in utero effects of xenoestrogens in mice and their relevance to

humans: an analytical review of the literature. Food and Chemical Toxicology 40: 905-

912, 2002.

Witorsch R.J.: Endocrine disruptors: Can biological effects and environmental risks be

predicted? Regulatory Toxicology and Pharmacology 36: 118-130, 2002.

Borgert, C.J., J.S. Lakind, and R.J. Witorsch.: A critical review of methods for comparing

estrogenic activity of endogenous and exogenous chemicals in human milk and infant

formula. Environmental Health Perspectives 111: 102*-****-****.

Cooke, P.S., D.R. Holsberger, R.J. Witorsch, P.W. Sylvester, J.M. Meredith, K.A. Treinen, and

R.E. Chapin, Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology,

reproduction, and toxicology. Toxicology and Applied Pharmacology.194: 309-335,

2004.

Goodman, J.E., E.E. McConnell, I.G. Sipes, R.J. Witorsch, T.M. Slayton, C.J. Yu, A.S. Lewis,

L.R. Rhomberg: An updated weight of the evidence evaluation of reproductive and

developmental effects of low doses of bisphenol A. Critical Reviews in Toxicology 36:

387-457, 2006.

Goodman,, J.E., R.J. Witorsch, E.E. McConnell, I.G. Sipes, T.M. Slayton, C.J. Yu A.M. Franz,

L.R. Rhomberg. Weight-of-evidence evaluation of reproductive and developmental

effects of low doses of bisphenol A: 2008 update. Critical Reviews in Toxicology 39: 1-

75, 2009.

Witorsch, R.J. and J.A. Thomas. Personal care products and endocrine disruption: A critical

review of the literature. Critical Reviews in Toxicology 40(S3): 1-30, 2010

(doi:10.3109/10408444.2010.515563). Listed among 2010 s most viewed toxicology

articles at informhealthcare.com.

Abstracts

Witorsch, R.J., A. Brodish: Hypothalamic CRF assayed in rats with hypothalamic lesions. Fed.

Proc. 27:217, 1968.

Witorsch, R.J.: Evidence for acute ACTH release by extrahypothalamic mechanisms. Ph.D.

Thesis, Yale University, 1968. Diss. Abst. (b) 30(2):826, 1969.

Witorsch, R.J. J.I. Kitay: Influence of the ovary, ACTH, and age on adrenal 5 alpha-reductase in

the rat. Fed. Proc. 29:707, 1970.

Witorsch, R.J. and J.I. Kitay: Inhibitory effect of prolactin on adrenal 5 alpha-reductase in the

13

rat. Excerpta Med. Internat. Cong. Series 210:170, 1970.

Myers, T.D., J.L. Poland, R.J. Witorsch, R.B. Brandt: Steroid influence on cardiac glycogen.

Virginia J. Science, Vol. 2, 1974.

Nolin, J.M., R.J. Witorsch: Endogenous prolactin (PRL) enters mammary alveolar cells. Fed.

Proc. 35:219, 1976.

Witorsch, R.J., J.P. Smith, J.M. Nolin: Evidence for androgen-dependent intracellular binding of

prolactin in rat ventral prostate gland. Proc. 58th Ann. Mtg., Endo. Soc.:66, 1976.

Witorsch, R.J.: Immunohistochemical demonstration of prolactin binding sites in some sex

accessory organs of the male rat. Proc. 59th Ann. Mtg. Endo. Soc.:281, 1977.

Maher, R.W., R.J. Witorsch: Evidence for prolactin binding in epithelial cells of rat epididymis

and vas deferens. Fed. Proc. 37:381, 1978.

Witorsch, R.J.: Prolactin binding in R3327 rat prostatic carcinoma cells. Fed. Proc. 37:897,

1978.

Witorsch, R.J.: Immunohistochemical studies of prolactin binding in male sex accessory organs.

Proc. 29th Ann. Mtg. Histochem. Soc.: S8, 1978.

Witorsch, R.J: Prolactin binding in normal and neoplastic prostate. Prostatic Cancer Newsletter

6:1-2, 1979.

Witorsch, R.J.: Histological evidence of human placental lactogen immunoreactivity in rat

pituitary gland. Proc. 61st Ann. Mtg. Endo. Soc. 223, 1979.

Witorsch, R.J., A.T. Robertson, A.C. Lord: Regional variations in prolactin binding activity and

its androgen dependence in rat prostate gland. Proc. 62nd Ann. Mtg. Endo. Soc.: 252,

1980.

Witorsch, R.J.: Prolactin binding in normal and neoplastic prostate. Prostatic Cancer Newsletter

7:4-5, 1980.

