Joseph W. Carl, Jr.
**** ********* **, ******, ******** 20723
Telephone 614-***-**** E-mail: ******.*.****.**@*****.***
OBJECTIVE
To utilize my signal processing engineering skills in a system biology field that aids in
understanding of immunological signal pathways.
RELATED EXPERIENCE
Lab bench skills
Flow cytometry (4 color intracellular and extracellular), Immunological staining
(H&E, Fast Blue), Immuno-fluorescent staining (DAPI, Widefield, confocal), mouse
husbandry (breeding, weaning, tail vein injection, CNS and immunological
dissection), T and B cell proliferation assays, autoimmune disease model s (EAE,
Sjogren s), adoptive transfer, PCR, RT-PCR, gel electroporisis, Western, EMSA,
ELISA, blood sugar monitoring.
Technology skills
C#, C, C++, UNIX, HTML, Windows (NT, 95, 3.1), JAVA (1.0, 1.1), JAVAScript, Mac,
OS2, Access Database, TCP/IP socket, FrontPage, CIP Automation Protocol,
Ethernet/IP Protocol.
ENGINEERING
Designed and wrote a visual C# program to capture and analyze water
consumption electronically via an Analog to Digital converter and automatically
count how often a mouse licks a water bottle during the onset of Sj gren s
Syndrome. Designed and wrote industry-wide conformance tests distributed
throughout the United States, Europe and Japan. Participated in the
specification development and documentation for quality control protocol
standards. Designed and wrote real-time code to operate control systems,
fingerprint identification systems, satellite imagery systems. Designed a real-time
"C" software program using the VMEexec development system, boot code,
timers, interrupts and command host communication.
Designed PC, VME, and special systems circuit boards using Programmable Logic
Devices. These circuit boards were the target for software implementing
fingerprint identification, mug shot processing, meteorological data processing,
memory manipulation. Designed a semiconductor chip implementing a digital
decimation filter for Harris Semiconductor Division.
EMPLOYMENT HISTORY
National Institute of Health: NIDCR, Bethesda, Maryland
Post Doctoral, October 2008 Present
THE OHIO STATE UNIVERSITY: MVIMG, Columbus, Ohio
Post Doctoral, September 2008 October 2008
THE OHIO STATE UNIVERSITY: IBGP, Columbus, Ohio
Graduate Research Associate, June 2004 September 2008
ROCKWELL AUTOMATION: Allen-Bradley Division, Mayfield Heights, Ohio
Senior Systems Test Engineer, October 1997 June 2004
DIEBOLD INCORPORATED: Interbold Division, North Canton, Ohio
Senior Systems Engineer, November 1994 September 1997
HARRIS CORPORATION: Government Information Systems Division, Melbourne, Florida
Lead Engineer, January 1992 November 1994
Senior Engineer, September 1987 January 1992
Joseph W. Carl, Jr.
EDUCATION
PhD: Doctor of Philosophy
Integrated Biological Graduate Program (IBGP)
The Ohio State University, COLUMBUS (July 2004 May 2008)
Dissertation: On the Role of CD24 in the Pathogenicity of Myelin Antigen Specific T
Cells
Advisor: Xue-Feng Bai Lab (September 2005 May 2008)
MSEE: Master of Science in Electrical Engineering
Thesis: Autoregressive Modeling Techniques for Radar Target Identification
The Ohio State University, COLUMBUS (1986 1987)
BSEE: Bachelor of Science in Electrical Engineering
The Ohio State University RSITY, COLUMBUS (1982 1986)
TEACHING EXPERIENCE
Graduate Teaching Associate, Bioinformatics, Winter Quarter 2007
IBGP 705 Bioinformatics Applied to Human Disease
Graduate Teaching Associate, Bioinformatics, Winter Quarter 2006
IBGP 705 Bioinformatics Applied to Human Disease
Mentoring Student Interns Summer 2010
AFFILIATIONS, COMMITTEES AND SERVICE
The American Association of Immunologists, 2007 - Present
Vice President Bennett Society (Student Medical Research Association), 2006
President Bennett Society, 2005
Treasurer Bennett Society, 2004
Tau Beta Pi (Engineering Honor Society), Lifetime Member
Research Day Undergraduate luncheon, 2006, 2007
Ohio State Science Fair Judge, 2005, 2006, 2007
American Go Association, National Tournament Coordinator, 2003-2004
PUBLICATIONS, HONORS AND AWARDS
1. Shujun Liu, Francesca Madiai, Jianhua Yu, Christopher Hickey, Joseph Carl, Carl Allen,
Chris Karafilov, Alan Litsky, Emily Huschart, Guido Marcucci, Sarandeep Huja, and Lai-Chu
Wu (2010) The large zinc finger protein ZAS3 is a key mediator of osteoclastogenesis in adult
bone development, The Journal of biological Chemistry (In Review)
2. Selected oral presentation NIDCR Fellows Retreat 2010, J.W. Carl, Jr., John Chiorini,
Monitoring the Progression of Sj gren s Syndrome through the Measurement of Drinking
Behavior
3. 84th Annual Meeting of the American Association of Neuropathologists, April 2008 Abhik
Ray-Chaudhury, Joseph W. Carl Jr. CD24 inhibits demyelination in a mouse cuprizone-
demyelination model. Abstract # 708.8
4. Carl JW Jr, Bai XF (2008), (Review) IL27: Its Roles in the Induction and Inhibition of
Inflammation, Int J Clin Exp Pathol 1(2):117-123.
5. Liu JQ, Carl JW Jr, Joshi PS, RayChaudhury A, Pu XA, Shi FD, Bai XF (2007), CD24 on the
Resident Cells of the Central Nervous System Enhances Experimental Autoimmune
Encephalomyelitis, The Journal of Immunology 178(10):6227-35.
6. Carl JW Jr., Liu JQ, Joshi P, Yin L, Zhen X, Whitacre CC, Liu Y, Bai XF (2008), Autoreactive T
Cells Escape Clonal Deletion in the Thymus by a CD24-Dependent Pathway, The Journal of
Immunology 181:320-328.
7. Selected oral presentation 94th Annual Meeting of the AAI May 2007, J.W. Carl, Jr., P.
Joshi, C.C. Whitacre, Y. Liu and X-F. Bai, CD24 Inhibits Thymic Deletion of Myelin Antigen-
Specific T cells. Abstract # 178: 129.34
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Joseph W. Carl, Jr.
REFERENCES
Gabor Geza Illei, MD
NIDCR (National Institute of Dental and Craniofacial Research)
Molecular Physiology & Therapeutics (MPTB)
10 Center Dr, Bldg 10 room 1N110
Bethesda MD 20892-1190
******@*****.***.***
John A Chiorini, PhD
NIDCR (National Institute of Dental and Craniofacial Research)
Molecular Physiology & Therapeutics (MPTB)
10 Center Dr, Bldg 10 room 1N110
Bethesda MD 20892-1190
*********@***.*****.***.***
Lai-Chu Wu, PhD
Department of Internal Medicine
The Ohio State University
480 Medical Center Drive
Columbus, OH 43210
******.**@*****.***
Xue-Feng Bai, PhD
Pathology Department
The Ohio State University
168 Hamilton Hall
1645 Neil Ave
Columbus, OH 43210
***-*@******.***.***
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