Witorsch, R.J.: Immunohistochemical evidence that Golgi-localized prolactin binding sites in rat

ventral prostate are specific hormone receptors. 63rd Ann. Mtg. Endo. Soc.:220, 1981.

Compton, M.M., R.J. Witorsch: Alteration of prolactin immunoactivity in rat prostate gland.

63rd Ann. Mtg. Endo. Soc.:352, 1981.

Witorsch, R.J.: Prolactin binding in normal and neoplastic prostate. Prostatic Cancer Newsletter

8:1, 1981.

Compton, M.M., R.J. Witorsch: Proteolytic fragmentation of prolactin by the rat ventral prostate

gland. 64th Ann. Mtg. Endo. Soc.:361, 1982.

Dave, J.R., R.S. Vick, R.J. Witorsch: Indomethacin decreases both prolactin binding and fluidity

of rat ventral and dorso-lateral prostate. 8th Meeting of the American Society of

Andrology. J. Androl. 49, 1983.

Vick, R.S., J.R. Dave, R.J. Witorsch: Studies on immunohistology of prolactin binding sites and

morphology of ventral prostates of rats treated with indomethacin. 8th Meeting of the

American Society of Andrology. J. Androl. 4:35, 1983.

Dave, J.R., R.J. Witorsch: Indomethacin decreases both luteinizing hormone binding and

fluidity of testicular microsomal membranes in rat. Abstracts of Cancer Research

Seminar, Virginia Division of American Cancer Society. Abstract #39, 1983.

Abbey, L.M., R.J. Witorsch, J.C. Burns: Immunohistochemical demonstration or prolactin

binding activity in normal human minor salivary glands. 37th Annual Meeting of the

American Academy of Oral Pathology. Abstract # 22, 1983.

Compton, M.M., R.J. Witorsch: Peptide fragment generation from rat prolactin by lysosomal

fractions of rat ventral prostate gland and other tissues. 65th Ann. Mtg. Endo. Soc.:1109,

1983.

14

Dave, J.R., R.J. Witorsch: Prostatic prolactin binding sites in rat are increased by membrane

fluidizers. 65th Ann. Mtg. Endo. Soc.:795, 1983.

Vick, R.J., J.R. Dave, R.J. Witorsch: Quantitative immunohistochemistry of prolactin binding

sites in ventral prostate of rats treated with indomethacin. Virginia J. Science. Abstract

#7, 1983.

Dave, J.R., R.J. Witorsch: Age-dependent changes in prolactin binding and lipid microviscosity

of rat prostatic membranes. Annual Meeting of the Aging Association. Abstract #59,

1983.

Witorsch, R., R. Vick, M. Wilson: Age-dependent changes in histology and prolactin binding in

ventral prostates of AXC rats. Annual Meeting of Aging Association. Abstract #60,

1983.

Dave, J.R., R.J. Witorsch: Prolactin increases serum lipid fluidity and prolactin binding of rat

prostatic membranes. 9th Meeting of the American Society of Andrology. J. Androl.

4:P-16, 1984.

Dave, J.R., R.S. Krieg., R.J. Witorsch: Alcohol ingestion decreases both lipid fluidity and

prolactin binding capacity of male prostatic and female hepatic membrane in the rat.

Second Congress of International Society of Biomedical Research on Alcoholism.

Alcoholism: Clinical and Experimental Research 8:87, 1984.

Abbey, L, R.J. Witorsch.: Prolactin binding in benign and malignant minor salivary gland

neoplasms. 38th Meeting of the American Academy of Oral Pathology. Abstract #29,

1984.

Wong, V.L.Y., M.M. Compton, R.J. Witorsch: Proteolytic modification of prolactin by lactating

rat mammary gland. 67th Ann. Mtg. Endo. Soc.:177, 1985.

Gardner, D.F., R.D. Utiger, S.L. Schwartz, R.J. Witorsch: Effects of oral erythrosine (2', 4', 5', 7'

- tetraiodofluorescein) on thyroid function in normal men. 67th Ann. Mtg. Endo.

Soc.:720, 1985.

Meyers, B., D. Gardner, R. Witorsch, S. Ingbar, L. Braverman: A small increase in dietary iodine

affects thyroid function in euthyroid subjects. Clin Res. 34: 429, 1986.

Vick, R., V. Wong, R. Witorsch: Receptor binding and proliferative activity of target-tissue

generated cleaved prolactin. 68th Ann. Mtg. Endo. Soc. 123, 1986.

Jennings, A.S., S.L. Schwartz, D.F. Gardner, P.Witorsch, R.J. Witorsch: Effects of oral

erythrosine on the pituitary-thyroid axis in rats. 69th Ann. Mtg. Endo. Soc.: 810, 1987.

Fletcher, S., M.Y. Kalimi, R.J. Witorsch: Prolactin-glucocorticoid interactions in Nb2 lymphoma

cells, Virginia J. Sciences 40: 92, 1989.

Fletcher, S., R.J. Witorsch: Glucocorticoid-prolactin interactions in Nb2 lymphoma cells. 72nd

Ann. Mtg. Endo. Soc.: 84, 1990.

Wu, J., R. Witorsch, P. Witorsch: Respiratory effects of socioeconomic status, gas stove usage,

and other environmental factors in children: An analytical survey of the literature.

Abstracts and program of the Fourth International Conference on the combined effects of

environmental factors (ICCEF '90): 31, 1990.

Hood, R.D., J.M. Wu, R.J. Witorsch, P. Witorsch: Environmental tobacco smoke exposure and

respiratory health in children: An updated critical review and analysis of the

epidemiological literature. Abstracts of the International Conference on Priorities for

Indoor Air Research and Action, Montreux, Switzerland, May 29-32, 1991, Indoor

Environment 1: 46, 1992

Witorsch, R.J., J.M. Wu, R. Hood, P. Witorsch: A protocol for the analysis of confounding

variables in epidemiological studies of the respiratory system: Its use in studies of

15

parental smoking effects. Abstracts of the International Conference on Priorities for

Indoor Air Research and Action, Montreux, Switzerland, May 29-32, 1991, Indoor

Environment 1: 47, 1992.

Witorsch, R.J., J.M. Wu, R.D. Hood, P. Witorsch: Further analyses of the role of confounding

variables in epidemiologic studies of ITS and the respiratory system of school-age

children. Proceedings of the International Symposium on Indoor Air Quality in Asia,

Bangkok, Thailand, November 28-29, 1991.

Witorsch, P., R.J. Witorsch: Analysis of potential confounding variables in epidemiologic

studies of ITS effects in pre-school children. Proceedings of the International Conference

on Indoor Air Quality and Ventilation, Athens, Greece, April 27-28, 1992.

Lu R., Y. Shafogoj, R. Witorsch, M. Kalimi: Potent cannabinoid CP-55,940 inhibits proliferation

and enhances lysis of Nb2 lymphoma cells. FASEB J 6: A 1305, 1992.

Witorsch, R.J., E.B. Day, H.A. Lavoie, J.K. Taylor: Studies of dexamethasone effects in a

hormone-independent clone of Nb2 cells. 74th Ann. Mtg Endo. Soc. 317, 1992.

LaVoie, H.A.. R.J. Witorsch: Investigation of intracellular signals mediating the anti-cytolytic

action of prolactin in Nb2 lymphoma cells. 75th Mtg. Endo. Soc. 358, 1993.

LaVoie, H.A., R..J. Witorsch: Pervanadate inhibits dexamethasone-induced apoptosis in

prolactin-dependent Nb2 lymphoma cells. 76th Mtg. Endo. Soc. 642, 1994.

Witorsch, R..J., Demonstration of selected pro- and anti-apoptotic signals in Nb2 rat lymphoma

cells (37th Annual Meeting of the Society of Toxicology). Toxicological Sciences 42

(Number 1-S), 186, 1998.

Graham, M, A. Willey, J. Zhu, .J. Schreher, R. Witorsch, H. Sugerman: Glucocorticoid receptor

characteristics, nuclear translocation & molecular effects in human intestinal smooth

muscle (HISM) cells. Gastroenterology 114: PA97, 1998.

Guanzon, A.P., R.J. Witorsch: Visualization of intracellular signals before and during

dexamethasone-induced apoptosis of Nb2 rat lymphoma cells (38th Annual Meeting of

the Society of Toxicology). Toxicological Sciences 48 (Number 1-S), 153, 1999.

Borgert, C.J., R.J. Witorsch, L. McCarty, L., Do 'estrogen equivalents' make sense for risk

assessment? (42nd Annual Meeting of the Society of Toxicology) Toxicological

Sciences 72 (Number 1-S), 137, 2003.

Witorsch, R.J., J.K. Taylor, C.S. Jones: Microassay for the detection of glucocorticoid

agonist/antagonist activity in environmental chemicals.(45th Annual Meeting of the

Society of Toxicology). The Toxicologist, Supplement to Toxicological Sciences: 90: 399,

2006.

Rhomberg, L.R., J.F. Goodman, E.E. McConnell, I.Sipes, R.J. Witorsch, T.M Slayton, C.J. Yu,

A.S. Lewis. An updated weight of evidence evaluation of reproductive and

developmental effects of low doses of Bisphenol A. (46th Annual Meeting of the Society

of Toxicology). The Toxicologist, Supplement to Toxicological Sciences 96: 427, 2007.

Witorsch, R.J.: Amplification of glucocorticoid-induced cytotoxicity of Nb2 lymphoma cells by

resveratrol: Evidence for a novel mode of action for potential endocrine disruptors. (48th

Annual Meeting of the Society of Toxicology). The Toxicologist, Supplement to

Toxicological Sciences 108: Abstract No.144, 2009.

Books, Chapters, Magazine Articles

Witorsch, R.J.: Visualization of prolactin binding sites in prostate tissue. In: The Prostatic Cell.

Eds. G.P. Murphy, A.A. Sandberg and J.P. Karr. Alan R. Liss, Inc., New York, pp 89-

16

113, 1981.

Witorsch, R.J.: Use of gonadotropic hormones and sex steroids in assessing male reproduction. J.

Amer. College of Toxicol. 5: 235-247, 1986.

Witorsch, R.J., J.R. Dave, R.A. Adler: Prolactin Receptors: The status of knowledge and

current concepts concerning the mechanism of action of prolactin. In: Peptide Hormone

Receptors. Eds. M. Y. Kalimi and J.R. Hubbard, Walter de Gruyter and Co., Berlin. pp

63-127, 1987.

Witorsch, R.J., P. Witorsch: Maternal smoking and pulmonary performance in children: a critical

analysis. In: Proceedings of the 4th International Conference on Indoor Air Quality and

Climate, Volume 2. Eds. B. Seifert, H. Esdoorn, M. Fischer, H. Ruden, and J. Wegner,

Institute for Water, Soil, and Air Hygiene, Berlin. 175-179, 1987.

Hubbard, J.R., M.Y. Kalimi, R.J. Witorsch: Review of Endocrinology and Reproduction,

Renaissance Press, Richmond, 1988 (Textbook).

Witorsch, R.J., Immunohistochemical and biochemical studies of the prolactin-prostate

interrelationship. In: Prolactin and Lesions in the Breast, Prostate and Uterus, Ed. H.

Nagasawa, CRC Press, Inc., Boca Raton. pp 197-221, 1989.

Dave, J.R., R.S. Vick, V.L.Y. Wong, R.J. Witorsch: Chapter 7: Studies of prolactin-prostate

interactions: Receptors, receptor regulation, membrane fluidity, and prolactin processing.

In: The Prostate as an Endocrine Gland, Eds. W.E. Farnsworth and R. Ablin, CRC Press

Inc., Boca Raton. pp 97-119, 1990.

Witorsch, R.J.: Parental smoking and respiratory health and pulmonary function in children: A

review of the literature and suggestions for future research, Proceedings of the

International Symposium on Environmental Tobacco Smoke at McGill University 1989.

Ecobichon, D.J., Wu, J.M. (eds.), Lexington Books, Lexington, pp 206-226, 1990.

Witorsch, R.J.: Panel discussion on reproductive effects of environmental tobacco smoke.

Proceedings of the International Symposium on Environmental Tobacco Smoke at

McGill University 1989. Ecobichon, D.J., Wu, J.M. (eds.), Lexington Books, Lexington,

pp 284-286, 1990.

Witorsch, P., R. Witorsch: Chapter IV. Respiratory effects of ITS other than cancer. In: Other

People's Tobacco Smoke: Environmental, Social, and Health Issues. Armitage, A.T.

(ed.), Galen Press, London, pp 53-79, 1991.

Wu, J., R. Witorsch, P. Witorsch: Respiratory effects of socioeconomic status, gas stove usage,

and other environmental factors in children: An analytical survey of the literature.

Proceedings of the Fourth International Conference on the Combined Effects of

Environmental Factors. Published jointly by: The Department of Environmental Health

Sciences and the Environmental Health Sciences Center of the Johns Hopkins University

School of Hygiene and Public Health, Baltimore, pp 29-43, 1991.

Witorsch, R.J., J.M. Wu, R.D. Hood, P. Witorsch: Further analyses of the role of confounding

variables in epidemiologic studies of ETS and the respiratory system of school-age

children. Proceedings of the International Symposium on Indoor Air Quality in Asia.

Reverente Jun, B.R., Weetman, D.F., Wongphanich, M. (eds.), Indoor Air International,

The International Association for Indoor Air Quality, Rothenfluh, pp 313-360, 1993.

Witorsch, R.J. (ed.): Reproductive Toxicology, Second Edition. Target Organ Toxicology

Series, Hayes A.W., Thomas, J.A., and Gardner, D.E., Eds., Raven Press New York,

1995.

Sundaram, K., R.J. Witorsch: Toxic effects on the testes. In: Reproductive Toxicology,

Second Edition. Witorsch, R.J. (ed.) Target Organ Toxicology Series, Hayes A.W.,

17

Thomas, J.A., and Gardner, D.E., Eds., Raven Press New York, pp 99-121,1995.

Witorsch, R.J., M.Y. Kalimi, J.R. Hubbard: Reproductive toxic effects of alcohol, tobacco, and

substance abuse. In: Reproductive Toxicology, Second Edition. Witorsch, R.J. (ed.)

Target Organ Toxicology Series, Hayes A.W., Thomas, J.A., and Gardner, D.E., Eds.,

Raven Press New York, pp 283-318, 1995.

Shafogoj Y., R. Witorsch, M. Sholley, W. Regelson, M. Kalimi: Dehydroepiandrosterone-

dexamethasone interactions on Nb2 lymphoma cell proliferation.

Dehydroepiandrosterone (DHEA), Kalimi, M., Regelson, W. (eds.), Walter de Gruyter

GmbH&Co KG, Berlin, pp 407-418, 1999.

Witorsch, R.J., Endocrine disruption - history, fact and fantasy of gender bending chemicals.

Update, Food and Drug Law Institute, Issue 6, November/December, pp. 32-34, 2002 .

Witorsch, R.J. Hormone replacement therapy: clinical trials and controversy. Update, Food and

Drug Law Institute, Issue 3, May/June, pp. 44-47, 2003.

Technical reports

Witorsch, R.J., A.S. Jennings, S.L. Schwartz: Effects of Dietary FD&C Red No. 3 on the

pituitary-thyroid axis of adult male rats. Submitted to FDA, November, 1984.

Witorsch, R.J., D.F. Gardner, L.E. Braverman, S.L. Schwartz: Effect of oral erythrosine on

thyroid function in normal men. Submitted to FDA, April, 1985.

Witorsch, R.J., D.F. Gardner, L.E. Braverman, S.L. Schwartz: Supplemental report on studies of

the effects of erythrosine on thyroid function in normal men: Effect of low doses of

iodide on thyroid function in normal men. Submitted to FDA, July, 1985.

Other

My immunohistochemical approach to the study of hormone receptors was discussed (including

photomicrographs) in the second and third editions of "Immunocytochemistry" by L.A.

Sternberger, John Wiley and Sons, New York, 1979, 1986.

Participant: Training Workshop on Hybridomas and Monoclonal Antibodies, Medical College of

Virginia, April 6-7, 1984.

Panelist: Panel discussion by outstanding lecturers on "The Faculty as Teachers"; Orientation

for New Faculty, MCV/VCU School of Medicine, September 18, 1984.

Member: MCV Cancer Center, 1986-1990.

Organizing committee: Prolactin and Immune Function Working Group, February, 1990.

Consultant/expert witness on general and endocrine physiologic and reproductive abnormalities

that may result from potential environment health hazards. Consultation has been given

with regard to the following issues: effects of agent orange, trichloroethylene,

polychlorobiphenyls (PCBs) and related compounds, perflourocarbons (PFCs), ethylene

oxide, formaldehyde, environmental tobacco smoke, alcohol; Red Dye No. 3 and thyroid

function; polydimethylsiloxanes (silicones) and breast cancer; oral contraceptives and

cerebrovascular effects; estrogens, alcohol, and breast cancer; bisphenol A and endocrine

18

disruption; arsenic toxicity, statins, anabolic steroids.

I have been quoted with regard to endocrine disruption in the following articles:

Tea bone stakes. David Adam. 7 April 2000. Nature. Science Update.

(http://www.nature.com/news/2000/000407/full/news000413-1.html)

BPA Addendum: Witorsch questions human relevance of low dose research on mice.

Cites major differences in hormone levels during pregnancy.. George Lawton.

Endocrine/Estrogen Letter. Vol 9. No.5. 2003 (Available as pdf on request)

Q&A with RJ Witorsch on BPA Report George Lawton. Endocrine/Estrogen Letter

Vol. 9, No. 6, 2003. (Available as pdf on request)

A cause without a disease. Holger Breithaupt. EMBO (European Molecular Biology

Organization) Reports Vol. 5, No. 1.16-18, 2004.

(http://www.nature.com/embor/journal/v5/n1/full/7400063.html)

(Updated July 12, 2012)

19

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